Mohammed Rahmatullah

Mohammed Rahmatullah
University of Development Alternative | UODA · Faculty of Life Sciences

Ph.D.

About

625
Publications
299,941
Reads
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10,415
Citations
Introduction
Current research interest is on Natural Products and Drug Discovery. My research team is using in silico techniques for discovering antiviral drugs.
Additional affiliations
January 2009 - December 2012
University of Development Alternative
April 2002 - present
University of Development Alternative
Position
  • Dean
October 1992 - May 2000
Weiss Center for Research
Position
  • Researcher
Education
September 1978 - January 1982

Publications

Publications (625)
Chapter
With reports of 9.9 million people being infected with tuberculosis by WHO, there is a dire need to curtail the spread of tuberculosis. In spite of having faced many impediments like lack of certified radiologist and chest radiography hardware which are expensive, diagnosis of tuberculosis still remains undetected at early stage. Chest radiography...
Article
Full-text available
COVID-19, caused by the coronavirus SARS-CoV-2, emerged in late December 2019 in Wuhan, China. As of 8 April 2022, the virus has caused a global pandemic, resulting in 494,587,638 infections leading to 6,170,283 deaths around the world. Although several vaccines have received emergency authorization from USA and UK drug authorities and two more in...
Article
Full-text available
Background Curcumin is an active compound derived from turmeric, Curcuma longa , and is known for its benefits to human health. The amoebicidal activity of curcumin against Acanthamoeba triangularis was recently discovered. However, a physiological change of intracellular pathways related to A. triangularis encystation mechanism, including autophag...
Article
Full-text available
Analgesic tolerance is a major problem in the clinic for the maintenance of opioid-induced long-term pain relief. Opioids with mixed activity on multiple opioid receptors promise reduced antinociceptive tolerance in preclinical studies, but these compounds typically show poor bioavailability upon oral, subcutaneous, intraperitoneal, or intravenous...
Article
The secondary metabolites of endemic plants from the Rutaceae family, such as Burkillanthus malaccensis (Ridl.) Swingle from the rainforest of Malaysia, has not been studied. Burkillanthus malaccensis (Ridl.) Swingle may produce antibacterial and antibiotic-potentiating secondary metabolites. Hexane, chloroform, and methanol extracts of leaves, bar...
Article
Full-text available
Citation: Zulkipli, M.; Mahbub, N.; Fatima, A.; Wan-Lin, S.L.; Khoo, T.-J.; Mahboob, T.; Rajagopal, M.; Samudi, C.; Kathirvalu, G.; Abdullah, N.H.; et al. Isolation and Characterization of Werneria Chromene and Dihydroxyacidissimol from Burkillanthus malaccensis (Ridl.) Swingle. Plants 2022, 11, 1388.
Article
Nanomedicines emerged from nanotechnology and have been introduced to bring advancements in treating multiple diseases. Nano-phytomedicines are synthesized from active phytoconstituents or plant extracts. Advancements in nanotechnology also help in the diagnosis, monitoring, control, and prevention of various diseases. The field of nanomedicine and...
Article
Hydrogels are a promising and attractive option as polymeric gel networks, which have immensely fascinated researchers across the globe because of their outstanding characteristics such as elevated swellability, the permeability of oxygen at a high rate, good biocompatibility, easy loading, and drug release. Hydrogels have been extensively used for...
Article
Obesity is a significant health concern, as it causes a massive cascade of chronic inflammations and multiple morbidities. Rheumatoid arthritis and osteoarthritis are chronic inflammatory conditions and often manifest as comorbidities of obesity. Adipose tissues serve as a reservoir of energy as well as releasing several inflammatory cytokines (inc...
Article
Full-text available
Lectins or clusters of carbohydrate-binding proteins of non-immune origin are distributed chiefly in the Plantae. Lectins have potent anti-infectivity properties for several RNA viruses including SARS-CoV-2. The primary purpose of this review is to review the ability of lectins mediated potential biotherapeutic and bioprophylactic strategy against...
Article
Severe acute respiratory syndrome (SARS)-CoV-2 virus causes novel coronavirus disease 2019 (COVID-19) with other comorbidities such as diabetes. Diabetes is the most common cause of diabetic nephropathy, which is attributed to hyperglycemia. COVID-19 produces severe complications in people with diabetes mellitus. This article explains how SARS-CoV-...
Article
The focus of this roadmap is to evaluate the possible efficacy of Artemisia herba-alba Asso. (Asteraceae) for the treatment of COVID-19 and some of its symptoms and several comorbidities using a combination of in silico (molecular docking) studies, reported ethnic uses, and pharmacological activity studies of this plant. In this exploratory study,...
Article
Full-text available
The focus of this roadmap is to evaluate the possible efficacy of Artemisia herba-alba Asso. (Asteraceae) for the treatment of COVID-19 and some of its symptoms and several comorbidities using a combination of in silico (molecular docking) studies, reported ethnic uses, and pharmacological activity studies of this plant. In this exploratory study,...
Article
Severe acute respiratory syndrome (SARS)-CoV-2 virus causes novel coronavirus disease 2019 (COVID-19) with other comorbidities such as diabetes. Diabetes is the most common cause of diabetic nephropathy, which is attributed to hyperglycemia. COVID-19 produces severe complications in people with diabetes mellitus. This article explains how SARS-CoV-...
Article
Full-text available
Phytopharmaceuticals have been widely used globally since ancient times and acknowledged by healthcare professionals and patients for their superior therapeutic value and fewer side-effects compared to modern medicines. However, phytopharmaceuticals need a scientific and methodical approach to deliver their components and thereby improve patient co...
Chapter
Cyperus rotundus (nut grass in English) is a perennial erect sedge plant and is distributed in over 90 countries of the world, where it has been mostly classified as a highly invasive weed. Despite this classification, the plant has been considered from traditional times to be medicinally important. The traditional uses of the plant in various coun...
Chapter
Various types of viral diseases are emerging as the largest menace human beings have faced in the last few decades. Since the arrival of human immunodeficiency virus, the world has seen the emergence of deadly viruses like bird flu, Ebola, Nypah, Hanta, SARS, MERS, and currently the SARS-CoV-2. Other viral diseases like herpes, human papilloma viru...
Article
Despite the huge loss of lives and massive disruption of the world economy by the COVID-19 pandemic caused by SARS-CoV-2, scientists are yet to come out with an effective therapeutic against this viral disease. Several vaccines have obtained ‘emergency approval’, but difficulties are being faced in the even distribution of vaccines amongst high- an...
Article
Full-text available
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has caused a severe global pandemic with major public health issues. Public health sectors implemented several control strategies, such as social distancing, hygienic measures, and the development of anti-viral drugs and vaccines. However, the situation is still critical due to sever...
Article
Acanthamoeba keratitis infection extends due to the growing number of contact lens users. Indigenous plants including Garcinia mangostana play a vital role in human health and well being. Many species of this plant have been reported with myriads of potent medicinal properties. However, the aims of this study were, for the first time, to isolate co...
Article
Recent years have witnessed the emergence of several viral diseases, including various zoonotic diseases such as the current pandemic caused by the Severe Acute Respiratory Syndrome Coro-navirus 2 (SARS-CoV-2). Other viruses, which possess pandemic-causing potential include avian flu, Ebola, dengue, Zika, and Nipah virus, as well as the re-emergenc...
Article
Opioids are widely used as therapeutic agents against moderate to severe acute and chronic pain. Still, these classes of analgesic drugs have many potential limitations as they induce analgesic tolerance, addiction and numerous behavioural adverse effects that often result in patient non-compliance. As opium and opioids have been traditionally used...
Article
Full-text available
Coronavirus disease 2019 (COVID-19) is a potentially lethal and devastating disease that has quickly become a public health threat worldwide. Due to its high transmission rate, many countries were forced to implement lockdown protocols, wreaking havoc on the global economy and the medical crisis. The main protease (M pro) of severe acute respirator...
Article
Full-text available
Among the large number of plants that are part of the Ayurvedic system of medicine in India and Bangladesh, Zingiber officinale Roscoe (Zingiberaceae), or ginger in English, holds a special place and is often referred to as “Mahaushadha” (great medicine) and “Vishvabhesaja” (worldwide or universal herb) to signify its special status. The plant and...
Article
Full-text available
The rapid spread of a novel coronavirus known as SARS-CoV-2 has compelled the entire world to seek ways to weaken this virus, prevent its spread and also eliminate it. However, no drug has been approved to treat COVID-19. Furthermore, the receptor-binding domain (RBD) on this viral spike protein, as well as several other important parts of this vir...
Article
COVID-19, caused by the SARS-CoV-2 virus, can lead to massive inflammation in the gastrointestinal tract causing severe clinical symptoms. SARS-CoV-2 infects lungs after binding its spike proteins with alveolar angiotensin-converting enzyme 2 (ACE2), and it also triggers inflammation in the gastrointestinal tract. SARS-CoV-2 invades the gastrointes...
Article
Obesity is one of the major problems facing human beings at present. Because of the consumption of refined sugar and foods rich in carbohydrates, as well as adoption of a more sedentary lifestyle (often by necessity as is the case with most office workers), people in all countries are increasingly getting obese, which in turn is leading to other di...
Article
Objective To evaluate the efficacy of reported anti-malarial phytochemicals as lead compounds for possible drug development against COVID-19. Methods An in silico approach was used in this study to determine through molecular docking the binding affinities and site of binding of these phytochemicals to the 3C-like protease of COVID-19 which is con...
Article
The COVID-19 disease has currently overwhelmed all other health issues throughout the world. There can be many repercussions on existing public health issues, especially tuberculosis (TB), which is endemic in many low and middle-income countries (LMICs). In most of the LMICs, the health services are poorly equipped, the resources being diverted to...
Article
Full-text available
Peganum harmala, a well-known medicinal plant, has been used for several therapeutic purposes as it contains numerous pharmacological active compounds. Our study reported an antiparasitic activity of P. harmala seed extract against Acanthamoeba triangularis. The stress induced by the extract on the surviving trophozoites for Acanthamoeba encystatio...
Article
Rheumatoid arthritis is a chronic autoimmune disorder that can lead to disability conditions with swollen joints, pain, stiffness, cartilage degradation, and osteoporosis. Genetic, epigenetic, sex-specific factors, smoking, air pollution, food, oral hygiene, periodontitis, Prevotella, imbalance in the gastrointestinal microbiota are possible source...
Article
Full-text available
Acanthamoeba spp. can cause amoebic keratitis (AK). Chlorhexidine is effective for AK treatment as monotherapy, but with a relative failure on drug bioavailability in the deep corneal stroma. The combination of chlorhexidine and propamidine isethionate is recommended in the current AK treatment. However, the effectiveness of treatment depends on th...
Article
Corona virus SARS-CoV-2-induced viral disease (COVID-19) is a zoonotic disease that was initially transmitted from animals to humans. The virus surfaced towards the end of December 2019 in Wuhan, China where earlier SARS (Severe Acute Respiratory Syndrome) had also surfaced in 2003. Unlike SARS, SARS-CoV-2 (a close relative of the SARS virus) creat...
Article
Dysentery is a gastrointestinal infection characterized by mucus and blood with stool usually caused by bacteria and parasites from contaminated food and water with faeces. The disease is widely recorded in developing countries, especially with poor health and hygiene conditions. Shigellosis and amoebiasis are two major types of dysentery that caus...
Article
The current pandemic of COVID-19 caused by the coronavirus SARS-CoV-2 has as of December 2, 2020 resulted in 64,504,648 infected cases resulting in 1,493,082 deaths. Although at least three vaccines against the virus are on their way to get emergency approval from the United States Food and Drug Administration possibly by December 15, 2020, this ma...
Article
Full-text available
Olanzapine is an antipsychotic drug and has been reported to induce impaired glucose tolerance leading to high blood glucose levels. In oral glucose tolerance tests (OGTT), methanolic extract of steamed cabbage (Brassica oleracea L. var. capitata) (MEBO) leaves have been shown to reduce elevated blood glucose levels in glucose-loaded mice. It was t...
Article
Full-text available
The new corona virus known as SARS-CoV-2 or otherwise COVID-19 has caused widespread concerns due to its contagiousness, fatality rate, and the absence of drug(s), which can adequately treat the viral disease. However, while the virus appears to be thriving in both developed and developing countries (16,494,128 infections and 653,434 deaths worldwi...
Preprint
Diarrhea and dysentery along with other gastrointestinal tract (GI-tract) disorders are fairly common throughout Bangladesh because of lack of quality drinking water, poor sanitation facilities, and somewhat unhygienic mode of living among the poorer but majority sections of the population. Modern medical facilities are largely unavailable to the r...
Article
Full-text available
Aims: Corona virus SARS-CoV-2, otherwise known as COVID-19 has created a pandemic resulting in social and financial crisis throughout the world. The virus has no known drugs or vaccines for preventive or therapeutic purposes. The objective of the present study was to screen phytochemicals from Cassia occidentalis L. in virtual screening (in silico)...
Preprint
Full-text available
Background: Various parts of Garcinia mangostana Linn, including its pericarp have been traditionally used to treat different types of diseases. This study was carried out to determine the anti-Acanthamoeba activity of G. mangostana pericarp extract against Acanthamoeba triangularis. Methods: The G. mangostana ethanolic pericarp extract was screene...
Article
Recent outbreak of novel coronavirus and its rapid pandemic escalation in all over the world has drawn the attention to urgent need for effective drug development. However, due to prolonged vaccine and drug development procedure against a newly emerged devastating SARS-CoV-2 virus pathogen, repurposing of existing potential pertinent drug molecules...
Article
Rotavirus is one of the common causes of gastroenteritis in children; in fact nearly every child in the world will have at least one rotavirus-induced gastroenteritis (marked by watery diarrhea) before age 5. Despite the introduction of vaccines, over 200,000 children die annually from rotavirus induced severe dehydrating gastroenteritis, most of t...
Chapter
Globally liver diseases are on the rise; some of the causes include viral hepatitis, liver carcinoma, non-alcoholic or too much alcohol consumption-induced fatty liver disease, immune disorders, cholestatic and metabolic disorders, adverse effects (hepatotoxicity) arising from food and allopathic or traditional medications, fungal infections, schis...
Chapter
Globally liver diseases are on the rise; some of the causes include viral hepatitis, liver carcinoma, non-alcoholic or too much alcohol consumption-induced fatty liver disease, immune, cholestatic and metabolic disorders, adverse effects (hepatotoxicity) arising from allopathic or traditional medications, fungal infections, schistosomiasis, and inf...
Article
The recent coronavirus (known as COVID-19 or SARS-CoV-2) has created a pandemic of unheard proportions affecting virtually every country and region of the world. As of April 15, 2020 the virus has resulted in over 2 million infections, and over 100,000 deaths and has brought world economic activities to a standstill, and has led to social isolation...
Chapter
Globally liver diseases are on the rise; some of the causes include viral hepatitis, liver carcinoma, non-alcoholic or too much alcohol consumption-induced fatty liver disease, immune disorders, cholestatic and metabolic disorders, adverse effects (hepatotoxicity) arising from food and allopathic or traditional medications, fungal infections, schis...
Article
Full-text available
In this review we have explored the various alternatives that are being developed and explored for the effective control, prevention, and treatment of Dengue fever. Dengue fever affects approximately 2.5 billion people or half the world's population. Specifically, in the Tropics regions, it has acquired an endemic proportion. As a consequence, the...
Article
Full-text available
Corona virus SARS-CoV-2, otherwise known as COVID-19 has since its outbreak in late December 2019, till as of June 23, 2020 has infected 9,162,375 people throughout the world and caused deaths of 473,087 persons. The Bangladesh statistics for COVID-19 are 122,660 infections and 1,582 deaths. Although the figures seem low for Bangladesh, it can surg...
Conference Paper
The liver is responsible for many vital functions within the body such as metabolism and excretion. It becomes diseased or injured and loss those functions which causes signicant damage of the body. Despite the recent therapeutic advances and signicant development of modern medicine, hepatic diseases remain a health problem worldwide. Many morder...
Article
Full-text available
Objectives: The objective of the present study was to document a novel treatment method using Jasminum sambac and Eleusine indica to treat snakebite in Bagshayesta village of Rajshahi district, Bangladesh. Methods: The whole process of treatment was photographed in presence of a few onlookers (including another FMP) with the consent of the patient...
Article
Full-text available
The pandemic of antibiotic resistance necessitates the development of new therapeutic measures. In the quest, to find alternatives and/or adjuvant to antibiotics scientists across the globe have explored various methods. Among the study for various alternatives, exploring phytochemicals for their antibacterial properties have had successful outcome...
Chapter
Bangladesh, although being a small country, contains more than 5000 floral species of which around 1500 are now recognized to be used as medicinal plants. Such plants are used in the classical formats of traditional medicine like Ayurveda, Unani, and homeopathy; and by folk medicinal practitioners, folk herbalists, and tribal medicinal practitioner...
Chapter
Cyperus rotundus (nut grass in English) is a perennial erect sedge plant and is distributed in over 90 countries of the world, where it has been mostly classified as a highly invasive weed. Despite this classification, the plant has been considered from traditional times to be medicinally important. The traditional uses of the plant in various coun...
Article
Full-text available
Living under non-hygienic conditions, lacking access to quality water for cooking and drinking, and presence of a variety of enteric pathogens contribute to a large number of gastrointestinal tract (GI-tract) disorders and death, particularly among children of rural and urban slum areas of Bangladesh. On average, a rural child suffers from 4.6 ep...