Mohd Hafiz ArzmiInternational Islamic University Malaysia | iium · Department of Fundamental Dental and Medical Sciences
Mohd Hafiz Arzmi
BSc. (Microbiology) hons. (Uni. Malaya), MDSc. (Uni. Malaya), PhD (Oral Microbiology and Immunology)(Uni. Melbourne) and Diploma in Islamic Studies (IIUM)
About
58
Publications
13,873
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268
Citations
Citations since 2017
Introduction
I am an ordinary researcher of polymicrobial interaction of Candida albicans, Actinomyces naeslundii, Streptococcus mutans, synbiotics (probiotics and prebiotics) and its role in oral carcinogenesis. I am very keen to learn more about this field which I have been exploring since 2007. I am very happy to collaborate with anyone who is keen to explore more in the world of oral polymicrobial. Hope to learn more from all the experts!
Additional affiliations
January 2018 - present
November 2016 - present
November 2016 - February 2025
Education
June 2017 - November 2018
June 2012 - April 2016
June 2008 - June 2011
Publications
Publications (58)
Individuals with a history of coronavirus disease 2019 (COVID-19) exhibit memory immunity acquired during natural infection. However, a decline in immunity after infection renders these individuals vulnerable to re-infection, in addition to a higher risk of infection with new variants. This systematic review examined related studies to elucidate th...
The development of alternative food packaging films using bio-based residues is in great demand for replacing petroleum-based packaging materials. However, large-scale application is severely limited by costly production and poor performance. This study investigates the ex-situ modification of bacterial cellulose (BC) produced by Acetobacter xylinu...
Oral biofilms are comprised of extracellular polysaccharides and polymicrobial microorganisms. The objective of this study was to determine the effect of synbiotic Smallanthus sonchifolius (yacon) with Streptococcus salivarius K12 (K12) on polymicrobial biofilm formation of Candida albicans with the hypothesis that polymicrobial biofilm biomass of...
Breast cancer is one of the leading causes of death in women worldwide and early detection is critical to improving survival rates. In this study, we present a modified deep learning method for automatic feature detection for breast mass classification on mammograms. We propose to use EfficientNet, a Convolutional Neural Network (CNN) architecture...
Oral biofilms comprise extracellular polysaccharides and polymicrobial microorganisms. The objectives of the study were to characterize the deer velvet antler (DVA) compounds and their effect on Candida species biofilm formation with the hypothesis that DVA inhibits the biofilm of Candida spp. Liquid Chromatography-Quadrupole Time of Flight-Mass Sp...
Oral carcinogenesis is preceded by oral diseases associated with inflammation such as periodontitis and oral candidiasis, which are contributed by chronic alcoholism, smoking, poor oral hygiene, and microbial infections. Dysbiosis is an imbalance of microbial composition due to oral infection, which has been reported to contribute to oral carcinoge...
This study aimed to determine the effect of synbiotic Musa acuminata skin extract (MASE) and Streptococcus salivarius K12 (K12) on Candida species biofilm formation. Liquid chromatography quadrupole time-of-flight (LC-Q-TOF-MS) was conducted to characterize MASE. To determine the effect of synbiotic on Candida biofilm, 200 µL of RPMI-1640 containin...
Patients that are diagnosed with oral cancer has more than an 83% survival chance if it is detected in its early stages. However, through conventional labour-intensive means, only 29% of cases are detected. It is worth mentioning that 90% of oral cancer is Oral Squamous Cell Carcinoma (OSCC) and is often caused by smoking and alcohol consumption. C...
Oral disease has been a worldwide concern as the incidence and cost of treatment continues to rise. Management of the disease is challenging as success is often influenced by an individual’s lifestyle and diet. Nigella sativa (N. sativa) or black seed is a medicinal plant that has received growing interest due to its effectiveness against various c...
The data presented here is the liquid chromatography and mass spectrometry (LC-MS) profile of phytochemical compounds in the aqueous extract of Syzygium polyanthum (Wight) Walp. leaves. This plant is consumed raw and sometimes added to local dishes of people in Southeast Asia countries. Most importantly, it has ethnomedicinal values mainly in treat...
Candida albicans causes candidiasis, particularly in immunocompromised patients. Streptococcus salivarius K12 (K12) is a probiotic isolated from a healthy oral cavity. The study aimed to determine the effect of K12 on C. albicans aggregation, biofilm formation and dimorphism. C. albicans ATCC MYA-4901, acquired immunodeficiency syndrome (AIDS) isol...
Introduction: The roots of E. longifolia jack (E.L.) or Tongkat Ali have been used in traditional medicine as well as supplements and food additives. Many chemical compounds have been detected in extracts of its roots which are believed to be responsible for its medicinal properties. In this study, our objectives were to study the effects of EL roo...
Research misconduct is defined as fabrication, falsification, or plagiarism in proposing, performing, or reviewing research, or in reporting research results (Anderson, 2013; Breen, 2016; Resnik, 2019). It can occur at many stages of the research process. These include during proposal preparation, data collection, analysis and publication (Amin et...
Deer antler velvet (DAV) has been traditionally used in Chinese medicine, including treatment on toothache [1]. Due to its rapid and regenerative capacity, deer antlers were proposed to be the good model for bone remodelling in mammals [2]. The data presented in this work is on the liquid chromatography and mass spectrometry (LC-MS) profile and bio...
Candida krusei (C. krusei) is associated with oral candidiasis, particularly in immunecompromised patients. The objective of the study was to determine the effect of phenotypic switching to the susceptibility of C. krusei towards amphotericin B, nystatin and aqueous extract of Piper betle (P. betle). To induce phenotypic switching, C. krusei was in...
Medicinal plants have been discovered and used in traditional medicine and pharmaceutical industries since centuries. In the current study, Ziziphus mauritiana leaves was used as it is rich with many biological active compounds such as flavonoids, polyphenols, sapronins and tanins. Previous studies reported the antibacterial and antifungal effects...
Candida species including Candida albicans, Candida krusei and Candida glabrata are opportunistic microorganisms that inhabit oral cavity. The objective of this study is to determine the effect of dental caries on Candida spp. biofilm-forming ability on nano-composite with the hypothesis that dental caries enhances the colonization of Candida spp....
Oral squamous cell carcinoma is associated with many known risk factors including tobacco smoking, chronic alcoholism, poor oral hygiene, unhealthy dietary habits and microbial infection. Previous studies have highlighted Candida albicans host tissue infection as a risk factor in the initiation and progression of oral cancer. C. albicans invasion i...
Introduction: Actinomyces naeslundii is an oral microbiome that has been suggested to involve in actinomycosis particularly in immunocompromised patients. However, studies have also shown that the bacterium can inhibit the colonisation of Candida albicans and cariogenic bacterium, Streptococcus mutans. Even though various studies have been conducte...
Introduction: The prevalence of oral cancer has been reported annually along with high mortality rate. Probiotics have been suggested to possess anti-cancer properties, however the role of these microorganisms on oral cancer is remain unclear. The objective of the present study is to identify the mechanisms exerted by probiotics on oral carcinogene...
Introduction: Oral cancer is the sixth most common cancer worldwide with Candida albicans infection being one of the aetiological factors for the disease. Meanwhile, Streptococcus salivarius K12 is an oral probiotic that is beneficial to the oral cavity. The objective of the present study is to determine the effect of S. salivarius K12 on C. albica...
A balanced oral microbiome is essential in maintaining a healthy oral cavity. Oral microbiome comprises of various microorganisms that belong to different kingdoms, including bacteria (bacteriome) and fungal (mycobiome). Multiple factors have been shown in oral carcinogenesis including alcohol consumption, tobacco smoking, betel nut chewing and mic...
Introduction: Oral cancer is the sixth most common malignancy in the world. It is a major concern in Southeast Asia primarily due to betel quid chewing, smoking, and alcohol consumption. In Malaysia, oral cancer related cases accounts for 1.55% of the cause of deaths. Despite recent advances in cancer diagnoses and therapies, the survival rate of o...
Introduction: Candida albicans is an opportunistic fungus that is associated with oral carcinogenesis. In addition, biofilm formation has been one of the important virulence factors of the yeast. Streptococcus salivarius K12 is an oral probiotic while Musa acuminata is a well-known prebiotic. The objective of this study is to investigate the effect...
Introduction: Candida spp. are most common opportunistic pathogenic yeast that inhabit human oral cavity, epider- mis, gastrointestinal tract, and vagina leading to candidiasis. The transition of this yeast from commensal to potent pathogen is facilitated by numbers of virulence factors including biofilm formation. While most reports on candidi- as...
The oral microbiome is composed of microorganisms residing in the oral cavity, which are critical components of health and disease. Disruption of the oral microbiome has been proven to influence the course of oral diseases, especially amongst immunocompromised patients. Oral microbiome is comprised of inter‐kingdom microorganisms, including yeasts...
Introduction: Candida species are opportunistic microorganisms that inhabit oral cavity. The species of Candida that are normally isolated from the oral cavity include Candida albicans, Candida krusei and Candida glabrata. The objective of this study is to determine the effect of caries towards colonization of Candida spp. with the hypothesis that...
On 13th of April, 2018, the constitution of MySOMOI was endorsed during the formation meeting held at the Faculty of Dentistry, University of Malaya which was attended by 29 members from various universities in Malaysia. A Protem Committee was formed on the same day who worked for the registration of the proposed society, subsequently on 17th of Ju...
Microbial infection has been shown to involve in oral carcinogenesis; however, the underlying mechanisms remain poorly understood. The present study aimed to characterize the growth of oral microorganisms as both monospecies and polymicrobial biofilms and determine the effects of their products on oral keratinocytes. Candida albicans (ALC3), Actino...
Introduction: Oral cancer is classified as the sixth most common cancer in the world. It has been suggested that polymicrobial infection may have a role in oral carcinogenesis.
Objective: To determine the effect of mono-culture and polymicrobial biofilms effluent from C. albicans, Streptococcus mutans and Actinomyces naeslundii to the adhesion of...
Objective
This study aimed to investigate the relationship between tooth loss and the level of blood pressure with the hypothesis that tooth loss is associated with the increase of hypertension in postmenopausal women.
Materials and Methods
Sixty postmenopausal female patients aged 51–68 years were included in the study to assess the relationship...
Candida species are opportunistic microorganisms that have been shown to contribute in caries development and oral squamous cell carcinoma. The infection of Candida spp. is initiated by several virulence factors including phenotypic swithcing. Phenotypic switching is known as one of the important virulence factors for Candida albicans and Candida g...
Oral biofilms comprise of extracellular polysaccharides and polymicrobial microorganisms. The objective of this study was to determine the effect of polymicrobial interactions of Candida albicans, Actinomyces naeslundii, and Streptococcus mutans on biofilm formation with the hypotheses that biofilm biomass and metabolic activity are both C. albican...
Many oral diseases are related to the interaction between microorganisms in the oral cavity. These microbial interactions are necessarily associated with the development of dental plaque and can lead to oral diseases including dental caries and perhaps oral cancer. It is estimated that up to 70% of people with a healthy oral cavity possess Candida...
Introduction: Oral biofilms are formed by various microorganisms such as C. albicans, Actinomyces naeslundii and Streptococcus mutans. Biofilm forming ability is one of the virulent factors of C. albicans and this may be involved oral carcinogenesis. Our objective was to assess C. albicans, A. naeslundii and S. mutans interaction in the formation o...
Microbial interactions are necessarily associated with the development of polymicrobial oral biofilms. The objective of this study was to determine the co-aggregation of eight strains of Candida albicans with Actinomyces naeslundii and Streptococcus mutans. In auto-aggregation assays, C. albicans strains were grown in RPMI-1640 and artificial saliv...
Introduction: Microbial interactions have been found to be associated with the development of oral biofilms. Inter-kingdom co-aggregation within biofilms may be important in enhancing adherence, altering epithelial cytokines, which may ultimately be involved in carcinogenesis.
Objective: Our aim was to determine co-aggregation of C. albicans (CA),...
Candida infection (candidiasis) is potentially life threatening and can occur in almost all anatomical sites, including the mouth. Candida species are in fact the most common fungal pathogens isolated from the oral cavity and frequently cause superficial infections such as oral candidiasis and denture-associated erythematous stomatitis. Whilst syst...
Phenotypic switching is characterized as a virulence factor of Candida spp. This study was carried out to evaluate the phenotypic switching ability of C. krusei ATCC 14243 and to determine its effect on the biological properties, adherence capacity and susceptibility towards chlorhexidine digluconate (CHX). To induce switched generations C. krusei...
Objectives: The purpose of this study was to evaluate the consequences of phenotypic switching generation towards adherence; susceptibility towards chlorhexidine (CHX) and growth profile of each of the switched Candida krusei generations. Methods: Four generations of phenotype switched Candida krusei and pure ATCC 14243 Candida krusei were subcultu...
Questions
Questions (5)
Hi everyone,
I am searching for anyone who have OKF6 cell line or any cell line immortalised cell line that is isolated from normal epithelial cell. I have been trying to purchase the cell, but, until now, I can't find any company who sell the cell line. I would be very appreciate to get you advice. Thanks.
Hafiz
I was doing my PhD at University of Melbourne and planning to continue the study in my lab at International Islamic University Malaysia, Kuantan Campus. I would like to ask from fellow colleagues who have experience or know a way to transport cell line from one country to another on the following matter:
1) How do you prepare the sample to ensure it is survive once reach to the destination?
2) What are the document needed to do the shipping?
3) Do you have any suggestion on other alternative way to transport the cell line if not by courier?
Your advice is highly appreciated.
Thank you.
Probiotics have always been related to the bacteria that are consumed and giving benefit to the gastrointestinal tract. Lactobacillus casei for instant is know for its benefit in probiotics, however, it is also known as the agent of dental caries. As such, I would like to know what is actually oral probiotics based on your understanding? Thanks.
I'm doing my study on cytokines from epithelial cell prior infection of mixed biofilm Candida albicans. Therefore, I would like to know what is the best housekeeping gene if I want to study the expression of genes in oral epithelial cells.
My research is about mixed yeast-bacteria biofilm and I'm quite confused as to what kit I should use to isolate RNA from the mixed biofilm. I want to study the expression of both microbes with RT-PCR soon. What I know is, I can use any RNA extraction kit, but, the primer which I'm going to use in RT-PCR should be specific as to differentiate between yeast and bacteria. What you all guys think?
