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Monica Scognamiglio

Monica Scognamiglio
Università degli Studi della Campania "Luigi Vanvitelli" · Department of Environmental Biological and Pharmaceutical Sciences and Technologies

PhD

About

74
Publications
28,240
Reads
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1,386
Citations
Citations since 2017
30 Research Items
999 Citations
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
Introduction
Research activity is mainly focused on plant natural products, with the aim of understanding their physiological/ecological role on one hand and finding bioactive molecules on the other hand. These aims are pursued by combining classical phytochemical studies with the cutting-edge metabolomics approach.
Additional affiliations
December 2019 - August 2020
Università degli Studi della Campania "Luigi Vanvitelli
Position
  • Professor (Assistant)
Description
  • RTDb (ssd CHIM/06; organic chemistry)
March 2018 - November 2019
Max Planck Institute for Chemical Ecology
Position
  • PostDoc Position
Description
  • Project: Stable isotope labelling of spruce diterpenes
September 2015 - December 2017
Max Planck Institute for Chemical Ecology
Position
  • PostDoc Position
Description
  • Alexander von Humboldt fellow. Project: Metabolomic Studies of Allelopathic interactions.
Education
September 2009 - April 2010
Leiden University- Institute of Biology-Division of Pharmacognosy, Section Metabolomics
Field of study
November 2008 - December 2011
Second University of Naples, Caserta (Italy)
Field of study
  • Resources and Environment

Publications

Publications (74)
Article
Full-text available
Since the possibility to biotechnologically produce melanin by Streptomycetes using plant biomass has been so far poorly investigated, Posidonia oceanica egagropili, a marine waste accumulating along the Mediterranean Sea coasts, was explored as a renewable source to enhance extracellular melanin production by Streptomyces roseochromogenes ATCC 134...
Article
Full-text available
‘Asprinio’ is a white dry wine characteristic for its acidity and aromatic flavour, known as emerging DOP wine in Southern Italy. Nevertheless, little information is available on the metabolomic profile of this wine. Thus, in this paper we evaluated the colourimetric parameters, 1H NMR profiles and free amino acids content of ‘Asprinio’ wines, bott...
Article
Full-text available
Pomegranate is characterized by several local accessions and cultivars widespread across different countries, each with different bio-agronomic features. Physiological and biochemical processes occur during fruit ripening, leading to changes in size, color, and flavor, improving the fruit's acceptability for the consumer. The aim of this study was...
Article
Full-text available
Olea europaea germplasm is constituted by a huge number of cultivars, each one characterized by specific features. In this context, endemic cultivars evolved for a very long period in a precise local area, developing very specific traits. These characteristics include the production and accumulation of phytochemicals, many of which are also respons...
Article
Full-text available
In the search of new natural products to be explored as possible anticancer drugs, two plant species, namely Ononis diffusa and Ononis variegata, were screened against colorectal cancer cell lines. The cytotoxic activity of the crude extracts was tested on a panel of colon cancer cell models including cetuximab-sensitive (Caco-2, GEO, SW48), intrin...
Article
Full-text available
Dietary supplements based on Teucrium chamaedrys L. subsp. chamaedrys aerial parts were banned, due to the hepatotoxicity of furan-containing neo-clerodane constituents. Indeed, the plant leaf content in phenolic compounds could be further exploited for their antioxidant capability. Accordingly, bio-guided fractionation strategies have been applied...
Article
Exploitation of tuff deposits represents an intensive and destructive human activity that can completely modify natural soils, sometimes leading to their total disappearance. Soil reclamation of quarry areas can usually be done by soil rebuilding, employing complex and expensive techniques. In this research, we aimed to evaluate reconstructed Techn...
Article
Full-text available
Sumac (Rhus coriaria L.), a spice obtained by grinding whole sumac berries, is a complex natural product with a plethora of biological activities that can be favorably explored in nutraceutical and pharmaceutical fields. Sicilian sumac is herein chemically investigated by means of a combined NMR/HR MS-based profiling. A hydroalcoholic extract was p...
Article
Full-text available
Myrtaceae Juss. is a very large family of flowering plants, that are a valuable source of bioactive compounds. From the phytochemical point of view, apart from ubiquitous tannins, flavonoid derivatives and volatile oils, Myrtaceae plants are very rich in phloroglucinol derivatives, divided in two principal subclasses: oligomeric acylphloroglucinols...
Article
Ethnopharmacological relevance Allium hooshidaryae Mashayekhi, Zarre & R.M. Fritsch sp. nova (sect. Compactoprason) is a wild plant in northwestern Iran. The plant is traditionally used, besides as spice, also for its medicinal properties. Aim of the study Due to the shortcoming evidence in scientific research and the importance of this plant in f...
Article
Full-text available
Bacteria are social organisms able to build complex structures, such as biofilms, that are highly organized surface-associated communities of microorganisms, encased within a self- produced extracellular matrix. Biofilm is commonly associated with many health problems since its formation increases resistance to antibiotics and antimicrobial agents,...
Article
Full-text available
The need for plants to defend themselves, communicate, and somehow contribute to the social life in their ecosystems has triggered the evolution of an astonishing number of diverse chemicals, some of which involved in plant–plant interactions. In the present study, specific aspects of allelopathy are investigated. A combination of bioassays and met...
Article
Full-text available
Cannabidiolic acid (CBDA) is the main phytocannabinoid in fiber and seed-oil hemp (Cannabis sativa L.) plants, but its potential health-related capabilities have been masked for years by a greater scientific interest towards its neutral derivative cannabidiol (CBD). This review aims to collect from the literature and critically discuss all the info...
Article
Full-text available
Phenolic compounds (PCs) – with special reference to secondary plant metabolites – were characterised in two Mediterranean olive groves (Olea europaea L.). Representative pedological profiles were dug to identify and characterise the pedotype. Qualitative and quantitative analyses were carried out on soil core samples gathered at fixed depths (0–20...
Article
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Few topics are able to channel the interest of researchers, the public, and industries, like nutraceuticals. The ever-increasing demand of new compounds or new sources of known active compounds, along with the need of a better knowledge about their effectiveness, mode of action, safety, etc., led to a significant effort towards the development of a...
Chapter
Metabolomics is the analysis of endogenous and exogenous low molecular mass metabolites within cells, tissues, or biofluids of an organism in response to an external stressor. In this chapter, we highlight the importance of the subdiscipline of environmental metabolomics, which investigates the interactions of organisms with environmental stressors...
Article
Full-text available
Astragalus is a cosmopolitan genus characterised by a large number of species with an exceptional rate of diversification. Many of these species are used since ancient times in the Traditional Chinese Medicine (TCM) to cure a condition of general weakness known as “qi”-deficiency. The main phytochemical constituents of these species have been ident...
Article
Introduction: Mediterranean plants are characterised by a high content of bioactive secondary metabolites that play important roles in plant-plant interactions as plant growth regulators and could be useful for the development of new eco-friendly herbicides. Objective: An NMR-based metabolomics approach was reported to seek selective phytotoxic...
Article
Full-text available
In several European countries, especially in Sweden, the seeds of the species Astragalus boeticus L. were widely used as coffee substitutes during the 19th century. Nonetheless, data regarding the phytochemistry and the pharmacological properties of this species are currently extremely limited. Conversely, other species belonging to the Astragalus...
Article
Wastewater irrigation of crops may be effective to avoid depletion (about 70%) of freshwater resources. However, the use of reclaimed waters containing persistent microcontaminants such as antineoplastic drugs is of high environmental concern. These active compounds may affect human health with potentially severe adverse effects. To better understa...
Article
Full-text available
The seeds of hemp (Cannabis sativa L.) have been an important source of nutrition for thousands of years in Chinese and European cultures but, nowadays, in spite of the multiple clinical evidence, which highlights their huge health-promoting properties, people are still unaware about their nutritional as well as nutraceutical benefits. Indeed, the...
Article
Full-text available
In a search for new potential multitarget anti-HIV compounds from natural products, we have identified in Hypericum scruglii, an endemic and exclusive species of Sardinia (Italy), a potent plant lead. The phytochemical study of the hydroalcoholic extract obtained from its leaves led to the isolation of its most abundant secondary metabolites, belon...
Article
Full-text available
The discovery of bioactive compounds from natural sources entails an extremely lengthy process due to the timescale and complexity of traditional methodologies. In our study, we used a rapid NMR based metabolomic approach as tool to identify secondary metabolites with anti-proliferative activity against a panel of human colorectal cancer cell lines...
Article
The phytochemical profile, antioxidant activity and α-glucosidase inhibitory activity of Hypericum scruglii Bacchetta, Brullo et Salmeri and Hypericum hircinum L. were analyzed and compared to those of the best-known Hypericum perforatum L. Samples were prepared using three different extraction methods (maceration in 70% ethanol, extraction in MeOH...
Article
Naturally derived compounds represent a potential source of pharmacologically active drugs able to contrast different diseases, including gastric cancer, a multifactorial disease, in which the important role played by H. pylori infection has been demonstrated. Carexanes, stilbene derivatives, isolated from plants of the Carex distachya Desf., are u...
Article
Strawberry grape is considered beneficial due to its extensive phytochemical properties. To expand the knowledge about the chemical constituents and the biological activities of the whole plant, 2D-NMR investigation has been carried out on pulp, peel, seeds, stalks and leaves. Catechin and epicatechin were identified as the main constituents of the...
Article
In this study, the effects of the allelochemical coumarin through a metabolomic, proteomic and morpho-physiological approach in Arabidopsis adult plants (25 days old) were investigated. Metabolomic analysis evidenced an increment of amino acids and a high accumulation of soluble sugars, after 6 days of coumarin treatment. This effect was accompanie...
Article
Three unusual amino-phloroglucinols, named helichrytalicines A-C, along with seventeen known compounds including acetophenones, tremetrone derivatives, low-molecular weight phenols, flavonol glucosides, have been isolated from the medium-polar extract of Helichrysum italicum (Roth) G. Don, a medicinal plant typical of the Mediterranean vegetation....
Article
Abstract The phytochemical study of Bellis sylvestris has been carried out. This study led to the isolation of 28 secondary metabolites belonging to different classes. The structures of these compounds have been elucidated on the basis of extensive 2D-NMR spectroscopic analyses, including COSY, TOCSY, HSQC, CIGAR-HMBC, H2BC and HSQC-TOCSY, along wi...
Article
Full-text available
A new iridoid (1) and a new phenylethanoid glycoside (4), together with five known compounds (2, 3, 5, 6 and 7), were isolated for the first time from the ethyl acetate soluble part of the hydroalcoholic extract of the aerial parts of Cistanche violacea Desf. (Orobanchaceae), an endemic species of the North of the Sahara. The structures of these co...
Chapter
Saponins are a group of naturally occurring bioactive compounds often classified in several groups based on their variable structural features. They are constituted by an aglycone or sapogenin (with triterpenoid or steroid skeletons) and one or more sugar chains of different length and branching. Based on their complexity, the structural elucidatio...
Article
Full-text available
An NMR-based metabolomic approach has been applied to analyse seven aromatic Mediterranean plant species used in traditional cuisine. Based on the ethnobotanical use of these plants, the approach has been employed in order to study the metabolic changes during different seasons. Primary and secondary metabolites have been detected and quantified. F...
Article
Full-text available
Allelopathy is a very complex phenomenon, infl uenced by many inherent and environmental factors. Due to this complexity, its elucidation is a challenging task, requiring expertises from several fi elds. A valuable approach to study these interactions is systems biology, a holistic approach giving a broad view of biological systems and relying on o...
Article
Full-text available
Bacterial biofilms are highly organized surface-associated communities of bacteria encased within an extracellular matrix produced by themselves, capable of growing in connection with different biological or inert surfaces such as artificial joints or catheters. Biofilms are commonly associated with many health problems, such as endocarditis, otiti...
Article
In recent years, the ongoing need for novel pharmaceuticals to be introduced in human medicine has substantially benefited from the widespread research activity on the role of bioactive microbial compounds involved in the regulation of interactions with other organisms. A good example is represented by 3-O-methylfunicone, a benzo-γ-pyrone metabolit...
Article
The understanding of molecular mechanisms underlying host-pathogen interactions in plant diseases is of crucial importance to gain insights on different virulence strategies of pathogens and unravel their role in plant immunity. Among plant pathogens, Phytophthora species are eliciting a growing interest for their considerable economical and enviro...
Article
Allelopathy is the chemical mediated communication among plants. While on one hand there is growing interest in the field, on the other hand it is still debated as doubts exist at different levels. A number of compounds have been reported for their ability to influence plant growth, but the existence of this phenomenon in the field has rarely been...
Article
Plants show seasonality in the secondary metabolite production and the resulting variability can influence plant bioactivity. A study aimed at determining the seasonal metabolic changes in Phillyrea angustifolia and the effects of them on its biological activity has been carried out. The NMR profiles of the extracts obtained from leaves monthly col...
Article
Chemical investigation of the endophytic strain A1021B ascribed to the Fusarium incarnatum-equiseti species complex led to the isolation of a novel pyridine alkaloid related to fusaric acid. The structure was elucidated by 1D and 2D NMR experiments (1H, 13C, COSY, HSQC, CIGAR-HMBC, H2BC). The compound induced cytotoxic effects on six human cancer c...
Article
Full-text available
The genus Penicillium is ubiquitous and its species are commonly recovered from every kind of substrate and environmental conditions. Therefore, not surprisingly, Penicillium strains are commonly reported in investigations dealing with fungal endophytic assemblages of plants in both natural and anthropic contexts. As such they are implicated in mor...
Article
Full-text available
Allelopathy (the chemical based communication among plants) is gaining more and more attention thanks to its likely outcomes in several fields, but it is, in the meantime, a questionable topic, due to a difficult determination. Despite the broad literature, allelopathic interactions are far from being clarified. Conclusive evidence in this field i...
Article
Two new acylated drimane sesquiterpenoid glucosides, saxifragoside A and B, have been isolated from the methanol extract of Petrorhagia saxifraga, a perennial herbaceous plant typical of the Mediterranean vegetation. The structures of these compounds have been elucidated on the basis of extensive 2D NMR spectroscopic analyses, including COSY, TOCSY...
Article
The title paper reports a study on the structural elucidation by spectroscopic and computational methods of the products obtained from the reaction of two conformers of quercetin with the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH(•)). Many points of criticism, concerning both theoretical principles and experimental data, are highlighted in the pr...
Article
Four novel γ-pyrone (=4H-pyran-4-one) metabolites, petrorhagiosides A–D, along with four known analogs, have been isolated from the MeOH extract of Petrorhagia saxifraga, a perennial herbaceous plant typical of Mediterranean vegetation. The structures of the new compounds were established on the basis of extensive spectroscopic analyses including 1...
Article
Full-text available
The polyphenolic composition and antioxidant properties of the methanol leaf extract of Vitis × labruscana cv. 'Isabella' has been performed by means of different spectrophotometric antioxidant methods. Intracellular ROS production was measured by cell fluorescence after loading with 2',7'-H2DCF-DA. The extract promising efficacy has laid the basis...
Article
A metabolomic-based approach for the study of allelopathic interactions in the Mediterranean area is proposed using Aegilops geniculata Roth (Poaceae), a Mediterranean herbaceous plant, as test species. Its metabolome has been elucidated by 1D and 2D NMR experiments. Hydroponic plant cultures of A. geniculata were treated with specific compounds of...
Article
The antioxidant properties of six flavones from Teucrium polium L., one of them isolated for the first time, have been established through the determination of their abilities to inhibit free radicals using DPPH, ABTS radicals and ORAC test. The structure of the new metabolite has been elucidated by 1-D ((1)H, (13)C and DEPT) and 2-D (COSY, TOCSY,...
Article
A metabolomic-based approach for the study of allelopathic interactions in the Mediterranean area is proposed using Aegilops geniculata Roth (Poaceae), a Mediterranean herbaceous plant, as test species. Its metabolome has been elucidated by 1D and 2D NMR experiments. Hydroponic plant cultures of Aegilops geniculata were treated with specific compou...
Article
Six oleanane saponins were isolated for the first time from leaves of Bellis sylvestris Cyr., the southern daisy. Their structures were established by the extensive use of 2D-NMR experiments, including COSY, TOCSY, NOESY, HSQC, HMBC, CIGAR, H2BC, and HSQC-TOCSY, along with Q-TOF HRMS(2) analysis. All of the compounds are constituted by bayogenin as...
Article
Over time, a large number of cultivars of Olea europaea, one of the oldest cultivated trees in the world, appeared as a result of events such as outcrossing, mutation, and selective pressure (including grower requirements) on the original olive germplasm. Some cultivars are characteristic of a particular country, whereas others are scattered over a...
Article
► This is the first report on the phytochemical investigation of Phleum subulatum. ► Fourteen phenol glucosides were isolated from aerial part of P. subulatum. ► The structure of a new glucoside has been elucidated by NMR spectroscopy and MS data. ► This is a chemotaxonomic contribution to better understanding of Poaceae family.
Article
Eleven alkylphenols were isolated from the aerial parts of Dactylis glomerata subsp. hispanica, six of them described for the first time. The structural characterization of these compounds has been elucidated by 1D and 2D NMR techniques. The fragmentation patterns of the metabolites obtained by GC–MS analysis allowed the side chain to be elucidated...
Chapter
There is a growing interest in the search of new natural products to be used as additives, instead of synthetic compounds, in preserving flavour, improving taste and appearance and preventing food and drinks from mouldy or stale. Mediterranean area is known to be an hot spot of a very high plant species biodiversity and, for its strong environmenta...
Article
Seven neo-clerodanes (teupolins VI-XII) and eleven known compounds were isolated and characterized from leaf extracts of Teucrium polium L., a medicinal plant used in traditional and herbal medicine for its hypolipidemic, hypoglycemic, antioxidant and antiproliferative properties. The structures of these compounds were elucidated by 1D (1H, 13C and...
Article
In the assessment of the antioxidant properties of edible plants, the widely consumed Vitis × labruscana cv. 'Isabella', known in Italy as "fragola" (strawberry) grape, was of interest. Phenol and flavonoid contents of the methanolic extracts of peel, pulp, seed, leaf, and stalk components of the plant were determined. The metabolic profile of the...
Article
► A new drimane glucoside has been isolated from Petrorhagia velutina roots. ► The complete 1H and 13C NMR assignments have been reported. ► A sesquiterpene metabolite is reported in the genus for the first time.
Article
From the aerial parts of Petrorhagia velutina, a new dimeric p-coumaroyl glucose and two monomeric cis p-coumaroyl and feruloyl derivatives have been isolated along with three known related compounds. The structural characterization of these compounds has been elucidated by 1D and 2D NMR techniques. CAD mass spectra have allowed to confirm the spec...
Article
Eight flavonoid C-glycosides, including three new analogues, have been isolated from leaf and root methanolic extracts of Petrorhagia velutina, a Mediterranean herbaceous plant. The antiproliferative activity against human hepatoblastoma cancer cell line HepG2 has been analyzed by the MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium br...
Article
Six new 17(15→16)-abeo-abietanes, along with seven known compounds, were isolated and characterized from ethyl acetate root extract of Teucrium polium L., a medicinal plant belonging to the Labiatae family reported to have hypolipidemic, hypoglycaemic, anti-nociceptive and anti-inflammatory effects. Their structures were elucidated by 1D ((1)H, (13...