Mohd Helmi Sani

Mohd Helmi Sani
Universiti Teknologi Malaysia | UTM · Department of Biosciences Faculty of Science

Ph.D Biochemical Engineering (UCL, UK)

About

21
Publications
6,899
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98
Citations
Introduction
I believe that a robust framework for rapid bioprocess development using scale-down bioreactors is the future for the process optimization of biopharmaceutical products such as antibodies, vaccines. For existing processes, the improvement in process development is needed to define the basis for rapid and accurate reproducibility and product formation of biopharmaceuticals.
Additional affiliations
September 2012 - December 2015
Universiti Teknologi Malaysia
Position
  • Tutor
September 2011 - September 2015
University College London
Position
  • Engineer
September 2007 - September 2012
Universiti Teknologi Malaysia
Position
  • Tutor

Publications

Publications (21)
Article
Full-text available
At present, there are a number of commercial small scale shaken systems available on the market with instrumented controllable microbioreactors such as Micro-24 Microreactor System (Pall Corporation, Port Washington, NY) and M2P Biolector, (M2P Labs GmbH, Aachen, Germany). The Micro-24 system is basically an orbital shaken 24-well plate that operat...
Article
Full-text available
Bacterial cellulose (BC) has gained attention among researchers in materials science and bio-medicine due to its fascinating properties. However, BC’s fibre collapse phenomenon (i.e., its inability to reabsorb water after dehydration) is one of the drawbacks that limit its potential. To overcome this, a catalyst-free thermal crosslinking reaction w...
Article
Full-text available
In recent years, photoautotrophic microalgae are widely recognised due to their diverse yet significant natural values, particularly in healthcare, including pharmaceuticals, cosmetics and feedstock industries. One of the most exploited blue-green microalgae, Arthrospira sp. has been addressed as a potent superfood. However, the microalgal massprod...
Article
Full-text available
Purpose of review This review is intended to address the issues of unsafe disposal of antibiotics from various sources to the environment, its incomplete degradation, the resulting antibiotic resistance properties on microorganisms exposed to these antibiotics as well as some currently available techniques to remove both the antibiotic-resistant ba...
Article
Full-text available
Purpose of Review Hexavalent chromium, Cr(VI), and trivalent chromium, Cr(III), are two chromium compounds with practical importance due to their high occurrence and solubility in the environment. Current Cr(VI) treatment techniques involve chemical reduction of Cr(VI) to Cr(III), which posed serious threat to workers and environment notably from l...
Preprint
Full-text available
Bacterial cellulose (BC) has gained research attention in materials science and biomedicine due to its fascinating properties. BCs' fiber collapse phenomenon (inability to reabsorb water after dehydration) is one of the drawbacks that limit its potentials. To overcome this, a catalyst-free thermal crosslinking reaction was employed to modify the BC...
Article
Full-text available
In this study, single, mix, multilayer Polyvinyl alcohol (PVA) electrospun nanofibers with epidermal growth factor (EGF) and fibroblast growth factor (FGF) were fabricated and characterized as a biological wound dressing scaffolds. The biological activities of the synthesized scaffolds have been verified by in vitro and in vivo studies. The chemica...
Article
The aim of this work is to utilize a process simulator SuperPro Designer v5.5 (Intelligent, NJ, USA) for investigation on the most optimum scenario for the recovery of flexirubin pigment that was produced from a fermentation process using Chryseobacterium artocarpi strain. Process flow sheeting was based on the production of 300 kg per annum of fle...
Chapter
Hydrogen gas (H2) is a clean fuel and contained a relatively high energy density which is about 142 kJ g⁻¹. Recently, increasing attention has been given to the production of H2 from biological route. The biological H2 (biohydrogen) process is an H2 production by microorganisms that utilize renewable energy resources as substrates. Possible biohydr...
Article
Full-text available
Nanofibers have obtained considerable interest for use in various applications. Polyvinyl alcohol (PVA) has been used to achieve many benefits for diverse pharmaceutical and biomedical applications. We investigated in this study the effects of applied voltage, needle diameter, and flow rate on morphologies of PVA nanofibers. A constant volume of th...
Article
Full-text available
Thousands of prokaryotic genera have been published, but methodological bias in the study of prokaryotes is noted. Prokaryotes that are relatively easy to isolate have been well-studied from multiple aspects. Massive quantities of experimental findings and knowledge generated from the well-known prokaryotic strains are inundating scientific publica...
Article
Type I pullulanase from Anoxybacillus sp. SK3-4 (PulASK) is an unusual debranching enzyme that specifically hydrolyzes starch α-1,6 linkages at long branches producing oligosaccharides (≥G8), but is nonreactive against short branches; thus, incapable of producing reducing sugars (G1–G7). We report on the effects of both single and co-immobilization...
Article
Full-text available
α-Amylase from Anoxybacillus sp. SK3-4 (ASKA) is a thermostable enzyme that produces a high level of maltose from starches. A truncated ASKA (TASKA) variant with improved expression and purification efficiency was characterized in an earlier study. In this work, TASKA was purified and immobilized through covalent attachment on three epoxide (ReliZy...
Thesis
The increased use of antibodies for human therapy has driven rational approaches to accelerate bioprocess development in producing cost effective and highly productive antibodies. The potential of microwell based systems and miniature bioreactors (MBR) to mimic the scalability and operations of conventional bench reactors are seen as an alternative...
Poster
Full-text available
ABSTRACT Microbioreactors are increasingly used for cell screening and early bioprocess development of mammalian cell cultures. However, many commercially available microbioreactor systems have limitations concerning automated liquid additions and parallel control of pH, temperature and dissolved oxygen. The micro-Matrix (Applikon Biotechnology) ad...
Presentation
Full-text available
Micro-bioreactors:- the challenges & opportunities of down scale R&D
Conference Paper
Full-text available
The application of modern biotechnologies has significantly increased the use of antibodies and antibody fragments for human therapy. In order to meet this demand there is a need to establish rational approaches to accelerate bioprocess development in producing cost effective and highly productive antibodies. This research describes a microwell app...

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