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Monica Munoz-Lopez

Monica Munoz-Lopez
University of Castilla-La Mancha, Medical School · Medical Sciences and Regional Centre for Biomedical Sciences

PhD Cognitive Neuroscience

About

49
Publications
9,648
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Introduction
Monica Munoz-Lopez currently is at the Medical Sciences and Regional Centre for Biomedical Sciences, University of Castilla-La Mancha, Medical School, Human Neuronatomy Laboratory. Their current project is 'Consecuences of perinatal hypoxia/ischemia in the brain and cognition in children at school age and adolescence'. She is an honorary research fellow at the University of Edinburgh, where her research is focused in identifying the neuropsychological phenotype of prematurity.
Additional affiliations
January 2016 - July 2018
University of Glasgow
Position
  • Lecturer
December 2009 - January 2016
University of Castilla-La Mancha
Position
  • Professor (Associate)
Description
  • Presently in secondment
April 2005 - May 2010
University College London Institute of Child Health & Great Ormond Street Hospital for Children NHS Foundation Trust
Position
  • PostDoc Position

Publications

Publications (49)
Article
Measurements of medial temporal lobe (MTL) neurodegeneration derived using MRI have been shown to be sensitive to changes during the early stages of AD. The specificity of these measurements to tau neurofibrillary tangle (NFT) pathology is limited by other frequently comorbid non‐AD factors which also cause structural changes in the MTL. Here, we d...
Article
Quantitative three‐dimensional maps of tau neurofibrillary tangles (NFT) burden derived from dense serial histology have potential application for in‐vivo biomarker studies. We constructed a group‐level NFT burden map from 15 medial temporal lobe (MTL) specimens, majority with Primary Age‐Related Tauopathy (PART) or low‐level Alzheimer’s disease ne...
Article
Full-text available
Tau neurofibrillary tangle (NFT) pathology in the medial temporal lobe (MTL) is closely linked to neurodegeneration, and is the early pathological change associated with Alzheimer’s disease (AD). To elucidate patterns of structural change in the MTL specifically associated with tau pathology, we compared high-resolution ex vivo MRI scans of human p...
Chapter
Neurofibrillary tangle (NFT) pathology in the medial temporal lobe (MTL) is closely linked to neurodegeneration, and is the early pathological change associated with Alzheimer’s Disease (AD). In this work, we investigate the relationship between MTL morphometry features derived from high-resolution ex vivo imaging and histology-based measures of NF...
Article
Tau protein neurofibrillary tangles are closely linked to neuronal/synaptic loss and cognitive decline in Alzheimer’s disease and related dementias. Our knowledge of the pattern of neurofibrillary tangle progression in the human brain, critical to the development of imaging biomarkers and interpretation of in vivo imaging studies in Alzheimer’s dis...
Preprint
Full-text available
Tau protein neurofibrillary tangles (NFT) are closely linked to neuronal/synaptic loss and cognitive decline in Alzheimer's disease (AD) and related dementias. Our knowledge of the pattern of NFT progression in the human brain, critical to the development of imaging biomarkers and interpretation of in vivo imaging studies in AD, is based on convent...
Article
Structural magnetic resonance imaging (MRI) biomarkers are important for early detection of Alzheimer’s Disease (AD). However, atrophy measures can be confounded by changes due to aging and comorbid non‐AD neurodegenerative pathologies. Linking postmortem MRI of the medial temporal lobe (MTL) to histopathology may identify focal patterns of change...
Article
Finding effective biomarkers that can support early‐stage clinical trials is a major challenge in Alzheimer’s Disease (AD). MRI measures of structural change in the medial temporal lobe (MTL) have proven to be sensitive to change in the early stages of AD. However, other frequently comorbid non‐AD factors (e.g. cerebrovascular disease, TDP‐43 patho...
Article
Full-text available
The medial temporal lobe (MTL) is a hotspot of different neurodegenerative pathologies, and recent studies have shown associations of severity of pathology with atrophy measured on antemortem MRI. However, these studies are limited by the interval between time of scan and death and the relatively low resolution of the commonly acquired in vivo MRI...
Article
Full-text available
A key issue in neurobiological studies of episodic‐like memory is the geometric frame of reference in which memory traces of experience are stored. Assumptions are sometimes made that specific protocols favour either allocentric (map‐like) or egocentric (body‐centered) representations. There are, however, grounds for suspecting substantial ambiguit...
Article
Full-text available
The temporal pole (TP) has been involved in multiple functions from emotional and social behavior, semantic processing, memory, language in humans and epilepsy surgery, to the fronto-temporal neurodegenerative disorder (semantic) dementia. However, the role of the TP subdivisions is still unclear, in part due to the lack of quantitative data about...
Article
Full-text available
Prematurity presents a risk for higher order cognitive functions. Some of these deficits manifest later in development, when these functions are expected to mature. However, the causes and consequences of prematurity are still unclear. We conducted a longitudinal study to first identify clinical predictors of ultrasound brain abnormalities in 196 c...
Article
Full-text available
The Gyrus ambiens is a gross anatomical prominence in the medial temporal lobe (MTL), associated closely with Brodmann area 34 (BA34). It is formed largely by the medial intermediate subfield of the entorhinal cortex (EC) [Brodmann area 28 (BA28)]. Although the MTL has been widely studied due to its well-known role on memory and spatial information...
Article
Full-text available
Participants of the annual World Memory Championships regularly demonstrate extraordinary memory feats, such as memorising the order of 52 playing cards in 20 s or 1000 binary digits in 5 min. On a cognitive level, memory athletes use well-known mnemonic strategies, such as the method of loci. However, whether these feats are enabled solely through...
Article
Full-text available
The cortical mantle is not homogeneous, so that three types of cortex can be distinguished: allocortex, periallocortex and isocortex. The main distinction among those three types is based on morphological differences, in particular the number of layers, overall organization, appearance, etc., as well as its connectivity. Additionally, in the phylog...
Chapter
Full-text available
The purpose of this chapter is to review the neuroanatomical basis of nonhuman primate Hippocampal Formation. The term “Hippocampal Formation” is defined to include the dentate gyrus, hippocampal CA fields and subiculum, on one hand, and on the other hand, presubiculum and parasubiculum and entorhinal cortex. The circuitry supporting hippocampal fu...
Article
Full-text available
The medial prefrontal areas 32, 24, 14, and 25 (mPFC) form part of the limbic memory system, but little is known about their functional specialization in humans. To add anatomical precision to structural and functional MRI data, we aimed to identify these mPFC subareas in histological preparations of human brain tissue, determine sulci most consist...
Article
Full-text available
Neonatal hypoxia can lead to hippocampal atrophy, which can lead, in turn, to memory impairment. To test the generalisability of this causal sequence, we examined a cohort of 41 children aged 8-16, who, having received the arterial switch operation to correct for transposition of the great arteries, had sustained significant neonatal cyanosis but w...
Article
Full-text available
Increasing evidence is emerging for sexual dimorphism in the trajectory of white matter development in children assessed using volumetric MRI and more recently diffusion MRI. Recent studies using diffusion MRI have examined cohorts with a wide age range (typically between 5 and 30 years) showing focal regions of differential diffusivity and fractio...
Article
Full-text available
The anatomical organization of the lateral prefrontal cortex (LPFC) afferents to the anterior part of the temporal lobe (ATL) still needs to be clarified. The LPFC has two subdivisions, dorsal (dLPFC) and ventral (vLPFC) which have been linked to cognitive processes. The ATL includes several different cortical areas, namely temporal polar cortex an...
Article
Full-text available
Auditory recognition memory in non-human primates differs from recognition memory in other sensory systems. Monkeys learn the rule for visual and tactile delayed matching-to-sample within a few sessions, and then show one-trial recognition memory lasting 10-20 min. In contrast, monkeys require hundreds of sessions to master the rule for auditory re...
Article
Full-text available
Given the central role of hippocampal function in spatial and episodic memory, the concept of enhancing it when compromised is attractive. This might be realised behaviourally, pharmacologically or via more radical routes such as brain stimulation. Successful approaches in each of these domains include trial-spacing, rest, and NMDA or cholinergic r...
Article
Full-text available
Over 100 years of research on the hippocampal formation has led us understand the consequences of lesions in humans, the functional networks, anatomical pathways, neuronal types and their local circuitry, receptors, molecules, intracellular cascades, and some of the physiological mechanisms underlying long-term spatial and episodic memory. In addit...
Article
Full-text available
The optic radiation (OR) is a component of the visual system known to be myelin mature very early in life. Diffusion tensor imaging (DTI) and its unique ability to reconstruct the OR in vivo were used to study structural maturation through analysis of DTI metrics in a cohort of 90 children aged 5-18 years. As the OR is at risk of damage during epil...
Article
Full-text available
Neonates treated for acute respiratory failure experience episodes of hypoxia. The hippocampus, a structure essential for memory, is particularly vulnerable to such insults. Hence, some neonates undergoing treatment for acute respiratory failure might sustain bilateral hippocampal pathology early in life and memory problems later in childhood. We i...
Article
Full-text available
To re-examine whether or not selective hippocampal damage reduces novelty preference in visual paired comparison (VPC), we presented two different versions of the task to a group of patients with developmental amnesia (DA), each of whom sustained this form of pathology early in life. Compared with normal control participants, the DA group showed a...
Article
Full-text available
The white matter of the brain undergoes a range of structural changes throughout development; from conception to birth, in infancy, and onwards through childhood and adolescence. Several studies have used diffusion magnetic resonance imaging (dMRI) to investigate these changes, but a consensus has not yet emerged on which white matter tracts underg...
Article
Full-text available
Episodic memory or the ability to store context-rich information about everyday events depends on the hippocampal formation (entorhinal cortex, subiculum, presubiculum, parasubiculum, hippocampus proper, and dentate gyrus). A substantial amount of behavioral-lesion and anatomical studies have contributed to our understanding of the organization of...
Chapter
Full-text available
Episodic memory has been defined in a way that may make it unique to humans, but an alternative comparative perspective holds that 'episodic-like memory systems' occur in animals which are capable of remembering unique events in relation to the contexts in which they occur. Such systems are mediated by circuitry in the medial temporal lobe and its...
Article
Full-text available
Auditory memory in the monkey does not appear to extend beyond the limits of working memory. It is therefore surprising that this ability is impaired by medial temporal lobe (MTL) resections, because such lesions spare working memory in other sensory modalities. To determine whether MTL ablations might have caused the auditory deficit through inadv...
Article
Full-text available
Hippocampal formation plays a prominent role in episodic memory formation and consolidation. It is likely that episodic memory representations are constructed from cortical information that is mostly funnelled through the entorhinal cortex to the hippocampus. The entorhinal cortex returns processed information to the neocortex. Retrograde tracing s...
Article
Full-text available
Convergence of sensory modalities in the nonhuman primate cerebral cortex is still poorly understood. We present an anatomical tracing study in which polysensory association cortex located at the fundus and upper bank of the rostral superior temporal sulcus presents reciprocal connections with primary olfactory structures. At the same time, project...
Article
Full-text available
Entorhinal cortex (EC) relays information from the hippocampus to the cerebral cortex. The origin of this entorhino-cortical pathway was studied semiquantitatively and topographically with the use of 23 retrograde tracer injections in cortical areas of the frontal, temporal, and parietal lobes of the monkey. To assess possible alternative, parallel...
Article
Full-text available
The Medical School of the University of Castilla-La Mancha (UCLM, Albacete Spain) was launched in 1998 and is the most recent one in Spain. Teaching is based on small groups of students (20-25 students/group). An objective-oriented self-learning approach provides maximal autonomy and independence in the achievement of objectives by the students in...
Article
Full-text available
The parahippocampal gyrus, located at the medial temporal lobe, is a key structure in declarative memory processing. We have analyzed the general organization of the parahippocampal gyrus in the baboon, a nonhuman primate species relatively close to human. This region is rostrocaudally made up of the temporopolar, perirhinal, entorhinal (divided in...
Article
Full-text available
The entorhinal cortex is an essential component in the organization of the human hippocampal formation related to cortical activity. It transfers, neocortical information (ultimately distributed to the dentate gyrus and hippocampus) and receives most of the hippocampal output directed to neocortex. At birth, the human entorhinal cortex presents sim...
Poster
Full-text available
Removals of the superior temporal gyrus (STG) that include the lateral temporal pole impair auditory short-term memory (Saunders et al., Soc. Neurosci. Abstr. 24: 1907, 1998). Furthermore, recent FDG-PET studies in monkeys suggest that the temporal pole plays a special role in processing complex auditory stimuli. For example, this area shows eviden...
Poster
Full-text available
Bilateral damage to the medial temporal lobe in humans results in a severe and permanent global amnesia (Scoville and Milner, 1957). Recent findings in monkeys have demonstrated that bilateral removal of the perirhinal cortex results in both a visual and somatosensory recognition deficit (Meunier et al., 1993; Malkova et al., 2001; Buffalo et al.,...
Article
Full-text available
Episodic memory consolidation requires the integrity of the anatomical pathways between the cerebral cortex and the hippocampal formation. Whilst the largest cortical output of the hippocampal formation originates in the entorhinal cortex, direct projections from CA1, subiculum and presubiculum to the cortex have been reported. The aim of this stud...

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