Monique Mendelson

• PhD
• Maître de conférences at Grenoble Alpes University

To develop a simplified magnetic resonance imaging method (MRI) to assess total adipose tissue (AT) and adipose tissue free mass (ATFM) from three single MRI slices in people with overweight/obesity in order to implement body composition follow-up in a clinical research setting. Body composition of 310 participants (70 women and 240 men, age: 50.8...

Introduction Continuous positive airway pressure (CPAP) is the first line therapy for obstructive sleep apnea (OSA). CPAP is highly effective for improving symptoms and quality of life but the major issue is adherence, with up to 50% of OSA discontinuing CPAP in the first 3 years after CPAP initiation. Areas covered We present the individual and s...

Background Obstructive sleep apnea syndrome is a common sleep-breathing disorder associated with adverse health outcomes including excessive daytime sleepiness, impaired quality of life and is well-established as a cardiovascular risk factor. Continuous positive airway pressure is the reference treatment, but its cardiovascular and metabolic benefi...

Over recent years positive airway pressure (PAP) remote monitoring has transformed the management of obstructive sleep apnea and produced a large amount of data. Accumulated PAP data provide valuable and objective information regarding patient treatment adherence and efficiency. However, the majority of studies analyzing longitudinal PAP remote mon...

High altitude exposes humans to hypobaric hypoxia, which induces various physiological and molecular changes. Recent studies point toward interaction between circadian rhythms and the hypoxic response, yet their human relevance is lacking. Here, we examine the effect of different high altitudes in conjunction with time of day on human whole-blood t...

Rationale: Continuous positive airway pressure (CPAP), the first line therapy for obstructive sleep apnea (OSA), is considered effective in reducing daytime sleepiness. Its efficacy relies on adequate adherence, often defined as >4 hours per night. However, this binary threshold may limit our understanding of the causal effect of CPAP adherence an...

Objectif Les essais cliniques randomisés sont la référence pour mettre en évidence une relation causale. Une alternative reconnue est l’utilisation des données observationnelles pour se rapprocher des conditions d’une randomisation. L’objectif est d’introduire les approches causales pour données observationnelle en considérant plusieurs traitements...

Background Considering the potential greater cardiocirculatory effects of high intensity interval training (HIIT), we hypothesized that a 2-month supervised a high volume short interval HIIT would induce greater improvements in CRF and cardiometabolic risk and increase long-term maintenance compared to isocaloric moderate intensity continuous train...

The aim of this study was to assess the impact of the nationwide total lockdown (LD) in France on weight loss and body composition modifications in subjects participating in a weight loss program and to evaluate the impact of remote consultations on participants’ adherence to the weight loss program. The CO-RNPC study was a prospective multicentre...

Continuous positive airway pressure (CPAP) is the most efficient treatment of obstructive sleep apnea (OSA). Little is known about the impact of spousal relationship profiles on CPAP adherence. We aimed to identify clusters of couples of OSA patients, and their association with CPAP adherence 120 days after CPAP initiation. In a multicenter prospec...

Study objectives: Sleep apnea (SA) is prevalent among patients with coronary artery disease (CAD) and increases cardiovascular risk. A previous study showed that 1 month of cardiac rehabilitation (CR) reduced severity of SA in patients with CAD by reducing fluid accumulation in the legs during the day and the amount of fluid shifting rostrally int...

Objective: Obstructive sleep apnea (OSA) syndrome is one of the most frequent chronic diseases in the general population. The nocturnal rostral fluid shift is accepted as a key mechanism in OSA pathogenesis in medical conditions associated with fluid overload. The main objective of this study was to assess the prevalence of OSA in patients with ly...

Diagnosis of sleep apnea (SA) using simple tools has the potential to improve the efficacy of cardiac implants in the prevention of cardiac arrhythmias. The aim of the present study was to validate a transthoracic impedance sensor for SA diagnosis in patients with cardiac implants. We compared the apnea-hypopnea index (AHI) obtained from polysomnog...

Study objectives: Snoring is perceived to be directly proportional to sleep apnea severity, especially obstructive sleep apnea (OSA), but this notion has not been thoroughly and objectively evaluated, despite its popularity in clinical practice. This might lead to overdiagnosis or underdiagnosis of OSA. The goal of this study is to examine this no...

Maximal aerobic capacity is a strong health predictor and peak oxygen consumption ( V ′ O 2 peak ) is considered a reflection of total body health. No systematic reviews or meta-analyses to date have synthesised the existing data regarding V ′ O 2 peak in patients with obstructive sleep apnoea (OSA). A systematic review of English and French articl...

A systematic review of English and French articles using Pubmed/Medline and Embase included studies assessing objective physical activity levels of obstructive sleep apnea (OSA) patients and exploring the effects of exercise training on OSA severity, body mass index (BMI), sleepiness, and cardiorespiratory fitness [peak oxygen consumption (VO2peak)...

Funnel spot for studies reporting steps per day.

Background/objectives Physical activity is promoted in patients with sleep disorders and obesity. The aim of the present study was to assess physiological factors influencing objectively measured spontaneous physical activity in already treated patients for obstructive sleep apnea (OSA) by nocturnal continuous positive airway pressure (CPAP). Subje...

Purpose: Obstructive sleep apnea (OSA) is prevalent in patients with cardiovascular disease and is often undiagnosed. The purpose of this study was to determine the utility of communicating OSA risk with the patients in a diabetes and cardiac rehabilitation program (CRP) and primary care physicians. Methods: Following an OSA education session, 2...

Overnight fluid shift from the legs to the neck and lungs may contribute to the pathogenesis of obstructive sleep apnoea (OSA) and central sleep apnoea (CSA). We hypothesised that exercise training will decrease the severity of OSA and CSA in patients with coronary artery disease (CAD) by decreasing daytime leg fluid accumulation and overnight rost...

To examine the role of ventilatory constraint on cardiorespiratory fitness in obese adolescents. Thirty obese adolescents performed a maximal incremental cycling exercise and were divided into two groups based on maximal oxygen uptake (VO2peak): a group presenting low (L; n=15; VO2peak: 72.9±8.6 % predicted) or normal (N; n=15; VO2peak: 113.6±19.2%...

Decreased sleep duration and altered sleep quality are risk factors for obesity in youth. Structured exercise training has been shown to increase sleep duration and improve sleep quality. This study aimed at evaluating the impact of exercise training for improving sleep duration, sleep quality and physical activity in obese adolescents (OB). Twenty...

Study objectives: Obstructive sleep apnea (OSA) has been associated with hypertension, which is one of the intermediary mechanisms leading to increased cardiovascular morbidity. This study aimed at evaluating the effects of a combination of continuous positive airway pressure (CPAP) and telemedicine support on blood pressure (BP) reduction in high...

Background Exercise training has been shown to improve cardiometabolic health in obese adolescents. Objectives Evaluate the impact of a 12-week exercise-training programme (without caloric restriction) on obese adolescents' cardiometabolic and vascular risk profiles. Methods We measured systemic markers of oxidation, inflammation, metabolic variabl...

L'obésité est associée à une morbidité cardiovasculaire et métabolique accrue. La littérature récente souligne l'importance du sommeil comme élément contributif de l'obésité. En effet, cette relation est bidirectionnelle : le sommeil peut participer à la pathogenèse de l'obésité et cette dernière joue également un rôle étiologique dans le développe...

Reçu le 4 décembre 2012 – Accepté le 8 mai 2012 Résumé. Le lipoxmax correspondàcorrespondà l'intensité d'exercice pour laquelle l'oxydation des lipides est maximale. Cet indice métabolique est déterminé par calorimétrie lors d'uné epreuve d'effort progressive. Le lipoxmax peutêtrepeutêtre utilisé comme cible d'entraˆınemententraˆınement dans différ...

Obstructive Sleep Apnea (OSA) is associated with cardiovascular morbidity including hypertension. Beyond the severity of nocturnal hypoxia, others factors such as metabolic abnormalities but also sedentary behaviors and insufficient physical activity may contribute to elevated blood pressure (BP). To clarify the respective role of these factors as...

L’activité physique est un adjuvant important dans la prise en charge de la personne obèse. Toutefois, l’obésité est souvent associée à une intolérance à l’effort. L’objectif de cet article didactique est de clarifier les facteurs respiratoires, cardiovasculaires, métaboliques et ostéo-articulaires qui contribuent à l’intolérance à l’effort de la p...

L’activité physique régulière constitue une modalité importante de la prise en charge de l’obésité en participant à la diminution de la morbidité cardio-vasculaire et métabolique. Cet article didactique se focalise sur les effets bénéfiques de la pratique d’une activité physique dans la prise en charge de l’obésité sur le plan physiopathologique. L...

The aim of this study was to examine ventilatory responses to training in obese adolescents. We assessed body composition, pulmonary function and ventilatory responses (among which expiratory flow limitation and operational lung volumes) during progressive cycling exercise in 16 obese adolescents (OB) before and after 12 weeks of exercise training...

To verify whether exercise intensities at the crossover point (COP) and maximal lipid oxidation (Lipox(max)) can be used interchangeably regardless of exercise mode, this study compared COP, Lipox(max) and maximal fat oxidation rate (MFO) obtained during two modes of submaximal metabolic exercise tests: stationary cycling under laboratory condition...

During a maximal incremental ergocycle test, the power output associated with Respiratory Exchange Ratio equal to 1.00 (RER = 1.00) predicts maximal lactate steady state (MLSS). We hypothesised that these results are transferable for runners on the field. Fourteen runners performed a maximal progressive test, to assess the speed associated with RER...