Mohd Fadzly Amar Jamil

As COVID-19 dispersion occurs at different levels of gradients across geographies, the application of spatiotemporal science via computational methods can provide valuable insights to direct available resources and targeted interventions for transmission control. This ecological-correlation study evaluates the spatial dispersion of COVID-19 and its...

Introduction: Understanding the various aspects of infectious disease transmissibility in the context of "place" is crucial for implementing disease control and harm reduction strategies. This study aimed to determine the dynamics of spatial dispersion of COVID-19 epidemic in Malaysia and its associated indicators. Methods: This ecological study in...

Introduction: Conventional methods through population-based surveys to measure public perceptions and reactions during emergencies or pandemic times is a costly, labour intensive and time-consuming effort. To understand phenomenological experiences "now," it is crucial to complement measurement tools with real-time "infoveillance" approaches. We ai...

The rapid transmission of highly contagious infectious diseases within communities can yield potential hotspots or clusters across geographies. For COVID-19, the impact of population density on transmission models demonstrates mixed findings. This study aims to determine the correlations between population density, clusters, and COVID-19 incidence...

Table S1: District-Wise Population Level Information and COVID-19 Cases

Understanding infectious disease transmissibility in the context of “place" is crucial for implementing disease control and harm reduction strategies. This study was aimed to determine the dynamics of spatial dispersion of COVID 19 in Malaysia and its associated indicators.

Exploring phenomenological experiences “now" during pandemic times facilitate timely construction of risk communication framework for pubic health interventions. We aimed to explore public perceptions and reactions towards the COVID 19 pandemic in Malaysia via thematic- content analyses using Twitter.

The impact of density on infectious disease contagion has yet to be known. The practicality surrounding transmission dynamics within human populations is catalyzed by a theoretical postulation that dense areas would elevate interactions among people, causing rapid pandemic spread. This study aims to evaluate population density as a factor spread fo...

Table S1: Supplementary information of papers included.

The escalated burden of diabetes on the population's health has catalyzed rigorous scientific research to produce appropriate evidence for treatment and control. Malaysia suffers from the leading diabetes epidemic within the Western Pacific region. It is crucial to map the scientific landscape of diabetes research for the country to identify trends...

In this issue, we are delighted to showcase our Hospital Director, Dr Haji Saiful Azlan Bin Haji Sharif perspectives of COVID 19 as a special feature. Leading surgeon Dr Nagarajan Vellasamy and infectious disease physician Dr Cheng Joo Thye reflect themselves as real time front liners in battling COVID 19. Dr Cheah Wee Kooi a physician and geriatri...

Diabetes causes significant disabilities, reduced quality of life and mortality that imposes huge economic burden on societies and governments worldwide. Malaysia suffers a high diabetes burden in Asia, but the magnitude of healthcare expenditures documented to aid national health policy decision-making is limited. This systematic review aimed to d...

Diabetes causes significant disabilities, reduced quality of life and mortality that imposes huge economic burden on societies and governments worldwide. Malaysia suffers a high diabetes burden in Asia, but the magnitude of healthcare expenditures documented to aid national health policy decision-making is limited. This systematic review aimed to d...

The uncertainties around disease management and control measures have not onlymotivated clinicians to keep abreast of new evidence available in the scholarly literature, but also tobe rigorously engaged in medical research, dissemination and knowledge transfer. We aimed toexplore clinicians’ publication output from the Malaysian perspective. A self...

This study aimed to explore scientific productivity and it’s associated factors among clinicians in a Malaysian research hospital.

Background: Evidence Based Medicine (EBM) has forced clinicians to incorporate up-to-date information from clinical trials into practice for effective patient care and disease management. Active engagement in medical publishing of applied research can provide a conduit for accelerated translation of basic science to clinical practice. Objectives: T...

Main Findings of Clinicians Scientific Productivity

The expanded mission of Discover aims to join forces with our stroke counterparts to release a specialized theme edition entitled “Malaysia’s Stroke Care Revolution!”

Background and objectives: The continuum of evidence-based medicine (EBM) depends solely on clinicians' commitment to keep current with the latest clinical information. Exploration on clinicians' understanding of biostatistical results in the medical literature is sparse to date. This study aimed to evaluate clinicians' perceived understanding of b...

Erythroxylum cuneatum (EC) is a local herb and commonly known as "Chinta mula." Its leaves are used by the native traditional healers as an anti-addiction treatment. However, its effects were not fully explored scientifically, resulting in a lack of documented information on its therapeutic anti-addiction effects. The objectives of this study are t...

The Medical Journal of Penang Hospital Supplement Issue is published in conjunction with Penang Research Day 2018

Erythroxylum cuneatum (EC) is a local herb and commonly known as "Chinta mula." Its leaves are used by the native traditional healers as an anti-addiction treatment. However, its effects were not fully explored scientifically, resulting in a lack of documented information on its therapeutic anti-addiction effects. The objectives of this study are t...

Mitragyna speciosa Korth is known for its euphoric properties and is frequently used for recreational purposes. Several poisoning and fatal cases involving mitragynine have been reported but the underlying causes remain unclear. Human ether-a-go-go-related gene (hERG) encodes the cardiac IKr current which is a determinant of the duration of ventric...

Erythroxylum cuneatum has been traditionally proven to possess benefi cial properties in treating drug addiction and other illness. Due to less information on this plant, this elusive plant was investigated further to evaluate the in vivo toxicity profi le of the plant and to investigate the effect of E. cuneatum on cognitive performance in rats. T...

Mitragynine is a major bioactive compound of Kratom, which is derived from the leave extracts of Mitragyna speciosa Korth or Mitragyna speciosa (M. speciosa), a medicinal plant from South East Asia used legally in many countries as stimulant with opioid-like effects for the treatment of chronic pain and opioid-withdrawal symptoms. Fatal incidents w...

ETHOPHARMACOLOGICAL RELEVANCE: Mitragynine is an indole alkaloid compound of Mitragyna speciosa (M.speciosa) Korth. (Rubiaceae). This plant is native to the southern regions of Thailand and northern region of Malaysia and is frequently used to manage the withdrawal symptoms in both countries. AIM OF STUDY: To investigate the effect of mitragynine a...

CYP450 enzymes are key determinants in drug toxicities, reduced pharmacological effect and adverse drug reactions. Mitragynine, an euphoric compound was evaluated for its effects on the expression of mRNAs encoding CYP1A2, CYP2D6 and CYP3A4 and protein expression and resultant enzymatic activity. The mRNA and protein expression of CYP450 isoforms w...

A major obstacle in treating drug addiction is the severity of opiate withdrawal syndrome, which can lead to unwanted relapse. Mitragynine is the major alkaloid compound found in leaves of Mitragyna speciosa, a plant widely used by opiate addicts to mitigate the harshness of drug withdrawal. A series of experiments was conducted to investigate the...

ETHOPHARMACOLOGICAL RELEVANCE: Mitragyna speciosa Korth (Rubiaceae) is one of the medicinal plants used traditionally to treat various types of diseases especially in Thailand and Malaysia. Its anti-inflammatory and analgesic properties in its crude form are well documented. In this study, the cellular mechanism involved in the anti-inflammatory ef...