Monika Trzpis-Bremer

Monika Trzpis-Bremer
University of Groningen | RUG · Anorectal Physiology Laboratory Groningen

PhD

About

48
Publications
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Introduction
Monika Trzpis-Bremer currently works at the Anorectal Physiology Laboratory Groningen, University of Groningen. Monika does research in Human Biology.

Publications

Publications (48)
Article
Hemorrhoids are common anorectal pathology, with high recurrence rates after surgical treatment. It is hypothesized that high straining forces during paradoxical contractions and inadequate relaxation are causally related to hemorrhoids. This review aimed to assess the coprevalence of functional constipation and dyssynergic defecation in a populati...
Preprint
Abstract Background It is not clear about the safe distance between the intra-operative resection line and the distal rectal tumor visible margin after preoperative radiotherapy. We aimed to investigate the furthest tumor intramural spread distance in fresh tissue to determine safe distal intraoperative resection margin length. Methods Twenty spec...
Article
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IntroductionFamilial occurrence of Hirschsprung's disease may have a positive effect on patients' ability to cope with the disease. The aim was to compare long-term bowel function and generic quality of life between patients with familial and non-familial Hirschsprung's disease.Methods This was a nationwide, cross-sectional study in which we includ...
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IntroductionChronic constipation can be treated by injecting botulinum toxin into the anal sphincter to decrease anal basal pressure. To assess the effect of botulinum toxin, we investigated the factors that contribute to changes in anal basal pressure after injection.Methods This was a retrospective study conducted in a tertiary hospital in the Ne...
Article
Aim: Our hypothesis is that there may be a neural pathway with sensory afferent neurons in the anal canal that leads to rectal contraction to assist defaecation. We aimed to compare rectal motility between healthy participants with or without anal anaesthesia. Method: This prospective intervention study consisted of two test sessions: a baseline...
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Objectives: Knowledge on long-term outcomes in patients with Hirschsprung's disease is progressing. Nevertheless, differences in outcomes according to aganglionic lengths are unclear. We compared long-term bowel function and generic quality of life in Hirschsprung patients with total colonic or long-segment versus rectosigmoid aganglionosis. Meth...
Article
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Purpose: We aimed to compare the prevalence rates and associated symptoms of constipation and fecal incontinence in children and young adults and evaluate how these patient groups cope with these disorders. Methods: A cross-sectional study was performed in which 212 children (8-17 years) and 149 young adults (18-29 years) from the general Dutch...
Article
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Introduction: As survival rates of colon cancer increase, knowledge about functional outcomes is becoming ever more important. The primary aim of this systematic review and meta-analysis was to quantify functional outcomes after surgery for colon cancer. Secondly, we aimed to determine the effect of time to follow-up and type of colectomy on postop...
Article
Background: The anal-external sphincter continence reflex and the puborectal continence reflex control fecal continence by involuntary contractions of the external anal sphincter and puborectal muscle. To date it is unknown what the effect of liquid stool is on these reflexes. Objective: The purpose of this study was to analyze the consequence o...
Article
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PurposeThis study aims to analyze the quality of life in patients with an ileal pouch-anal anastomosis (IPAA) and to investigate the association between height and type of the anastomosis, the number of stage procedures and age, and the fecal continence outcomes.Methods This is a cross-sectional retrospective study in patients who had undergone IPA...
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Background: Diagnosing constipation remains difficult and its treatment continues to be ineffective. The reason may be that the symptom patterns of constipation differ in different demographic groups. We aimed to determine the pattern of constipation symptoms in different demographic groups and to define the symptoms that best indicate constipatio...
Article
Background: Bowel dysfunction after low anterior resection is often assessed by determining the low anterior resection syndrome score. What is unknown, however, is whether this syndrome is already present in the general population and which nonsurgical factors are associated. Objective: The purpose of this study was to determine the prevalence o...
Article
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Aim: The ability of patients with poor pudendal nerve function to voluntary contract their external anal sphincter is limited. However, it is not known whether the condition of the pudendal nerve influences the voluntary puborectal muscle contraction. Recently, we described the puborectal continence reflex that maintains fecal continence by involu...
Article
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Background: Increased rectal volume is believed to be associated with diminished rectal sensation, i.e., rectal hyposensitivity. Aims: To demonstrate that patients with increased rectal volumes do not automatically have diminished rectal filling sensations. Methods: We, retrospectively, observed 100 adult patients with defecation problems, and...
Article
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Background It is unclear whether functional outcomes improve or deteriorate with age following surgery for Hirschsprung's disease. The aim of this cross‐sectional study was to determine the long‐term functional outcomes and quality of life (QoL) in patients with Hirschsprung's disease. Methods Patients with pathologically proven Hirschsprung's dis...
Article
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We aimed to study constipation and fecal incontinence in terms of prevalence, recognizing the disorders, help-seeking behavior, and associated symptoms. In this cross-sectional study, 240 children (8 to 18 years) from the general Dutch population completed a questionnaire about defecation disorders. After exclusions for anorectal/pelvic surgery or...
Article
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Introduction: The International Children's Continence Society (ICCS) defines urinary incontinence (UI) as 'involuntary leakage of urine' [1], a condition that can have a negative impact on a child's life. Although UI is common among children, the reported prevalences worldwide vary. Regarding children in the Netherlands, only a few studies report...
Article
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Introduction Many children with acute abdominal pain and suspicion of appendicitis are diagnosed with constipation. Nevertheless, it can be difficult to differentiate between acute constipation and acute appendicitis because of similar symptoms and lack of diagnostic criteria. Consequently, constipation is often missed despite repeated consultation...
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PurposeTo study the distribution of subtypes and symptoms of fecal incontinence in the general Dutch population. Methods We performed a cross-sectional study in a representative sample of the general Dutch population. All respondents (N = 1259) completed the Groningen Defecation and Fecal Continence questionnaire. We assigned the respondents to a s...
Article
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Purpose: Fecal continence is maintained by voluntary and involuntary contraction of the anal sphincter, and voluntary contractions of puborectal muscle. We investigated whether the puborectal muscle can control fecal continence not only by voluntary contractions but also by involuntary contractions. Methods: We performed anorectal function tests...
Article
Objectives: Current questionnaires on defecation disorders are often brief and fail to include questions considering causative factors. Furthermore, adult and pediatric questionnaires differ, which makes it impossible to monitor defecation disorders during the transition from childhood to adulthood. With these points in mind, we developed the Groni...
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Objectives: To evaluate whether anorectal manometry (ARM), which is used to test the rectoanal inhibitory reflex (RAIR), is a safe alternative for reducing the number of invasive rectal suction biopsy (RSB) procedures needed to diagnose Hirschsprung's disease (HD). Methods: Between 2010 and 2017, we prospectively collected the ARM results of 105...
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Background It is assumed that pregnancy and childbirth increase the risk of developing fecal incontinence (FI). Objective We investigated the incidence of FI in groups of nulliparous and parous women. Methods Retrospectively, we studied a cross-section of the Dutch female population (N = 680) who completed the Groningen Defecation & Fecal Contine...
Article
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PurposeNumerous studies have investigated the prevalence of constipation and fecal incontinence (FI) in the general population and, even though these disorders are known to co-occur, they were studied independently of each other. Our aim was to investigate the prevalence of constipation and FI, and their co-occurrence, in the general population in...
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Background: Hereditary spherocytosis (HS) is a heterogeneous hemolytic anemia treated with splenectomy in patients suffering from severe or moderate disease. Total splenectomy, however, renders patients vulnerable to overwhelming postsplenectomy infection despite preventive measures. Although subtotal splenectomy has been advocated as an alternati...
Article
Objective: To determine whether the frequency and severity of congenital anorectal malformations (CARMs) differs by sex. Study design: We included 129 patients (0-319 weeks old) diagnosed with CARMs, who had been referred to our Department of Pediatric Surgery between 2004 and 2013. Rectoperineal and rectovestibular fistulas were classified as m...
Article
Objective: To determine the prevalence of congenital heart defects (CHDs) in patients with mild or severe congenital anorectal malformations (CARMs), and whether all patients with CARM need pediatric cardiology screening. Study design: We included 129 patients with CARM born between 2004 and 2013, and referred to University Medical Center Gronin...
Article
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Aims: To determine the prevalence and risk factors associated with urinary incontinence (UI) among adults in the Netherlands. Methods: In this cross-sectional study, we included 1257 respondents aged ≥ 18 years, who completed the validated Groningen Defecation and Fecal Continence Checklist. UI was defined as any involuntary leakage of urine dur...
Article
Chronic anal fissure is a painful disorder caused by linear ulcers in the distal anal mucosa. Even though it counts as one of the most common benign anorectal disorders, its precise etiology and pathophysiology remains unclear. Current thinking is that anal fissures are caused by anal trauma and pain, which leads to internal anal sphincter hyperton...
Article
The epidermal growth factor (EGF) receptor and its ligands are crucially involved in the renal response to ischaemia. We studied the heparin binding-epidermal growth factor (HB-EGF), a major ligand for the EGF receptor, in experimental and human ischaemia/reperfusion injury (IRI). HB-EGF mRNA and protein expression was studied in rat kidneys and cu...
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The human epithelial cell adhesion molecule (hEpCAM) is involved in epithelial morphogenesis and repair of epithelial tissues. We hypothesized that changes in hEpCAM expression in vivo correlate with regeneration of renal epithelia after ischaemia/reperfusion injury (IRi). Unilateral IRi was performed on kidneys of hEpCAM transgenic mice. Changes i...
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The Epithelial Cell Adhesion Molecule (EpCAM) is expressed virtually on normal epithelia in vertebrates. Among different species, the amino acid sequence of EpCAM is highly homologous, indicating that EpCAM is an evolutionary conserved protein. However, differences in the expression pattern of EpCAM homologues have been reported. We hypothesized th...
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Embryonic development is one of the most complex biological phenomena that involves the appropriate expression and synchronized interactions of a plethora of proteins, including cell adhesion molecules (CAMs). Many members of the diverse family of CAMs have been shown to be critically involved in the correct execution of embryonic development. The...
Article
Full-text available
Embryonic development is one of the most complex biological phenomena that involves the appropriate expression and synchronized interactions of a plethora of proteins, including cell adhesion molecules (CAMs). Many members of the diverse family of CAMs have been shown to be critically involved in the correct execution of embryonic development. The...
Article
The epithelial cell adhesion molecule (EpCAM, CD326) is a glycoprotein of approximately 40 kd that was originally identified as a marker for carcinoma, attributable to its high expression on rapidly proliferating tumors of epithelial origin. Normal epithelia express EpCAM at a variable but generally lower level than carcinoma cells. In early studie...
Article
Full-text available
The epithelial cell adhesion molecule (EpCAM) is expressed by most epithelia and is involved in processes fundamental for morphogenesis, including cell-cell adhesion, proliferation, differentiation, and migration. Previously, a role for EpCAM in pancreatic morphogenesis was confirmed in vitro. Furthermore, changes in the EpCAM expression pattern we...
Article
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EGP-2, also known as Ep-CAM, is expressed at high levels on the surface of most carcinomas and is therefore considered an attractive target for anticancer strategies. To explore the mechanisms regulating the expression of EGP-2, sequences 3.4 kb upstream of the transcription start site were isolated and assayed for their ability to control the expr...

Projects

Project (1)