Mohammad javad Mojahedi

Mashhad University of Medical Sciences | MUMS · Department of Internal Diseases

Objective: This study was designed to investigate the effect of camel milk and Tarangabin (manna of Alhagi maurorum) combination therapy in addition to conventional treatments in patients with chronic kidney disease (CKD). Materials and methods: Forty-four patients of 15 to 70 years old, with CKD due to hypertension or diabetes, and estimated gl...

Introduction: End-stage renal disease (ESRD) is one of the most common diseases, which affects many aspects of patients’ lives. The measurement of exercise capacity through peak oxygen uptake is an important factor in predicting mortality and survival in patients with ESRD. Objectives: In the current study, we aimed to examine the relationship betw...

Metabolic syndrome (MS) is characterized by a combination of cardiovascular (CV) risk factors (hypertension, dyslipidemia, obesity, and alterations in glucose homeostasis). Insulin resistance is suggested to be the common pathogenic background. This syndrome is also a risk factor for diabetes and chronic kidney disease. In renal transplant recipien...

Background: Vitamin D is a lipophilic hormone that affects homeostasis of calcium and phosphorus. Recent studies have shown that vitamin D deficiency may be a risk factor for metabolic syndrome (MS). Also, metabolic syndrome is highly prevalent in renal transplant patients and it can be associated with graft survival reduction. Objectives: This stu...

Background Many small trials showed a significant improvement in blood pressure following renal artery stenting in patients with severe atherosclerotic renal artery stenosis, but data on renal function improvement is more conflicting. Recently, few trials have been conducted to evaluate the effect of this procedure on Left Ventricular Mass (LVM) an...

Introduction: Fibroblast growth factor 21 (FGF21) is a metabolic regulator with multiple beneficial effects on glucose and lipid homeostasis and insulin sensitivity. Objectives: The aim of this study was to investigate the relation between the serum level of FGF21 with and metabolic syndrome (MS) in kidney transplant recipients. Patients and Method...

Background: Chronic kidney disease (CKD) is one of the most important health problems worldwide and in our country with increasing prevalence rate. Knowledge about the prevalence of this disease in various parts and investigating the relationship between it and clinical and paraclinical data can help in planning to control this condition. Materials...

Inadequate cyclosporine blood levels may cause acute rejection in transplanted renal graft, and its increase is accompanied with graft toxicity. Cyclosporine has variable bioavailability and pharmacokinetics among patients at different times after transplantation. In this study, we compared the effects of cyclosporine blood levels (trough versus 2-...

Consumption of home-distilled alcohol may lead to epidemic or sporadic cases of severe acute methanol poisoning. The difficulty of establishing strict indications for hemodialysis in acute methanol poisoning is a widely recognized issue. The determination of the clinical, especially hemodialysis, and para clinical factors influencing patient surviv...

Thyroid hormones affect kidney function and may alter with changes in kidney function, as well. We evaluated changes in serum levels of triiodothyronine (T3), thyroxin (T4), and thyroid-stimulating hormone (TSH) early after kidney transplantation and their relationship with delayed graft function (DGF). Fifty-five consecutive kidney allograft recip...

Cyclosporine is the backbone of immunosuppression in kidney transplantation. However, it is associated with side effects, some of which are dose-dependent. We evaluated association between cyclosporine trough level and its side effects. In 50 kidney transplant recipients, serum cyclosporine level, fasting blood glucose, and serum creatinine were me...

Microalbuminuria is a marker of vascular endothelial damage. In addition, it is reported that high serum levels of C-reactive protein (CRP) is a novel cardiovascular risk factor that impairs endothelial function. The aim of this study was to evaluate the relationship between microalbuminuria and elevated serum level of high-sensitivity CRP (HS-CRP)...

This study was conducted to assess the effect of oral calcitriol on glucose metabolism in patients on hemodialysis (HD). A total of 27 patients on HD at the Mashhad University of Medical Sciences, Iran, none of whom had received calcitriol or had history of diabetes, were selected. The patients were randomly divided into two groups; Group I: patien...

The key to successful long-term peritoneal dialysis (PD) is permanent and safe access to peritoneal cavity. The two most commonly used Tenckoff catheters for PD are the straight and coiled catheters. The present study was undertaken to assess the catheter survival, catheter associated infections, and all cause mortality and to compare the straight...

Background: Post-transplant diabetes mellitus (PTDM) contributes to the risk for cardiovascular diseases andinfection, reducing graft and patient survival. This study was conducted to identify the incidence and risk factorsfor development of PTDM.Methods: We studied 50 non-diabetic adult dialyzed patients awaiting renal transplantation prospectivel...

Peritoneal effluent cancer antigen 125 (CA125) concentration is a marker of mesothelial cell mass in patients on continuous ambulatory peritoneal dialysis (CAPD). Accordingly, we aimed to observe the effects of CAPD duration, sex, and peritoneal membrane efficacy on CA125 levels in peritoneal effluent. In 30 patients who were on CAPD for 6 months,...

Renal itch is a relatively common and distressing problem for patients with chronic renal failure. Granisetron, is a potent and selective inhibitor of 5-HT3 receptors. There have been some studies about the effect of ondansetron in uremic pruritus and one case report has recently described relief of renal itch with granisetron. To evaluate the effe...

The aim of this study was to evaluate the results of kidney transplantation in patients with Alport syndrome. A total of 15 patients with Alport syndrome underwent kidney transplantation and the result of their transplantation was compared with the results in patients without Alport Syndrome. Rejection episodes and the presence of antiglomerular ba...

Tuberculosis (TB) is an important infection encountered posttransplantation, especially among patients in developing countries, where there are high incidences of morbidity and mortality. One hundred and twenty subjects (1%) from 15 major kidney transplantation centers in Iran from 1984 to 2003 were compared with 440 controls who were matched for o...