Mohammad Yasir

Maulana Azad National Institute of Technology | MANIT · Department of Biological Science and Engineering

Cancer remains a major global health burden, necessitating innovative approaches for improved diagnosis and treatment. Aptamer-based theranostics have gained attention in the field of cancer research and treatment. Aptamers can be used as targeting ligands for the delivery of therapeutic agents to cancer cells, as well as for the detection and imag...

Biomaterials play a vital role in targeting therapeutics. Over the years, several biomaterials have gained wide attention in the treatment and diagnosis of diseases. Scientists are trying to make more personalized treatments for different diseases, as well as discovering novel single agents that can be used for prognosis, medication administration,...

Cooking oil is an important source of essential nutrients for human health. Prolonged heating of vegetable oil can lead to the emergence of health conditions. This study examined the physicochemical characteristics of sesame seed oil after heating at 180°C for 4 or 8 hours. We assessed the acid value, iodine value, peroxide value, p -anisidine valu...

The given investigation examined the neuroprotection role of 5‐HT1b/1d agonist in reserpine induced Parkinson's disease (PD) in male Wistar rats. PD was induced in rats by reserpine at 5 mg/kg ip for 3 days and thereafter the rats were provided with the following treatments for 4 days, zolmitriptan (ZLM) group (30 mg/kg ip); STD group (levodopa + c...

Objectives Present report evaluates the protective effect of geraniol on high fat diet (HFD) induced obesity in rats and also determines the molecular mechanism of it. Methods Rats were induced with obesity with administration of HFD for four weeks and geraniol 200 and 400 mg/kg p.o. was administered for the next four week in the respective groups...

Background: Present investigation evaluates the neuroprotective effect of Trachyspermum ammi essential oil (TAEO) against monosodium glutamate induced excitotoxicity. Methods: Glutamate excitotoxicity was induced in rats by administrating monosodium glutamate [MSG; 2 g/kg body weight, intraperitoneally (i.p.)] for seven days and further animals wer...

The virus causes an infection that every year threatens the health of people all over the world and costs a lot of money. Even though there are now new types of viruses, antiviral drugs are still the best way to treat them. Computer-aided drug design (CADD) offers the chance to make new drugs quickly and effectively, which is different from the pro...

Therapeutic proteins are potent medications that have shown substantial promise in treating a wide range of illnesses and conditions. Immunogenicity is a unique obstacle that must be overcome when dealing with protein therapy. The immune response is triggered when there is a change in the structure of the protein, which may occur because of posttra...

Autophagy is a cell correction process and impairment in it contributes to the development of cancer. Autophagy-related gene coded proteins contribute a role in the regulation of autophagic cellular loss. There are two ubiquitin-like conjugation systems are required for autophagy. Autophagy is a catabolic process that utilizes lysosomal degradation...

Present investigation evaluates the protective effect of vanillin against sepsis. Sepsis was induced by cecal ligation and puncture (CLP) in rat and vanillin was administered at dose of 100 and 200 mg/kg p.o. for five days after induction of sepsis. Effect of vanillin was observed on the percentage of survival, body weight and food intake were dete...

Women are diagnosed with breast cancer (BC) on a global basis every year, making it the most prevalent kind of cancer in women. A link between BC and various female hormones is significant because these hormones are used for a variety of purposes, including contraception and menopause treatment, by both reproductive and/or post-menopausal females....

Methyl isocyanate (MIC), a low molecular weight synthetic aliphatic compound, having an isocyanate group (−NCO), has industrial application. In this study, the effects of methyl isocyanate and its mechanism on outer membrane protein of Escherichia coli were observed using experimental and computational methods. In vitro exposure of N-succinimidyl N...

The severe acute respiratory syndrome is a viral respiratory disease recognised as COVID-19, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Formerly, no precise remedies are available, and many studies regarding COVID-19 prevention and treatment are under development. Several targets for the design of drugs are identified,...

Aim Snakebites are a serious health problem throughout the world, particularly in Asia. Several medicinal plants are used traditionally for the treatment of various ailments including snakebites. The aim of the study is to screen medicinal plants, which are traditionally used for the management of snakebites by tribal people and local practitioners...

Colorectal cancer (CRC) is one of the most deadly groups of diseases. Apart from genetic mutations, other aspects such as environmental factors, unhealthy lifestyle and poor diet cause distress in gastrointestinal environment by changing physio-biochemical properties of luminal content which provides favourable environment for carcinogenesis. Admin...

The severe acute respiratory syndrome is a viral respiratory infection and commonly called as COVID-19, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). It widely transmitted through direct or indirect contact. Currently, no specific treatment against SARS-CoV-2 are available; only prevention and supportive strategy are the p...

Snakebite is considered as one of the acute severe medical problems across the world. Snake venoms composed of various group of toxins, enzymes and non-toxic enzymes. Phospholipases A2 present in Naja naja snake venom plays a significant role in lipid signalling and contributes to different inflammation in the human body. Dryopteris cochleata rhizo...

Biofluids contains a wide range of molecules and these molecules help us to reflect our body's state by their physiochemical, biochemical properties and their concentration parameters. Initially, biofluids used for detection of diseases were blood, urine and many others, but now saliva and sweat can be exploited for the detection of diseases. Saliv...

INTRODUCTION: Due to unavailability of rapid diagnostics and lack of awareness, oral squamous cell carcinoma is detected at late metastasis stage. oral cavity is the most malignant epithelial carcinoma site affecting life cycle of a person. EVIDENCE ACQUISITION: All the available information regarding oral squamous cell carcinoma, various biomarker...

Snakebite is a severe medical, economic, and social problem across the world, mostly in the tropical and subtropical area. These regions of the globe have typical of the world's venomous snakes present where access to prompt treatment is limited or not available. Snake venom is a complex mixture of toxin proteins like neurotoxin and cardiotoxin, an...

Background The lungs are directly exposed to pollutants, pathogens, allergens, and chemicals, which might lead to physiological disorders. During the Bhopal gas disaster, the lungs of the victims were exposed to various chemicals. Here, using molecular modelling studies, we describe the effects of these chemicals (Dimethyl urea, Trimethyl urea, Tri...

Background Medicinal plants are rich source of large variety of lead compounds. The plants of genus Glycosmis or its different parts valued for its therapeutic and medicinal qualities. Glycosmis belongs to the family Rutaceae. Objective The genus Glycosmis is a rich source of pharmacologically and biologically active secondary metabolites, such as...

Background: Today infectious microbial diseases are causing complications world-wide, since resistance to a number of antimicrobial agents (β-lactam antibiotics, macrolides, quinolones, and vancomycin). A range of clinically important species of microorganisms has become a significant health problem globally. Methods: In quest of new antimicrobial...

Background Silver nanoparticles have excellent medical and nonmedical properties and application compared with other metallic nanoparticles. In the present study, fresh leaves of Syngonium podophyllum have been used for synthesis of silver nanoparticles. Objectives In this study, we evaluated the anticandidal activity of S. podophyllum and the syn...

Objectives Medicinal plants are vital sources of bioactive compounds that are useful for the treatment of patients with snake bites or are indirectly applicable for boosting the effects of conventional serum therapy. These plants are being used traditionally by local healers and tribes for the treatment of patients with snake bites and therefore ca...

The usage of medicinal or herbal plants has been a particular application throughout human life, whose information, collected through the involvement of countless generations. Medicinal or herbal plants signify a vital source of bioactive constituents which are useful to the treatment of snake bites patient, or indirectly, applicable as boosts to c...

This article reports in silico analysis of methyl isocyanate (MIC) on different key immune proteins against Mycobacterium tuberculosis. The analysis shows that MIC is released in the Bhopal gas tragedy in 1984, which is highly toxic and extremely hazardous to human health. In this study, we have selected immune proteins to perform molecular docking...

Objective: To investigate the role of dumped residues in the loss of immunity using human immune proteins, which provides protection against Mycobacterium tuberculosis. Methods: In this study, toxic chemicals were docked with immune proteins using AutoDock 4.0, and further, molecular dynamics simulations were performed for refinement of the docked...

In this study, antifungal and antioxidant activities of hydroalcoholic and aqueous extracts of the roots of Glycosmis pentaphylla were assessed. Total phenolic content of 22.45 +/- 1.49 and 5.23 +/- 1.11 mu g gallic acid equivalents per mg of sample and total flavonoids content 98.312 +/- 1.21 and 59.52 +/- 0.33 mu g rutin equivalents per mg of sam...

The present study examines the interaction of toxic chemicals like Alphanaphthol which were dumped in premises around the Union Carbide India Limited (UCIL) Bhopal, with human immuno-proteins that provide immunity against Mycobacterium tuberculosis. The study employed molecular modelling techniques and was accomplished by performing molecular docki...

Changes in lifestyle and depletion in the atmospheric ozone layer during the last decades have led to an increase in the skin cancer (both melanoma and non-melanoma). Recently, considerable attention has been focused to identify natural products capable of antiskin cancer activity. The preliminary phytochemical examination of Glycosmis pentaphylla...

This study is an attempt to find the reason for immunological suppression in victims of Bhopal gas tragedy during 1984 against Mycobacterium Tuberculosis (Mtb) infection. Here we tried to understand this problem by studying interactions between immune proteins associated with susceptibility to Tuberculosis and hydrolytic products of methyl isocyana...

Acacia arabica commonly known as babool are used in traditional Indian medicine for treatment of diabetes mellitus. The hypoglycemic effect of aqueous extract (hot and cold water) and hydroalcoholic extract of Acacia arabica was investigated. Oral administration of cold water extract of Acacia arabica bark to diabetic and normal rats at a dose of 4...

Natural product drugs play a dominant role in pharmaceutical care. Nature is an attractive source of new therapeutic candidate compounds as a tremendous chemical diversity is found in millions of species of plants, animals, marine organisms and microorganisms. Several plant-derived compounds are currently successfully employed in cancer treatment....

Over the past decades, herbal medicine has become a thing of global significance with medicinal and economic implications. Wide spread use of herbs throughout the globe has raised serious concerns over its quality, safety, and efficacy. Thus, exact scientific assessment has become a precondition for acceptance of herbal health claims. Persea americ...