Monireh Khordadmehr

Monireh Khordadmehr
University of Tabriz · Department of Pathobiology

DVSc

About

69
Publications
7,352
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456
Citations
Citations since 2017
49 Research Items
386 Citations
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
Introduction
Monireh Khordadmehr currently works at the pathobiology, School of Veterinary Medicine, University of Tabriz, Iran. Monireh does research in Pathology, Oncology, Parasitology. Their current project is 'pathology'.

Publications

Publications (69)
Article
Pigeons are common birds around the world and may act as intermediate hosts of the tissue cyst-forming apicomplexan parasites Toxoplasma gondii, Neospora caninum and Sacrocystis spp. This study aimed to provide an overview on the prevalence of and exposure to these parasites in Iranian domestic rock pigeon (Columba livia domestica) through molecula...
Article
There are few reports of ectopic fasciolosis in lungs of ruminants. Here we report a rare case of ectopic pulmonary migration of Fasciola sp. in a water buffalo (Bubalus bubalis). In October 2021, during routine veterinary inspection of carcass and edible offal of a 3-year-old female buffalo in Tabriz industrial slaughterhouse, a severe liver infec...
Article
Background: MicroRNAs (miRNAs) can play essential roles in the modulation of cancer cell growth, survival, and resistance to chemotherapy. Thus, we hypothesized that restoration of miR-451a-5p (a tumor suppressor) might affect sensitivity to chemotherapeutics in breast cancer cells. Methods: For this purpose, malignant breast cancer cells (MDA-MB-2...
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Full-text available
Article history: Breast cancer (BC) is a significant cause of global mortality in women. This study was aimed to evaluate the immune-activation of malignant BC via the administration of attenuated Mycobacterium obuense. For this purpose, an in vivo model was developed with BALB/c mice. Mice were injected with 2.00 × 10 6 4T1 cells with breast tumor...
Preprint
Full-text available
MicroRNAs (miRNAs) are a class of small non-coding RNAs of 21–25 nucleotides in length and display an essential role in regulating cancer initiation, development, and progression. In this study, the impacts of microRNA-451a-5p and miR-34a-5p (tumor suppressors), individually and combined, transfections were conducted on the apoptosis, proliferation...
Article
Purpose of the study: Ambient air pollution (AAP) has become an important health problem globally. Besides, several pieces of evidence indicate that air pollutants such as sulfur dioxide (SO2) and ozone (O3) are major contributors to a wide range of non-communicable diseases. The present study investigated the effects of AAP, sulfur dioxide, and o...
Article
Pupose: MicroRNAs (miRNAs) can contribute to cancer initiation, development, and progression. In this study, the effect of miRNA-4800 restoration on the growth and migration inhibition of human breast cancer (BC) cells was investigated. Methods: For this purpose, transfection of miR-4800 was performed into MDA-MB-231 BC cells using jetPEI. Subseque...
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Sulfur dioxide (SO2) is a ubiquitous air pollutant. Recent studies suggest that SO2 is a momentous risk factor for diabetes mellitus (DM). The present investigation aimed to evaluate the effects of SO2 exposure on histopathology and morphometry of pancreatic islet cells and serum glycemic indices in rats. Sixteen male Wistar rats were divided equal...
Article
MicroRNAs (miRNAs) are known as a group of short noncoding ribonucleic acids (ncRNAs). Mainly, they can manage gene expression at the posttranscriptional level in the essential biological and physiological functions. Significantly, more than 50% of the discovered miRNAs genes are placed in cancer‐related genomic regions, which can act as oncomiR or...
Article
Objective Hard-to-heal wounds, such as pressure ulcers and diabetic ulcers, are a major challenge for wound dressings. The aim of this study was to develop a bioactive dressing based on polymers and natural materials with unique biological and therapeutic properties. Method The dressing was composed of an active layer containing polyvinyl alcohol...
Article
Vaccination against dog–sheep transmission cycle is necessary to control cystic echinococcosis (CE) infection. A multi-epitope multi-antigenic recombinant vaccine was developed–comprising the three putative vaccine antigens EG95, Eg14-3-3 and EgEnolase–was cloned and expressed. In a pilot experiment, the multi-antigen vaccine was assessed in 15 dog...
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Background and objectives: Tsukamurella species are Gram-positive rods that exist in a broad range of environments. In this study, the efficacy of heat-killed Tsukamurella inchonensis on growth performance, intestinal morphology, and humoral immune responses of broiler chicken was evaluated. Materials and methods: Ross broiler chicks in the cage...
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Capillaria hepatica (syn. Calodium hepaticum) is a globally distributed nematode with a high affinity to the liver of a wide range of mammalian hosts, including humans. Documented reports of the nematode in cats and associated histopathology are rare. Here, we describe a case of C. hepatica infection in a 5-year-old male stray cat from Iran. At pos...
Article
Aflatoxins have been known as an important cause of animal disease for 30 years. The toxins occur naturally on animal feeds either in the field or during storage when moisture content and temperatures are sufficiently high for mould growth. The present paper describes clinical signs besides of gross and histopathological features of aflatoxicosis i...
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Background: Recent evidence presented the significant role of the microRNA-193 (miR-193) family in biological processes by the contribution of specific targeting, which mainly display as a tumor suppressor in various cancers. In the present study, we evaluated the effect of miR-193a-5p replacement on some metastasis gene expression in metastatic br...
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Purpose: Recent evidence presented the important role of microRNAs in health and disease particularly in human cancers. Among those, miR-193 family contributes as a tumor suppressor in different benign and malignant cancers like breast cancer (BC) via interaction with specific targets. On the other hand, it was stated that miR-193 is able to modula...
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Full-text available
Purpose: Type 1 diabetes mellitus (T1DM) has dramatically increased in recent years, especially in young people, and limits the life quality of the patients involved. Thus, many researchers are performing extensive studies to find alternative treatments for DM. Methods: Here, we evaluated the improvement effects of the heat-killed Actinomycetales...
Article
Cryptosporidiosis acutely impacts the digestive and/or respiratory tract of the birds in many species of various orders. More importantly, it is also well known as a significant zoonotic disease, which can lead to diarrhea in humans and livestock. Regarding increasing demand for free-range products and increasing the number of free-range poultry fa...
Article
A Rho-associated coiled-coil kinase (ROCK) is identified as a critical downstream effector of GTPase RhoA which contains two isoforms, ROCK1 (also known as p160ROCK and ROKβ) and ROCK2 (also known as Rho-kinase and ROKα), the gene of which is placed on chromosomes 18 (18q11.1) and 2 (2p24), respectively. ROCKs have a principal function in the gener...
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Hodgkin’s disease is a malignant lymphoproliferative disease with various gross morphology. The present paper reports gross and microscopic features of Hodgkinʼs-like lymphoma in a dog. An eight years-old dog was presented to our hospital due to complete blindness associated with the presence of proliferative tissue on the globe surface. The tissue...
Article
Mammary tumours are mentioned as the most common tumours in female dogs and approximately half of them are detected malignant. p53 gene mutations are demonstrated to be the most common genetic alteration in canine mammary tumours. The present study was conducted to evaluate exon-1 of p53 gene mutations in tissue samples of canine mammary tumours by...
Article
Background Infection with the protozoan parasite Toxoplasma gondii is widely prevalent in animals and humans. In goats and sheep this infection has a high economic impact as it causes abortions and lamb losses. Although there are several studies reporting seroprevalence in small ruminants in Iran, molecular-based information is scarce. Purpose Thi...
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Background: This study evaluated the possible protective effects of Gordonia bronchialis (Gb) on oxidative stress and some subsequent alterations on testis from rats undergoing an experimentally induced type 1 diabetes. Methods: A total of 40 male rats were randomly divided into four groups of ten. Diabetes was induced by injection of 55 mg/kg stre...
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Background: Hepatotoxicity—the most important side effect of the Methotrexate (MTX)—seems to relate to the generation of reactive oxygen species. Pomegranate has high anti-oxidant capacities. We studied if MTX-induced hepatotoxicity can be protected by pomegranate peel and seed methanolic extracts (PPE and PSE) in rats. Methods: Forty-eight Wistar...
Article
Objectives Enteropathy is one of the most important complications of diabetes mellitus. The present study determined the possible effects of Tsukamurella inchonensis (Ti) on diabetes enteropathy on rat small intestine. Materials and methods A total of 40 rats were divided into four groups of 10. Diabetes was induced by streptozotocin. Oral adminis...
Article
MicroRNAs (miRNAs) are proposed as a family of short noncoding molecules able to manage and control the expression of the gene targets at the posttranscriptional level. They contribute in several fundamental physiological mechanisms as well as a verity of human and animal diseases such as cancer progression. Among these tiny RNAs, miR‐451 placed on...
Article
microRNAs (miRNAs) are known as a large group of short noncoding RNAs, which structurally consist of 19–22 nucleotides in length and functionally act as one of the main regulators of gene expression in important biological and physiological contexts like cell growth, apoptosis, proliferation, differentiation, movement (cell motility), and angiogene...
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Full-text available
Cornelian cherry (Cornus mas) is a valuable source of phenolic antioxidants. The present study was aimed to investigate whether Cornus mas fruit hydro-methanolic extract (CMFE) can modulate the cisplatin-induced changes in liver antioxidant enzymes and histological structure. Forty Wistar rats were divided into a control group, cisplatin (Cis) grou...
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Abstract Objective- This study investigated the effect of amlodipine on intestinal ischemia-reperfusion injury in rats Design-Experimental study Animals-Fifteen male Sprague-Dawly rats weighing 200-220g Procedure- Rats were randomly divided into 3 groups: IR group (operation with clamping), sham group (operation without clamping), and IRA group (op...
Article
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Pancreatic cancer (PC) is mentioned as one of the fourth major cause of cancer-related deaths and also is considered as one of the most malignancies worldwide. Sadly, widely metastasis is frequently observed at the time of PC detection and there are, thereby, almost poor prognosis and ineffective treatment in PC patients. microRNAs (miRNAs), a grou...
Article
microRNAs (miRNAs) are a family of small noncoding RNAs that play a pivotal role in the regulation of main biological and physiological processes, including cell cycle regulation, proliferation, differentiation, apoptosis, stem cell maintenance, and organ development. Dysregulation of these tiny molecules has been related to different human disease...
Article
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Background: Cisplatin (Cis) is a chemotherapeutic agent and nephrotoxicity is a serious adverse effect of the drug. This study investigated the protective effects of Cornus mas fruit hydro-methanolic extract (CME) on cisplatin-induced nephrotoxicity in a rat model. Methods: Forty Wistar rats were divided into the control group, CME group, CME 300 +...
Article
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Introduction Nerium oleander is a plant of the Apocynaceae family toxic to humans, animals, and insects. This study was performed to determine the cardiac and neurotoxicity of the plant extract by oral administration in Wistar rats and Balb/c mice and to compare the susceptibility of these animal models to oleander toxicity. Material and Methods F...
Article
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Hadjelia truncata belongs to the family Habronematidae which affects different groups of birds such as Columbiformes. A large number of Sarcocystis sp. may infect birds as intermediate hosts, but wild Columbiformes, include pigeons, are rarely affected. The present study describes mixed infection of two pigeon flocks with sarcocystosis and nematodi...
Article
Full-text available
Introduction:Nerium oleander is a plant of the Apocynaceae family toxic to humans, animals, and insects. This study was performed to determine the cardiac and neurotoxicity of the plant extract by oral administration in Wistar rats and Balb/c mice and to compare the susceptibility of these animal models to oleander toxicity. Material and Methods: F...
Preprint
Full-text available
Mammary tumours are mentioned as the most common tumours in female dogs and approximately half of them are detected malignant. p53 gene mutations are demonstrated to be the most common genetic alteration in canine mammary tumours. The present study was conducted to evaluate exon-1 of p53 gene mutations in tissue samples of canine mammary tumours by...
Article
Full-text available
Most of the neoplastic diseases affecting poultry have a viral etiology, such as Marek’s disease, avian leukosis/sarcoma and reticuloendotheliosis. In the present paper, histopathology and molecular methods were performed, in addition of necropsy and gross morphology evaluation, for the differential diagnosis of these diseases in two green peafowls...
Article
Full-text available
Introduction: One of the post-surgical complications is contact dermatitis caused by several factors such as scrub solution, suture materials, bandages and even surgical gloves. Conventional treatment for this problem is the use of corticosteroids that may cause undesirable side-effects. Curcumin is the active component of turmeric that have known...
Article
Objective is a member of the Method The present paper was carried out to compare the toxic effect of oral administration of Results Significant differences were observed in the level of the ALT, AST, BUN and creatinine. Interestingly, the biochemical changes were more severe in AST in rats compared with mice (15–16 and 4–5 times compared to contr...
Article
Background and aim: Diabetic nephropathy results from an increasing in oxidative stress. The phenolic components of mulberry (Morus nigra L.) leaves extract have antioxidant components and may modulate oxidative stress. In this study, the beneficial effects of mulberry leaves extract were assessed in diabetic nephropathy. Materials and methods: Dia...
Article
Full-text available
In the present study, the efficacy of Verbascum speciosum on growth performance, gastrointestinal structure, immune and biochemical parameters in rainbow trout were evaluated. Verbascum speciosum was supplemented at 40 (low dose group), 250 (medium dose group), and 500 (high dose group) mg kg-1 diet and fed to fish (~9.7 g initially) for 55 days. V...
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The subgroup J avian leukosis virus favors the myelocytic series cells and causes myeloid leukosis (myeloblastosis and myelocytomatosis). Natural cases of myeloblastosis (myeloblastic myeloid leukosis) are uncommon and usually occur in adult chickens. This paper describes clinical signs and gross and histopathologic features of myeloblastosis in an...
Article
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Pyrrolizidine alkaloids (PAs) are natural phytotoxins found in thousands of plant species around the world. They are probably the most common poisonous plants affecting livestock, wildlife and humans. The disease occurs almost entirely as a consequence of chronic poisoning and in general ends fatally. In the present study, PAs poisoning was investi...
Article
Macroscopic and histopathologic lesions of the integumentary system were studied in 105 camels slaughtered in the central part of Iran. The gross appearance of lesions, particularly in cross section, was studied comparatively. Gross lesions consisted of focal-multifocal skin thickening with or without hair loss and crust formation, ulcerative lesio...
Article
Neospora caninum is a coccidian protozoan parasite which is a major cause of bovine abortions and neonatal mortality in cattle, sheep, goat and horse. Occasionally, cultured cells are used for isolation and multiplication of the agent in vitro with several purposes. In this study the tachyzoite yields of N. caninum were compared in various cell cul...
Article
In this study the tachyzoite yields of Neospora caninum were compared in two cell lines: Vero (African Green Monkey Kidney) and suspension culture of murine macrophage (J774) cell lines. Then, N. caninum were continuously passaged in these cell lines for 3months and the effect of host cells on virulence of tachyzoites was assessed by broiler chicke...
Article
Full-text available
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Article
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may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety toOJVR.Thi...
Article
Full-text available
Neospora caninum is a cyst-forming coccidian parasite, which is highly pathogenic for cows and dogs. Determination of parasite virulence has been applied in the development of live vaccines against protozoan parasites. In this sense, we wanted to determine whether chicken embryonated egg could be an animal model to show different virulence of N. ca...
Article
Full-text available
During postslaughter inspection of a 4-year-old male dromedary camel (Camelus dromedarius), numerous small nodules to large masses up to 4 cm in diameter were found on the serosal surfaces of forestomachs, large intestines, mesentery, liver, and spleen. Grossly, the masses were discrete, round, smooth, and white to gray that bulged from the serosal...
Data
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Blood samples were randomly collected from 110 (40 male and 70 female) 20-week-old healthy ring-necked pheasants (Phasianus colchicus), and serum bio-chemical parameters were investigated. Significant differ-ences in serum total protein, cholesterol, creatinine, total bilirubin, and alkaline phosphatase (ALP) activity were found among both males an...
Article
Gross and histopathologic lesions of the integumentary system were studied in 103 camels (Camelus dromedarius) slaughtered in Yazd Province of Iran. Dermatophilosis was diagnosed in 14 (13.6%) of the studied camels. Grossly, patchy thickening of the skin with dark brown scabs or crusts were observed on the rump, flanks, abdomen, shoulders, and neck...
Article
Four Sarcocystis species, i.e., Sarcocystis fusiformis and Sarcocystis buffalonis with cats as definitive hosts, Sarcocystis levinei with dogs as definitive host, and Sarcocystis dubeyi with unknown definitive host, have previously been described from water buffalo (Bubalus bubalis). The aim of the present study was genetic characterization of the...
Article
Full-text available
Blood samples were randomly collected from 88 female and 143 male sixteen-week-old healthy Iranian chukar partridges (Alectoris chukar), and serum biochemical parameters were measured. Inorganic phosphorous, creatinine and total bilirubin showed significant differences between male and female birds. No significant sex-based differences were observe...
Article
Linguatula serrata is a cosmopolitan zoonotic parasite with its adult form occurring in the nasal and respiratory passages of canids as the definitive hosts, while its immature stages localize in the mesenteric lymph nodes, liver, spleen, lungs, and, rarely, in other organs, such as the ocular region of herbivorous intermediate hosts. Humans can be...
Article
A total of 103 camels of different ages and both sexes slaughtered at Yazd slaughterhouse of Iran were inspected and out of these 6 had infection with Onchocerca fasciata. Grossly, one or multiple nodules about 2-4 cm in diameter containing the worm were observed in subcutaneous tissues of neck and less frequently, in the head and shoulders. Histop...

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Archived project
This review will discuss the immunotherapy approaches, particularly immune checkpoints and T cell therapy, which are the most common clinical applications in cancer immunotherapy.