Mona Harissi-Dagher

Centre hospitalier de l'Université de Montréal (CHUM) | CHUM · Département Ophtalmologie

Purpose: To evaluate preferred diagnostic tools and treatment decision-making factors in cases suspicious of mucous membrane pemphigoid (MMP) amongst ophthalmologists and cornea specialists. Methods: Web-based survey, consisting of 14 multiple choice questions, posted to the Cornea Society Listserv Keranet, the Canadian Ophthalmological Society...

Objective: The Boston Keratoprosthesis (KPro) has gained recognition as an alternative for patients with severe corneal disease and a poor probability of success with traditional penetrating keratoplasty. This review summarizes the knowledge clinical trials have brought to KPro and discusses ongoing trials. Design: Systematic review. Methods:...

Corneal blindness is a leading cause of visual impairment worldwide. The most common treatment is to replace the diseased cornea with standard corneal transplantation. In eyes at high risk of graft failure, the Boston keratoprosthesis type 1 (KPro) can be used to restore vision and is currently the most frequently used artificial cornea in the worl...

Purpose: Pterygium and ocular surface squamous neoplasia (OSSN) have been recognized as likely related conditions and share similar risk factors such as ultraviolet and chronic inflammation. The purpose of this study is to review the incidence of OSSN in pathology specimens sent as pterygium at a single tertiary centre between 2010 and 2022. Meth...

ENGLISH SUMMARY Corneal blindness is a leading cause of visual impairment worldwide. The most common treatment is to replace the diseased cornea by standard corneal transplantation. In eyes at high risk of graft failure, the Boston keratoprosthesis type 1 (KPro) can be used to restore vision and is currently the most frequently used artificial corn...

Purpose: This study investigates the efficacy and safety of phototherapeutic keratectomy (PTK) with topography-guided photorefractive keratectomy (T-PRK) corneal regularization followed by sequential hypo-osmolar riboflavin accelerated CXL in KC eyes with < 400 μm stromal bed thickness after excimer ablation. Setting: Multisurgeon multicenter st...

Penetrating keratoplasty (PKP) yields excellent results for restoring vision in end-stage corneal diseases. However, its success is limited to high-risk diseases such as aniridia, chemical burns, autoimmune corneal diseases, and herpetic eye disease. Boston type 1 keratoprosthesis (BKPro) offers another option to these patients. Since 1992, improve...

Background/objectives: To compare long-term outcomes of the Boston type 1 keratoprosthesis (KPro) with penetrating keratoplasty (PKP) in patients with a failed first PKP. Subjects/methods: In this retrospective comparative case series, 48 eyes of 48 patients who underwent a second corneal replacement procedure after a first failed PKP at the Cen...

Objective: To assess participant attendance and engagement for an in-person Canadian Ophthalmological Society (COS) annual meeting (2019) compared with a virtual COS annual meeting (2020). Design: Retrospective case-control study of key event metrics of the 2019 and 2020 COS meetings as well as Twitter activity. Methods: Key annual meeting met...

Purpose: The purpose of this study was to evaluate the incidence, rate of formation, and risk factors of retroprosthetic membrane (RPM) after Boston type 1 keratoprosthesis (BKPro) as well as identify secondary complications linked to its formation and describe its treatment. Methods: This was a retrospective cohort study. One hundred thirty-thr...

Purpose: To determine the role and optimal timing of glaucoma surgery in relation to Boston keratoprosthesis type 1 (KPro) implantation. Design: Retrospective, comparative, non-randomized clinical study. Methods: Single-center study of a total of 100 eyes (100 patients) implanted with a KPro between 2008-2017 and diagnosed with glaucoma before...

Purpose : To evaluate the incidence of vitreoretinal complications, treatment modalities, and the visual outcomes in a large cohort of eyes that underwent Boston Keratoprosthesis (KPro) implantation. Design : Retrospective, interventional case series. Methods : 132 eyes of 114 patients who underwent KPro implantation at the Centre Hospitalier de...

Objective To assess the knowledge of corneal transplantation, willingness toward corneal donation, and the efficacy of a short informational and motivational video in increasing the willingness toward corneal donation among Canadian adults. Methods Cross-sectional interventional study. A survey targeted Canadian adults, assessing their knowledge a...

Animal models of the Boston keratoprosthesis type 1 (KPro) are needed to study glaucoma damage after KPro implantation to control confounding comorbidities common in human KPro recipients. The purpose of this study was to determine the feasibility of establishing a reproducible mouse model of glaucoma after KPro surgery, specifically that of a mini...

Background To compare the rate of long-term complications in Boston keratoprosthesis type 1 (KPro) patients with and without soft contact lens wear (SCL). Methods A chart review was performed on patients who underwent KPro type 1 surgery from January 2008 to June 2018 performed by a single surgeon at the University of Montreal Hospital Centre. Nin...

Purpose: Inflammatory cytokines are involved in glaucoma pathogenesis. The purpose is to compare cytokine levels in the tear film of Boston keratoprosthesis (KPro) patients with and without glaucoma, relative to controls, and correlate levels with clinical parameters. Methods: This cross-sectional study enrolled 58 eyes (58 patients): 41 KPro ey...

Objective Pterygium surgery requires the removal of pterygium tissue and repair of the conjunctiva with either sutures or fibrin glue. The literature suggests that the cost of fibrin glue could be compensated by reducing procedure time and be more cost-effective. However, to our knowledge, no formal studies have examined this hypothesis. Method Re...

Objective To compare 10-year clinical outcomes of frozen versus fresh corneal graft carriers for the Boston Keratoprosthesis type 1 (KPro). Design Prospective, nonmasked randomized controlled trial. Participants Nineteen eyes of 19 patients having undergone Boston KPro type 1 implantation using a fresh or frozen graft carrier. Methods All patien...

Background/aims To compare long-term outcomes of primary versus secondary (postgraft failure) Boston keratoprosthesis type 1 (KPro) implantation. Methods Medical records of patients at the Centre hospitalier de l’Université de Montréal having undergone KPro implantation between 2008 and 2017 were reviewed and included if they had a preoperative Sn...

Purpose : To evaluate glaucoma risk factors and associated outcomes of the Boston keratoprosthesis type I (KPro). Design : Clinical case-control study. Methods : Single-center study of 140 eyes of 118 patients who underwent KPro surgery between October 2008 and March 2017 by a single surgeon. 118 eyes of 118 patients with at least 6 months of fol...

PRéCIS:: Ocular surface disease (OSD) in glaucoma is an area for improvement in the management of patients with glaucoma. This study explores the knowledge of glaucoma subspecialists toward OSD in glaucoma, then provides a suggested treatment algorithm. Purpose: To assess the attitudes, knowledge, and level of comfort of Canadian glaucoma special...

Purpose: To identify the incidence, risk factors, and outcomes of infectious keratitis after Boston type 1 keratoprosthesis (kpro) implantation. Methods: Retrospective case series of kpro procedures at the Stein Eye Institute and the Centre Hospitalier de l'Université de Montréal between May 1, 2004, and December 31, 2018. Data were collected re...

Purpose: To determine the incidence and recurrence of Boston type I keratoprosthesis (KPro)-associated endophthalmitis, and its microbiological profile, risk factors, and outcomes. Methods: This is a retrospective study of 158 consecutive KPro procedures with a median follow-up of 78.4 months. Medical charts were reviewed for ocular history, con...

Aim: To examine the mid-term visual and anatomical prognosis of patients who require reimplantation of a second Boston keratoprosthesis type 1 (B-KPro). Methods: Retrospective observational case series of 122 patients (141 eyes) who received a B-KPro at a single institution were reviewed. Eyes that underwent a second B-KPro were included in the st...

Purpose To determine incidence, risks factors for, and outcomes of idiopathic vitritis (IV) after Boston type 1 keratoprosthesis (KPro) implantation. Methods Retrospective, consecutive case series. Risk factors were analyzed between IV group and No IV group. Results IV occurred in 32/350 procedures (9.1%), for an average incidence of 0.02 cases p...

Introduction The Boston Keratoprosthesis (KPro) is the most used artificial cornea. It restores vision in patients with a poor prognosis with penetrating keratoplasty. Significant improvements have occurred recently in terms of implant design and postoperative care. Nonetheless, glaucoma remains the primary reason for vision loss after KPro implant...

Purpose: To examine the outcomes of cyanoacrylate tissue adhesive (CTA) application for impending or frank corneal perforations and assess for predictors of treatment response. Methods: A multicenter cohort study was conducted to assess the clinical outcomes of adult patients who underwent CTA gluing for impending or frank corneal perforations b...

Background/aims To evaluate long-term visual outcomes of Boston type I keratoprosthesis (KPro) surgery and identify risk factors for visual failure. Methods Single surgeon retrospective cohort study including 85 eyes of 74 patients who underwent KPro implantation to treat severe ocular surface disease, including limbal stem cell deficiency, postin...

Objective: To measure the difference in intraocular pressure (IOP) before and after pharmacologic mydriasis in normal subjects using Goldmann applanation tonometer (GAT) and the Diaton transpalpebral tonometer (DT). Design: Prospective case series study. Participants: Sixty-seven adult patients attending a tertiary general ophthalmology eye ca...

The Boston Keratoprosthesis is the most widely used artificial cornea or keratoprosthesis. It is a treatment option for corneal disease not amenable to standard penetrating keratoplasty. Continued advances in design and superior postoperative care have resulted in improved outcomes and an exponential increase in the use of the device in the last de...

Purpose: To determine patient-reported vision-related quality of life (VR-QoL) after Boston type I keratoprosthesis (BKPro) and its determinants. Methods: A cross-sectional study including consecutive consenting BKPro patients was conducted. The French National Eye Institute Visual Function Questionnaire-25 measured postoperative VR-QoL. Medical...

Purpose: To evaluate the outcomes of transscleral cyclophotocoagulation (CPC) in the control of glaucoma in eyes with a Boston keratoprosthesis (KPro) type 1. Methods: This study is a retrospective case series of patients who have undergone at least 1 CPC treatment after KPro implantation. Eighteen eyes of 17 patients were included. Intraocular...

Purpose: To describe the incidence, presentation, and clinical course of vitritis occurring after Boston keratoprosthesis type 1 implantation. Design: Retrospective chart review. Participants: Medical records of all patients undergoing type 1 Boston keratoprosthesis implantation over a 4-year period were reviewed. Methods: Cases of vitreous...

Mucolipidosis type IV is a rare autosomal recessive lysosomal storage disorder with psychomotor developmental delay, visual impairment, and achlorhydria. A mutation in the MCOLN1 gene causes an alteration of the protein mucolipin-1 that results in the accumulation of lipids and proteins in cytoplasmic vacuoles derived from lysosomes. Visual impairm...

Purpose To report the first successfully treated case of recurrent tube exposure in a patient with the Boston Keratoprosthesis type 1 with a collagen matrix patch graft (Ologen). Observations A 50 year-old female with a Boston Keratoprosthesis type 1 and a history of Axenfeld-Reiger syndrome presents to our department with recurrent glaucoma drain...

Purpose: To propose a new treatment paradigm for chemical burns to the eye - in the acute and chronic phases. Methods: Recent laboratory and clinical data on the biology and treatment of chemical burns are analyzed. Results: Corneal blindness from chemical burns can now be successfully treated with a keratoprosthesis, on immediate and intermed...

Objective To review the use and preparation of serum drops for the treatment of ocular surface disease in Canada and to assess the need for an improved access to this therapy. Design Cross-sectional study. Participants Cornea specialist members of the Canadian Ophthalmological Society and Canadian laboratories preparing serum tears. Methods A co...

Introduction: The Boston Keratoprosthesis type 1 (B-KPro) is the most used keratoprosthesis worldwide. It offers hope to a subset of patients who have a poor prognosis to standard penetrating keratoplasty (PKP). The device is designed in such a way that it is implanted into a carrier corneal graft, usually a fresh corneal donor. However, worldwide...

Purpose: To report outcomes and complications of Boston type 1 keratoprosthesis (KPro) implantation in children. Design: Retrospective, multicenter case series. Participants: All children 16 years of age or younger who underwent KPro surgery at 3 ophthalmology centers in Canada between January 2010 and November 2014. Methods: Records of pati...

Purpose: To report the first case of acute angle closure due to a high-pressure Descemet membrane detachment following deep anterior lamellar keratoplasty (DALK) using the “big bubble” technique. Observations: A 25-year-old man underwent DALK surgery for keratoconus using the “big bubble” technique in which an air bubble is injected in deep stroma...

Purpose To determine the incidence rate, principal causes, and clinical course of eyes developing no light perception (NLP) visual acuity (VA) following Boston Keratoprosthesis (B-KPro) type 1 surgery. Secondary objectives include determining the incidence rate, relative risk (RR), and survival probability with respect to NLP acuity among eyes with...

Corneal blindness is a major cause of blindness in the world and corneal transplantation is the only widely accepted treatment to restore sight in these eyes. However, it is becoming increasingly difficult for eye banks to meet the increasing demand for transplantable tissue, which is in part due to population aging. Donor tissue shortage is theref...

Purpose: To determine the presentation, risk factors, and outcomes of keratolysis after Boston type I keratoprosthesis (B-KPro). Methods: Retrospective chart review. Results: A total of 16 (14%) of the 110 eyes (96 patients) which underwent B-KPro implantation developed keratolysis at an average 20 ± 11 months. Retroprosthetic membrane (RPM),...

Purpose: This study evaluates the correlation between corneal densitometry and epithelial ingrowth (EI) after laser in situ keratomileusis (LASIK). Methods: Corneal densitometry of 3 patients who developed EI after LASIK was measured with the Oculus Pentacam. Corneal densitometry readings of each patient were obtained preoperatively and postoper...

Introduction: corneal ectasia is a group of related diseases characterized by progressive corneal steepening and thinning. It includes keratoconus, pellucid marginal degeneration (PMD), and post-laser ectasia. Traditionally, treatment of these conditions has involved visual rehabilitation with spectacles or contact lenses, with often eventual need...

Objective: To evaluate the risks and benefits of sequential bilateral Boston type 1 keratoprosthesis (KPro) implantation for bilateral corneal blindness. Design: Comparative retrospective study. Participants: Patients who underwent a sequential bilateral KPro surgery. Methods: All 11 patients who underwent sequential bilateral KPro surgery a...

Purpose: To compare the long-term clinical outcomes of fresh versus frozen corneal graft carriers for the Boston Keratoprosthesis type 1 (B-KPro). Design: Prospective, single-center, nonblinded, randomized controlled trial. All participants were followed through the initial study protocol of 24 months and were approached to enter an extension ph...

Objective: To describe the current clinical, surgical, and other educational activities of Canadian ophthalmology residents. Design: Cross-sectional study. Participants: Canadian ophthalmology residents postgraduate year (PGY) 2 to 5. Methods: An online survey was sent to residents in 2011 and 2014. The data sets were merged and analyzed usi...

Purpose: To report the ocular findings of a rare case of mutation in the nuclear-encoded mitochondrial aminoacyl-tRNA synthetase IARS2. Methods: A 33-year-old woman known for infantile cataracts, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, and skeletal dysplasia was referred to us for multiple failed corneal grafts...

To evaluate associations between preoperative diagnosis, soft contact lens (SCL) retention and complications. A retrospective chart review was conducted of 92 adult patients (103 eyes) who received a Boston keratoprosthesis type I at the Massachusetts's Eye and Ear Infirmary or the Flaum Eye Institute. Records were reviewed for preoperative diagnos...

With advances in microsurgical techniques and postoperative management, standard keratoplasty and ocular surface reconstruction have become increasingly successful in the visual rehabilitation of patients with corneal blindness. However, there remains patients for whom such procedures carry a very poor prognosis. This includes patients with autoimm...

The goal of this study was to determine the changes in surgical techniques and leading indications for corneal transplantations performed in the last decade. The impact of administrative changes of corneal banking in Quebec was also evaluated. The records of all corneal transplantations performed between January 2000 and December 2011 in the territ...