Monica BUTNARIU

Monica BUTNARIU
Banat’s University of Agricultural Sciences and Veterinary Medicine “King Michael I of Romania” from Timisoara · Chemistry & Biochemistry Discipline

Chemist, PhD/ https://orcid.org/0000-0002-2032-5000 /
Nutritional Biochemistry, Pharmacology&Toxicology,NaturalProducts(different aspects),MedicalBiochemistry,ChemicalEcology

About

281
Publications
319,529
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
3,091
Citations
Introduction
Monica BUTNARIU heads the Romania Biotechnology and Environmental Sciences Group-Council for Nutritional and Environmental Medicine and also National Correspondent of the International Association for Plant Biotechnology, has 79 articles published in the Web of Science Core Collection-Clarivate Analytics that have been cited over 1730 times, with H-index =32 (WoS), and she has been serving as an editorial board member of reputed Journals and she has peer review activity. Prof. Butnariu has written several books and book chapters in different areas of chemistry. Her research interests focus on the Agricultural chemistry (biotechnology, environmental protection); Applied chemistry(instrumental analysis, biocides, biochemistry, agrofood waste); Material chemistry:(biomaterials);
Additional affiliations
March 1998 - present
University of Timisoara
Position
  • Professor
Description
  • Teaching chemistry and biochemistry; investigation of heavy metal pollution, identification species for biomonitoring; obtaining/characterization/use pharmacological effects, interrelations of plant nutrition/ metabolism.
Education
July 2013 - July 2013
University Cluj–Napoca (http://www.usamvcluj.ro/index.php/doctorat/abilitare)
Field of study
  • biotechnology

Publications

Publications (281)
Article
Full-text available
The objective of the study was to summarize the methods for isolating and identifying natural sulfur compounds from Allium ursinum (ramson) and to discuss the active constituents with regard to antifungal action. Using chromatographic techniques, the active constituents were isolated and subsequently identified. Analyses by high-performance liquid...
Article
Full-text available
This study aimed to quantify the active biological compounds in C. officinalis flowers. Based on the active principles and biological properties of marigolds flowers reported in the literature, we sought to obtain and characterize the molecular composition of extracts prepared using different solvents. The antioxidant capacities of extracts were as...
Article
Full-text available
This study aimed to quantify the allelopathic potential of Datura stramonium (Jimson weed). Sorghum halepense (Johnsongrass) tolerance was assessed by germinating, seed and growing seedlings, dosing of photo-synthesis pigments, followed by treatment with D. stramonium extract tropane alkaloids. Preliminary chemical analysis of the extracts showed t...
Article
Full-text available
The use of natural products based on aqueous extract of propolis and lycopene in the skin's protective mechanisms against UVA radiation was evaluated by means of experimental acute inflammation on rat paw edema. The aim of the present study was to evaluate the harmlessness of propolis - lycopene system through evaluation of skin level changes and a...
Article
Full-text available
Thymoquinone (TQ) is a secondary metabolite found in abundance in very few plant species including Nigella sativa L., Monarda fistulosa L., Thymus vulgaris L. and Satureja montana L. Preclinical pharmacological studies have shown that TQ has many biological activities, such as anti-inflammatory, antioxidant and anticancer. Both in vivo and in vitro...
Article
Full-text available
Propolis, a resinous substance produced by honeybees from various plant sources, has been used for thousands of years in traditional medicine for several purposes all over the world. The precise composition of propolis varies according to plant source, seasons harvesting, geography, type of bee flora, climate changes, and honeybee species at the si...
Article
Full-text available
Oral cancer (OC) is the eighth most common cancer, particularly prevalent in developing countries. Current treatment includes a multidisciplinary approach, involving chemo, radio, and immunotherapy and surgery, which depends on cancer stage and location. As a result of the side effects of currently available drugs, there has been an increasing inte...
Article
Full-text available
Human immunodeficiency virus (HIV) is one of the leading causes of death worldwide, with African countries being the worst affected by this deadly virus. Curcumin (CUR) is a Curcuma longa-derived polyphenol that has attracted the attention of researchers due to its antimicrobial, anti-inflammatory, antioxidant, immunomodulatory and antiviral effect...
Article
Full-text available
Background: Breast cancer is one of the most common types of cancer diagnosed and the second leading cause of death among women. Breast cancer susceptibility proteins of type 1 and 2 are human tumor suppressor genes. Genetic variations/mutations in these two genes lead to overexpression of human breast tumor suppressor genes (e.g., BRCA1, BRCA2),...
Chapter
Full-text available
Hazard analysis is part of a broader concept, namely, risk management. It considers all aspects related to the operation of an industrial unit to prevent and properly treat an unwanted event. The hazard management includes hazard assessment, hazard mitigation measures, and emergency response plans. The update includes reassessment of hazard, implem...
Chapter
Full-text available
Reducing environmental pollution is a theme of environmental policy, of economic–ecological policy, and is becoming a main theme. This problem is in fact an economic, social, developmental theme, and a human rights theme, which touches all aspects of human and nature. An important aspect in achieving the priorities of the relationship between ecolo...
Chapter
Full-text available
All life forms, including medicinal plants and herbs and spices (MPHSs), which are now known, are based on common natural organic compounds (NOCs) with similar biochemical properties. It has not been practically demonstrated that there is an alternative for obtaining the products of catabolism and anabolism reactions specific to biochemical metabol...
Chapter
Full-text available
Medicinal plants and herbs and spices' (MPHSs) cell metabolism, represented by numerous biochemical reactions, is subject to various studies aimed at clarifying certain sequences of biochemical reactions, the connections between different metabolic pathways, the way of regulation, and secondary compounds (SMs). Metabolic products, natural organic c...
Chapter
Full-text available
Secondary compounds (SMs) are essential for the proper functioning of the medicinal plants and herbs and spices (MPHSs) either throughout their existence or at certain stages of their development. Among the SMs, anthocyanins have a special significance whose accumulation intensifies in the case of cellular or physiological stress caused by abiotic...
Article
Full-text available
Tradescantia is a genus of herbaceous and perennial plants belonging to the Commelinaceae family and organized into three infrageneric classifications and 12 sections. More than 80 species within the genus have been used for centuries for medicinal purposes. Phytochem-ical compounds (from various species of the genus) such as coumarins, alkaloids,...
Article
Full-text available
Metabolism consists of closely coordinated series of enzyme-mediated chemical reactions that take place in the plant organism, resulting in the synthesis and use of a wide variety of molecules in the category of carbohydrates, amino acids, fatty acids, nucleotides and polymers derived from them (polysaccharides, proteins, lipids, DNA, RNA, etc.). A...
Article
Full-text available
Prolactin (PRL) is a peptide hormone secreted from anterior pituitary involved in milk production in the females and regulation of sex drive in both sexes. PRL has pro-inflammatory and anti-inflammatory functions. High PRL serum level or hyperprolactinemia is associated with different viral infections. In coronavirus disease 2019 (Covid-19), which...
Article
Full-text available
Bergapten (BP) or 5-methoxypsoralen (5-MOP) is a furocoumarin compound mainly found in bergamot essential oil but also in other citrus essential oils and grapefruit juice. This compound presents antibacterial, anti-inflammatory, hypolipemic, and anticancer effects and is successfully used as a photosensitizing agent. The present review focuses on t...
Article
Full-text available
Natural antimicrobial peptides (AMPs) have high therapeutic potential and have bactericidal, anti-inflammatory and anticancer action, with high selectivity for bacterial cells compared to mammalian cells. The use of AMPs is at an early stage, with most of the work being in vitro and with very few animal studies. AMPs probably interact with the cell...
Article
Full-text available
MicroRNA (miRNA), a noncoding ribonucleic acid, is considered to be important for the progression of gene expression in plants and animals by rupture or translational repression of targeted mRNAs. Many types of miRNA regulate plant metabolism, growth, and response to biotic and abiotic factors. miRNA characterization helps to expose its function in...
Article
Prolactin (PRL) is a peptide hormone secreted from anterior pituitary involved in milk production in the females and regulation of sex drive in both sexes. PRL has pro-inflammatory and anti-inflammatory functions. High PRL serum level or hyperprolactinemia is associated with different viral infections. In coronavirus disease 2019 (Covid-19), which...
Article
Full-text available
Crocus species are mainly distributed in North Africa, Southern and Central Europe, and Western Asia, used in gardens and parks as ornamental plants, while Crocus sativus L. (saffron) is the only species that is cultivated for edible purpose. The use of saffron is very ancient; besides the use as a spice, saffron has long been known also for its me...
Presentation
Full-text available
Article
Full-text available
Pastinaca sativa L. ssp. sylvestris [Mill.] is a biennial, vegetable plant, whose root is tuberous and pivoting and the stem is tall and branched. The leaves are feather-sectate and the flowers are yellow, umbrella-shaped, compound. The fruits are dicariopse with winged edges. The plant is used in food and as a natural remedy in folk medicine. P. s...
Article
Full-text available
The use of phytochemicals is gaining interest for the treatment of metabolic syndromes over the synthetic formulation of drugs. Senna is evolving as one of the important plants which have been vastly studied for its beneficial effects. Various parts of Senna species including the root, stem, leaves, and flower are found rich in numerous phytochemic...
Article
Full-text available
The genus Papaver is highly esteemed in the pharmacy industry, in the culinary field, and as ornamental plants. These plants are also valued in traditional medicine. Among all Papaver species, Papaver somniferum L. (opium poppy) is the most important species in supplying phytochemicals for the formulation of drugs, mainly alkaloids like morphine, c...
Article
Full-text available
Antimicrobial peptides (AMPs) are natural antibiotics, synthesized by ribosomes, with an effect on the natural immunity of animal organisms. AMPs differ in composition [sequence and type of amino acids (AAs)] and structure, which contribute to rapid lysis and have a varied spectrum of antimicrobial activity. AMPs are: peptides (Pps) with alpha-heli...
Article
Full-text available
The genus Hyssopus is widespread in central Asia, East Mediterranean, and Mongolian areas. It has six main species which are used as herbal remedies, such as Hyssopus officinalis which is used as a condiment and flavoring agent in food industry. The other five species are H. ambiguus, H. cuspidatus, H. latilabiatus, H. macranthus, and H. seravschan...
Chapter
Full-text available
In recent decades, pollution of marine ecosystems has gained much attention. Ocean transport of oil, the extraction and processing of offshore hydrocarbon deposits, and manufacturing in refineries near coastal regions, as well as other anthropogenic activities, pose a number of hazards that can lead to water pollution. Marine (navigation) accidents...
Chapter
Full-text available
Heavy metals are considered important toxic pollutants that enter the biogeochemical circuits and accumulate in natural and artificial ecosystems, including in the Black Sea ecosystem. Heavy metals are continuously released into the biosphere by volcanic eruptions and natural weathering of rocks, but also by numerous anthropogenic activities such a...
Article
Full-text available
Cellulose has been on Earth since the advent of trees and plants, being the main constituent of plant cell walls. Cellulose is currently the most widespread polysaccharide in nature and is being observed by scientists, with changes in the processing, use and genetics of plants (many farmers are interested in genetic mutations to produce larger amou...
Article
Full-text available
Benincasa hispida (Thunb.) Cogn. (Cucurbitaceae) is an annual climbing plant, native to Asia with multiple therapeutic uses in traditional medicine. This updated review is aimed at discussing the ethnopharmacological, phytochemical, pharmacological properties, and molecular mechanisms highlighted in preclinical experimental studies and toxicologica...
Article
Full-text available
This study aimed to compare the antibiotic resistance levels of the indicator bacteria Esch-erichia coli in wastewater samples collected from two hospitals and two urban communities. Anti-microbial susceptibility testing was performed on 81 E. coli isolates (47 from hospitals and 34 from communities) using the disc diffusion method according to the...
Article
Full-text available
Cancer is the second most killer worldwide causing millions of people to lose their lives every year. In the case of women, breast cancer takes away the highest proportion of mortality rate than other cancers. Due to the mutation and resistance-building capacity of different breast cancer cell lines against conventional therapies, this death rate i...
Article
In the context of climate change, especially for the temperate continental climate, new potential crop species are emerging, originating from the tropics. One of them is quinoa (Chenopodium quinoa Willd.) with multiple benefits for seed and leaf production. Quinoa is native to South America, grown mainly for seeds, with a high ecological plasticity...
Article
Full-text available
Paclitaxel is a broad-spectrum anticancer compound, which was derived mainly from a medicinal plant, in particular, from the bark of the yew tree Taxus brevifolia Nutt. It is a representative of a class of diterpene taxanes, which are nowadays used as the most common chemotherapeutic agent against many forms of cancer. It possesses scientifically p...
Article
Full-text available
Paclitaxel is a broad-spectrum anticancer compound, which was derived mainly from a medicinal plant, in particular, from the bark of the yew tree Taxus brevifolia Nutt. It is a representative of a class of diterpene taxanes, which are nowadays used as the most common chemotherapeutic agent against many forms of cancer. It possesses scientifically p...
Article
Full-text available
Citrus fruits such as oranges, grapefruits, lemons, limes, tangerines, and mandarins, whose production is increasing every year with the rise of consumer demand, are among the most popular fruits cultivated throughout the globe. Citrus genus belongs to the Rutaceae family and is known for its beneficial effects on health for centuries. These plant...
Article
Full-text available
Paclitaxel is a broad-spectrum anticancer compound, which was derived mainly from a medicinal plant, in particular, from the bark of the yew tree Taxus brevifolia Nutt. It is a representative of a class of diterpene taxanes, which are nowadays used as the most common chemotherapeutic agent against many forms of cancer. It possesses scientifically p...
Article
Full-text available
Diplolepis rosae (Hymenoptera: Cynipidae) is a monophagous species (attacks species of the genus Rosa, family Rosaceae), monovoltine with uncertain origin, though assigned as an ancestral area is the eastern Mediterrana. The species is present in North America, Asia, Australia-Oceania and Europe. In Romania, the species was first reported in 2008,...
Article
Full-text available
Autism spectrum disorder (ASD) is a neurodevelopmental disorder, where social and communication deficits and repetitive behaviors are present. Plant-derived bioactives have shown promising results in the treatment of autism. In this sense, this review is aimed at providing a careful view on the use of plant-derived bioactive molecules for the treat...
Article
Full-text available
Cardiovascular diseases (CVD) are one of the main causes of mortality in the world. The development of these diseases has a specific factor-alteration in blood platelet activation. It has been shown that phenolic compounds have antiplatelet aggregation abilities and a positive impact in the management of CVD, exerting prominent antioxidant, anti-in...
Article
Full-text available
Monica BUTNARIU heads the Romania Biotechnology and Environmental Sciences Group-Council for Nutritional and Environmental Medicine and also National Correspondent of the International Association for Plant Biotechnology, has 79 articles published in the Web of Science Core Collection-Clarivate Analytics that have been cited over 1730 times, with H...
Article
Full-text available
This work proved antioxidant and antimicrobial effects and chemical content of Cichorium intybus L. Methanol extract of C. intybus L. aerial parts were tested for antimicrobial activity, and for antioxidant effect. The results showed that the extract has a significant antimicrobial activity, it inhibited the growth of the Gram-negative bacteria and...
Article
Full-text available
Cancers are complex diseases orchestrated by a plethora of extrinsic and intrinsic factors. Research spanning over several decades has provided better understanding of complex molecular interactions responsible for the multifaceted nature of cancer. Recent advances in the field of next generation sequencing and functional genomics have brought us c...
Article
Full-text available
Genistein is an isoflavone first isolated from the brooming plant Dyer’s Genista tinctoria L. and is widely distributed in the Fabaceae family. As an isoflavone, mammalian genistein exerts estrogen-like functions. Several biological effects of genistein have been reported in preclinical studies, such as the antioxidant, anti-inflammatory, antibacte...
Article
Full-text available
The study describes the current state of knowledge on nanotechnology and its utilization in medicine. The focus in this manuscript was on the properties, usage safety, and potentially valuable applications of chitosan‑based nano‑materials. Chitosan nanoparticles have high importance in nanomedicine, biomedical engineering, discovery and development...
Chapter
Full-text available
Essential oils (EOs) are complex liquid mixtures consisting of volatile organic compounds of vegetable origin, with a fragrant, insoluble in water, soluble in organic solvents or fats. EOs are extracted from flowers, leaves, fruits, bark and sometimes from the wood (camphor wood), using organic solvents or by distillation and steam entrainment. Che...
Article
Full-text available
The study describes the current state of knowledge on nanotechnology and its utilization in medicine. The focus in this manuscript was on the properties, usage safety, and potentially valuable applications of chitosan-based nano-materials. Chitosan nanoparticles have high importance in nanomedicine, biomedical engineering, discovery and development...
Article
Full-text available
Drinking alcohol does not cause problems but consuming it above the limit can be harmful. What is commonly referred to as alcoholism is considered to be alcoholism, an expression of an abnormal personality, often psychopathic. Alcohol becomes dangerous when consumed frequently and in large quantities, causing intoxication called alcoholism. This si...
Article
Full-text available
Datura stramonium L. (Solanaceae) possesses a rich tropane alkaloids (TAs) spectrum. The plant contains, in particular, the allelopathic compounds scopolamine and atropine, which are poorly soluble in water, thus limiting their use in agrochemical formulations as biocidal and deterrent agents against herbivore insects. The efficacy of the hydrophob...
Chapter
Essential oils (EOs) are complex liquid mixtures consisting of volatile organic compounds of vegetable origin, with a fragrant, insoluble in water, soluble in organic solvents or fats. EOs are extracted from flowers, leaves, fruits, bark and sometimes from the wood (camphor wood), using organic solvents or by distillation and steam entrainment. Che...
Article
Cardiovascular ailments are the number one cause of mortalities throughout the globe with 17.9 million deaths per year. Platelet activation and aggregation play a crucial role in the pathogenesis of arterial diseases, including acute coronary syndrome, acute myocardial infarction, cerebrovascular transient ischemia, unstable angina, among others. F...
Article
Full-text available
One of the most recently reported arthropod species in Europe is the oak lace bug, Corythucha arcuata (Insect Class: Order Hemiptera: Tingidae Family). Through this paper we aimed to highlight the adaptation of the insect on new plant species and the implications it has on it. Our study focused on a species very present in the decorative arrangemen...
Article
Full-text available
Background Diabetes mellitus (diabetes mellitus) is a metabolic disorder caused by disruption of carbohydrate metabolism. Hyperglycemia, its main feature, is determined by a secretory deficiency of insulin or a resistance of the tissues to the action of this hormone. Statistical data recently published by the World Health Organization (WHO) reveal...
Chapter
Full-text available
The need of knowledge on bioremediation and ecological reconstruction technologies and their application in environmental degradation consists in achieving of the objectives regarding the remediation of soils and waters contaminated by anthropogenic activities, especially industrial ones. The general goal is sustainable use and development of natur...
Article
Full-text available
A fundamental metabolic feature of cancerous tissues is high glucose consumption. The rate of glucose consumption in a cancer cell can be 10-15 times higher than in normal cells. Isolation and cultivation of tumor cells in vitro highlight properties that are associated with an intensive glucose utilization, the presence of minimal oxidative metabol...
Article
Full-text available
Cancer is a complex disease orchestrated by various extrinsic and intrinsic pathways. In recent years, there has been a keen interest towards the development of natural extracts-based cancer therapeutics with minimum adverse effects. In pursuit of effective strategy, a wide variety of natural products-derived compounds have been addressed for their...
Article
Full-text available
Plants of the genus Brassica occupy the top place among vegetables in the world. This genus, which contains a group of six related species of a global economic significance, three of which are diploid: Brassica nigra (L.) K. Koch, Brassica oleracea L., and Brassica rapa L. and three are amphidiploid species: Brassica carinata A. Braun, Brassica jun...
Chapter
Biochemical cycles and microorganisms (primarily heterotrophic microorganisms) are responsible for the maintenance of the biosphere. They exploit the chemical reactions favorably to obtain carbon and energy from biomass. As a result of the microbial degradation processes, the essential nutrients present in the biomass of a generation of organisms a...
Article
Full-text available
The effect of medicinal plants is due to the chemicals contained in them, called active principles. Unlike drugs, which often contain a single chemical in large quantities, herbs contain a mixture of many active ingredients that act synergistically to produce a therapeutic effect. Medicinal plants also contain a wide variety of minerals and vitamin...