Mohammed Ehsanul Hoque Mazumder

The University of Sydney

In the present study, several clinical field trials were conducted to evaluate the efficacy and safety of moxidectin oral drench for sheep. Trial I was designed to evaluate the efficacy and toxicity 0.2 % moxidectin (Rivermec(R)) oral drench, whereas in trial II, a comparative efficacy between Rivermec(R) LV and Cydectin LV containing 0.2% moxidect...

This study evaluated the in vitro antioxidant and cytotoxic potential of methanolic extract of the root of Calotropis procera (R. BR.). The Antioxidant activity of the extract was investigated by the In-vitro Anti-Oxidant activity (DDPH Scavenging activity) assays. The IC50 of the Calotropis procera studied by the above mention method was found bel...

Paederia foetida is a native Bangladeshi plant, used for the treatments of various diseases in folklore medicine. In this study, the antioxidant potential of Paederia foetida extract was evaluated by using a series of well established antioxidant assay systems. Paederia foetida extract scavenge DPPH radical in a dose dependent manner. The extract w...

Cancer sufferers are often found to use herbal products along with targeted therapy although not much information (whether beneficial or harmful) is available about the effects of such combinations. In this study, we investigated synergism from the combination of platinum drugs and a number of tumour-active phytochemicals including curcumin, epigal...

In this study, synergism in activity from the sequenced combinations of three trans-palladiums (denoted as TH5, TH6 and TH7) with green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG), as well as that with cisplatin, was investigated in a number of human ovarian tumour models as a function of sequence of administration. Cellular accumulation o...

The present study deals with the synthesis, characterization, and activity against human ovarian cancer cell lines A2780, A2780(cisR) , A2780(ZD0473R) , and SKOV-3 of three trans-planaraminepalladium(II) complexes of the form trans-PdL(2) Cl(2) , coded as EH1, EH3, and EH4, for which L=2-methylpyridine, imidazole, and 1,2-α-imidazopyridine, respect...

Musa sapientum L. ssp. sylvestris (Family: Musaceae) is a popular edible fruit. It is used by the traditional healers in the treatment of diarrhoea and dysentery. In the present study, methanolic extracts of peel (MSPE), pulp (MSPU) and seed (MSSE) of the fruit were investigated for in vitro antioxidant activity using DPPH (1,1-diphenyl-2-picrylhyd...

The aim of this study was to evaluate the antimicrobial and cytotoxic activities of the different extracts of Musa sapientum L. subsp. sylvestris fruits. The methanolic extracts of Musa sapientum L. subsp. sylvestris peel (MSPE), pulp (MSPU) and seed (MSSE) were investigated for antimicrobial activity by disc diffusion method and for cytotoxic acti...

This study evaluated the in vitro antioxidant and cytotoxic potential of methanolic extract of the root of Calotropis procera (R. BR.). The Antioxidant activity of the extract was investigated by the In-vitro Anti-Oxidant activity (DDPH Scavenging activity) assays. The IC50 of the Calotropis procera studied by the above mention method was found bel...

The present study was designed to investigate the antioxidant, analgesic and anti-inflammatory potential of the methanolic extract along with its organic soluble fractions of the herb Eclipta prostrata. In addition, total phenolic and flavonoid content and total antioxidant capacity were also determined. Antioxidant potential of the extract/fractio...

Musa sapientum (M.sapientum) commonly known as 'banana' is widely used in Bangladeshi folk medicine for the treatment of various ailments including diarrhea. Hence, the present study was designed to investigate antidiarrheal, antioxidant and antibacterial potential of the methanolic extract of M.sapientum seed (MMSS). The extract was studied for an...

In course of investigation on natural antioxidants, the present study was aimed to report the antioxidant activities, both in vitro and in vivo, of the crude methanolic extracts of the whole plant of Oxalis corniculata Linn along with its various organic fractions. The different assay methods, including total antioxidant activity, scavenging free r...

Nigella sativa L. has long been used in the traditional medicine for treatment of many diseases including infections, immunomodulations and cancers. In this study, the immunostimulating activity of ethanolic extract of N. sativa was investigated in light of the production of immunoglobulin M (IgM) and the proliferation of murine splenic cells in vi...

In this study, hydromethanol extracts of fruit pulp, pericarp, seed and leaf (coded as ALP, ALPC, ALS and ALL respectively) of Artocarpus lacucha at 200 and 400 mg/kg b.w., p.o., were evaluated for possible anxiogenic activity using standard animal behavioural models, such as hole cross, open field, elevated plus-maze (EPM) and dark/light box tests...

Chitosans are naturally occurring biologically safe and non-toxic polymer of polysaccharides. In the present study, Chitosan [(1-4) 2-amino-2-deoxy-β-D-glucan] was extracted from the exoskeleton of Black Tiger ( Penaeus monodon ) shrimp shells by alkaline deacetylation of chitin. Three different chitosan extracts, coded as Chito A (3.33% w/w), Chit...

Thymoquinone (TQ) is the major biologically active component (about 54%) of volatile oil of black seed that has been shown to exert anti-inflammatory, antioxidant and anti-neoplastic effects both in vitro and in vivo. TQ induces apoptosis, disrupts mitochondrial membrane potential and triggers the activation of caspases 8, 9 and 3 in myeloblastic l...

Nitrogen containing heterocyclic compounds such as oxindoles especially isatins (β‐lactams) and their derivatives have excellent biological properties such as anti‐inflammatory, antimicrobial, anticancer activity. In the present study the antioxidant activity of the said class of compounds was investigated by DPPH method with respect to ascorbic ac...

Bacopa monniera is locally referred as Brahmi Shak, has been reputed to use in the Ayurvedic system of medicine for centuries. In our ongoing study to identify the scavenger of ONOO -from natural sources, the aerial parts of Bacopa monniera Linn. was evaluated to scavenge authentic peroxynitrites (ONOO -) and to inhibit total reactive oxygen specie...

Bacopa monniera is locally referred as Brahmi Shak, has been reputed to use in the Ayurvedic system of medicine for centuries. In our ongoing study to identify the scavenger of ONOO-from natural sources, the aerial parts of Bacopa monniera Linn. was evaluated to scavenge authentic peroxynitrites (ONOO-) and to inhibit total reactive oxygen species...

Analgesic potential of the pet ether (PECB), chloroform (CCB), n-butanol (NBCB) and hydromethanolic (HMCB) fractions of the aerial parts of Commelina benghalensis Linn. was evaluated for centrally acting analgesic property using hotplate and tail immersion method and peripheral pharmacological actions using acetic acid-induced writhing test to scie...

The objective of the present study was to evaluate the comparative antioxidant potential of methanol, ethyl acetate, pet ether and water extracts of Celastrus paniculatus seed. Antioxidant activity was evaluated by using total phenol and flavonoid content determination assays, total antioxidant capacity, 1,1-diphenyl-2-picryl-hydrazil (DPPH) free r...

Lysogenic bacteriophages are considered as a major player for the introduction of foreign genes into bacterial strains. At the time of introduction foreign genes do not fit well into the translation system of the recipient host bacterium as they tend to retain the characteristics of the donor bacterium from which they have been transferred. Consequ...

Hydromethanol extracts of 15 Bangladeshi medicinal plants, traditionally used in different ailments, were evaluated for antioxidant potential using DPPH (1,1-diphenyl-2-picryl hydrazyl) radical scavenging assay. Among the extracts Cocos nucifera, Caesalpinia pulcherrima, Punica granatum and Syzygium cumini were found displaying strong (90% or more)...

The present study was designed to investigate sedative and anxiolytic properties of the four different fractions (chloroform, pet ether, n-butanol and hydromethanol soluble fractions, coded as CFCB, PECB, NBCB and HMCB, respectively) of the aerial parts of Commelina benghalensis using rodent behavioral models, such as hole cross, open field and thi...

The antioxidant potential of the ethanol extract of Vitex negundo L. was evaluated by using 1, 1- diphenyl-2-picrylhydrazyl (DPPH), hydrogen peroxide, total antioxidant capacity and erythrocyte (RBC) membrane stabilization assays. The extract showed significant activities in all antioxidant assays compared to the reference antioxidant ascorbic acid...

Xanthium indicum Koenig. is a medicinal herb belonging to the family Compositae, which has been reported to possess strong diaphoretic, antimalarial, anticancer and demulcent properties according to indigenous systems of medicine in Indian Sub-Continent. But its antidiarrhoeal and antioxidant potential is still unknown. Therefore, the present study...

Exposure to lead during early development and even in adulthood has been implicated in behavioural abnormalities and cognitive deficits. Animal (Sprague-Dawley rat) studies have shown the lead-induced severe injury/damage to the hippocampus, alterations of acetyl cholinesterase activity and memory impairment. However the correlation between memory...

Exposure to lead during early development and even in. adulthood has been implicated in behavioural abnormalities and cognitive deficits. Animal (Sprague-Dawley rat) studies have shown the lead-induced severe injury/damage to the hippocampus, alterations of acetyl cholinesterase activity and memory impairment. However the correlation between memory...

The antioxidant potential of the 70% methanolic extract of Ichnocarpus frutescens was assessed by the 1, 1-diphenyl-2-picrylhydrazyl (DPPH), the hydrogen peroxide, the nitric oxide, the reducing power and the lipid peroxidation inhibition (thiobarbituric acid-reactive substances production) and the red blood cell (RBC) membrane stabilization assays...

A growing body of evidence suggests that cellular damage or oxidative injury arising from production of free radicals or reactive oxygen species (ROS) are critical causative factors in the pathogenesis of many neurodegenerative disorders, inflammatory conditions, autoimmune diseases, diabetes, and gastrointestinal disorders. Results from biological...

A growing body of evidence suggests that oxidative stress is the key player in the pathogenesis of lead-induced toxicity. The present study investigated lead-induced oxidative DNA damage, if any in rat blood cells by alkaline comet assay. Lead was administered intraperitoneally to rats at doses of 25, 50 and 100 mg/kg body weight for 5 days consecu...