Mohammad Reza Keramati

Mohammad Reza Keramati
Tehran University of Medical Sciences | TUMS · Department of Surgery - Division of Colorectal Surgery

MD FEBS FASCRS - Associate Professor of Surgery - Colorectal Surgeon (Tehran University of Medical Sciences)

About

92
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738
Citations
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October 2002 - present

Publications

Publications (92)
Preprint
Background and objectives: Exosomes therapy is a promising technique that can decrease the concern related to the fate of transplanted stem cells to the fistula location. The unique properties of mesenchymal stem cells (MSCs)-derived exosomes can improve fistula healing because of their high ability to regulate and modify immune responses. This pro...
Preprint
Background and objectives: Exosomes therapy is a promising technique that can decrease the concern related to the fate of transplanted stem cells to the fistula location. The unique properties of mesenchymal stem cells (MSCs)-derived exosomes can improve fistula healing because of their high ability to regulate and modify immune responses. This pro...
Article
The current surgical strategy for syndactyly is multistage operations in which every other web is released, leaving adjacent webs unoperated for the next stage to avoid a presumed possible digital vascular compromise. In this series, we present our experience with single-stage multiple syndactylies release. A total of 7 patients, including 2 patien...
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Tissue engineering is a promising field for treating various diseases using tissue-like structures generated through biomaterials, scaffolds, nanoparticles, biomolecules, and stem cells. This advanced method is considered one of the next-generation therapeutic techniques that may solve the therapeutic challenges in treating perianal fistula based o...
Article
Encapsulating peritoneal sclerosis (EPS) is the most serious complication in patients undergoing peritoneal dialysis (PD). Although conservative treatments are suggested in early stages of EPS, the condition may need surgical management in severe stages. This study presents the outcome of surgical treatment of patients with severe stages of EPS. Be...
Preprint
Background This is the first randomized clinical trial evaluating and comparing bowel function and early and late outcomes of two different hand-sewn surgical techniques used for the closure of diverting protective loop ileostomy.Methods In this prospective, randomized, single-blind clinical trial, a total of 40 patients with a history of rectal ca...
Article
Regenerative medicine is an emerging therapeutic method that aims to reconstruct tissues and organs. This advanced therapeutic approach has demonstrated great potential in addressing the limitations of medical and surgical procedures for treating perineal fistula in patients with Crohn's disease. Recent developments in stem cell technology have led...
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Purpose: Anastomotic leakage, a known major postoperative complication, potentially leads to readmission, reoperation, and increased mortality rates in patients, such as rectal cancer patients following a low anterior resection (LAR). Currently, vacuum-assisted closure, as featured by B-Braun (B-Braun Medical B.V.), is already being used for the t...
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Introduction Splenic flexure volvulus (SFV) occurs as a result of twisting or torsion of a redundant colon around its mesentery. The SFV can be divided into primary and secondary types. Presentation of case An 82-year-old woman with a previous history of Parkinson's disease, diabetes mellitus and hypertension presented with a primary complaimt of...
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Introduction Low anterior resection (LAR) for rectal cancer affects bowel function after the operation, causing a group of symptoms known as LAR Syndrome (LARS). LARS score is a patient-reported questionnaire to assess bowel dysfunction after the LAR operation. This study performed to validate the Persian (Farsi) translation of the LARS score and t...
Article
Extensive plantar skin defects pose a difficult situation for reconstructive surgeon, but the decision of reconstruction with multiple operations or primary below knee amputation is still open to discussion. Sole of the foot is a specialized tissue; it is important to reconstruct “like for like,” that is, a kind of tissue that can endure the wear a...
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Background: In a resource-demanding COVID-19 pandemic, guidelines can free up health care resources needed for providing better care to those with COVID-19 and other patients. This study was performed to design a guideline to manage patients with colorectal cancers during the COVID-19pandemic. Methods: To design this guideline, major topics and...
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Background: In a resource-demanding COVID-19 pandemic, guidelines can free up health care resources needed for providing better care to those with COVID-19 and other patients. This study was performed to design a guideline to manage patients with colorectal cancers during the COVID-19pandemic. Methods: To design this guideline, major topics and hea...
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We describe a biomarker-based approach to delivering chemotherapy that entails monitoring treatment changes in the circulating metabolome that reflect efficacy. In-vitro, multiple tumor cell lines were exposed to numerous chemotherapeutics. Supernatants were collected at baseline and 72 hours post treatment. MTT assays were used to quantify growth...
Data
Table A In S1 Table: List of metabolites important in discriminating response from no-response in 5-fluorouracil treated colorectal cancer cells (HCT-116, HT-29 and HCT-8); Table B in S1 File:. List of metabolites important in discriminating response from no-response in oxaliplatin treated colorectal cancer cells (HCT-116, HT-29 and HCT-8); Table C...
Article
Background Arthroscopic total wrist arthrodesis is a procedure with minimal violation of extensor compartments and less scar formation, compared with open wrist arthrodesis. In this paper, we would like to present our experience with a modified surgical technique for arthroscopic total wrist arthrodesis. Description of Technique After an arthroscop...
Article
Stapled transanal rectal resection (STARR) is a new surgical procedure and minimally invasive transanal operation for rectocele and mucosal/rectal prolapse. In this study, we aimed to assess the frequency of post-operation complications in chronically constipated patients. In this cross-sectional study, 17 patients who underwent STARR in Rasool-e-A...
Article
Background: Prophylactic laparoscopic omentopexy is a safe technique to prevent peritoneal dialysis (PD) catheter obstruction. For the first time, we would like to describe a surgical technique in which the omentopexy is done using a single PD port which is used for the omentopexy, PD catheter insertion, and the rectus sheath tunneling of the cath...
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Background: Acute appendicitis is the most common nonobstetric surgical problem in pregnancy. Common signs and symptoms of appendicitis are less reliable during pregnancy due to physiological changes; thus, the role of imaging becomes prominent. Thus, in the present study, we aimed at assessing the accuracy of sonography in diagnosing acute appendi...
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Despite many advances in the treatment of breast cancer, it is still the second most common cause of death in women in the United States. It has been shown that inflammation plays a major role in the treatment of these cancers and inflammatory factors enhance tumor growth, invasion, metastasis, and vascularization. In this study, we would like to a...
Article
p> Background: The mortality rate of Congenital Diaphragmatic Hernia (CDH) is still high in many centers. Most important factors influencing the outcome are pulmonary hypoplasia and associated anomalies. In this study, postnatal factors affecting short term outcome of patients with isolated CDH will be studied in an educational children hospital....
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Breast clinic enhances the experience and expertise of the surgeons while gathering large amount of data which provides opportunity for further study and research. The aim of this study was to find the distribution of presenting complaints among patients coming to a referral hospital breast clinic and their relation to presence of benign vs. malign...
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Background: Using a proper laparoscopic trocar for making a downward rectus sheet tunneling (RSHT) during the implementation of peritoneal dialysis (PD) catheters leads to a longer survival of catheter and less catheter dysfunction. As no specific laparoscopic trocar has been invented for insertion of PD catheters, we designed a new trocar. In thi...
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Background: Bile Duct Injuries (BDI) during cholecystectomy are now being recognized as major health problems. Objectives: Herein, we present our experience with handling major BDIs and report long-term outcome of hepaticojejunostomies followed by trans-jejunal hepatic duct stenting performed to reconstruct extra-hepatic biliary tracts. Materia...
Chapter
Esophageal cancer is one of the common gastrointestinal cancers around the world. Lymph nodes, liver, and peritoneum are the most common sites of its metastasis. Rarely, it can also metastasize to the brain. The size of the primary tumor and the stage of disease seem to be associated with the brain metastasis, although the pathway that esophageal c...
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Background: Visfatin is an adipocytokine secreted by visceral adipose tissue. It has been shown that adipocytokines may contribute to the induction of carcinogens and progression of tumors. Previously, we found a significant increase in the visfatin serum level in colorectal cancer patients. Herein, we investigated if this cytokine increases in pa...
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Background: Peripheral arterial disease is a source of morbidity and mortality. Surgical vascular reconstruction is a treatment option but probability of failure and complications are important concerns. In this study, we evaluated outcome of surgical infrainguinal reconstruction and factors affecting graft patency for a period of one year. Metho...
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Background: Modified radical mastectomy (), as a surgical treatment in MRM breast cancer patients, may lead to important complications with significant morbidities including seroma formation. In this study, we used topical phenytoin to evaluate its impact on breast and axillary wound drainage and seroma formation after. MRM Methods: In a double-bli...
Article
Karydakis flap (K-flap) and excision with healing by secondary intention (EHSI) are currently accepted methods for surgical management of sacrococcygeal pilonidal disease. This clinical trial study aimed to compare early and late outcomes of these two surgical techniques. In this controlled, prospective, randomized clinical trial, patients diagnose...
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Rectal cancer is the second most common cancer in large intestine. The prevalence and the number of young patients diagnosed with rectal cancer have made it as one of the major health problems in the world. With regard to the improved access to and use of modern screening tools, a number of new cases are diagnosed each year. Considering the locatio...
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Although there are various therapeutic modalities to manage patients suffering from sacrococcygeal pilonidal sinus disease, there remains controversy over a standard method to treat such patients. In this study the postoperative outcomes after three different surgical methods of wound repair in patients with sacrococcygeal pilonidal sinus were comp...
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A barium enema is a diagnostic and therapeutic procedure commonly used for colon and rectum problems. Rectal perforation with extensive intra- and/or extraperitoneal spillage of barium is a devastating complication of a barium enema that leads to a significant increase in patient mortality. Due to the low number of reported cases in recent scientif...
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Colorectal lymphoma is an extremely rare disease, representing less than 0.5% of all primary colorectal neoplasms. The disease is usually diagnosed in the advanced stages because of its primary non-specific symptoms. The most common involved site is cecum followed by rectum and ascending colon. Diffuse large B-cell lymphoma is a more frequent subty...
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Endoscopic carpal tunnel release (ECTR) has gained recognition as an alternative to the current gold standard, the open carpal tunnel release (OCTR). Detailed technical points for the ECTR have not been explained in the literature, especially for surgeons who are considering trying this technique. In this paper, we present our 5-year experience wit...
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Background: Marjolin's ulcer is a rare, aggressive condition that arises on chronic skin lesions and diseases. Inthis article, we will report 83 cases of this disease. Methods: Retrospectively, we retrieved 83 records of patients with cancer arising from chronic skin conditions.Data concerning demography, type of original skin insult, time inter...
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Bowel stent insertion has a variety of complications one major of which is colonic perforation. The purpose of this article is to reveal two cases with delayed colonic perforation after stent placement to relieve bowel obstruction caused by rectal cancer. The first patient was a 55 year-old man who was a candidate for stent placement to avoid palli...
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Delorme's procedure is infrequently applied in young adults because of its assumed higher recurrence rate. The aim of this prospective study was to assess the efficacy of the Delorme's technique in younger adults. Fifty-two consecutive patients were entered in our study. We followed patients for at least 30 months. Their complaints and clinical exa...
Article
Objective: Adipocytokines have been reported to contribute to the pathogenesis of colorectal cancer (CRC). The aim of this matched case-control study was to explore circulating novel adipocytokines, such as serum visfatin, omentin-1 and vaspin levels in patients with CRC. Method: Serum visfatin, omentin-1, and vaspin levels were measured in 69 s...
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Diagnosis of aortic coarctation is important as it is a difficult condition to evaluate, especially in adults. A Doppler echocardiographic index could provide a simple tool to evaluate coarctation. This study was performed to compare Doppler echocardiographic profiles before and after stenting and to assess the diagnostic value of a complete list o...
Article
Objective: Interphalangeal joint contracture is a challenging complication of hand trauma, which reduces the functional capacity of the entire hand. In this study we evaluated the results of soft tissue distraction with no collateral ligament transection or volar plate removal in comparison with traditional operation of contracture release and par...
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Introduction Air guns, either modern or traditional models, are powerful weapons that are capable of causing serious or life-threatening injuries. Case presentation Here, we present a case of an air gun pellet injury, with the pellet trapped between the thyroid cartilage and the lining mucosa of a 58-year-old Iranian man. Conclusion Entrapment of...
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Wound healing has always been among important and crucial subjects in medicine. Morphine dependency has also been a social and health problem in the Middle East. This study was aimed to investigate the effects of morphine dependency on pro-inflammatory and fibroblast cell recruitment, as well as re-epithelialization and the revascularization proces...
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In the modern day cities, home treadmill usage is increasing. Toddlers are prone to a special injury by the treadmill, during workout the toddler tries to get on the belt and the roller action pulls the fingers under the belt and get caught between the belt and a metal rod under the machine and the belt scrapes the fingers. If untreated some of the...
Article
For continuous hemodialysis, an appropriate vascular access, mostly through an arteriovenous fistula (AVF), is crucial. The Brescia-Cimino (BC) method is a common surgical method for AVF creation. However, this method is sometimes not possible, due to a small venous diameter or its wide distance from the artery. We evaluated the success rate of bif...
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The pulsatility index (PI) shows continuous blood flow to the end organs and is a significant factor believed to decrease in aortic coarctation. Correction of this factor is of great importance in the treatment of stenotic lesions of the aorta. However, there are minimal data regarding the trend of changes in the PI after stent implantation. Furthe...
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Irritable bowel syndrome (IBS) is a widespread chronic health condition which is significantly more prevalent in women. We conducted a gender difference analysis by comparing findings of men and women to determine whether any significant differences exist or not. This single-center study was conducted in Tehran, Iran during 2009-2010. IBS was diagn...
Article
The aim of this study was curriculum quality evaluation of MA level of educational Management and planning field in the public universities of Tehran city. Six criterions considered in this study which is related to curriculum implementation, “objectives and content, Space and anatomical features, students’ freedom, Professional characteristics of...
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Several complications have been reported with inguinal hernias. Although hematuria and flank pain, either as the presentation or as a complication of inguinal hernia, are infrequent, this condition may lead to the development of obstructive uropathy, which can have diverse manifestations. A 71-year-old Iranian man with Persian ethnicity presented w...
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Non-alcoholic fatty liver disease (NAFLD) has been recognized as the most common cause of chronic liver disease worldwide. It occurs in patients who do not consume alcohol in large amounts. Alanine aminotranferase (ALT) and aspartate aminotransferase (AST) are indicators of hepatocellular injury. To determine correlation between histopathologic spe...
Article
A persistent sciatic artery (PSA) results from lack of regression of the fetal arterial blood supply of the leg and is often combined with an abnormally developed superficial femoral artery. Here in we would like to present a 63 year old woman presenting for the first time with blue toe and on further evaluation diagnosis of PSA was made. Our case...
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Insulin-like growth factor 1 (IGF-I) is an anabolic growth factor that affects nitrogen balance and its changing trend is not clearly understood in critically ill patients. This study was carried out to evaluate the association between serum IGF-I levels and its changing trend in critically ill patients. In this nested case-control study, all conse...
Article
BACKGROUND: Insulin-like growth factor 1 (IGF-I) is an anabolic growth factor that affects nitrogen balance and its changing trend is not clearly understood in critically ill patients. This study was carried out to evaluate the association between serum IGF-I levels and its changing trend in critically ill patients. METHODS: In this nested case-con...
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We present an expanded latissimus dorsi musculocutaneus (LDMC) flap to treat circumferential upper extremity defects via resurfacing and "spiral reconstruction" in 5 patients during a 17-year period. Five patients with different indications for tissue expansion from burns to congenital hairy nevi were operated. The expansion was done in a longitudi...
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To characterize the histopathologic specifications of non-alcoholic steatohepatitis (NASH) according to age and gender. An analytical cross-sectional study was conducted in two private gastroenterology clinics on biopsy proven patients suffering from NASH. Biopsy histopathologic findings as well as demographic and laboratory data of the patients at...
Article
Purpose: The study was conducted to evaluate the effect of various degrees of fatty infiltration in patients with nonalcoholic fatty liver disease on hepatic artery resistance index and hepatic vein waveform patterns. Methods: After identification and grading of fatty infiltration, 60 patients and 20 normal healthy subjects were examined using c...
Article
Glomus tumors are hamartomas that account for 1% to 5% of all soft tissue tumors of the hand. These tumors are usually benign. However, malignant degeneration can sometimes occur. They are usually characterized clinically by paroxysmal pain. Herein, we present our experience with 8 patients diagnosed with glomus tumors treated within the past 10 ye...
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Introduction: Irritable bowel syndrome (IBS) is a multifactorial functional gastrointestinal disorder, characterized by recurrent abdominal pain and altered bowel habits. Proinflammatory cytokines can play an important role in intestinal inflammation, while their production is under genetic control. Methods: This study was performed in a group o...