Mohammad Hasan Maleki

University of Qom · Department of Management

Metabolic-associated fatty liver disease (MAFLD) is a chronic liver disorder characterized by fatty liver disease alongside overweight or obesity and/or type 2 diabetes mellitus (T2DM). Timely intervention is crucial for a potential cure. This study aimed to investigate the effects of bilirubin, an endogenous antioxidant, on lipid metabolism and in...

Background Diabetes is a major global health concern and plays a significant role in male infertility and hormonal abnormalities by altering the tissue structure of spermatogenic tubes and decreasing the number of spermatogonia. This study investigated the effect of artichoke (Cynara scolymus L) hydroalcoholic extract and Bifidobacterium longum pro...

Background and purpose As an endogenous antioxidant, bilirubin has surprisingly been inversely correlated with the risk of non-alcoholic fatty liver disease (NAFLD). Thereupon, the current evaluation was designed to assess the positive effects of bilirubin on the autophagy flux, as well as the other pathogenic processes and parameters involved in t...

Aim To investigate the effects of β‐hydroxybutyrate (BHB) and melatonin on brown adipose tissue (BAT) plasticity in rats fed a high‐fat diet (HFD). Methods We employed a 7‐week experimental design for a study on 30 male Sprague–Dawley rats divided into five groups: (1) a control‐diet fed group; (2) a high‐fat diet (HFD)‐fed group; (3) a group that...

Background Alzheimer’s disease is a neurological disease characterized by the build-up of amyloid beta peptide (Aβ) and lipopolysaccharide (LPS), which causes synapse dysfunction, cell death, and neuro-inflammation. A maladaptive unfolded protein response (UPR), excessive autophagy, and pyroptosis aggravate the disease. Melatonin (MEL) and hydroxyb...

Background Atherosclerosis is a chronic inflammatory condition affecting the large arteries and is a major cause of cardiovascular diseases (CVDs) globally. Increased levels of adhesion molecules in cardiac tissue serve as prognostic markers for coronary artery occlusion risk. Given the antioxidant properties of bilirubin and its inverse correlatio...

Background Lipotoxicity, caused by adipocyte triglyceride over‐accumulation, contributes to obesity‐related comorbidities such as hypertension, type 2 diabetes, coronary heart disease, respiratory dysfunction, and osteoarthritis. This study focuses on determining how sirtuin‐1 (SIRT‐1) mediates quercetin's (QCT) effect on 3T3‐L1 adipocytes. Key asp...

Background Inflammation is an important factor contributing to obesity-induced metabolic disorders. Different investigations confirm that local inflammation in adipose issues is the primary reason for such disorder, resulting in low-grade systemic inflammation. Anti-inflammatory, antioxidant, and epigenetic modification are among the varied propert...

The incidence of nonalcoholic fatty liver disease (NAFLD) is on the rise, mirroring a global surge in diabetes and metabolic syndrome, as its major leading causes. NAFLD represents a spectrum of liver disorders, ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), which can potentially progress to cirrhosis and hepat...

Background Clear cell renal cell carcinoma (ccRCC) plays a significant role in the mortality associated with kidney cancer. Targeting biological processes that inhibit cancer growth opens up new treatment possibilities. The unfolded protein response (UPR) and apoptosis have crucial roles in RCC progression. This study investigates the impact of β-h...

Background Epigenetic modifications, particularly histone acetylation-deacetylation and its related enzymes, such as sirtuin 1 (SIRT1) deacetylase, may have substantial roles in the pathogenesis of obesity and its associated health issues. This study aimed to evaluate global histone acetylation status and SIRT1 gene expression in children and adole...

Introduction Adipose triglyceride lipase (ATGL) is a crucial enzyme responsible for the release of fatty acids from various tissues. The expression of ATGL is regulated by insulin and this enzyme is linked to insulin resistance. On the other hand, ATGL‐mediated lipolysis is connected to macrophage function and thus ATGL is involved in inflammation...

The purpose of this paper to evaluate the level of antifragility in the supply chain of a Daroopakhsh company. To improve the company's competitive position and Confrontation to disruptions and breakdowns, the supply chain must move towards antifragility. Accordingly, the supply chain, in addition to being prepared to deal with and respond to disru...

Background: Colorectal cancer (CRC) is one of the commonest neoplasms worldwide, which its pathogenesis is strongly correlated with p53 mutations. Antioxidants are believed to decelerate the CRC progression, possibly through interfering with p53 and its downstream target genes and mechanisms. Regarding the potential antioxidant effects of bilirubi...

Purpose By replacing traditional fossil fuels, renewable energy (RE) has the potential to become an outstanding sustainable energy supply. However, owing to technological, economic, social and legal constraints, RE is still in its early stages of development. Hence, this paper aims to analyze the sustainable development hindrances in the RE supply...

The cement industry is one of the strategic and important industrial sectors in the country in terms of meeting the needs of areas such as housing, construction and many construction projects. Currently, this industry is facing problems such as oversupply, wear and tear of equipment and devices, incorrect location of factories. The current research...

Background Monosodium glutamate (MSG) is a food ingredient that is increasingly used commercially. MSG leads to oxidative stress, consequently suppressing steroid hormone production that causes defects in male reproductive system. This study aimed to evaluate the effect of L-carnitine as an antioxidant on testicular damage in MSG-induced male rats....

The purpose of this study is to investigate the relationship between supply chain integration and the performance of companies active in the field of drug production and medical equipments through quality management. The statistical population of the study is all companies producing drugs and medical equipments in Iran. Sampling method is a simple...

The discussion of spirituality in tourism has recently been raised and the creation of peace, a sense of unity and integrity is very attractive for tourists. The aim of the current research is to identify and prioritize the factors affecting the performance of businesses active in the field of spiritual tourism. The current research in terms of par...

To create and develop appropriate technology capabilities, plays a significant role in improving the resilience structure of an electronic supply network against any disruption and failure. The present study seeks to identify and examine the most important technological capabilities to create and improve resilience in electronic supply chains. This...

Aim & Background: by increasing the occurrence of disruptions and unexpected changes in the business, the development of a resistant supply chain is a key opportunity for leading companies to gain a competitive advantage and turn threats into unique opportunities. on the other hand, in order to develop a resistant system, the need to monitor and ev...

Purpose This study aims to formulate exploratory scenarios of the textile industry in Iran based on MICMAC and soft operational research methods. Design/methodology/approach In this study, to formulate plausible scenarios, literature reviews and external experts’ opinions of this field have been gathered through the Delphi approach and uncertainty...

Purpose The purpose of this study is to formulate exploratory scenarios of Operations Research through the critical uncertainty approach and Soft Systems Methodology. Design/methodology/approach In this study, to formulate plausible scenarios, the discipline of operation research internal and external experts’ opinions of this field have been gath...

The inclusive growth of information and communication technology has had a significant impact on the banking industry. Providing banking services to customers through mobile phones is one of the latest technologies. Evidence suggests that using mobile-bank among the customers of banks is expanding. The purpose of the present research is to provide...

Paradigms are some principles and assumptions, which define frameworks and research priorities in each discipline. Many believe that operational research (OR) is not a science and like many other sciences does not have any paradigm. However, since OR is committed to scientific methods, therefore it contains a methodological paradigm. The purpose of...

One of the primary concerns on many countries is to determine different important factors affecting economic growth. In this paper, we study some factors such as unemployment rate, inflation ratio, population growth, average annual income, etc to cluster different countries. The proposed model of this paper uses analytical hierarchy process (AHP) t...

Concurrent engineering (CE) is one of the widest known techniques for simultaneous planning of product and process design. In concurrent engineering, design processes are often complicated with multiple conflicting criteria and discrete sets of feasible alternatives. Thus multi-criteria decision making (MCDM) techniques are integrated into CE to pe...

One of the most critical activities that the PhD. Student maybe faced is selecting supervisor for her dissertation. Most often these decisions are in the form of a selection problem from a finite number of choices. The selection is based on a set of criteria, such as professors' reputation, knowledge, and matching of interests among others. However...

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In today competitive world, banks in order to promote and progress should constantly utilize approaches and patterns for evaluating their function in organization. Concerning the importance of discussion, evaluating banks functions seems to be necessary for using an approach in order to determine all criterions and key factors. Thus, in resultant r...

Work system safety is a function of many factors, besides its dynamic and complex structure. There may be relations and dependencies among the safety factors. Therefore, work system safety should be analyzed in a holistic manner. In this study, the faulty behavior risk (FBR) which is significant in work system safety is tried to be determined throu...

Strengths, Weaknesses, Opportunities and Threats (SWOT) analysis do not provide an analytical means to determine the importance of the identified factors or the ability to assess decision alternatives according to these factors. Although the analysis successfully pinpoints the factors, individual factors are usually described briefly and very gener...

Understanding of the key features, barriers, elements and weaknesses of six sigma methods will allow the organizations to support their strategic directions and increasing need for coaching supervision and training. This also creates appropriate opportunities for implementation of six sigma projects. This article considers the evolutionary review o...