Mohammad Reza Vaez Mahdavi

Shahed University · Department of Physiology

Individuals with lower socioeconomic status experience higher rates of mortality and are more likely to suffer from numerous diseases. While some studies indicate that humans who suffer from social inequality suffer generally worse health, to our knowledge no controlled experiments of this nature have been done in any species. Lipofuscin is a highl...

Insights into long-term clinical consequences of sulfur mustard have emerged from some investigations but less is known about the basic and molecular mechanisms of these complications. Sardasht-Iran Cohort Study is a comprehensive historical cohort study on Sardasht chemical victims' population which was designed to find out the long-term complicat...

Eyes are very sensitive to sulfur mustard (SM) gas because they have wet surfaces. The severity of ocular damage is related to the dose and duration of exposure to SM, and recovery may take up to several years after the exposure. We conducted a large cohort study to evaluate the ocular signs and symptoms of 367 chemical war victims in Sardasht City...

Early-life environmental conditions affect offspring's development. Maternal deprivation (MD) can induce persistent changes that give rise to neuropsychiatric diseases including substance abuse disorders. However, long-lasting mechanisms that determine vulnerability to drug addiction remain unknown. We hypothesized that MD could induce changes in O...

Background Mustard gas as a chemical weapon has been used in wars and its long-term side effects are substantial in the human body. This study was aimed to apply an extension of allostatic load, known as synthetic biological health score (BHS), including the wear-and-tear of four physiological systems (endocrine, inflammatory, cardiovascular and me...

Inequality in health and its multiple dimensions is an essential aspect of social injustice. Several studies have shown that mental and physical health in adulthood is not a phenomenon independent of one’s childhood. Those from lower socioeconomic status have higher mortality and shorter life expectancy. Individualism and utilitarianism in social r...

Background: The nervous, endocrine, and immune systems contribute to the response and dynamic adaption to various stresses. Activation of the hypothalamic-pituitary-adrenal axis has been demonstrated in various active critical illnesses. Novel Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2...

In the original publication of this article [1], there are two corrections:

ackground and Purpose: Osteoarthritis is a joint disease in which cartilage and bone tissues are gradually destroyed. The disease is a global problem and its prevalence is higher in Asia than Europe and the United States. According to WHO recommendations on the use of medicinal plants in the regional nature of any country, the present study aimed t...

Objective: The present study was conducted to investigate the effect of Viola odorata extracted syrup on the quality and patterns of sleep in patients with depression or obsessive-compulsive disorder (OCD) as add-on therapy. Design: A pilot double-blind randomized placebo-controlled trial. Settings/Location: Psychiatric Clinic of Imam Hossein Hos...

Background: Iran's Parliament passed a Law in 2010 to merge the existing health insurance schemes to boost risk pooling. Merging can be challenging as there are differences among health insurance schemes in various aspects. This qualitative prospective policy analysis aims to reveal key challenges and implementation barriers of the policy as intro...

Background: Sulfur mustard (SM) exposure produces extensive systemic and ocular adverse effects on the victims. One of the most important effects is immunological insults that can lead to other organ damages, including the eyes. Methods: In this descriptive study, 128 SM-exposed veterans with severe eye injury were compared with 31 healthy contr...

Introduction: Sulfur mustard (SM) is a potent toxic agent that cause local and systemic changes in the human body such as dysregulation of the immunological system. This gas affects different organs such as lungs, skin, eyes and the gastrointestinal tract. Methods: 128 veterans with SM-induced eye injuries were examined and compared to 31 gender...

Background: Chronic ocular complications of Sulfur Mustard (SM) exposure leads to severe ocular morbidity during time. The aim of this study was to compare serum levels of Interleukin 17 (IL-17), IL-12, vascular endothelial growth factor (VEGF)-C, VEGF-D and nitric oxide (NO) in SM-exposed patients versus the control group and to measure tear conc...

Background: Studies indicate that food restriction (FR) reinforces the effects of morphine. The exact mechanisms by which FR influences the reward circuitry of morphine have not yet been determined. Objectives: We hypothesized that the effects of FR on the oxytocin (OXT) system and HPA axis can be associated with substance abuse disorders. In this...

Background: Iranian traditional medicine prioritizes the health maintenance and its promotion rather than diseases treatment and has also expressed some logical principles for maintaining health. Given the health workers’ healthiness promotion, as one of the most efficacious forces in health care domains which has considerable importance and it is...

Background: Mental health is one of the main aspects of social well-being. Tehran -capital of Iran- is metropolitan, where the mental health status of citizens is not prioritized effectively. Objectives: The purpose of this study was identifying contributors of mental health inequality between lower and higher economic groups in Tehran through O...

Background: Health systems have a set of limited resources for meeting the needs of communities. Health priority setting based on criteria and values is inevitable in such situation. This paper aims to identify the social values that are considered in Iranian health system. Methods: This qualitative study was conducted in 3 steps including colle...

Osteoporosis is a widespread disease among older peoples. The aim of this study is to estimate the prevalence of self-reported osteoporosis and assessing its association with socio-economic status. A population-based cross-sectional study was conducted in Tehran, Iran in 2011. Participants were 45,990 individuals aged above 20 years from 22 urban d...

Background & objective Many biochemical features of sulfur mustard (SM) intoxication have remained unknown. So far, the direct association between biochemical parameter changes and ocular problems in patients exposed to SM is not evaluated. The current study aimed at evaluating the associations between the ocular findings in patients with SM intoxi...

Objective(s): We aimed to show that the immune system is sensitive to the detrimental effects of inequality and social injustice, and splenic vulnerability to apoptosis may also increase. Methods: In order of better determination of immune responses to chronic social stress, we implemented food deprivation, food intake inequality, and unstable soci...

Background and purpose: The first conflict with disability takes place in the family, which is associated with certain socio-economic and psychological aspects. Social capital is one of the social factors that affects health. The aim of this study was to identify the relationship between social capital and mental health of families with disabled me...

Sleep disruption after myocardial infarction (MI) by affecting ubiquitin–proteasome system (UPS) is thought to contribute to myocardial remodeling and progressive worsening of cardiac function. The aim of current study was to test the hypothesis about the increased risk of developing heart failure due to experience of sleep restriction (SR) after M...

Background: Acne vulgaris is a very common chronic inflammatory disorder, yet its pathogenesis is not clearly understood. As part of the SICS, this study was conducted to evaluate the association between the incidence of acne vulgaris in SM-exposed subjects (20 years after the exposure) and serum levels of proinflammatory cytokines (IL-1α, IL-1β,...

The aim of present study was to investigate whether food restriction combined with exercise training could attenuate the oxidative stress and promote angiogenesis in a rat model of heart failure. 50 male wistar rats weighing 250-300 g were randomly divided into 5 groups including: 1) sham; they were fed ad libitum food, n=10. 2) Heart failure group...

امام ششم(ع) در تبیین ساختمان وجودی بدن می فرماید: «اِنَّما بُنِیَ الْجَسَدُ عَلَی الْخُبْزِ؛ تن آدمی بر نان بنا شده است کافی، ج 6، ص 286. رسول خدا(ص) می فرماید: «اَکْرِمُوا الْخُبْزَ وَ عَظِّمُوهُ فَاِنَّ اللَّهَ تَبَارَکَ وَ تَعالی اَنْزَلَ لَهُ بَرَکاتٍ مِنَ السَّماءِ وَ اَخْرَجَ بَرَکاتِ الْاَرْضِ مِنْ کَرَامَتِهِ اَنْ لا یُقْطَعَ وَلا یُوطَأ؛[...

Background: Despite observed post Sulfur Mustard (SM) exposure hemolysis, serum bilirubin concentration does not significantly increase in SM-exposed casualties. The concentration of serum bilirubin can be related to serum levels of inflammatory cytokines. Objectives: In this study, the relationship between the serum levels of Interleukin (IL)-1α,...

Background: Social capital has been defined as norms, networks, and social links that facilitate collective actions. Social capital is related to a number of main social and public health variables. Therefore, the present study aimed to determine the factors associated with social capital among the residents of Tehran, Iran. Methods: In this large...

Objective: To assess the prevalence of dental pain in the past year among adults in Tehran-Iran, and its determinants. Basic research design: Cross-sectional population study. Participants: A sample of 20,322 adults (18-64 years old). Methods: A questionnaire survey was conducted across the 22 districts using the multi-stage random sampling...

در این ارائه، مداخلات اجرایی برای کاهش نا برابری ها در شهر تهران مورد نظر قرار گرفته است. اساس مداخلات بر توانمند سازی اجتماعی، جلب مشارکت مردم و سازماندهی مردم محلی و آموزش آنان استوار گردیده است. در همایش 25 اسفند ماه، 374 محله شهر تهران گزارش اقدامات خود را ارائه و در قالب پوستر در معرض دید شرکت کنندگان قرار دادند. در این ارائه مراحل عملی تحقق م...

p> Background: Health systems, as part of the social system, consider public values. This study was conducted to examine the role of social values in the health priority setting in the Iranian health system. Methods: In this qualitative case study, three main data sources were used: literature, national documents, and key informants who were purpo...

There are fragmentations in Iran's health insurance system. Multiple health insurance funds exist, without adequate provisions for transfer or redistribution of cross subsidy among them. Multiple risk pools, including several private secondary insurance schemes, have resulted in a tiered health insurance system with inequitable benefit packages for...

Low Back Pain from the Perspective of Traditional Iranian Medicine (TIM) Authors: Mohammad Reza Vaez Mahdavi,1,2 Mohsen Naseri,1 Nafiseh Hoseini -Yekta,1,4 Younes Roohany,3 Fatemeh Emadi,4,1 Soghrat Faghihzadeh 5 1: Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran. 2: Department of Physiology faculty of medici...

Introduction: Diabetes mellitus is an important public health challenge worldwide. The prevalence of type 2 diabetes varies across countries. The aim of this study is to estimate the prevalence of type 2 diabetes and to determine related factors including socioeconomic factors in a large random sample of Tehran population in 2011. Methods: In th...

Background: Chronic pain has been estimated to affect between 2% - 40% of the adult population and its prevalence is increasing. Objectives: This study aimed to provide epidemiological data of chronic pain and associated factors in Tehran, capital of Iran. Patients and Method: We analyzed the data of 23457 people, from the Urban HEART-2 (health e...

اساس سخن در این ارائه بر ارتباط 6 عامل قرار دارد 1-فقر، نابرابری های اجتماعی، محرومیت ، 2- استرس مزمن، استرس اجتماعی، 3- اهمیت کارکرد سالم روانی-اجتماعی افراد برای موفقیت سلامت روان 4- مقاومت در برابر مصائب و دشواری ها و نابسامانی ها و آسیب ها 5- اعتیاد : 6- ایجاد شرایط مقاومت دربرابر اعتیاد => پیشگیری

To estimate and compare prevalence of overweight and obesity among adult people across the 22 districts of Tehran in 2011. This was a cross-sectional study using data on 47,406 women and 47,525 men aged≥ 15 years from a large population-based survey (Urban HEART-2). Age-standardized prevalence (ASP) of overweight (25≤BMI<30) and obesity (BMI≥30) we...

Myocardial Infarction (MI) is a main cause of death and disability worldwide, which involves a number of genetic, physiopathologic and socio-economic determinants. The aim of this study was to assess the patterns of association between education, wealth and some other risk factors with non-fatal MI in Tehran population. Data derived from a second r...

Background: The prevalence of obesity is increasing in Iran. Previous studies showed mixed results in relation to association between socioeconomic status and obesity in the country. The current study aimed to examine educational inequalities among adults in Tehran in 2011. Method: Data on 90,435 persons 18 years and older from Urban Health Equity...

Successful health system planning and management is dependent on well informed decisions, so having complete knowledge about medical services' utilization is essential for resource allocation and health plans. The main goal of this study is identification of factors effecting inpatient and outpatient services utilization in public and private secto...

Spermatogenic cells are susceptible to oxidative stress and apoptosis. Food deprivation (FD) has been reported as a stressor that could increase reactive oxygen species. In the present study, FD-induced oxidative stress and apoptosis, as well as the protective effects of melatonin, were evaluated in the testes. Wistar rats in the control group were...

Abstract Objective: The main objective of this study was to compare changes in the mental health status of the residents of Tehran from 1999 till 2011. Materials and Methods: This study was an overview of two cross-sectional, descriptive researches that were performed in 1998 and 2011. Samples of these two studies were recruited by regular randomiz...

Abstract Background and Objective: Findings represent the role of social stress in aging, disease and mortality of individuals. Since the body responses to environmental stress by anxiety behaviors, in this study we compared the effects of "food restriction", "food deprivation" and "social inequality" on anxiety-like behaviors. Materials and Method...

Hypertension is an important public-health challenge worldwide. The prevalence of hypertension greatly varies across countries. The aim of this study was to estimate the prevalence of self-reported hypertension and to determine related factors in a large random sample of Tehran population in 2011. In this cross sectional study, 69173 individuals ag...

Social stress is viewed as a factor in the etiology of a variety of psychopathologies such as depression and anxiety. Animal models of social stress are well developed and widely used in studying clinical and physiological effects of stress. Stress is known to significantly affect learning and memory, and this effect strongly depends on the type of...

The goals of the study are evaluation the effects of food deprivation and isolation situation as a social stress on fertility; and in the following, investigation of the improving effect of melatonin as an antioxidant component. In this experimental study, We investigated histopathological and serological effects of melatonin and social stress (foo...

Backache is among the most common causes of patients’ visits to health professionals. In conventional medicine, treatments for backache mostly comprise maintenance/supportive therapy and despite the advancements in imaging techniques, the variety of treatments and increased costs, better treatment outcome for this condition has yet to be observed....

Current investigations regarding social stress primarily focus on the health consequences of being in stressful social hierarchies. The repetitive nature of social conflicts seems to favor an induction of hyperalgesia or hypoalgesia, both in rodents and humans. Additionally, social conflicts may affect the immune system. In order to better establis...

Background Current evidence consistently confirm inequalities in health status among socioeconomic none, gender,ethnicity, geographical area and other social determinants of health (SDH), which adversely influence health ofthe population. SDH refer to a wide range of factors not limited to social component, but also involve economic, cultural,educa...

Background & Objectives: Chronic pain is one of main public and individual health problems and its epidemiological understanding needs reliable estimates of prevalence. The aim of this study was to investigate the epidemiology of chronic pain in all 368 neighborhoods of Tehran using small area estimation method. Methods: The pain section from the s...

Context: Sulfur mustard (SM), with an old manufacturing history still remains as potential threat due to easy production and extensive effects. Objectives: Increasing studies on SM indicates the interest of researchers to this subject. Almost all human body organs are at risk for complications of SM. This study offers organ-by-organ information...

Hemorrhoids complaint is one of the most common problems in most society, especially in Asian countries. Current drug treatment protocols cannot cure the disease, and they are palliative. According to Persian traditional medicine, Commiphora Mukul (CM) resin is a medication choice. This randomized study was undertaken to evaluate the efficacy and s...

Cardiovascular disorders continue to constitute major causes of morbidity and mortality in diabetic patients. In this study, the effect of chronic administration of sesame (Sesamum indicum L) seed feeding was studied on aortic reactivity of streptozotocin (STZ)-diabetic rats. Male diabetic rats received sesame seed-mixed food at weight ratios of 3%...