Molly Housley Smith

Molly Housley Smith
University of Kentucky | UKY · Oral and Maxillofacial Pathology

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24
Publications
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176
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Publications

Publications (24)
Article
Full-text available
Background Syphilis is a sexually-transmitted infectious disease caused by Treponema pallidum. Cases of primary and secondary syphilis are on the rise in the United States, with a 14.4% increase in new cases noted from 2017 to 2018 and an escalation of 71% between the years 2014 and 2018. Fulfilling its nickname of “the great imitator,” oral manife...
Article
Background Ameloblastic fibro-odontoma (AFO) is a benign odontogenic tumor first described by Hooker in 1967. Its etiology and behavior have long been debated, as some investigators have proposed that AFO may represent a stage in development of an odontoma. For this reason, AFO was eliminated from the most recent Odontogenic and Maxillofacial Bone...
Article
Background The jaws are an uncommon location for primary aneurysmal bone cysts (ABCs), and few gnathic cases have been tested for USP6 rearrangement. Rearrangements of CDH11 and/or USP6 are identified in approximately 70% of primary extragnathic ABCs. MATERIALS/METHODS Herein, this multi-institutional, IRB-approved study investigates the USP6 stat...
Article
Background: Glomus tumors are benign neoplasms that most commonly present in the subungual region. Their occurrence in the oral cavity is exceedingly rare. Here, we present 2 cases from the oral cavity, detail their clinical and histopathologic features, and review the literature for solitary cases involving the oral regions. Study design: The E...
Article
Full-text available
Merkel cell carcinoma (MCC) is an uncommon relatively aggressive neuroendocrine dermal neoplasm first described in 1972 as a tumor of the sun exposed skin. Although most MCC affect the skin of the head and neck, rare primarily oral mucosal cases have been documented. Merkel cells are nondendritic neuroendocrine cells that are found not only in the...
Article
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Solitary fibrous tumors (SFT) and myofibromas (MF) historically have belonged to the same morphologic spectrum and have been lumped together under the nonspecific umbrella term, “hemangiopericytoma” along with other pericytic/myoid tumors. While current evidence shows clear distinction between the two entities, they frequently remain in the same hi...
Article
Several medications have been reported as possible etiologic factors for oral lichen planus (OLP) and oral lichenoid lesions (OLLs). This study investigated the medication profile and medical history of patients with biopsy-proven OLP or OLLs, also classified by the clinically nonspecific term oral lichenoid mucositis (OLM), in a busy oral medicine...
Article
Background and overview: Segmental odontomaxillary dysplasia (SOD) is a characteristic developmental abnormality that demonstrates posterior maxillary enlargement, dental abnormalities, altered bone trabeculation, and possible cutaneous findings. Only 62 cases have been reported in the English-language literature. Case description: The authors d...
Article
Background: Radiculomegaly, or root gigantism, is a rare dental abnormality with important clinical implications. It is highly specific for oculo-facio-cardio-dental (OFCD) syndrome, which places dentists at the forefront of diagnosis of this syndrome. Only 1 case of nonsyndromic radiculomegaly has been reported in the literature since the descrip...
Article
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Spindle cell/sclerosing rhabdomyosarcoma (S-ScRMS) was recently recognized in 2013 by the World Health Organization (WHO) as a stand-alone entity (Parham et al., WHO classification of tumours of soft tissue and bone, IARC Press, Lyon, 2013). Historically, the spindle cell and sclerosing variants were subcategorized under embryonal type rhabdomyosar...
Article
Objectives: Myofibromas are uncommon soft tissue tumors exhibiting considerable histopathologic overlap with other benign and malignant entities. The treatment of lesions arising in the oral cavity is controversial. Here, we present 24 new cases and review the literature. Study design: A search for oral myofibromas was performed within the archi...
Article
Full-text available
Melanoma of the oral cavity is a rare malignancy that carries a poor prognosis. We identified 46 new cases of both primary and metastatic melanoma to the oral cavity. Following IRB approval, these cases were obtained from the Oral Pathology Biopsy Service archives of the UF College of Dentistry (1994-2014), the UK College of Dentistry (1997-2015),...
Article
Objective: Malignant transformation of oral premalignant lesions is the key process in the progression to oral squamous cell carcinoma (OSCC). Previously, we identified miR-7 and miR-21 as candidate oncogenes and miR-375 and miR-494 as candidate tumor suppressors in OSCC. We aim to evaluate these microRNAs as biomarkers of malignant transformation...
Article
Evidence suggests that there is a link between oral health problems and systemic health, quality of life, and overall longevity. As many elders residing in long-term care (LTC) facilities are dependent on staff and caregivers for help with activities of daily living, including daily hygiene practices, research shows that only a fraction of LTC resi...
Article
Synthetic soluble Aβ oligomers are often used as a surrogate for biologic material in a number of model systems. We compared the activity of Aβ oligomers (synthetic and cell culture media derived) on the human SH-SY5Y neuroblastoma and C2C12 mouse myoblast cell lines in a novel, modified MTT assay. Separating oligomers from monomeric peptide by siz...

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