Monica N. Toba

Monica N. Toba
Université de Picardie Jules Verne | UPJV · LNFP, Laboratoire de neurosciences fonctionnelles et pathologies

PhD

About

40
Publications
5,067
Reads
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600
Citations
Citations since 2016
22 Research Items
390 Citations
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2016201720182019202020212022020406080
2016201720182019202020212022020406080
Introduction
Monica N. Toba currently works at the LNFP, Laboratoire de neurosciences fonctionnelles et pathologies, Université de Picardie Jules Verne. Monica does research in Neuropsychology, Neuroscience, Cognitive Science and Cognitive Psychology.
Additional affiliations
September 2014 - present
Université de Picardie Jules Verne
Position
  • Professor (Associate)
September 2013 - August 2014
Université de Rouen
Position
  • Professor (Assistant)
September 2012 - August 2013
Université de Caen Normandie
Position
  • Professor (Assistant)

Publications

Publications (40)
Article
Background and objectives Although action slowing is the main cognitive impairment in stroke survivors, its mechanisms and determinants are still poorly understood. The objectives of the present study were to determine the mechanisms of post-stroke action slowing (using validated, highly specific simple reaction time (SRT) and tapping tests) and id...
Article
Full-text available
Spatial neglect usually concerns left-sided events after right-hemisphere damage. Its anatomical correlates are debated, with evidence suggesting an important role for fronto-parietal white matter disconnections in the right hemisphere. Here, we describe the less frequent occurrence of neglect for right-sided events, observed in three right-handed...
Article
Brain plasticity can be defined as the ability of local and extended neural systems to organize either the structure and/or the function of their connectivity patterns to better adapt to changes of our inner/outer environment and optimally respond to new challenging behavioral demands. Plasticity has been traditionally conceived as a spontaneous ph...
Article
Introduction La négligence spatiale unilatérale (NSU) est un trouble de l’attention visuo-spatiale, résultant principalement d’une lésion de l’hémisphère droit. Ces patients ont des difficultés à répondre et à s’orienter vers des stimuli présentés du côté opposé à la lésion cérébrale. Objectifs Le PHRC regional NEGLECT (essai multicentrique en dou...
Preprint
Full-text available
Spatial neglect usually concerns left-sided events after right hemisphere damage. Its anatomical correlates are debated, with evidence suggesting an important role for fronto-parietal white matter disconnections in the right hemisphere. Here we describe the less frequent occurrence of neglect for right-sided events, observed in three right-handed p...
Article
Full-text available
Background and Purpose We used differential actigraphy as a novel, objective method to quantify motor neglect (a clinical condition whereby patients mimic hemiplegia even in the absence of sensorimotor deficits), whose diagnosis is at present highly subjective, based on the clinical observation of patients’ spontaneous motor behavior. Methods Pati...
Article
Full-text available
A recent tasked-based fMRI study unveiled a network of areas implicated in the process of visuo-proprioceptive integration of the right hand. In this study, we report a case of a patient operated on in awake conditions for a glioblastoma of the left superior parietal lobule. When stimulating a white matter site in the anterior wall of the cavity, t...
Preprint
Full-text available
Attention, working memory, and executive control are commonly considered distinct cognitive functions with important reciprocal interactions. Lesion studies pioneered by Donald Stuss have demonstrated both overlap and dissociation in their behavioral expression and anatomical underpinnings. Here, we provide an overview of cognitive models as well a...
Preprint
Full-text available
Objectives Patients with unilateral brain damage may avoid moving the limbs contralateral to their lesion, even in the absence of sensorimotor deficits. However, when asked to move their limbs these patients typically show normal strength and dexterity. In their seminal 1983 article on the Journal of Neurology, Neurosurgery and Psychiatry , Laplane...
Article
Please cite this article as: Malkinson TS, Migliaccio R, Migeot H, Picq C, Cerrato A, Pradat-Diehl P, Bartolomeo P, Toba MN, A dissociation between preserved abstract spatial knowledge and impaired navigation in a blind patient, CORTEX, https://doi.
Article
Full-text available
White matter bundles linking gray matter nodes are key anatomical players to fully characterize associations between brain systems and cognitive functions. Here we used a multivariate lesion inference approach grounded in coalitional game theory (multiperturbation Shapley value analysis, MSA) to infer causal contributions of white matter bundles to...
Article
Full-text available
The study of brain-function relationships is undergoing a conceptual and methodological transformation due to the emergence of network neuroscience and the development of multivariate methods for lesion-deficit inferences. Anticipating this process, in 1998 Godefroy and co-workers conceptualized the potential of four elementary typologies of brain-...
Article
The ‘Sprague Effect’ described in the seminal paper of James Sprague (Science 153:1544–1547, 1966a) is an unexpected paradoxical effect in which a second brain lesion reversed functional deficits induced by an earlier lesion. It was observed initially in the cat where severe and permanent contralateral visually guided attentional deficits generated...
Article
Objectives: The ability of voxel-based lesion-symptom mapping (VLSM) to define the functional anatomy of the human brain has not been fully assessed. With a view to assessing VLSM's validity, the present study analyzed the technique's ability to determine the known clinical-anatomic correlates of hemiparesis in stroke patients. Design: Lesions (dam...
Article
Visual neglect is a disabling consequence of right hemisphere damage, whereby patients fail to detect left-sided objects. Its precise mechanisms are debated, but there is some consensus that distinct component deficits may variously associate and interact in different patients. Here we used a touch-screen based procedure to study two putative compo...
Article
Visual neglect is a heterogeneous, multi-component syndrome resulting from right hemisphere damage. Neglect patients do not pay attention to events occurring on their left side, and have a poor functional outcome. The intra-hemispheric location of lesions producing neglect is debated, because studies using different methods reported different locat...
Article
Full-text available
Anatomical studies conducted in neurological conditions have developed our understanding of the causal relationships between brain lesions and their clinical consequences. The analysis of lesion patterns extended across brain networks has been particularly useful in offering new insights on brain–behavior relationships. Here we applied multiperturb...
Article
Full-text available
Behavioral and electrophysiological studies in humans and non-human primates have correlated frontal high-beta activity with the orienting of endogenous attention and shown the ability of the latter function to modulate visual performance. We here combined rhythmic transcranial magnetic stimulation (TMS) and diffusion imaging to study the relation...
Article
Full-text available
In visual search tasks, neglect patients tend to explore and repeatedly re-cancel stimuli on the ipsilesional side, as if they did not realize that they had previously examined the rightward locations favoured by their lateral bias. The aim of this study was to explore the hypothesis that a spatial working memory deficit explains these ipsilesional...
Conference Paper
In order to investigate whether visually impaired and sighted teenagers interact in a similar way via mediated communication, we designed a protocol in which two participants interact via two connected perceptual supplementation devices. The two participants were asked to cooperate for locating a public object. We compared the probability for corre...
Article
We studied the neural correlates of target omissions in five patients with right hemisphere damage and varying signs of left spatial neglect. Benefiting from the high temporal resolution of magneto-encephalography, we directly compared brain regional synchrony events of detected and omitted left-sided targets. Results showed that before stimulus pr...
Article
Posterior cortical atrophy (PCA) is rare neurodegenerative dementia, clinically characterized by a progressive decline in higher-visual object and space processing. After a brief review of the literature on the neuroimaging in PCA, here we present a study of the brain structural connectivity in a patient with PCA and progressive isolated visual and...
Article
Keywords Transcranial magnetic stimulation; RTMS; Stroke; Neglect; Clinical trial; Double blind Right hemisphere strokes commonly give rise to a visuo-spatial neglect syndrome, a neurological condition considered to be a better predictor of functional dependency than the actual stroke severity (Cherney and Halper, 2001; Parton et al. 2004). The pr...
Article
Patients with right hemisphere lesions and visual neglect fail to orient and respond to left-sided objects. There is general agreement that neglect is a heterogenous, multi-componential syndrome, but the location and identity of the relevant lesion sites remain debated. Twenty-five right-handed patients with subacute strokes in the right hemisphere...
Article
Signs of left unilateral neglect often occur after damage to the right hemisphere and entail a left-right imbalance in stimulus processing. Typically, neglect patients deviate rightward when bisecting lines. An underestimation of the left portion of the line and/or a right overestimation could explain this effect. Here we dissected their respective...

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Projects

Project (1)
Project
La mémoire prospective nous permet de retenir les actions à réaliser dans le futur, comme éteindre le gaz, prendre un médicament au bon moment, où se rendre à un rendez-vous à l’heure. Bien que, quel que soit notre âge, nous pouvons être victimes de certains oublis liés à une défaillance de cette forme de mémoire, son fonctionnement reste encore en partie ignoré. Par exemple, l’impact de la motivation sur la mémoire prospective reste méconnu. De plus il n’existe pas d’outil en français permettant de détecter les défaillances de la mémoire prospective pour pouvoir les prévenir des risques et y remédier le plus tôt possible. Ce projet cherche à étudier l’impact de la motivation sur la mémoire prospective et à développer un test pour permettre d’identifier des difficultés chez des personnes âgées, ou chez des malades atteints d’Alzheimer ou encore des victimes d’Accident Vasculaire Cérébral (AVC). Pour cela, nous adopterons une démarche pluridisciplinaire en couplant l’approche psychologique avec des outils informatique, d’imagerie (IRM) et d’électrophysiologie (EEG) afin de mieux comprendre le fonctionnement cérébral lié à la mémoire prospective.