Monica Cretan Stamate

• PhD
• Professor (Assistant) at Grigore T. Popa University of Medicine and Pharmacy

Background: Rheumatoid arthritis is a chronic autoimmune disease that leads to severe disability and requires improved therapeutic strategies to optimize anti-inflammatory treatment. This study aimed to address this challenge by developing and characterizing an extended-release polymer matrix tablet containing ketoprofen and a ketoprofen–β-cyclodex...

Background: Diabetes is a growing global health crisis that requires effective therapeutic strategies to optimize treatment outcomes. This study aims to address this challenge by developing and characterizing extended-release polymeric matrix tablets containing metformin hydrochloride (M-HCl), a first-line treatment for type 2 diabetes, and honokio...

For quantitative determination of honokiol (HNK) and metformin hydrochloride (M-HCl) by HPLC from formulations and from dissolution studies, a QbD approach using three factors - three levels design was implemented to optimize the chromatographic conditions. To study the impact of each variable on the peak area of both compounds and retention time o...

Capsules as a pharmaceutical dosage form have evolved through the years in many ways, from the development of capsule content for various modified release models, to innovations for new capsule shells, as an alternative to conventional gelatin shells. Hard capsules offer a wide range of alternative gelatin substituents for shell formulation, given...

The current studies entail quality by design (QbD)-enabled development of a simple, rapid, precise, accurate, and cost-effective high-performance liquid chromatographic method for estimation of metformin hydrochloride (M-HCl). Design of experiments (DoE) was applied for multivariate optimization of the experimental conditions of the HPLC method. Ri...

The purposes of the study were the comparison between the levels of different polyphenol groups in Crataegus pentagyna (CP) leaf and Viburnum opulus (VO) fruit extracts, the assessment of their 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and the in vitro determination of their permeability parameters. CP extract had higher tota...

Smart polymeric micelles (PMs) are of practical interest as nanocarriers for the encapsulation and controlled release of hydrophobic drugs. Two hydrophobic drugs, naturally-based curcumin (Cur) and synthetic 5-fluorouracil (5-FU), were loaded into the PMs formed by a well-defined pH-sensitive poly(2-vinyl pyridine)-b-poly(ethylene oxide) (P2VP90-b-...

Psoriasis is an inflammatory, autoimmune dermatosis with multifactorial etiology and chronic evolution, with major repercussions on the patient’s quality of life (QoL). The main therapeutic purpose in psoriasis is to alleviate the symptomatology of the disease, to prevent recurrences and to increase the patient’s QoL. The therapeutic management of...

The technological achievements of the past decades have allowed the development of the pharmaceutical form of tablet both in terms of formulation and preparation technologies, and in terms of quality parameter evaluation. The aim of our article is to continue to analyze the development of this pharmaceutical dosage form by describing the methods fo...

Caffeine is a drug substance primarily known in the form of refreshing and energizing drinks such as tea, coffee, hot chocolate etc. Although the origin of using coffee beans ‘toners’ is lost in the mists of time, scientific data on this substance, classified as cortical stimulant, are relatively recent and begin in 1820 when it was isolated from c...

Caffeine is a drug substance primarily known in the form of refreshing and energizing drinks such as tea, coffee, hot chocolate etc. Although the origin of using coffee beans ‘toners’ is lost in the mists of time, scientific data on this substance, classified as cortical stimulant, are relatively recent and begin in 1820 when it was isolated from c...

Nowadays, European Pharmacopoeia defines tablets as solid dosage forms containing one or more active substances obtained by compressing a volume of powder or by extrusion, moulding or lyophilization techniques. This pharmaceutical form has experienced a spectacular evolution over the years. The first patents for some tablet formulations were regist...

Wax represents an important group of ingredients used for the implementation of cosmetic and decorative products. From a chemical point of view, waxes are complex mixtures of hydrocarbons and fatty acids combined with esters. They have a long-lasting consistency and are highly resistant to moisture, oxidation and microbial attack. The paper aims to...

IMAQ Vision includes a set of optimized functions for image processing (filtering and geometric transformations) and analysis of different areas of interest (perimeter, area, orientation, height, length and width). Also with this program, it may determine the edges of objects, distances and angles between the edges, an object can be searched based...

This paper presents experimental analysis of the phenomenon of friction that occurs between two surfaces, one of polyethylene and other ceramics. Alumina ceramic is being recognized like a good biomaterial for its high strength and toughness. This ceramic, is used to manufacture the femoral head for arthroplasty of the hip joint in association with...

Joint prosthesis involves the combination in the form of friction couplings of the different materials such as two metals, metal-polymer and polymer-ceramic. This paper aims to analyze the wear particles produced from the friction between two biomaterials: ultra hight molecular weight polyethylene( uhmwpe ) and magnesium aluminosilicate ceramic. To...

The present paper aims to study the possibility to modify the properties of polyvinyl alcohol (pva) cryogels prepared in the presence of ketoprofen in order to replace the damaged articular cartilage. Articular cartilage is the most important part of articulation characterized by very low friction, high wear resistance, and poor regenerative qualit...

This paper presents a theoretical method for simulation and three-dimensional reconstruction of the anatomical elements of the spine in order to achieve hydrogel disc prosthesis by 3D printing. For these simulations are used computed tomography (CT) scan image and AutoCAD reconstruction program, to provide high quality prediction of the 3D spine st...

This paper analyzes the tribological properties of a polymer prosthetic component, which was optimized by coating polymer layers containing medicinal substances. Polymer component is made of ultra high molecular weight polyethylene (uhmwpe) and is used in prosthetic hip replacement for acetabular cup with a metal component of cobalt-chromium alloy...

Drug-release systems are studied lately for increasing absorption in the body and improve the therapeutic effectiveness is key objective. Whatever form it may take a drug release system: tablet, implant, injectable suspension or transdermal system, the basic unit on which effective therapeutic drug particle. Knowledge of particle size distribution...

Rehabilitation of joints that underwent major surgery, involves reducing postoperative pain and inflammation. Many pharmaceutical product used in reducing joint pain are based on the extended-release technology and becoming increasingly important in research domain. The performance of extended-release matrix tablets is dependent on the solid dosage...

In this paper, the mechanical properties of extended drug release systems were studied. A binder is a material that is added to a formulation in order to improve the mechanical strength of a drug release system. The drug release systems investigated were cylindrical tablets containing mixtures of various ketoprofen types and binders. Among the bind...

Since, anti-inflamatory drugs have a high demand due to increased incidence of pain associated with different pathology; the objectives of this paper are the synthesis, the physicochemical characterization and analysis of the tribological properties for the ketoprofen-cyclodextrin complexes. The analysis of solubility for these complexes was carrie...

Degenerative disc disease in the lumbar spine is marked by a dehydration of the intervertebral disc and loss of biomechanical function of the spinal unit. Since the current surgical procedures are ineffective in restoring natural biomechanical function back to the diseased disc, researchers have looked to replace the intervertebral disc. These desi...

Biological materials are constantnly subject to contact or remote forces.Often there is confusion about the diferences between forces and loads. Forces are any action that tends to change the shape, size, or state of inertia or the motion of body. A load is a force or moment applied to the material.In other words, the number of cycles through wich...

Detailed surface characteristics of the particles produced during fretting may well be significant in determining their biological effects. Apart from a broad size determination very few attempts have been made at devising means of describing profile textures of particles. An approach is presented for describing the nature of particle shape and sur...