Monika Lewandowska

• Institute of Physiology and Pathology of Hearing

Cel pracy Zaburzenia psychosomatyczne to heterogenna grupa jednostek chorobowych przebiegających bez wyjaśnionej przyczyny somatycznej. Z racji złożoności symptomów stanowią one istotny problem medyczno-społeczno-ekonomiczny, a diagnostyka i leczenie chorób wciąż pozostaje dużym wyzwaniem klinicznym. Celem prowadzonych badań była próba znalezienia...

Speech understanding, watching a movie, listening to music etc., requires perception of the temporal order of at least two incoming events. A history of performing these tasks may be reflected in spontaneous brain activity. Here, we examined the relationship between the complexity (temporal dynamics) of resting‑state EEG (rsEEG) signal, assessed us...

Both navigation abilities and gait can be affected by the atrophy in the medial temporal cortex. This study aimed to determine whether navigation abilities could differentiate seniors with and without medial temporal lobe atrophy who complained about their cognitive status. The participants, classified to either the medial temporal atrophy group (...

Previous studies indicate changes in neurotransmission along the auditory pathway in subjective tinnitus. Most authors, however, investigated brain regions including the primary auditory cortex, whose physiology can be affected by concurrent hearing deficits. In the present MR spectroscopy study we assumed increased levels of glutamate and glutamin...

Background The study aimed to determine how the resting-state EEG (rsEEG) complexity changes both over time and space (channels). The complexity of rsEEG and its sex/gender differences were examined using the multivariate Multiscale Entropy ( mMSE ) in 95 healthy adults. Following the probability maps (Giacometti et al. in J Neurosci Methods 229:84...

Abstratct published in: Acta Neurobiologiae Experimentalis, 2023, Volume 83 Supplement. Psychosomatic diseases (PD) are defined as medically unexplained symptoms affecting one or more organ systems (e.g., gastrointestinal, musculo‑skeletal, cardiovascular and others). The exact causes as well as the pathophysiological brain mechanisms that underli...

Abstract published in: Acta Neurobiologiae Experimentalis, 2023, Volume 83 Supplement Psychosomatic disorders (PD) are characterized by physical symptoms not fully explained by general medical conditions, affecting many organ systems and significantly impairing patient`s quality of life (Kirmayer et al., 2004). Actual causes of PD have been hypothe...

Subjective tinnitus is a prevalent, though heterogeneous, condition whose pathophysiological mechanisms are still under investigation. Based on animal models, changes in neurotransmission along the auditory pathway have been suggested as co-occurring with tinnitus. It has not, however, been studied whether such effects can also be found in other si...

Background The study aimed to determine the resting-state EEG (rsEEG) dynamics quantified using the multivariate Multiscale Entropy (mMSE), and the sex/gender (s/g) differences in the mMSE features. The rsEEG was acquired from 95 healthy adults. For each channel set the AUC, that represents the total complexity, the MaxSlope and AvgEnt referring to...

The study aimed to determine the relationship between the millisecond timing, measured by visual temporal order threshold (TOT), i.e. a minimum gap between two successive stimuli necessary to judge a before-after relation, and resting-state fMRI functional connectivity (rsFC). We assume that the TOT reflects a relatively stable feature of local int...

CelCelem badania pilotażowego było sprawdzenie zależności pomiędzy rozdzielczością czasową w zakresie milisekundowym, pamięcią roboczą oraz inteligencją psychometryczną z uwzględnieniem analizy jakościowej błędów w Teście Matryc Ravena w wersji dla Zaawansowanych TMZ. MetodaTrzydzieści sześć osób (24 mężczyzn i 12 kobiet, w wieku 17–19 lat) wykonał...

There are discrepancies in the literature regarding the course of central auditory processes (CAP) maturation in typically developing children and adolescents. The purpose of the study was to provide an overview of age – related improvement in CAP in Polish primary and secondary school students aged 7–16 years. 180 children/adolescents, subdivided...

A decline in the Spatial Navigation (SN) abilities has been observed in the course of healthy aging. Walking is an inseparable part of the navigation process; however, research tasks overlook this aspect in studies involving seniors. The present study was designed to overcome this limitation by recording gait parameters during natural environment n...

Ośrodkowe zaburzenia słuchu (Central Auditory Processing Disorders, CAPD), czyli deficyty w zakresie opracowywania informacji akustycznej na wyższych piętrach układu nerwowego, są dość powszechnym zjawiskiem wśród dzieci i młodzieży. Często towarzyszą one specyficznym zaburzeniom czytania i pisania, nadpobudliwości psychoruchowej czy zaburzeniom ko...

Praca prezentuje ocenę wpływu terapii Stymulacja Percepcji Słuchowej – Metoda Skarżyńskiego (SPS-S), opracowanej w Instytucie Fizjologii i Patologii Słuchu w Kajetanach, na płynność mowy oraz centralne funkcje słuchowe u pacjentów jąkających się. Do badań włączono 27 dzieci z niepłynnością mowy (25 chłopców i 2 dziewczynki) w wieku 8–17 lat (M=11 l...

Cel Celem pracy jest określenie wzorców spoczynkowej bioelektrycznej aktywności mózgu u pacjentów z przewlekłymi obustronnymi szumami usznymi. Materiał i metody U 6 pacjentów z szumami usznymi i 7 osób bez szumów usznych, dopasowanych do grupy klinicznej pod względem płci i wieku, zarejestrowano spoczynkową aktywność bioelektryczną mózgu w stanie...

Cel Celem pracy jest określenie wzorców spoczynkowej bioelektrycznej aktywności mózgu u dzieci z dysleksją. Materiał i metody W badaniach uczestniczyło 36 dzieci z rozpoznaną dysleksją oraz 27, dobranych pod względem płci i wieku, dzieci bez zaburzeń czytania (grupa kontrolna). Rejestrację sygnału EEG przeprowadzono w dwóch oddzielnych blokach rel...

Tinnitus jest percepcją dźwięku bez zewnętrznego źródła stymulacji akustycznej. Większość osób habituuje fantomowe dźwięki, jednakże około 1–2% ludzi odczuwa szumy uszne jako bardzo dokuczliwe, pogarszające jakość ich życia. Z uwagi na fakt, że szumy są często związane z niedosłuchem pochodzenia ślimakowego, źródła ich generacji upatrywano w ślimak...

Szumy uszne to złożone (nie tylko słuchowe) zaburzenie, któremu bardzo często towarzyszą problemy natury poznawczo-emocjonalnej. Pomimo iż szumy stanowią coraz większy problem społeczny, wciąż nie do końca poznany jest mechanizm ich powstawania. Ze względu na złożoną naturę zaburzenia nadal nie ma standardów diagnostycznych oraz w pełni skutecznych...

Cel pracy Identyfikacja czynników mogących wpływać na uciążliwość szumów usznych. W analizach uwzględniono wiek i płeć pacjentów, ich poziom lęku i depresji oraz czas trwania szumów usznych. Materiał i metody Trzydziestu ośmiu pacjentów (16 kobiet) w wieku od 21 do 71 lat (średni wiek 42 lata i 1 miesiąc ±12 lat i 10 miesięcy) z przewlekłymi (>0,5...

W ostatnich latach na świecie obserwuje się zwiększenie liczby dzieci z deficytami w zakresie ośrodkowych procesów przetwarzania słuchowego (ang. central auditory processing, CAP). Mimo dużej skali zjawiska, w Polsce, jak dotąd, nie opracowano wystandaryzowanych narzędzi psychometrycznych służących do diagnozy CAP. Nie istnieją także ogolnopolskie...

Zdolność do rozpoznawania zniekształconych bodźców słownych jest ważnym aspektem przetwarzania informacji słuchowej. Testy sprawdzające tę umiejętność powinny wchodzić w skład baterii przesiewowych czułych na wykrywanie ośrodkowych zaburzeń przetwarzania słuchowego (ang. Auditory Processing Disorder, APD). W prezentowanej pracy przedstawiono podsta...

Pojęcie czasu znajduje się w kręgu zainteresowań zarówno humanistów (poetów, filozofów), jak i badaczy reprezentujących nauki matematyczno-przyrodnicze (lekarze, fizycy, psychologowie). Coraz więcej klinicystów jest również świadomych, że nieprawidłowa percepcja czasu nie tylko obniża jakość życia pacjentów, lecz także może być symptomem chorób neu...

Neural complexity is thought to be associated with efficient information processing but the exact nature of this relation remains unclear. Here, the relationship of fluid intelligence (gf) with the resting‐state EEG (rsEEG) complexity over different timescales and different electrodes was investigated. A 6‐min rsEEG blocks of eyes open were analyze...

Objectives The study aimed at determining the EEG correlates of concentration on either low or high-distressed tinnitus. Methods Sixty-seven patients (36 women, mean age = 50.34 ± 12.94 years) with chronic tinnitus were assigned to either a high (HD) or low (LD) tinnitus-related distress group based on THI results. All participants took part in th...

Two examples of muli-level explanations of brain activity are provided. First study is aimed at extraction of information from EEG to recognize which brain regions are active using spectral fingerprinting. It is based on forward and inverse modeling of electric potentials measured by sensors placed on the scalp, and computing power spectra from dif...

Alpha rhythm, described by Hans Berger, is mainly recorded from the occipital cortex (OCC) of relaxed subjects with their eyes closed. Early studies indicated the thalamo‑cortical circuit as the origin of alpha rhythm. Recent works suggest an additional relationship between alpha rhythm and the Default Mode Network (DMN). We simultaneously recorded...

In this study, we showed an abnormal resting-state quantitative electroencephalogram (QEEG) pattern in children with central auditory processing disorder (CAPD). Twenty-seven children (16 male, 11 female; mean age = 10.7 years) with CAPD and no symptoms of other developmental disorders, as well as 23 age- and sex-matched, typically developing child...

Although the tonotopic organisation of the human primary auditory cortex (PAC) has already been studied, the question how its responses are affected in sensorineural hearing loss remains open. Twenty six patients (aged 38.1 ± 9.1 years; 12 men) with symmetrical sloping sensorineural hearing loss (SNHL) and 32 age- and gender-matched controls (NH) p...

The aims of our study were: (1) to examine changes in the whole-brain functional network under increased cognitive demands of working memory during an n-back task, and their relationship with behavioral outcomes; and (2) to provide a comprehensive description of local changes that may be involved in the formation of the global workspace, using hub...

Background The goal of the fMRI experiment was to explore the involvement of central auditory structures in pathomechanisms of a behaviorally manifested auditory temporary threshold shift in humans. Material/Methods The material included 18 healthy volunteers with normal hearing. Subjects in the exposure group were presented with 15 min of binaura...

Recent demographic prognoses show tendencies toward a significant increase in the number of elderly people, especially in developed countries. This makes geriatric therapy, rehabilitation, and care difficult, especially with maintaining as long as possible the highest quality of life and independence in activities of daily living. Lack of specializ...

This study is the first to demonstrate outcomes of slow cortical potential (SCP) Neurofeedback training in chronic tinnitus. A 50-year old male patient with tinnitus participated in three SCP training blocks, separated with 1-month breaks. After the training the patient reported decreased tinnitus loudness and pitch, as well as improved quality of...

The aim of the study was to evaluate mental distress and health-related quality of life in patients with bilateral partial deafness (high-frequency sensorineural hearing loss) before cochlear implantation, with respect to their audiological performance and time of onset of the hearing impairment. Thirty-one patients and 31 normal-hearing individual...

Background The aim of the present work is to investigate the relationship between spontaneous electroencephalographic (EEG) brain activity at 8–13 Hz frequency (Berger’s rhythm) and thalamus activation. The leading theory of how Berger’s rhythm is generated suggests a thalamo–occipital circuit, but there is still much uncertainty as to the role of...

Introduction: Simultaneous EEG-fMRI registration is rapidly evolving and has received substantial attention. This technique provides precise information in both spatial and temporal domain. The biological basis of the EEG and fMRI signal is different which, on the one hand makes results interpretation more difficult but, on the other hand, gives m...

Background Previous studies indicate that many different aspects of attention are impaired in children diagnosed with developmental dyslexia (DD). The objective of the present study was to identify cognitive profiles of DD on the basis of attentional test performance. Material/Methods 78 children with DD (30 girls, 48 boys, mean age of 12 years ±8...

Background In recent years, there has been a growing interest in Central Auditory Processing Disorder (C)APD. However, the neural correlates of (C)APD are poorly understood. Previous neuroimaging experiments have shown changes in the intrinsic activity of the brain in various cognitive deficits and brain disorders. The present study investigated th...

Streszczenie Tinnitus jest percepcją dźwięku bez zewnętrznego źródła stymulacji akustycznej. Większość osób habituuje fantomowe dźwię-ki, jednakże około 1-2% ludzi odczuwa szumy uszne jako bardzo dokuczliwe, pogarszające jakość ich życia. Z uwagi na fakt, że szumy są często związane z niedosłuchem pochodzenia ślimakowego, źródła ich generacji upatr...

Background The neural underpinnings of auditory information processing have often been investigated using the odd-ball paradigm, in which infrequent sounds (deviants) are presented within a regular train of frequent stimuli (standards). Traditionally, this paradigm has been applied using either high temporal resolution (EEG) or high spatial resolut...

Recent demographic prognoses show tendencies toward a significant increase in the number of elderly people, especially in developed countries. This makes geriatric therapy, rehabilitation, and care difficult, especially with maintaining as long as possible the highest quality of life and independence in activities of daily living. Lack of specializ...

Streszczenie Szumy uszne to złożone (nie tylko słuchowe) zaburzenie, któremu bardzo często towarzyszą problemy natury poznawczo-emo-cjonalnej. Pomimo iż szumy stanowią coraz większy problem społeczny, wciąż nie do końca poznany jest mechanizm ich po-wstawania. Ze względu na złożoną naturę zaburzenia nadal nie ma standardów diagnostycznych oraz wpeł...

Background In this paper we showed predictive relationships between central auditory processes, phonological abilities, and reading abilities in children diagnosed with developmental dyslexia (DD). Both empirical data and theoretical approaches indicate that central auditory processing deficits may contribute to developmental dyslexia; however, ass...

Introduction The objective of the presented study was to develop and evaluate a P300 experimental protocol for simultaneous registration of event-related potentials (ERPs) and functional MRI (fMRI) data with continuous imaging. It may be useful for investigating attention and working memory processes in specific populations, such as children and ne...

Experimental studies have often reported close associations between rapid auditory processing and language competency. The present study was aimed at improving auditory comprehension in aphasic patients following specific training in the perception of temporal order (TO) of events. We tested 18 aphasic patients showing both comprehension and TO per...

Objective: Aim of this study was to evaluate auditory cortex responses to chirp stimulation in patients with partial deafness. Auditory cortex functioning is an important factor of successful rehabilitation after cochlear implantation, particularly in partially deafened patients who have to integrate the natural acoustic hearing with the electric o...

Cel: Celem pracy jest określenie wzorców spoczynkowej bioelektrycznej aktywności mózgu u pacjentów z przewlekłymi obustronnymi szumami usznymi. Materiał i metody: U 6 pacjentów z szumami usznymi i 7 osób bez szumów usznych, dopasowanych do grupy klinicznej pod względem płci i wieku, zarejestrowano spoczynkową aktywność bioelektryczną mózgu w stanie...

Background Recently, there has been a surge of interest in neuroimaging techniques that might help to objectively evaluate the residual hearing abilities of patients with hearing abilities of patients considered for partial deafness treatment (PDT). Such an evaluation might allow a wider range of PD candidates to benefit from cochlear implantation...

This chapter focuses on hearing loss and auditory processing disorders (APD) with reference to culture and identity. Hearing impairments constitute a world-wide problem. They affect both language communication and social interactions, and hence, influence personal identity. APD are discussed from both audiological and neuropsychological perspective...

This study focuses on age-related differences concerning two kinds of spatial memory assessed by: (1) Paired Associates Learning (PAL) test from the CANTAB and (2) a test of Real Idiothetic Memory (RIM) using real-life settings. Despite a clear age-related drop in PAL that is reported in existing studies, age-related differences in idiothetic navig...

This chapter reviews existing studies on neural representation of time and timing processes. New findings in clinical neuropsychology, functional magnetic resonance imaging, electrophysiology, and psychophysics are presented to explain how the temporal information is processed within our brains. The literature data are illustrated with results of o...