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Introduction
The core objective of my research is to uderstand how cell stress responses (autophagy & UPR) contribute to different cell fate decisions (differentiation, proliferation or cell death).
Using molecular and system biology approaches, we are trying to gain depth insights on the differential role of Autohagy, UPR and Regulated Cell Death between physiological and pathological conditions.
Our ultimate goal is to develop innovative therapeutic routes for controling cancer and senescence.
Additional affiliations
April 2012 - March 2020
April 2011 - present
Publications
Publications (96)
In recent years, there is a growing interest in nutraceutical-rich functional foods for promoting human health. Wild fruits and berries are excellent sources of phytochemicals even though the most deeply studied are the polyphenolic compounds, among them, the major ones such as flavonoids, anthocyanins, or tannins. This review aimed to comprehensiv...
Drug resistance is one of the clinical challenges that limits the effectiveness of chemotherapy. Recent reports suggest that the unfolded protein response (UPR) and endoplasmic reticulum stress-adaptation signalling pathway, along with increased activation of its inositol-requiring enzyme 1α (IRE1α) arm, may be contributors to the pathogenesis of c...
Autophagy is a catabolic lysosomal-dependent pathway involved in the degradation of cellular materials, supplying precursor compounds and energy for macromolecule synthesis and metabolic needs [...]
Background
The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled “International Natural Product Sciences Taskforce” (INPST) was established in 2018, to bring...
Background: The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled "International Natural Product Sciences Taskforce" (INPST) was established in 2018, to brin...
Background: The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled “International Natural Product Sciences Taskforce” (INPST) was established in 2018, to brin...
The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled “International Natural Product Sciences Taskforce” (INPST) was established in 2018, to bring together i...
Background:
Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally.
Methods:...
The unfolded protein response (UPR) is an evolutionarily conserved adaptive pathway, which is activated by the stress of the endoplasmic reticulum (ER). ER stress often occurs due to the high protein demand in cells and protein folding errors in several diseases, such as different cancers and autoimmune diseases. UPR is mediated by three primary ar...
Exosomal release pathway and autophagy together maintain homeostasis and survival of cells under stressful conditions. Autophagy is a catabolic process through which cell entities, such as malformed biomacromolecules and damaged organelles, are degraded and recycled via the lysosomal-dependent pathway. Exosomes, a sub-type of extracellular vesicles...
Importance: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden.
Objective: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic...
Purpose: The prognosis of melanoma depends on early diagnosis and timely treatment. Autophagy plays a dual role in tumor progression. In the early stages, it prevents tumor formation, while in the advanced stages it promotes tumorigenicity. This study aimed at investigating the role of autophagy in different stages of melanoma and evaluating the re...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively kills various cancer cell types, but also leads to the activation of signaling pathways that favor resistance to cell death. Here, we investigated the as yet unknown roles of calcium signaling and autophagy regulatory proteins during TRAIL-induced cell death in leukemia cel...
Background:
Squamous cell carcinoma antigen (SCCA) is used as a prognostic marker for recurrence of squamous cell carcinoma in various sites, including head and neck. Studies suggest that its high serum levels are correlated to some clinical features, such as nodal metastasis. However, it is still unknown if high SCCA in patients with SCCA tissue...
Over the past two decades, nanotechnology has been involved in an array of applications in various fields, including diagnostic kits, disease treatment, drug manufacturing, drug delivery, and gene therapy. But concerns about the toxicity of nanoparticles have greatly hindered their use; also, due to their increasing use in various industries, all m...
Background
The prognosis of melanoma depends on early diagnosis and timely treatment. Autophagy as a mechanism of degradation/recycling of cellular debris, has potential to be evaluated as prognostic biomarker in current research.
Methods
In this study, ATG5 and Beclin 1 gene expression in different Clark levels of melanoma were evaluated in a ret...
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this
topic has received increasing attention, and many scientists have entered the field. Our knowledge base
and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular
basis updated guidelines for monit...
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this
topic has received increasing attention, and many scientists have entered the field. Our knowledge base
and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular
basis updated guidelines for monit...
the PDF can be download freely on pubmed.
https://pubmed.ncbi.nlm.nih.gov/33634751/
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monit...
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monit...
The safe, highly effective measles vaccine has been recommended globally since 1974,
yet in 2017 there were more than 17 million cases of measles and 83,400 deaths in
children under 5 years old, and more than 99% of both occurred in low- and
middle-income countries (LMICs)1–4. Globally comparable, annual, local estimates of
routine first-dose measl...
The safe, highly effective measles vaccine has been recommended globally since 1974, yet in 2017 there were more than 17 million cases of measles and 83,400 deaths in children under 5 years old, and more than 99% of both occurred in low- and middle-income countries (LMICs)1,2,3,4. Globally comparable, annual, local estimates of routine first-dose m...
There is a strong need to figure out which settings should be activated or inhibited in autophagy pathway to prevail drug resistance and also to improve current treatment options in leukemia. This study aimed to compare the effects of well‐known inhibitors of autophagy (as 3‐MA, BafA1, and HCQ) in leukemia KG‐1 and HL‐60 cells exposed to arsenic tr...
Despite the depth of knowledge concerning the pathogenesis of melanoma, the most aggressive type of skin cancer, the prognosis and survival of patients still remain a challenge. In addition, responses to chemotherapy and immunotherapy are still poor, which underscore an urgent need in the development of new therapeutic strategies for the treatment...
Background
Despite recent progressions in the treatment of melanoma, the response to conventional therapies and the long-term survival in melanoma patients still remain poor. Recently, the use of nanoparticles (NPs) has been highlighted for promoting the chemotherapeutic effects of cytotoxic drugs in melanoma. The aim of this study is to mechanisti...
The understanding of the cytokine storm profile and mechanism(s) are crucial to developing effective therapeutic interventions in COVID-19. Currently, cytokine storm blockers and immune-host modulators are being applied in severely ill COVID-19 patients to cope with the overwhelming inflammation. However, emerging reports indicate the different ele...
Background : Few current autophagy inhibitors may have beneficial effects for acute myeloid leukemia (AML) patients in clinical phases. However, there is a strong need to figure out which settings should be activated or inhibited in autophagy pathway to prevail drug resistance and improve current treatment options in leukemia. This study aimed to c...
Aims : Nanoparticle (NP)-based drugs have been recently introduced to improve the efficacy of current therapeutic strategies for the treatment of cancer; however, the molecular mechanisms by which a NP interacts with cellular systems still need to be delineated. Here, we utilize the autophagic potential of TiO2 NPs for improving
chemotherapeutic ef...
پيشرفت¬هاي علوم سلولي و مولكولي و همچنين مهندسي ژنتيك در سال¬هاي اخير به قدري سريع و چشم¬گير بوده است كه دانسته¬ هاي گذشته ما در برابر آن ناچيز مي¬باشد. مقالات پژوهشي و كتاب¬هاي متعددي در اين زمينه انتشار يافته است كه مطالعه آن براي ما و دانشجويان اين علوم كمك بسياري به افزايش دانسته¬ هاي ما مي¬كند. مؤلفان اين كتاب با توجه به اين نكات اقدام به تدوي...
The manipulation of autophagy provides a new opportunity for highly effective anti-cancer therapies. Recently, we showed that photodynamic therapy (PDT) with nitrogen-doped titanium
dioxide (N-TiO2) nanoparticles (NPs) could promote the reactive oxygen species (ROS)-dependent autophagy in leukemia cells. However, the differential autophagic effects...
Berberine is an alkaloid with a wide range of reported beneficial health effects. The current work provides an extensive literature analysis on berberine. Bibliometric data were identified by means of the search string TOPIC=(“berberin*” OR “umbellatine*”), which yielded 5,547 publications indexed in the Web of Science Core Collection electronic da...
Berberine is an alkaloid with a wide range of reported beneficial health effects. The current work provides an extensive literature analysis on berberine. Bibliometric data were identified by means of the search string TOPIC=(“berberin*” OR “umbellatine*”), which yielded 5,547 publications indexed in the Web of Science Core Collection electronic da...
In this study, a bright green-luminescent probe (His-GQD) was synthesized using a new one-pot “bottom-up” pyrolysis green-synthesis route, without consuming any water and chemical reagent. Citric acid as carbon source and Histidine as amino-functionalized agent, with optimized ratios, were used for fabricating His-GQDs as a novel, label-free, and s...
Purpose:
The aim of this study was to determine the biological function of pyridine nucleotide-disulfide oxidoreductase domain 1 (PYROXD1), a recently discovered protein, in colon cancer cell line HCT116.
Methods:
The small interfering RNA (siRNA) was designed rationally on the basis of the target sequence against PYROXD1. Relative PYROXD1 mRNA...
Backgrounds: Photodynamic therapy (PDT) has emerged as a promising therapeutic modality for the treatment of cancer by the mechanisms that rely on the modulation of cell death pathways such as apoptosis, necrosis and autophagy. In this study, we aimed to mechanistically study the effects of photodynamic N-doped titanium dioxide (N-TiO2) NP on cell...
Background: Melanoma is the most aggressive form of skin cancer, with a highly rising incidence and a poor prognosis in its advanced stages. Since melanoma is highly resistant to conventional chemotherapy and radiotherapy, various alternative treatments are being investigated to sensitize melanoma to chemotherapy. It has been recently reported that...
Autophagy is one of the main cellular catabolic pathways controlling a variety of physiological processes, including those involved in self-renewal, differentiation and death. While acute promyelocytic leukemia (APL) cells manifest low levels of expression of autophagy genes associated with reduced autophagy activity, the introduction of all-trans...
Background: Despite recent advances in the diagnosis and treatment of rheumatoid arthritis (RA), this inflammatory disease remains a challenge to patients and physicians. Recent evidence highlights the contribution of ER stress in the pathogenesis and treatment of RA. Herein, we study the expression of the ER stress sensor inositol-requiring enzyme...
Resveratrol is a stilbene-type bioactive molecule with a broad spectrum of reported biological effects. In this sense, the current work provides a comprehensive literature analysis on resveratrol, representing a highly-researched commercially available dietary ingredient. Bibliometric data were identified by means of the search string TOPIC=(“resve...
1st National congress on inflammation
Background:
According to the epidemiological studies, consuming olive products can decrease the incidence of the different types of cancers mostly due to the high anti-oxidant properties of their polyphenolic compounds.
Objectives:
To evaluate the anti-oxidant and anti-proliferative potentials of the olive fruits total polyphenols on the gastric...
Nanomaterials have gained a rapid increase in use in a variety of applications that pertain to many aspects of human life. The majority of these innovations are centered on medical applications and a range of industrial and environmental uses ranging from electronics to environmental remediation. Despite the advantages of NPs, the knowledge of thei...
Nanoparticles (NPs) are currently used in diagnosis and treatment of many human diseases, including autoimmune diseases and cancer. However, cytotoxic effects of NPs on normal cells and living organs is a severe limiting factor that hinders their use in clinic. In addition, diversity of NPs and their physico-chemical properties, including particle...
Leukemia stem cells (LSC) are the root of leukemia and known as the major cause of the relapse in leukemia patients. It is believed that therapeutic strategies based on targeting these drug resistance LSCs may ultimately result in eradication of leukemia and curing this disease. Here, we highlight the fundamental roles of nucleolar proteins, with a...
Nanoparticles (NPs) are widely used in diverse disciplines, including biology, medicine science. The central question that need to be answered is whether NPs have toxic effects on biological cells and molecules or are they safe. The safety of NPs including targeted drug delivery is critical and so is their toxicity in the environment. In recent yea...
Background: According to the epidemiological studies, consuming olive products can decrease the incidence of the different
types of cancers mostly due to the high anti-oxidant properties of their polyphenolic compounds.
Objectives:To evaluate the anti-oxidant and anti-proliferative potentials of the olive fruits total polyphenols on the gastric...
Diverse physiological and pathological conditions that impact on protein folding of the endoplasmic reticulum (ER) cause ER stress. The unfolded protein response (UPR) and the ER-associated degradation (ERAD) pathway are activated to cope with ER stress. In rheumatoid arthritis (RA), inflammation and ER stress work in parallel by driving inflammato...
The dysregulation of autophagy is involved in the pathogenesis of a broad range of diseases, and accordingly universal research efforts have focused on exploring novel compounds with autophagy-modulating properties. While a number of synthetic autophagy modulators have been identified as promising cancer therapy candidates, autophagy-modulating phy...
Here, we report that targeting Nucleostemin (NS), a recently discovered stem cells-enriched gene, by a specific small interference RNA (siNS), decreases the rate of proliferation of acute promyelocytic leukemia (APL) NB4 cells and induces differentiation and autophagy. In addition, NS silencing promotes the effects of all-trans-retinoic acid (ATRA)...
Development is an evolutionary process that is tightly regulated in mammalian species. Several different cascades are involved in different stages of development. Among these mechanisms, apoptosis, autophagy, and unfolded protein response play critical roles in regulation of development by affecting the cell fate. All of these pathways are involved...
Dysregulation of autophagy is currently known as a contributing factor to tumorigenesis. Accordingly, exploring novel compounds with autophagy - modulating properties is a priority in cancer research. While a number of synthetic compounds have been developed, autophagy - modulating Nanoparticles (NPs), such as titanium dioxide (TiO2), have been rec...
Colorectal cancer (CRC) is one of the most lethal cancers and despite numerous therapeutic and screening attempts; it still remains a major life threatening cancer. CRC etiology involves both genetic and environmental factors. Autophagy and unfolded protein response (UPR) are fundamental mechanisms involved in the regulation of cellular responses t...
Backgrounds and Objective: Titanium dioxide (TiO2) is a potent photosensitizer in photodynamic therapy (PDT) and is activated upon ultraviolet (UV) irradiation.The aim of this study was the assessment of the effect of nitrogen.nano doped of titanium dioxide in human A-375 melanoma cancer cell line. Materials and Methods: N-TiO2 nanoparticles were p...
Perturbation of endoplasmic reticulum (ER) homeostasis induces a stress condition described as “ER stress”, which in turn leads to a well-regulated program termed as unfolded protein response (UPR). The principal purpose of UPR is to reestablish the ER homeostasis. Some of the physiological and pathological situations that disrupt
the homeostasis...
In this study, the catalase-like activity of monomeric tau protein was reported in the presence of of zinc (Zn(II)) ions at low pH value. Monomeric tau protein contains two SH groups that are a target of disulfide bond formation. However these SH groups are able to interact with Zn(II) ion at pH 7.2 which creates a thiol bond as a mimetic model of...
Previous studies have suggested that quinazolinone derivatives are potent apoptosis-inducing agents in various cancer cell lines. In the present study, we have investigated cytotoxic, apoptosis induction, and molecular docking activities of the spiroquinazolinone benzamide derivatives family on MCF-7 human breast cancer cells. The MTT cytotoxicity...
In this study, we used nitrogen-doped titanium dioxide (N-TiO2) NPs in conjugation with visible light, and show that both reactive oxygen species (ROS) and autophagy are induced by this novel NP-based photodynamic therapy (PDT) system. While well-dispersed N-TiO2 NPs (≤ 100 µg/ml) were inert, their photo-activation with visible light led to ROS-med...
Photodynamic therapy (PDT) by nanoparticles (NPs) has been proposed as a new emerging therapeutic approach for the treatment of melanoma. In this study, the researchers investigate potential of photodynamic graphene oxide (GO)/TiO2 hybrid (GOT) NPs as new photosensitizers (PSs) in A375 melanoma cancer cell line. The results showed that while differ...
Titanium dioxide (TiO2) nanoparticles are one of the most important photocatalysts. Their good photocatalytic properties such as high oxidative power and photostability as well as low cost and nontoxicity, represent TiO2 nanoparticles as unique photo-active catalyst that used widely in a variety of fields. Recently, TiO2 has utilized in biological...
Human GNL3 (nucleostemin) is a recently discovered nucleolar protein with pivotal functions in maintaining genomic integrity
and determining cell fates of various normal and cancerous stem cells. Recent reports suggest that targeting this GTP-binding
protein may have therapeutic value in cancer. Although, sequence analyzing revealed that nucleostem...
Titanium dioxide (TiO2) nanoparticles are one of the most important photocatalysts. Their good photocatalytic properties such as high oxidative power and photostability as well as low cost and nontoxicity, represent TiO 2 nanoparticles as unique photo-active catalyst that used widely in a variety of fields. Recently, TiO 2 has utilized in biologica...
