• Home
  • Mohammadreza Soroush
Mohammadreza Soroush

Mohammadreza Soroush
Janbazan medical and engineering research center JMERC tehran Iran

About

126
Publications
27,575
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
2,203
Citations
Citations since 2016
31 Research Items
1119 Citations
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200

Publications

Publications (126)
Article
Full-text available
Aims: The complications of sulfur mustard (SM) in lungs, eyes, and skin of exposed survivors have already been studied. This study evaluates health problems of other than the usual affected organs in survivors with severe respiratory injuries. Instrument & Methods: In this descriptive cross-sectional study, 292 chemical warfare veterans with severe...
Article
Background: The serum and tear levels of four inflammatory chemokines were evaluated in sulfur mustard (SM)-exposed with serious ocular problems. Materials and methods: In this study, 128 SM-exposed patients and 31 healthy control participants participated. Tear and serum levels of chemokines were assessed by ELISA method. Results: There was n...
Article
Background and aims Many individuals with lower limb loss report concerns about other musculoskeletal symptoms resulting from amputation. The objective of this study was to assess chronic musculoskeletal pain in Iranian veterans with unilateral below-knee amputation. Methods The participants agreed to take part in a health needs assessment and wer...
Article
Context: Sulfur mustard (SM) as a cytotoxic and blistering agent can alkylate a variety of cellular components, causing the incidence of ongoing oxidative stress. Objective: The present study was conducted to assess oxidative stress index (OSI) in SM-exposed veterans with long-term pulmonary complications. Methods: Participants consisted of 289 SM-...
Article
INTRODUCTION The prevalence of limb amputation is increasing globally as a devastating experience that can physically and psychologically affect the lifestyle of a person. The residual limb pain and phantom limb pain are common disabling sequelae after amputation surgery. Assistive devices/technologies can be used to relieve pain in people with am...
Article
Full-text available
The prevalence of limb amputation is increasing globally as a devastating experience that can physically and psychologically affect the lifestyle of a person. The residual limb pain and phantom limb pain are common disabling sequelae after amputation surgery. Assistive devices/technologies can be used to relieve pain in people with amputation. The...
Article
Full-text available
Background: War-related traumas can lead to orthopedic and neurological disorders in victims. However, the scope of such disorders may expand months or even years after the trauma. Orthotic treatment as a rehabilitation process aims to enable people with disabilities to reach and maintain their optimal physical, sensory, intellectual, psychologica...
Article
Full-text available
Sulfur mustard is a vesicant chemical warfare agent, which has been used during Iraq-Iran-war. Many veterans and civilians still suffer from long-term complications of sulfur mustard exposure, especially in their lung. Although the lung lesions of these patients are similar to Chronic Obstructive Pulmonary Disease (COPD), there are some differences...
Data
miR-143-3p - G1 cell cycle arrest. (PDF)
Data
Conditions and data distributions. (PDF)
Data
miR-148-3p expression on individual samples. (PDF)
Data
Comparative scatter plots of conditions. (PDF)
Data
The affected cellular pathways influenced by 9 altered microRNAs in serum samples of SMVs, mild to severe intersection, BIOCARTA analysis. (XLSX)
Data
All candidate sets of Fig 4B in one table. (XLSX)
Data
The affected cellular pathways influenced by 15 altered microRNAs in serum samples of SMVs, normal to mild comparison, BIOCARTA analysis. (XLSX)
Data
The affected cellular pathways influenced by 29 altered microRNAs in serum samples of SMVs, normal to severe comparison, BIOCARTA analysis. (XLSX)
Article
Delayed effects of sulfur mustard (SM) exposure on the levels of five important damage/repair proteins were investigated in 40 SM-exposed veterans of Iran-Iraq war and 35 unexposed controls. A major DNA damage biomarker protein - phosphorylated H2AX - along with four DNA repair proteins in cell response to the genome damage MRE11, NBS1, RAD51, and...
Article
Full-text available
Methods: The study is a cross-sectional one and after random sampling 210 was studied. The trained interviewers collected the data through telephone interviews. After entering the data through SPSS software, descriptive and analytical statistics were performed using chi-square test and logistic regression analysis. Results: Overall 1800 cases incl...
Article
Background To determine the psychological morbidity in the long term after war related bilateral lower limb amputation. Methods Mental health status was determined by the Symptom Checklist-90-R (SCL-90-R) and a structured psychiatrist interview using Structured Clinical Interview for DSM Disorders-IV (SCID-IV) in 327 male amputees. The survey was...
Article
To evaluate mental health status of the survivors with sulfur mustard (SM) induced severe lung injury (n = 291), Iranian standardized symptom checklist 90-revised (SCL90-R) questionnaire was used. The global severity index (GSI) was compared with the cutoff point of Iranian general population (0.4). About (32.9%, n = 96) had a positive history of p...
Article
Full-text available
Objective (s): This study aimed to assess veterans and their families’ satisfaction with received supplementary pharmacy services, pharmacy location (distance) and the process of receiving costs. Methods: This was a cross-sectional study. The study population consisted of veterans and their families, including parents, spouses and their children. P...
Article
Full-text available
Background: Despite observed post Sulfur Mustard (SM) exposure hemolysis, serum bilirubin concentration does not significantly increase in SM-exposed casualties. The concentration of serum bilirubin can be related to serum levels of inflammatory cytokines. Objectives: In this study, the relationship between the serum levels of Interleukin (IL)-1α,...
Article
Full-text available
Context: Sulfur mustard (SM) was used during the Iraq-Iran war (1980–1988). Exposed veterans continue to suffer from its ocular, skin, and respiratory complications. Objective: We aimed to evaluate associations between early (at the time of acute exposure) and decades later skin manifestations in individuals with severe ophthalmologic complications...
Article
Introduction: This study aimed to describe the mental health status of sulfur mustard-exposed survivors suffering from severe respiratory and ophthalmological problems. Methods: Out of 450 invited Iran-Iraq War survivors of sulfur mustard exposure with severe symptoms, 350 participated in this cross-sectional study. Mental health status was asse...
Article
Full-text available
Background: Providing care to a disable relative at home exposes the caregiver to a potentially higher risk of physical and mental problems. We measured health-related quality of life (HRQOL) and its determinants among the caregivers of the Iranian survivors of the Iran-Iraq war (1980–1988) with bilateral lower-limb amputation. Methods: Data were...
Article
Full-text available
Objective: To determine the frequency of phantom limb sensation (PLS) and phantom limb pain (PLP) in children and young adults suffering landmine-related amputation. Materials & methods: All youths with amputation due to landmine explosions participated in this study. The proportions of patients with phantom limb sensation/pain, intensity and fr...
Article
Full-text available
Introduction: During trips the imposed costs are aggravated due to time and financial limits, not being familiar with treatment centers that are covered by the insurances and charges for accommodation. Insurance, especially supplementary treatment services insurance can be an appropriate solution to decrease these costs. These kinds of insurances c...
Article
Full-text available
Introduction & Objective: Severe burn is an important issue affecting public health in developing countries and one of the leading causes of death in Iran. In order to provide an overview on burn epidemiology in this country, we conducted a systematic review. Materials & Methods: Various published articles on risk factors and prevalence of burn in...
Article
Full-text available
Aims: The main objectives of Martyrs and Veterans Foundation is to provide medical services for the martyrs and veterans’ families, high satisfaction in insurance affairs, and improve the situation of the insured persons. Then, the aim of the study was to investigate the satisfaction level of the martyrs’ families insured by the complementary insur...
Article
Full-text available
Background: To describe the mental health status of 78 child and adolescent survivors of post-war landmine explosions. Methods: Child and adolescent survivors of landmine explosions who were younger than 18 years old at the time of the study were identified and enrolled in this study. The mental health status of the participants was assessed by...
Article
Full-text available
Objective: In spite of accumulating information about pathological aspects of sulfur mustard (SM), the precise mechanism responsible for its effects is not well understood. Circulating microRNAs (miRNAs) are promising biomarkers for disease diagnosis and prognosis. Accurate normalization using appropriate reference genes, is a critical step in miR...
Article
Background: Despite landmine-risk education programs and extensive demining activities on the Western border of Iran, landmines and unexploded ordnance (UXOs) still cause civilian and child casualties three decades after the Iraq-Iran war (1980-1988). The objective of this study was to understand the epidemiological patterns and risk factors of in...
Article
Full-text available
Sulfur mustard (SM) affects divergent cellular pathways including cell cycle, apoptosis, necrosis, and inflammatory responses. SM-induced lesions in skin include late-onset hyper-pigmentation, xerosis, and atrophy. It seems that TGF-b signaling pathway is a major player for SM pathogenesis. Here, we have employed a real-time polymerase chain reacti...
Article
Introduction: Physical disability, especially in childhood and adolescence can cause major psychological problems such as depression and anxiety. Burden of landmine in western border cities of Iran caused many disabled survivors through the years after Iran-Iraq war. Aims: To investigate the potential association of disability of activities of dail...
Article
Purpose: To evaluate quality of life (QOL) of caregivers of severely disabled war survivors and identify variables threatening caregivers' QOL. Methods: A cross-sectional study was performed on 532 caregivers of Iran-Iraq war related injured survivors by using Persian version of 36-item Short Form Health Survey (SF-36). Findings: Caregivers ha...
Article
Full-text available
MicroRNAs constitute a group of small non-coding RNAs that negatively regulate gene expression. Aside from their contribution to biological and pathological pathways, altered expression of microRNAs is reported in bio-fluid samples, such as serum. To employ serum's microRNAs as potential biomarkers, it is crucial to develop an efficient method for...
Article
To estimate the years of life lost (YLL), registered deaths due to Iraq-Iran war (1980-2005) were identified considering ICD10 codes of Y36.0 to Y36.9. Estimated YLL was calculated by taking age-weighting options and discount rates. Population life expectancy in each corresponding year was retrieved from the national health database. During 1980-20...
Article
Full-text available
Background: Bone marrow stromal cells (BMSC) have been successfully employed for movement deficit recovery in spinal cord injury (SCI) rat models. One of the unsettled problems in cell transplantation is the relative high proportion of cell death, specifically after neural differentiation. According to our previous studies, p75 receptor, known as...
Article
Full-text available
Background Sulfur mustard (SM) is an alkylating agent that induces short and long term toxicity on various organs. The aim of this study was to assess the long-term psychological symptoms among samples of exposed to sulfur mustard gas compared with unexposed civilians 20 years after exposure. Methods This historical cohort study was conducted on 4...
Article
Full-text available
Context: Sulfur mustard (SM), with an old manufacturing history still remains as potential threat due to easy production and extensive effects. Objectives: Increasing studies on SM indicates the interest of researchers to this subject. Almost all human body organs are at risk for complications of SM. This study offers organ-by-organ information...
Article
Sulfur mustard (SM) causes late complications in respiratory system of exposed individuals. In this preliminary study, the levels of IL-1α and β, TNF, IL-1Ra, IL-6 and fibrinogen in the spontaneous sputum of SM-exposed individuals were examined 20years after exposure and the correlation with pulmonary function was tested. The participants were cate...
Article
Full-text available
Sulfur mustard (SM) is a strong toxic agent that causes acute and chronic health effects on a myriad of organs following exposure. Although the primary targets of inhaled mustard gas are the epithelia of the upper respiratory tract, the lower respiratory tract is the focus of the current study, and upper tract complications remain obscure. To our k...
Article
Sulfur mustard (SM) is a potent alkylating vesicant warfare chemical agent which causes severe damages to the interface organs, skin, lungs and eyes. The most common chronic skin lesions are mustard scars, xerosis, eczema, seborrheic dermatitis, cherry angioma and hyperpigmentation. This study is part of Sardasht-Iran Cohort Study (SICS) which was...
Article
In this study the associations between ocular problems and serum levels of immunoglobulins in sulfur mustard (SM) exposed population 20years after exposure in context of Sardasht-Iran Cohort Study was explored. Serum immunoglobulins (Ig) levels including IgM, IgA, IgE, IgG, and subclasses of IgG (IgG1, IgG2, IgG3 and IgG4) in 372 SM-exposed patient...
Article
Sulfur mustard (SM) is an alkylating agent with prolonged adverse effects. The antioxidant paraoxonase 1 (PON1), an endogenous free radical scavenger, plays a protective role against oxidative stress. The possible roles of oxidative stress in the pathogenesis of SM, together with the antioxidant activity of PON1, are enough to warrant the analysis...
Article
Chemokines play an important role in acute and chronic pulmonary diseases. The aim of this study was to evaluate the levels of chemokines, MMP-9, and PMN elastase in spontaneous sputum and serum of patients 20years after SM exposure. In context of Sardasht-Iran Cohort Study (SICS) 40 male volunteers with a history of SM exposure in June 1987 and co...
Article
Exposure to SM leads to short and long term adverse effects on various organs including the skin. Cherry angioma is one of the late skin disorders in SM exposed individuals. The pathogenesis of abnormal angiogenesis in cherry angioma is not well known but the role of inflammatory mediators and certain hormones, including prolactin, in the regulatio...
Article
The aim of this study was to evaluate possible association between ophthalmic complications in sulfur mustard (SM) exposed patients with mild ocular injuries and serum soluble adhesion molecules. Serum levels of sICAM-1, sL-selectin, sP-selectin and sE-selectin in 367 SM-exposed individuals with or without eye injuries were checked and compared wit...
Article
Introduction: Ocular, respiratory and skin complications are the major late clinical complications induced by sulfur mustard (SM). In this study the association of systemic and local levels of TNF- α and long term SM induced ocular complications was assessed in a large group of Iranian veterans with SM induced seriously eye injuries. Material and M...
Article
Full-text available
Introduction: It is estimated that during the Iraq-Iran war of the 1980s, over 100,000 Iranians (military or civilian) were exposed to sulfur mustard (SM), and a considerable proportion of them are still suffering with long-term consequences of exposure. The aim of the present article is to address carcinogenesis of SM following these acute exposu...
Article
Full-text available
The relationship between compromised immune system and the development of malignancy, generalized dermatitis, and infection after sulfur mustard gas exposure has been established. We introduce a 58-year-old man with an abrupt, de novo and erythrodermic eruption in 2002 that was previously exposed to sulfur mustard during the Iran - Iraq war in 1987...
Article
Full-text available
Amputation and pain may have considerable impact on health-related quality of life. The purpose of this study was to assess the impact of pain on health-related quality of life in a population of war related bilateral lower limb amputees. The Veterans and Martyrs Affairs Foundation (VMAF) database documented 578 patients with bilateral lower limb a...
Article
Full-text available
Introduction: Ocular surface disorders and infections in sulfur mustard (SM) exposed patients are of particular clinical importance. The aim of the present study is to detect the conjunctival bacterial florae in patients with seriously SM induced eye injuries. Materials and methods: Conjunctival bacterial florae of 143 seriously eye injured subj...
Article
Objective: To determine the pattern of causalities of Iraqi ballistic missile attacks on Tehran, the capital of Iran, during Iraq-Iran war. Methods: Data were extracted from the Army Staff Headquarters based on daily reports of Iranian army units during the war. Results: During 52 days, Tehran was stroked by 118 Al-Hussein missiles (a modified...
Article
Full-text available
Sulfur mustard (SM) has been used as a chemical warfare agent since the early twentieth century. Despite the large number of studies that have investigated SM induced ocular injuries, few of those studies have also focused on the psychological health status of victims. This study has evaluated the most prominent influences on the psychological heal...
Article
Sulfur mustard, a chemical warfare agent, has short- and long-term effects on various organs including respiratory system. Its late toxic effects on biological macromolecules among exposed veterans have not been well studied. We performed a study to determine paraoxonase-1 (PON1) activity and phenotype distribution as well as its correlation with a...
Article
Iraq used chemical weapons against thousands of Iranian militaries and civilians. This study aimed to compare the chronic cutaneous side effects of exposure to sulfur mustard (SM) with nerve agents (NA). The study enrolled 154 SM exposed cases and 175 (NA) exposed cases. Presence of any late cutaneous manifestations was evaluated by a dermatologist...
Article
To determine the impact of pain in the vertebral column on the activities of daily living (ADL) level of war victims with bilateral lower limb amputation. All the war-related bilateral lower limb amputees were invited. More than half of them (n = 335) participated and underwent a thorough assessment after giving informed consent. The majority of th...
Article
Delayed keratitis is the most dangerous ocular complication of sulfur mustard (SM) exposure. This study aimed to evaluate the role of tear and serum levels of interleukin-8 (IL-8) in SM exposed subjects. In this historical cohort study, the experimental group included 370 participants who had been exposed to SM 20 years prior. Data were compared wi...
Article
Full-text available
Background: More than 55,000 Iranians suffer from complications due to chemical warfare agent (CWA) exposure, which occurred during 8 years of conflict between Iran- Iraq. Limited studies have addressed the impact of this exposure to CWA on the quality of life of these victims. Purpose: The aim of this study was to compare health related quality o...
Article
To report the clinical outcomes of lamellar keratoplasty (LKP) in patients with delayed-onset mustard gas keratitis and to compare visual acuity and graft survival rates between subgroups with simultaneous or sequential keratolimbal allograft and LKP. Retrospective, comparative, interventional case series. Fifty-two eyes of 37 male survivors of che...