Mohammad Hossein Sanei

• Isfahan University of Medical Sciences

Background: The liver controls blood glucose levels via regulation of anabolic (glycogen synthesis and gluconeogenesis) and catabolic (glycolysis and glycogenolysis) processes through activation of the PI3K-AKT signalling pathway. The aim of this study was to assess the effect of aerobic training, green coffee, and chlorogenic acid supplementation...

Background. The liver controls blood glucose levels via regulation of anabolic (glycogen synthesis and gluconeogenesis) and catabolic (glycolysis and glycogenolysis) processes through activation of the PI3K-AKT signalling pathway. The aim of this study was to assess the effect of aerobic training, green coffee, and chlorogenic acid supplementation...

The most probable diagnosis for a newly detected mass in the cancer patients is secondary metastasis. However, the multiple 13 primary tumors should not be off the table of diagnoses. In this study, a 70-year-old man with the history of transitional cell 14 carcinoma (TCC) was reported who had been referred due to a newly detected mass in the hepat...

Renal cell carcinoma is responsible for approximately 80% of malignant tumors of the kidney. Clear cell, papillary, and chromophobe forms comprise the most frequent histological subtypes of renal cell carcinoma. Thyroid-like follicular renal cell carcinoma is an extremely rare subtype of renal cell carcinoma that resembles thyroid follicular neopla...

Background & objective: Gastric cancer is the second most frequent cause of cancer death worldwide, despite dif- ferences in incidence around the world. The majority of gastric cancer cases concern gastric adenocarcinoma, which has a fairly high 5-year survival rate when coupled with early-stage diagnosis. Versican, a member of the aggregating cho...

Background: One of the new current treatment options for Diabetes Mellitus is about increasing glucagon-like peptide-1 (GLP-1) activity. GLP-1 with its incretin effect showed major role in glucose homeostasis. Gastroileostomy can increase GLP-1 secretion by rapid delivery of undigested food to the terminal ileum. We studied the early effects of a...

+e most prevalent type of soft tissue sarcoma is undifferentiated pleomorphic sarcoma (UPS) or previously known as malignant fibrous histiocytoma. It accounts over 20% of all soft tissue sarcomas and occurs most frequently in the extremities, trunk, and retroperitoneum. However, it has been rarely observed in the digestive system. Pancreas sarcoma...

Schwannomas origin from Schwann cells sheath and generally are benign, slow-growing, and asymptomatic neoplasms which frequently appear in the head and neck. Although gastrointestinal schwannoma is really rare, the most affected organ in GI system is the stomach. Gastric schwannoma forms 0.2% of all gastric tumors. This neoplasm is always detected...

Introduction: Mucormycosis of the gastrointestinal tract is a rare invasive fungal infectionanddue to late diagnosis, it is associated with a high mortality rate. Case Presentation: The studied patient was a 20-year-old woman, known case of Ulcerative colitis, admitted to emergency unit of Alzahra hospital of Isfahan University Of Medical Sciences,...

Background The objective of this study is to indicate the role of urokinase plasminogen activator receptor (uPAR), soluble uPAR (suPAR), and β1 integrin in tumor growth and invasion of lymph nodes from Hodgkin's lymphoma (HL) patients. Materials and Methods In this study, 25 lymph nodes from HL patients were analyzed for the expression of β1 integ...

Background: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a novel surgical technique liver resection in traditionally nonresectable primary intrahepatic tumors or colorectal liver metastases. Materials and methods: From June 2013 to March 2014, patients with primary tumor of liver or colorectal tumors wit...

Background: Chronic hepatitis is a common disease in the community. Differential diagnosis of hepatitis is very important in the treatment of this disease; as applying the wrong treatment method can lead to reinforcement and aggravate. This study aimed to determine the prevalence of histopathologic criteria for distinguishing between and for accura...

To evaluate the effect of protexin, black pepper powder on performance of broiler chicks 160 one day male broiler chicks were divided into 4 groups of 10 birds each and assigned to 4 treatment diets. Chicks were fed by basal diet as control with or without 0.2 % protexin probiotic or black pepper fine powder respectively. Feed intake (FI), body wei...

Introduction Chronic hepatitis is a common disease in the community which is caused mainly by viral agents or immune factors. Differential diagnosis of hepatitis in the treatment is very important due to different therapy. Aim This study is designed to determine importance of histological findings of autoimmune hepatitis (AIH) to distinguish from...

Food grade bacterium Lactococcus lactis is increasingly used for heterologous protein expression in therapeutic and industrial applications. The ability of L. lactis to secrete biologically active cytokines may be used for the generation of therapeutic cytokines. Interleukin (IL)-18 enhances the immune response, especially on mucosal surfaces, emph...

Objective(s): The aim of the present study was to evaluate the effect of Quercus brantii galls extract on the rat skin burn wound healing. Materials and Methods: Ethanol extract of the galls of Q. brantii was used to treat the induced burn wounds on the back of 32 Wistar rats divided into 4 groups. The groups were treated by placebo, 1%, 2% and 4%...

Background: Pancreaticouodenectomy (Whipple surgery) is the chosen treatment in patients with malignant or benign tumors of the pancreatic head. Pancreatic anastomosis is the most important part of Whipple surgery. Pancreatic fistula is the most common postoperative complication. Methods: This prospective study was conducted on patients with pancr...

Wegener’s granulomatosis is an uncommon inflammatory disease that manifests as vasculitis, granulomatosis, and necrosis. It usually involves the upper and lower respiratory tracts and kidneys. Although it may essentially involve any organ, gastrointestinal (GI) involvement is notably uncommon. A 20-year-old male patient presented with epigastric pa...

Background: The significance of techniques used for detecting micro-metastasis (MM) or isolated tumor cells (ITCs) is a controversial issue among investigators. We evaluated the different techniques used on sentinel lymph node (SLN) to detect MM/ITCs. Materials and methods: Ninety-one SLNs of 15 patients underwent serial section with 100 μm inte...

Background: Helicobacter pylori infection is associated with gastritis and marked infiltration of the gastric mucosa by several cytokines secreting inflammatory cells that contribute to sustained local inflammation. In this study, we sought to examine IL-6 expression in H. pylori-infected and uninfected gastric mucosa and elucidate the implication...

Natural killer (NK) cells play important roles in the immune defense against tumors such as colorectal cancer. In humans, NKG2D is an activating immune receptor constitutively expressed in most cytotoxic lymphocytes including NK and CD8+ T cells. In this study, the expression of NKG2D molecule was investigated in peripheral blood NK cells from colo...

Chronic inflammation is the hallmark of the pathogenesis of H. pylori-induced gastric cancer. IL-17A and IL-17F are inflammatory cytokines expressed by a novel subset of CD4+Th cells and play critical function in inflammation. We evaluated the relationship between IL-17A G197A, IL-17F A7488G and IL23R+2199 A/C polymorphisms with IL-6, IL-17, IL-21,...

Different approaches to treat myasthenia gravis showed variable outcomes probably because of remained ectopic thymic tissue. The aim of this study is to determine incidence of thymic tissue in cases without any thymic disease. Seventy-two patients scheduled for open heart surgery during 2000 and 2007 without thymic disease that were enrolled in the...

Background: Free radicals are the known mechanisms responsible for inducing colitis with two origins: Inflammatory cells and tissues. Only the inflammatory cells can be controlled by corticosteroids. Our aim was to assess the importance of neutrophils as one of the inflammatory cells in inducing colitis and to evaluate the efficacy of corticosteroi...

Background: Kiwifruit (Actindia Deliciosa) is demonstrated to have antibacterial and pro-angiogenic effects. It also contains proteolytic enzymes (actinidin) and ascorbic acid. In this study, the effects of Kiwifruit on neuropathic diabetic foot ulcer healing in clinical settings were evaluated. Materials and Methods: In this randomized clinical t...

Helicobacter pylori (H. pylori) is associated with gastric ulcer and gastric adenocarcinoma. Polymorphisms in the host genes coding for toll-like receptors (TLRs) may influence the innate and adaptive immune response to the infection, affecting the susceptibility to H. pylori or the disease outcomes. But the details and association to different pol...

The presence of metastatic lymph nodes is the most important prognostic factor for gastric carcinoma; however, the optimal system for the accurate staging of lymph node metastasis for patients with gastric cancer remains controversial. This study was designed to compare five systems in relation to the N classification of gastric carcinoma. This mul...

Kiwifruit (Actindia deliciosa) is demonstrated to have antibacterial and pro-angiogenic effect. Moreover, this fruit contains proteolytic enzymes (actinidin) and ascorbic acid. Considering these properties and based on the results of recent animal studies, we carried out this study to evaluate the effects of kiwifruit on bedsore in clinical setting...

Objectives. The aim of the present study was to evaluate the effect of Pistacia atlantica resin extract on the rat skin burn wound healing. Methods. Thirty-two Wistar rats were divided into four groups and treated by vehicle, 5%, 10%, and 20% concentration of Pistacia atlantica resin extract for 14 days (G1, G2, G3, and G4, resp.). The efficacy of...

Background: T-lymphocytes are considered as the most important immune cells fighting against various cancers. These cells are activated by different co-stimulatory receptors such as natural killer group 2D (NKG2D) molecules. Besides being stimulated via antigen-specific T-cell receptors, T-lymphocytes are further activated by NKG2D molecules. Up to...

A parathyroid lipoadenoma is a very rare cause of mediastinal mass. The clinical features of this pathologic entity is similar to those of the more common pathologic variants of parathyroid disease associated with primary hyperparathyroidism. A 58-year-old woman presented with huge multinodular goiter. Her thoracic CT scan was done before surgery,...

Cisplatin (CP) is widely used in clinic to treat the solid tumors. However, CP is associated with some major side effects including nephrotoxicity, hepatoxicity, and testicular toxicity. To found, which of the toxicities is the first side effect of CP. we conducted a pilot research on 12 adult male Wistar rats. One week after CP administration, the...

The clinical relevance of bone marrow micrometastasis (BMM) in non-small-cell lung cancer is undetermined, and the value of such analyses in advanced stage patients has not been clearly assessed previously. This study was conducted to estimate the accuracy of both polymerase chain reaction (PCR) and immunohistochemistry (IHC) in micrometastases det...

Aim: The CD133 antigen has been identified as a putative stem cell marker in colorectal cancer tissues. The aim of this study was to investigate the cell cycle state of CD133(+) and CD133(-) cells, isolated from primary human colorectal tumors. Materials and methods: After mechanical and enzymatic dissociation of the tumor samples, CD133(+) and...

Background: Evaluation and storage of serous fluid have a major role in clinical diagnosis and prognosis. We tried to evaluate and compare the quality of smears that have been prepared from refrigerated serous effusions according to preservative material in different days. Methods: This prospective, interventional, analytical study was performed on...

Solitary rectal ulcer syndrome (SRUS) is an uncommon rectal disorder. Massive rectal bleeding is a rare presentation of SRUS, and can pose an endoscopic challenge in differentiating from other causes of massive rectal bleeding. A 22-year-old man presented with massive rectal bleeding which had SRUS with spurting bleeding on lower endoscopic evaluat...

Intra operative cytology (IC), including touch imprint (TI) and crash preparations (CP), in general has been demonstrated to be a diagnostic tool for many organs but its validity and reliability for diagnosis of thyroid nodules remain controversial. We evaluate the diagnostic value of frozen section, touch imprint, crash preparation and the combina...

Her2/neu is one of the epidermal growth factor receptors families and seems to have prognostic significance of some solid tumors. The objective of this study is to evaluate the possibility of Her2 expression in gastric cancers and the possible relationship of Her2 with tumor's clinicopathologic parameters and also its prognostic role. This study wa...

The cause of ascites formation postliver transplantation (LT) is multifactorial. Sinusoidal obstruction syndrome (SOS) is a rare cause of ascites post-LT and has been reported to occur as a sequela of acute cellular rejection (ACR). We sought to examine the histologic features of patients developing ascites in the setting of ACR. By using the patho...

Background: Recent investigations in colon cancer biology suggest that cancer growth is driven by colon cancer stem cells (CSCs). CSCs are responsible for tumor initiation, maintenance, spreading and relapse. The aim of this study was to isolate and propagate tumorigenic colon CSCs in vitro. Methods: Tumor samples from colon cancers were subjecte...

Background: Fatty streaks are the primary lesions to form atherosclerosis. Lipid per oxidation by free- radicals, plays an important role in plaque formation. Vitamin E, as a lipid in soluble vitamin, is an important antioxidant and may prevent or delay the coronary heart disease by limiting LDL oxidation. Our goal was to evaluate the effect of vit...

Endothelial dysfunction (ED) is an independent predictor of cardiovascular events. ED is also a reversible disorder, and nitric oxide donors like L-arginine may promote this process. Despite the positive results from several studies, there are some studies that have shown that L-arginine administration did not improve endothelium-dependent dilation...

Experimental studies have shown that in myelomeningocele, the primary malformation is neural tissue damage resulting from exposure of neural tissue to amniotic fluid. In this study, the effects of amniotic fluid on histopathologic changes of exposed spinal cord in fetal sheep were evaluated. In an experimental trial, 10 fetal sheep in two groups co...

Several studies evaluated the relation between colorectal cancer prognosis and various factors such as: depth of tumor invasion, involved lymph nodes size, counts and locations, metastatic nest expansion. We assessed the prognostic significance of the ratio between metastatic nest and involved lymph node diameter in colorectal cancer cases. A histo...

Primary extra cranial and extra spinal meningioma is rare and is usually limited to the head and neck region or to the paravertebral soft tissues. Histologic diagnosis (in particular for fresh specimens) is often difficult. A 16-year-old girl with a cervical mass is presented. It was a relatively large mass with an approximate diameter of 5 cm. It...

Amniotic fluid exchange is a method for prevention of intestinal damage in gastroschisis, but its techniques are different in studies. We investigated the effects of amnioinfusion exchange on histological changes of intestine and feasibility and safety of amniotic fluid exchange through central vein catheter (CVC) placed in pregnant rabbit uterus....

p>Aggressive angiomyxoma is a rare soft tissue neoplasm that usually arises within the perineum. It often occurs as a vulvar mass and clinically simulates a Bartholin's gland cyst. Most patients are in the second or third decade of life, but some cases have also been reported in children. This is the report of a 21 year old woman with 4.5 × 3 × 1.5...

Incidences of ectopic thymic tissue in the neck have been reported in various conditions. Despite their diversity, there are only a few studies focusing on patients without any thymic disease. The goal of this study was to detect the frequency of ectopic thymic tissue in the necks of adult patients without any thymic disease. Ninety patients with t...

Background: The term subcutaneous emphysema has been used, because air or gas is found within the soft tissue. It occurs in many situation including perforated viscus, Boerhaave syndrome, mechanical ventilation, drug abuse, paraquat intoxication, respiratory disease, laparoscopic surgery, infection with gas producing microorganisms, SMA syndrome, r...

Cervical thymic cyst is not a common pathology encountered in either an adult or a child. Our case presentation is of an infant girl with a right cervical soft mass. It was totally resected and histological analysis revealed a thymic cyst. The diagnosis of thymic cyst is not possible prior to histological examination. Therefore, in children the dis...

BACKGROUND: When we perform surgery in utero, lungs have an appropriate time to decrease magnitude of hypoplasia, with surgery in uterus. METHODS: Six time-dated single-fetus ewes were selected to induce diaphragmatic hernia. Fetal lambs were divided proportionally into 2 groups, namely group 1, diaphragmatic hernia and tracheal ligation (TL group)...

Background: Solitary fibrous tumor is an atypical soft tissue neoplasm seen in thoracic as well as various extra thoracic areas. However, only one case of such a tumor arising from uterine cervix has been reported in the Literature. Case Report: A 51-year-old postmenopausal woman presented with an episode of vaginal bleeding. Gynecologic examinatio...

Background: Desmoid tumor is a rapidly growing tumor. It may be located in a variety of anatomic locations such as abdominal, intra-abdominal and extra-abdominal. However we have found only five cases in anterior mediastinum in the literature. Case Report: A 55-year-old woman presented with history of dyspenea. Chest X-ray and computed tomography (...

BACKGROUND: When we perform surgery in utero, lungs have an appropriate time to decrease magnitude of hypoplasia, with surgery in uterus.