
Mohammad MehrmohammadiUniversity of Rochester | UR
Mohammad Mehrmohammadi
PhD
About
183
Publications
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Introduction
Additional affiliations
August 2007 - December 2011
Education
August 2007 - January 2012
Publications
Publications (183)
Objective
To demonstrate the feasibility of using a ring array ultrasound (US) transducer, guided by ultrasound tomography (UST), for generating and monitoring mild hyperthermia (MHTh).
Methods
In silico and in vitro experiments were designed to evaluate the efficacy of a ring array US transducer for generating MHTh and monitoring changes in tempe...
The accuracy and efficacy of laser ablation procedures depend on the accurate placement of the laser applicator within the diseased tissue, monitoring the real-time temperature during the ablation procedure, and mapping the extent of the ablated region. Ultrasound (US) imaging has been widely used to guide ablation procedures. While US imaging offe...
Mild hyperthermia (MHTh) is often used in combination with chemotherapy and radiotherapy for cancer treatment. In the current study, the effect of MHTh on the enhanced uptake of the FDA-approved chemotherapy drug, liposomal doxorubicin (dox) in syngeneic 4T1 tumors was investigated. Doxorubicin has inherent fluorescence properties having an emissio...
This review provides unique insights to the scientific scope and clinical visions of the inventors and pioneers of the SoftVue breast tomographic ultrasound (BTUS). Their >20-year collaboration produced extensive basic research and technology developments, culminating in SoftVue, which recently received the Food and Drug Administration’s approval a...
In the past decade, photoacoustic (PA) imaging has attracted a great deal of popularity as an emergent diagnostic technology owing to its successful demonstration in both preclinical and clinical arenas by various academic and industrial research groups. Such steady growth of PA imaging can mainly be attributed to its salient features, including be...
Multimodal optical techniques are useful for the comprehensive characterization of material properties. In this work, we developed a new, to the best of our knowledge, multimodal technology that can simultaneously measure a subset of mechanical, optical, and acoustical properties of the sample and is based on the integration of Brillouin (Br) and p...
Purpose:
Photoacoustic tomography (PAT) is a non-invasive and high-resolution imaging technique that can provide functional and molecular information from the optical properties of pathological tissues, such as cancer. Spectroscopic PAT (sPAT) is capable of supplying information such as oxygen saturation (sO2), which is an important biological ind...
Multimodal optical imaging techniques are useful for various applications, including imaging biological samples for providing comprehensive material properties. In this work, we developed a new modality that can measure a set of mechanical, optical, and acoustical properties of a sample at microscopic resolution, which is based on the integration o...
Background
As of 2022, breast cancer continues to be the most diagnosed cancer worldwide. This problem persists within the United States as well, as the American Cancer Society has reported that ∼12.5% of women will be diagnosed with invasive breast cancer over the course of their lifetime. Therefore, a clinical need continues to exist to address t...
Advancements in ablation techniques have paved the way towards the development of safer and more effective clinical procedures for treating various maladies such as atrial fibrillation (AF). AF is characterized by rapid, chaotic atrial activation and is commonly treated using radiofrequency applicators or laser ablation catheters. However, the lack...
Brain shift is an important obstacle to the application of image guidance during neurosurgical interventions. There has been a growing interest in intra-operative imaging to update the image-guided surgery systems. However, due to the innate limitations of the current imaging modalities, accurate brain shift compensation continues to be a challengi...
Presently, breast cancer diagnostic methods are dominated by mammography. Although drawbacks of mammography are present including ionizing radiation and patient discomfort, not many alternatives are available. Ultrasound (US) is another method used in the diagnosis of breast cancer, commonly performed on women with dense breasts or in differentiati...
Superparamagnetic nanoparticles have become an important tool in biomedicine. Their biocompatibility, controllable small size, and magnetic properties allow manipulation with an external magnetic field for a variety of diagnostic and therapeutic applications. Recently, the magnetically-induced motion of superparamagnetic nanoparticles has been inve...
Cancer is a leading cause of death globally. For the effectual treatment of cancer, it is crucial to advance our knowledge of the pathophysiology of cancer, discover novel anti-cancer agents, and expand new biomedical technology. A large number of possible barriers exist in the efficient delivery of small-sized drugs to solid tumors. After intraven...
Cancer is a worldwide health issue, and there is an urgent need to identify additional effective, noninvasive biomarkers for early diagnosis, prognosis, and therapeutic targeting based on individual patient characteristics. Currently, cancer patients are categorized based on the site and tissue of origin of the disease. However, it is becoming incr...
Cancer refers to a heterogeneous multifactorial disease that continues to be a main cause of death worldwide. Several levels of codependent networks, including cellular, tissue, and systemic structures, are involved in the pathological process of converting normal tissues into cancerous ones. Malignant tumors are defined by three distinct cancer ti...
Advances in research contribute to the development of new fields. Some come and go, whereas others develop into well-recognized entities with promising applications in medicine and public health. Among the most promising emerging fields is nanotechnology, including nanomedicine. Nanotechnology is expected to propagate and further revolutionize the...
Targeting nanoparticle (NP) carriers to sites of disease is critical for their success as drug delivery systems. Along with optimization of physicochemical properties, researchers have focused on NP surface modification with biological ligands. Such ligands can bind specific receptors on target cell surfaces. Furthermore, biological ligands can fac...
Fetal, perinatal, and neonatal asphyxia are vital health issues for the most vulnerable groups in human beings, including fetuses, newborns, and infants. Severe reduction in oxygen and blood supply to the fetal brain can cause hypoxic-ischemic encephalopathy, leading to long-term neurological disorders, including mental impairment and cerebral pals...
Purpose: Transvaginal ultrasound (TVUS) is a widely used real-time and non-invasive imaging technique for fetal and maternal care. It can provide structural and functional measurements about the fetal brain, such as blood vessel diameter and blood flow. However, it lacks certain biochemical estimations, such as hemoglobin oxygen saturation (SO 2),...
The cervix plays a central role in pregnancy and delivery. A short cervix (≤ 25 mm), measured by ultrasound (US) imaging, at gestational ages between 22 to 24 weeks indicates a higher risk for preterm birth (PTB). Our previous publications had determined that a spectroscopic photoacoustic (sPA) imaging method in the near-infrared range has the pote...
Ablation therapies have played a pivotal role in treatment procedures ranging from tumor ablation in cancer therapies to arrythmias in atrial fibrillation treatments. The efficacy of ablation therapies heavily relies on the precise placement of the ablation device and real-time monitoring of the treatment outcome. Endoscopy and fluoroscopy are the...
Hyperthermia-enhanced chemo-and radiation therapies have been used in the treatment of various types of cancers such as breast, and soft-tissue sarcoma. Localized hyperthermia can increase the effectiveness of treatment and reduce the dosage requirements. Simultaneous temperature monitoring has generally required the use of additional modalities su...
To improve the efficacy of cancer therapeutics, highly sensitive imaging with precise accuracy is mandatory for timely diagnosis and selection of strategic approaches. Despite recent advances in technologies associated with tumor imaging, the application of conventional single-mode imaging is the subject of debate. Herein, two types of pH-responsiv...
Endovenous laser ablation (EVLA) is a minimally invasive surgical procedure, often guided by ultrasound (US) imaging, for treating venous insufficiencies. US imaging limitations in accurately visualizing the catheter and the lack of a temperature monitoring system can lead to sub-optimal outcomes. An integrated photoacoustic (PA)-guided EVLA system...
Objective: Brain shift is an importance obstacle for application of image-guidance during neurosurgical interventions. There has been a growing interest in intra-operative imaging systems to update the image-guided surgery systems with real-time data. However, due to the innate limitations of the current imaging modalities, accurate and real-time b...
The growing number of voice-enabled devices and applications consider automatic speaker verification (ASV) a fundamental component. However, maximum outreach for ASV in critical domains e.g., financial services and health care, is not possible unless we overcome security breaches caused by voice cloning algorithms and replayed audios. Therefore, to...
Inaccurate placement of the ablation catheter and the inability to monitor the real-time temperature within the tissue of interest such as veins curbs the treatment efficacy of laser ablation procedures during thermal therapies. Our previous studies have validated the efficacy of photoacoustic (PA) imaging during endovenous laser ablation (EVLA) pr...
Photoacoustic tomography (PAT) is a non-invasive, high-resolution imaging modality, capable of providing functional and molecular information of various pathologies, such as cancer. One limitation of PAT is the depth and wavelength dependent optical fluence, which results in reduced PA signal amplitude from deeper tissue regions. These factors can...
Objective
Cervical remodeling is an important component in determining the pathway of parturition; therefore, assessing changes in cervical tissue composition may provide information about the cervix’s status beyond the measurement of cervical length. Photoacoustic imaging is a non-invasive ultrasound-based technology that captures acoustic signals...
Early-stage cancer detection technologies can provide functional information and potentially decrease the mortality rate caused by cervical cancer. In our previous work, a miniaturized ultrasound and photoacoustic endoscopic system has been developed to image the cervical tissue through the cervical canal to fulfills the need for a safe, low-cost,...
Photoacoustic tomography (PAT) is a non-invasive, high-resolution imaging modality capable of providing functional and molecular information about various pathologies, such as cancer. In PAT imaging, the depth dependent light attenuation limits the fluence as a function of depth and thereby reduces the PA amplitude of signals from deeper regions of...
Significance: Photoacoustic imaging (PAI) has been greatly developed in a broad range of diagnostic applications. The efficiency of light to sound conversion in PAI is limited by the ubiquitous noise arising from the tissue background, leading to a low signal-to-noise ratio (SNR), and thus a poor quality of images. Frame averaging has been widely u...
Significance:
Photoacoustic imaging (PAI) has been greatly developed in a broad range of diagnostic applications. The efficiency of light to sound conversion in PAI is limited by the ubiquitous noise arising from the tissue background, leading to a low signal-to-noise ratio (SNR), and thus a poor quality of images. Frame averaging has been widely...
This study aims to engineer a new type of ultrahigh quantum yield carbon dots (CDs) from methotrexate (MTX-CDs) with self-targeting, imaging, and therapeutic effects on MDA-MB 231 breast cancer cells. CDs were synthesized via a straightforward thermal method using a methotrexate (MTX) drug source. The physicochemical characteristics of the prepared...
PurposeA real-time intra-operative imaging modality is required to update the navigation systems during neurosurgery, since precise localization and safe maximal resection of gliomas are of utmost clinical importance. Different intra-operative imaging modalities have been proposed to delineate the resection borders, each with advantages and disadva...
The next generation of intelligent robotic systems has been envisioned as micro-scale mobile and externally controllable robots. Visualization of such small size microrobots to track their motion in nontransparent medium such as human tissue remains a major challenge, limiting translation into clinical applications. Herein, we present a novel, non-...
Photoacoustic (PA) imaging combining the advantages of high resolution of ultrasound imaging and high contrast of optical imaging provides images with good quality. PA imaging often suffers from disadvantages such as clutter noises and decreased signal-to-noise-ratio at higher depths. One studied method to reduce clutter noises is to use weighting...
Catheter ablation is a common treatment for arrhythmia, but can fail if lesion lines are non-contiguous.Identification of gaps and non-transmural lesions can reduce the likelihood of treatment failure and recurrent arrhythmia.Intracardiac myocardial elastograph is a strain imaging technique that provides visualization of the lesion line. Lesion siz...
Although considerable efforts have been conducted to diagnose, improve, and treat cancer in the past few decades, existing therapeutic options are insufficient, as mortality and morbidity rates remain high. Perhaps the best hope for substantial improvement lies in early detection. Recent advances in nanotechnology are expected to increase the curre...
Preterm birth (PTB) is the leading cause of neonatal morbidity and mortality worldwide. The ability to predict patients at risk for preterm birth remains a major health challenge. The currently available clinical diagnostics such as cervical length and fetal fibronectin may detect only up to 30% of patients who eventually experience a spontaneous p...
This paper presents the innovative integration of both frontier submillimeter magnetic microrobot and integrated ultrasound and photoacoustic (USPA) imaging. The integrative technique will allow for potential real non-invasive microrobot operation in deep biological tissue for biomedical applications. In this study, the magnetic microrobot prototyp...
Objectives: To develop a combined endocavity ultrasound (US) and
photoacoustic (PA) imaging system (ECUPSA) for evaluation of blood
perfusion and oxygenation in the fetus and neonates.
Methods: The ECUSPA probe consists of a clinical transvaginal
US (TVUS) transducer (operating between 5-9 MHz) with a
custom-built light delivery system consisting o...
The uterine cervix plays a central role in the maintenance of pregnancy and in the process of parturition. Cervical remodeling involves dramatic changes in extracellular matrix composition and, in particular, of collagen and water content during cervical ripening (a term that describes the anatomical, biochemical, and physiologic changes in prepara...
Accurate margin delineation and safe maximal resection of glioma is one of the most challenging problems of neurosurgery, due to its close resemblance to normal brain parenchyma. However, different intraoperative visualization methods have been used for real-time intraoperative investigation of the borders of the resection cavity, each having advan...
Featured Application: Biological diagnostic applications based on endogenous or exogenous chromophores and early breast cancer detection in dense tissue. Abstract: Photoacoustic (PA) imaging is a methodology that uses the absorption of short laser pulses by endogenous or exogenous chromophores within human tissue, and the subsequent generation of a...