Mohammad Reza Shiri-Shahsavar

• PhD
• Professor (Assistant) at Qazvin University of Medical Sciences

Background Adolescence is a unique stage of life accompanied by physiological and psychological modifications, along with stress, confusion, and depression. Materials and methods The present descriptive-analytical cross-sectional research was done on 267 male adolescents who studied at high schools in Zanjan, Iran. Demographic characteristics ques...

Background and aim The long-term impact of COVID-19 on nutrition and community health is inevitably noticeable. These effects can change the nutritional behavior and lifestyle of survivors. Due to the COVID consequential fear and anxiety, the pandemic can alter the motivations for choosing, buying, and consuming food. The relationship between nutri...

Therefore, the aim of this research was to investigate the effect of garlic and blackberry consumption along with aerobic exercise on blood pressure and quality of life in patients with hypertension. 48 of them who did not do any sports activities in the last three months were selected. The condition of the research subjects in terms of quality of...

Objective This clinical trial was designed and conducted due to the anti-inflammatory potential of Oleoylethanolamide (OEA) to examine the effect of OEA supplement on glycemic status, oxidative stress, inflammatory factors, and anti-Mullerian hormone (AMH) in women with polycystic ovary syndrome (PCOS). Method This study was a randomized clinical...

OBJECTIVE: This research was designed and conducted to evaluate propolis supplementation effects on insulin resistance and inflammation in patients with type 2 diabetes. MATERIALS AND METHODS: In the double‑blind, randomized controlled study, 60 patients with type 2 diabetes were enrolled. Patients were randomly assigned to receive Iranian propolis...

Background: Proper nutrition is vital in promoting community health, yet insufficient knowledge and improper dietary practices can lead to deficiencies and diseases. Professional athletes depend on optimal nutrition for their performance and recovery, but a lack of understanding can impede their potential. The nutritional status of athletes impacts...

Introduction: Intense physical activity leads to muscle damage associated with increased oxidative stress and changes in antioxidant balance. This study aims to evaluate the effect of silymarin extract supplementation on damage indicators and cellular stress in active men after acute aerobic exercise. Materials and Methods: Twenty athletic men (av...

Introduction: Intense physical activity leads to muscle damage associated with increased oxidative stress and changes in antioxidant balance. This study aims to evaluate the effect of silymarin extract supplementation on damage indicators and cellular stress in active men after acute aerobic exercise. Materials and Methods: Twenty athletic men (ave...

Hemp seed oil (HSO), esteemed for its potential health benefits and therapeutic attributes, has garnered substantial attention in recent years. However, the escalating consumption of HSO has engendered apprehensions regarding its potential interactions with pharmaceutical medications, posing the risk of adverse effects or altered drug efficacy. Thi...

Background Although the burden of anemia in pregnant women and its consequences on the pregnancy outcome are well documented, there is limited evidence on the association between maternal hemoglobin concentration and low birth weight (LBW) in the study area. Objectives This study aimed to determine the association between maternal hemoglobin conce...

Background and Aim: Throughout the years, numerous pieces of research were conducted to either showcase health-promoting features or prove potential characteristics of probiotics, prebiotics, and the combination of the two (synbiotics). Although science-based outcomes seem promising and reliable for human health, proposing new helpful options and a...

Background and Aim: Probiotics are known for their health-promoting benefits for the consumer. In the past few years, probiotics of yeast origin have gained more attention regarding their role in different applications due to their exclusive characteristics and longer viability. The criteria for choosing the suitable practical probiotic species are...

Background and aim: An antibiotic is a substance produced by microorganisms that inhibits or entirely destroys other microorganisms. Since its discovery, diseases caused by bacterial infections have significantly reduced, and the health of millions of humans worldwide has improved. However, the emergence of antibiotic-resistance strains is becoming...

Background: It has been suggested that nutrition might contribute to multiple sclerosis etiology (MS). Aim: This case-control study aimed to determine the role of food habits and dietary patterns in preventing or developing MS in a multicenter study in Iran (Tehran and Shiraz). Methods: In this study, food intake of (106 patients with relapsing/rem...

PurposeEating disorder (ED) is a common complication with disturbance of eating or eating-related behaviors that lead to physical and psychosocial disorders. The purpose of this study was to evaluate the association between eating disorders and daily fast food consumption, family size, weight-caused stress, and sleep quality in teenagers in Zanjan,...

Introduction : Multiple sclerosis (MS) is a degenerative central nervous system disease derived by immune mechanisms, which ultimately results in clinical debilities. Numerous nutraceuticals have been cited to be effective in treatment of central nervous system complications. Objectives : This study investigated the effect of Cannabis sativa L. see...

Mammalian Target Of Rapamycine (mTOR) is a conserved serine/threonine kinase in the PI3K/Akt/ mTOR signaling pathway. This pathway is regulated by changes in cells such as change in energy level, growth factors, and stressful conditions as well as increased level of cytokines which cause cancer development. The increase in the function of this path...

Multiple Sclerosis (MS) is known as a neurodegenerative autoimmune disorder with a range of manifestations such as inflammatory lesions and demyelination in central nervous system (CNS) (1). It is responsible for substantial disabilities and causes considerable social and economic problems all around the world (2). At present, a total number of 2.5...

Background: Eating disorders (EDs) are diseases of mental origin, which are associated with unusual eating behaviors. The structure of eating behaviors may differ depending on body weight and sleep status. The present study aimed to assess the prevalence of disordered eating attitudes and its associations with weight and sleep status in female adol...

Stem cell therapy has indicated a promising treatment capacity for tissue regeneration. Multiple sclerosis is an autoimmune-based chronic disease, in which the myelin sheath of the central nervous system is destructed. Scientists have not discovered any cure for multiple sclerosis, and most of the treatments are rather palliative. The pursuit of a...

Background Hyperglycemia in diabetic people resulted in oxidative conditions. Propolis is the third most important component of bee products which has various functional properties such as anti-oxidant due to its components. The aim of this study was to evaluate the propolis effect on fructosamine level, the catalase activity, and the level of oxid...

Multiple sclerosis (MS) is an autoimmune disease with the impaired balance of CD4⁺T cells. This trial is a descriptive study to evaluate the expression of CD4⁺T cell cytokines, interleukin (IL) -2, IL-4, IL-17, TGF-β, and respectively related transcription factors, including T-bet, GATA3, RORγt and FoxP3 in MS patients. Sixteen relapsing-remitting...

Objectives: It has been shown that calcitriol and all-trans retinoic acid (ATRA) have modulatory effects on the immune system. The present study investigates the synergistic effects of combination treatment of calcitriol and ATRA in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Methods: The mice wer...

Vitamins are immunologically interesting due to their significant immunomodulatory activities. Experimental autoimmune encephalomyelitis (EAE) is one of the most commonly used experimental models for studying autoimmune disorder in multiple sclerosis (MS). The aim of this study was to evaluate the protective and ameliorative effects of novel combin...

Autoimmune diseases are pathological conditions characterized by abnormal. responses, accompanied by auto-antibodies to self-molecules. The roles vitamin D in autoimmune diseases has increased significantly in the recent past from its functions in calcium and phosphate homeostasis, it is now involved in the regulations and proliferations of Th1 and...

Multiple sclerosis (MS) is a disease which manifests demyelination of neuronal cells in the brain. Despite extensive research on the mechanisms of disease development and progression, the exact mechanism is not elucidated yet, which has hampered drug development and subsequent treatment of the disease. We have recently shown that the serum levels o...

Vitamins are immunologically interesting due to their significant immunomodulatory activities. Experimental autoimmune encephalomyelitis (EAE) is one of the most commonly used experimental models for studying autoimmune disorder in multiple sclerosis (MS). The aim of this studywas to evaluate the protective and ameliorative effects of novel combina...