Mohsen El Kossi

Mohsen El Kossi
Doncaster and Bassetlaw Hospitals NHS Foundation Trust · Renal Medicine

MBBCh, MSc, MD (Assiut University, Egypt), MD (Sheffield University, UK), Diploma of Health Research(Leeds University, UK), FRCP (UK).

About

47
Publications
10,067
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929
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Introduction
Skills and Expertise
Additional affiliations
January 2009 - November 2015
Doncaster and Bassetlaw Hospitals NHS Foundation Trust
Position
  • Consultant

Publications

Publications (47)
Article
Full-text available
Kidney allograft failure is a significant complication in kidney transplant recipients, and the surgical decision to perform allograft nephrectomy poses a strong dilemma because it is associated with significant morbidity and mortality. There is a debate over the effect of allograft nephrectomy on the development of allosensitization and the impact...
Article
The increased awareness of systemic sclerosis (SS) and its pathogenetic background made the management of this disease more amenable than previously thought. However, scleroderma renal crisis (SRC) is a rarely seen as an associated disorder that may involve 2%-15% of SS patients. Patients presented with earlier, rapidly progressing, diffuse cutaneo...
Article
Full-text available
Renal transplant is considered the best therapeutic option for suitable patients with end-stage kidney failure. Hematological complications that occur after kidney transplant include posttransplant anemia, leukopenia, neutropenia, and thrombocytopenia. Severely persistent leukopenia and neutropenia events predispose patients to infection, including...
Article
Full-text available
Background: Since the discovery of BK Virus (BKV) in 1971, it became a growing challenge in the renal transplant field. Many hypotheses over the latest years have been made to justify the increased risk of acquiring BKV infection post-renal transplantation. Excessive immunosuppression remains the primary risk factor. Risk factors such as older reci...
Article
Full-text available
Background The aim of this meta-analysis is to explore the effect of IL-2RA vs rATG on the rate of acute rejection, post-transplant infections, and graft as well as patient’s survival in standard- and high-risk renal transplant patients receiving tacrolimus-based maintenance immunotherapy.Methods Random effects model was the method used for identif...
Article
Full-text available
Transplant recipients are vulnerable to a higher risk of malignancy after solid organ transplantation and allogeneic hematopoietic stem-cell transplant. Post-transplant lymphoproliferative disorders (PTLD) include a wide spectrum of diseases ranging from benign proliferation of lymphoid tissues to frank malignancy with aggressive behavior. Two main...
Article
Full-text available
The real effect of parasitic infection on transplant recipients is not known. Interestingly, only 5% of human parasitic infections can affect functioning of transplanted organs. Parasitic infections manifest in two different ways: first, systemic illness, including anemia and constitutional symptoms, and second, local syndromes, which are usually c...
Article
Full-text available
A 56 year old CKD 5 patient due to diabetic nephropathy (biopsy proved) presented to our hospital in transplant clinic for transplant assessment. She is not yet on dialysis and her current eGFR is 20 ml/min. She was diagnosed at the age of 29 to have diabetes. It is not clear from notes whether she is type 1 or type II DM. She is currently on insul...
Article
Full-text available
Renal transplant, undoubtedly, is the best available approach for selected patients with end-stage kidney disease. It enhances life quality and improves life expectancy when compared with dialysis therapy. It is very pertinent to carefully assess patients who are referred for transplantation to identify factors that may limit patient and graft surv...
Article
Full-text available
Post-transplant mineral bone disease (PT-MBD) is associated with increased morbidity and mortality in kidney transplant recipients. Bone abnormalities can range from adynamic bone disease to severe persistent hyperparathyroidism with associated hypercalcemia and hypophosphataemia. In addition, these patients can develop other complications such as...
Article
For decades, kidney diseases related to inappropriate complement activity, such as atypical hemolytic uremic syndrome and C3 glomerulopathy (a subtype of membranoproliferative glomerulonephritis), have mostly been complicated by worsened prognoses and rapid progression to end-stage renal failure. Alternative complement pathway dysregulation, whethe...
Article
Full-text available
Nail-Patella syndrome is pleiotropic autosomal dominant disorder characterized by skeletal abnormalities and frequently renal disease. In this case report genetic analysis revealed a pathogenic heterozygous missense mutation of the LMX1B gene as c.[737G>A], p.([Arg246Gln)]. This variant is predicted to cause substitution of a basic arginine residue...
Article
Full-text available
Thrombotic microangiopathy (TMA) is one of the most devastating sequalae of kidney transplantation. A number of published articles have covered either de novo or recurrent TMA in an isolated manner. We have, hereby, in this article endeavored to address both types of TMA in a comparative mode. We appreciate that de novo TMA is more common and its p...
Article
Nail-Patella syndrome is pleiotropic autosomal dominant disorder characterized by skeletal abnormalities and frequently renal disease. In this case report genetic analysis revealed a pathogenic heterozygous missense mutation of the LMX1B gene as c.[737G>A], p.([Arg246Gln)]. This variant is predicted to cause substitution of a basic arginine residue...
Article
Full-text available
In view of the availability of new immunosuppression strategies, the recurrence of allograft glomerulonephritis (GN) are reported to be increasing with time post transplantation. Recent advances in understanding the pathogenesis of the GN recurrent disease provided a better chance to develop new strategies to deal with the GN recurrence. Recurrent...
Article
Full-text available
The glomerular diseases after renal transplantation can occur de novo, i.e., with no relation to the native kidney disease, or more frequently occur as a recurrence of the original disease in the native kidney. There may not be any difference in clinical features and histological pattern between de novo glomerular disease and recurrence of original...
Article
Full-text available
Renal transplantation remains the best option for patients suffering from end stage renal disease (ESRD). Given the worldwide shortage of organs and growing population of patients with ESRD, those waitlisted for a transplant is ever expanding. Contemporary crossmatch methods and human leukocyte antigen (HLA) typing play a pivotal role in improving...
Article
Full-text available
It is very natural to be concerned that immunosuppressive medications might be deemed hazardous to infant’s breastfed by mothers who are transplanted. This is due to lack of good quality guidelines supported by robust evidence. The drugs that are not safe during pregnancy are not necessarily unsafe during breastfeeding. On reviewing non-transplant...
Article
Full-text available
Patients with type 2 diabetes and nephropathy have high cardiorenal morbidity and mortality despite optimum treatment including angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs). Residual risk is related to residual albuminuria. We assessed whether CCX140-B, a selective inhibitor of C-C chemokine receptor type 2...
Chapter
Cardiovascular disease is the leading cause of mortality and morbidity in patients with different stages of chronic kidney disease (CKD). The phenotypic picture of cardiovascular disease differs between those on dialysis and patients with early stages of chronic kidney disease. Whilst atherosclerotic coronary artery disease is common in the early s...
Chapter
Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) refers to a triad of mineral, bone and vascular disorders that are associated with an increased risk of morbidity and mortality in CKD. The last 15 years have seen a huge increase in research activity in this field as a result of better understanding of pathogenesis of bone disease and its inte...
Chapter
The pivotal role of haemoglobin as one of the targets in the holistic management of dialysis patients was the focus of the first published anaemia guidelines by KDOQI in 1997. Since the introduction of erythropoietin to anaemia management in chronic kidney disease, there has been a continuous debate on the optimal haemoglobin target required to ach...
Article
Full-text available
Renin-angiotensin system (RAS) inhibitors are considered first-line agents for hypertensive patients with progressive chronic kidney disease (CKD). In a previous study, we showed that stopping RAS inhibitors increased estimated glomerular filtration rate (eGFR) in a significant number of advanced CKD patients. The present study tries to address who...
Article
Full-text available
Inhibition of the renin-angiotensin-aldosterone system (RAAS) has shown to slow chronic kidney disease (CKD) progression. This is most notable at the earlier stages of diabetic and proteinuric nephropathies. Objective. Here, we observed the impact of discontinuation of angiotensin converting enzyme inhibitors (ACEi)/angiotensin receptors blockers (...
Article
The pathogenesis of renal osteodystrophy is not clearly defined. We evaluate in this study the potential effect of demographic and biochemical markers on parathormone (PTH) level in patients with chronic kidney disease (CKD) stages 4 and 5. We retrospectively studied 138 patients with CKD stages 4 and 5 selected from the database of the Sheffield K...
Article
Full-text available
Limited survival data are available on chronic kidney disease stage 5 (CKD 5) patients who opt for conservative management rather than dialysis. To measure survival in such patients and investigate potential factors predicting survival. Retrospective survival analysis of a cohort of conservatively managed CKD 5 patients from a single center. Surviv...
Article
Cardiovascular disease (CVD) is the leading cause of mortality in hemodialysis (HD) patients. This could not be explained by the known traditional CVD risk factors. In this study, we attempted to elucidate the factors influencing atherosclerosis, as measured by carotid artery intima-media thickness (IMT), in HD patients and their impact on cardiova...
Article
Stem cell factor (SCF) has been implicated in many disease processes characterized by tissue remodelling and fibrosis. The growth factor (SCF) was evaluated in a rat model of nephrotoxic serum nephritis (NTN), characterized by early inflammation followed by later tissue fibrosis. NTN was induced in male Wistar Kyoto rats using rabbit anti-rat glome...
Article
Full-text available
The increasing global prevalence of chronic kidney disease (CKD) and end-stage renal disease with the associated spiraling cost has profound public health and economic implications. This has made slowing the progression of CKD, a major health-care priority. CKD is invariably characterized by progressive kidney fibrosis and at present, treatment aim...
Article
Recent evidence suggests that alloantibody may play an aetiological role in the pathogenesis of membranous glomerulopathy in native kidneys. There is an increased awareness of the significance of alloantibody on renal transplant outcome, particularly with the development of more sensitive assays. We describe a kidney transplant patient who develope...
Article
Caspase-3 has a central role in the execution of apoptosis. In a nephrotoxic nephritis (NTN) model, we previously demonstrated an up-regulation of caspase-3 that was associated with inappropriate renal apoptosis, inflammation, tubular atrophy, and renal scarring. We applied a pan caspase inhibitor, Boc-Asp (OMe)-fluoro-methyl-ketone (B-D-FMK), dire...
Article
Long-term follow-up of cardiac transplant recipients reveals a progressive decline in kidney function in a significant number of patients. This complication is one of the most important prognostic parameters for the outcome of cardiac transplantation. The risk factors implicated in the pathogenesis of renal dysfunction following cardiac transplanta...
Article
Numerous cells and cytokines have been implicated in the pathogenesis of crescentic glomerulonephritis (CGN). Recently, there has been growing awareness of the role of mast cells and their growth factor, stem cell factor (SCF), in the process of tissue inflammation and fibrosis. In this study, renal biopsy specimens from 28 patients with a histopat...
Article
Free radical generation and consequent oxidative stress in thrombotic cerebrovascular stroke have a distinctive role in the pathogenesis of ischemic brain injury. One of the potential injurious effects of homocyst(e)ine in occlusive vascular diseases is free radical generation. In the current study, we investigated the status of oxidant stress in t...

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