Mohammad Safiqul Islam

Noakhali Science & Technology University · Department of Pharmacy

Pharmacogenetics (PGx)-guided prescribing is an evidence-based precision medicine strategy. Although the past two decades have reported significant advancements in both the quality and quantity of PGx research studies, they are seldom done in developing countries like Bangladesh. This review identified and summarized PGx studies conducted in the Ba...

Background and objectives Obesity has become a global health issue, more precisely, a pandemic throughout the present world due to its high prevalence in the recent era. Increased risk of morbidity and mortality in obese patients can be attributed to its association with the development of different life-threatening conditions. Plants are considere...

Background and Objective: Nowadays, sulfonylurea including Glipizide have been tested to manage diabetes. However, their safety index yet not extensively studied. Our research aims were to assess neuro and the major organs' safety of Glipizide while their effects on different lipid and other biomedical parameters have been also tested. Materials an...

Abstract Background and Aims Pre‐eclampsia is a particular type of pregnancy condition. Although the primary etiology of pre‐eclampsia is unclear, it hypothesizes that the alteration of trace elements and macro‐minerals may play a crucial function in the pathogenesis of Pre‐eclampsia. Therefore, our research sought to ascertain the serum level of t...

Background: Monkeypox is a viral zoonotic disease caused by the monkeypox virus, a double-stranded DNA-enveloped virus that can be transmitted from animal to human or human to human. Consequently, it emerged as the most important orthopoxvirus for public health. Based on available online literature, this study reviewed the majority of the data rep...

Background Accumulating studies have evaluated the association between MAP3K1 polymorphisms and cancer prognosis. However, the results of these studies are conflicting. Given the potential impact of MAP3K1 rs889312 SNP on the prognosis of various cancers, this meta‐analysis was performed to obtain solid and credible evidence. Methods and Materials...

Background Among Bangladeshi males and females, colorectal cancer is the fourth and fifth most prevalent cancer, respectively. Several studies have shown that the transforming growth factor beta 1 (TGFβ1) gene and SMAD4 gene have a great impact on colorectal cancer. Objective The present study aimed to investigate whether TGFβ1 rs1800469 and SMAD4...

Objective Interleukin-17A ( IL-17A) genetic polymorphisms are associated with multiple cancer types, including colorectal cancer (CRC). However, no previous study was performed in the Bangladeshi population to evaluate the association. Our study aimed to find the association between two IL-17A variants (rs10484879 C/A and rs3748067 G/A) and suscept...

Objective: Although the prevalence of autism spectrum disorder (ASD) is increasing, appropriate diagnosis and prevention strategies are still lacking. This case-control study was designed to explore the association between ASD and the rs1867503 and rs9951150 polymorphisms of the TF and TCF4 genes, respectively. Methods: Ninety-six children with...

Objective The TP73 G4C14-A4T14 variant has been associated with elevated cancer risk, but the evidence is inconclusive. We performed a meta-analysis to clarify the role of this variant in cancer development. Methods Eligible literature was selected by searching PubMed, Google Scholar, Cochrane Library, and Embase. The meta-analysis was performed us...

Breast cancer is one of the most frequently diagnosed cancers globally, with the highest mortality in women. Despite remarkable advances in treatment approaches, breast cancer still holds the top position in cancer-associated deaths in women. Over the last few decades, researchers have been trying to reveal the exact etiology of this malignancy, fo...

Background: ACE1 I/D rs1799752 and ACE2 rs2285666 genetic polymorphisms could play a critical role in altering the clinical outcomes of SARS-CoV-2. The findings of previous studies remained inconclusive. This meta-analysis was performed to evaluate the association and provide a more reliable outcome. Methods: This study was completed following the...

COVID‐19 is not only limited to a defined array but also has expanded with several secondary infections. Two uncommon opportunistic fungal infections, COVID‐19 associated mucormycosis (CAM) and aspergillosis (CAA), have recently been highly acquainted by many worldwide cases. Two immune response deteriorating factors are considered to be responsibl...

Objectives: The TNFAIP8 gene family and TNFAIP2 gene are inextricably linked to an elevated risk of cancer development. This systemic review and meta-analysis seeks to establish the relationship between TNFAIP8 (rs11064, rs1045241, rs1045242, and rs3813308), TNFAIP8L1 (rs1060555), and TNFAIP2 (rs710100 and rs8126) polymorphisms with the risk of can...

Background: Transcription factor 21 (TCF21) genetic polymorphisms are correlated with different cardiovascular diseases (CVDs). TCF21 rs12190287 polymorphism at the 3′-untranslated region has been studied in Asian and African ethnicities for the risk of CVDs that resulted in inconsistent outcomes. Therefore, the present meta-analysis aimed to evalu...

Background and aims: Vitamin C has been predicted to be effective as an antioxidant in treating various ailments, including viral infections such as pervasive coronavirus disease (COVID-19). With this meta-analysis, we looked to ascertain the relationship between high-dose vitamin C administration and mortality, severity, and length of hospitaliza...

Background and aims: Abnormalities in hematological and biochemical markers are assumed to be associated with the progression of COVID-19 disease. This meta-analysis was performed to assess the consequences of abnormalities of biomarkers (D-dimers, C-reactive protein [CRP], serum ferritin, lactate dehydrogenase [LDH], random blood sugar [RBS], abs...

Intellectual disability (ID) is a mental ailment described by noteworthy limitations both in intellectual working and adaptive manners covering a range of everyday social and practical skills. About 2-3% of the general population globally are affected by ID. The objectives of this study was to explore the prevalence, etiology, abnormal behaviors, d...

Background The SHANK3 gene encodes a master synaptic scaffolding protein at the excitatory synapse’s postsynaptic density, which is predominantly responsible for constructing a synapse, maintaining synaptic structure, and functions. Recently, evidence from rare mutations and copy number variation provided an important clue about SHANK3 which acts a...

Background: MiR-196a2 rs11614913 polymorphism has been studied in a wide range of cancers throughout the years. Despite a large number of epidemiological studies performed in almost all ethnic populations, the contribution of this polymorphism to cancer risk is still inconclusive. Therefore, this updated meta-analysis was performed to estimate a me...

Objectives: Disruption in the natural immune reaction due to SARS-CoV-2 infection can initiate a potent cytokine storm among COVID-19 patients. An elevated level of IL-6 and IL-10 during a hyperinflammatory state plays a vital role in increasing the risk of severity and mortality. In this study, we aimed to evaluate the potential of circulating IL-...

Previous studies in nephrotic syndrome have shown that three common variants in the ABCB1 gene including, rs1128503, rs2032582, and rs1045642, change the expression and activity of ABCB1 that may be responsible for drug resistance. However, due to inconclusive outcomes of these studies, we performed a meta‐analysis to validate the association betwe...

Background: Several genetic association studies have analyzed the link between the catalase (CAT) C262T variant and different cancers, but the findings remain controversial. Our research centered on establishing a comprehensive correlation between the C262T variant and different cancers. Methods: This study was conducted using RevMan 5.4 software...

Background Alzheimer’s disease (AD) is the most common form of neurodegenerative disorder. The association of BIN1, CLU and IDE genetic polymorphisms with AD risk have been evaluated overtimes that produced conflicting outcomes. Objective We performed this meta-analysis to investigate the contribution of BIN1 (rs744373 and rs7561528), CLU (rs11136...

During the last few decades, cancer has remained one of the deadliest diseases that endanger human health, emphasizing urgent drug discovery. Cellular senescence has gained a great deal of attention in recent years because of its link to the development of cancer therapy. Senescent cells are incapable of proliferating due to irreversibly inhibited...

Background and aims: Lipid peroxidation end products are the major culprit for inducing chronic diseases in elderly people. Along with the elevated level of lipid peroxide biomarkers, there is a significant disruption of antioxidants balance, which combinedly propagate the diseases of elderly people. The aim of the present review is to bridge the...

Elevated oxidative stress and hormonal imbalance have been suggested associate with polycystic ovarian syndromes (PCOS), a causal factor for unsuccessful pregnancy outcomes and other associated complications in women. The aim of this study was to compare the oxidative stress markers and different relevant hormone between pregnant women with and wit...

Introduction: Lablab purpureus, under the family of Fabaceae, is a plant with various pharmacological activities. The present study was aimed to investigate the phytoconstituents, membrane stabilizing activity, central nervous system (CNS) depressant potential, and gastrointestinal (GI) motility of the methanol extract of L. purpureus seeds (MELPS)...

Background Nowadays, myocardial infarction (MI) is one of the major causes of death in developing countries including Bangladesh. Trace elements and macro-minerals play an important role in the pathogenesis of MI. This study aimed to determine the trace elements and macro-minerals in Bangladeshi patients with MI. Methods This case control study in...

Background Breast cancer (BC) is the most common disease in women and the leading cause of death from cancer globally. Epidemiological studies examined that nucleotide excision repair genes ERCC2 (rs13181) and ERCC4 (rs2276466) SNPs might increase cancer risk. Based on the previous investigation, this study was conducted to explore the correlation...

Background: Evidence suggests that circulating resistin levels are altered in colorectal cancer (CRC) and breast cancer (BC). Again, polymorphisms in resistin-encoding gene RETN have been evaluated in CRC and BC. However, there is a scarcity of data establishing the relationship of resistin and RETN polymorphisms (rs1862513 and rs3745367) with thes...

Psychotic illness is a major health burden at the present world. Common psychotic disorders like autism spectrum disorders and schizophrenia frequently share clinical manifestations caused by brain dysfunction. However, there is a clear distinction between early- and late-onset psychotic illnesses. Despite appreciable advancement in identifying the...

Objective: The cytokine family, especially interleukins, has a close interrelation with cancer development and progression. In this meta-analysis, we targeted IL-1β rs16944 polymorphism to reveal its associations in breast, cervical and ovarian cancer. Method: Studies with eligible criteria were selected from online verified databases like PubMe...

Objectives Previous observational studies evaluating the relationship of VEGFA rs2010963 polymorphism with cancer risk reported inconsistent outcomes. Materials and methods A total of 70 eligible studies, including 25,245 cancer patients and 28,219 controls, were retrieved from online databases and included studies that analyzed odds ratio (OR) w...

Background The outbreak of coronavirus infectious disease-2019 (COVID-19) is globally deemed a significant threat to human life. Researchers are searching for prevention strategies, mitigation interventions, and potential therapeutics that may reduce the infection’s severity. One such means that is highly being talked in online and in social media...

Objective: Oxidative stress caused by the pro-inflammatory cytokine interleukin (IL)-1b has been widely investigated for cancer risk. In this study, we focused on the role of IL-1b rs1143634 polymorphism to reveal its impact on cancer development. Methods: Related studies with fixed inclusion criteria were selected from electronic databases to May...

Background: Type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) are two deadly diseases caused by the complex interaction of multiple genetic loci, lifestyle and environmental factors. Genome-wide association studies described hundreds of susceptibility loci for T2DM and T2DM-related CVD, but it remains uncertain due to geographic and...

Though the prevalence of autism spectrum disorder (ASD) is increasing day by day, there is still a lack of a proper way to diagnose or prevent ASD. There is no study carried out in the Bangladeshi children with ASD to evaluate the association of Transferrin ( TF ) and Transcription Factor 4 ( TCF4 ) genetic polymorphisms. This genetic association s...

Cancer is the second leading global health burden in terms of incidence and mortality. The association between IL-6 rs2069840 variant and cancer risk has been evaluated previously by genome-wide association studies and case-control studies, but the results remained controversial. Our present meta-analysis aimed to reveal the association of IL-6 rs2...

Cancer is the second leading global health burden in terms of incidence and mortality. The association between IL-6 rs2069840 variant and cancer risk has been evaluated previously by genome-wide association studies and case-control studies, but the results remained controversial. Our present meta-analysis aimed to reveal the association of IL-6 rs2...

Introduction: Antithrombotic agents are the basic therapeutic option for patients with arterial thrombosis who underwent percutaneous coronary intervention (PCI). In Bangladesh, aspirin and clopidogrel are frequently prescribed as antithrombotics or platelet inhibitors. Studies reported the genetic polymorphisms of CYP2C19*2, CYP2C19*17, and ITGB3...

ABSTRACT: COVID-19 emerged as a pandemic that is persisting with massive casualties around the globe. To ensure clinical management, changes in hematological parameters are routinely monitored and considered essential in patients with coronavirus disease 2019 (COVID-19) to measure the disease prognosis. This study aimed to recognize alterations in...

Introduction End-stage renal disease (ESRD) is an abnormality where the kidneys are not usually working. This case-control study was planned to determine the extent of serum lipid peroxidation, non-enzymatic antioxidant (vitamin c), and trace elements in 50 patients with ESRD as cases and 50 normal healthy individuals as controls. Methods Determin...

Objectives Prostate cancer is the most frequent non-cutaneous malignancy in men. Numerous genetic factors play a crucial role in the progression of prostate cancer. This study was undertaken to reveal the correlation of TP53 rs1042522 and CDH1 rs16260 polymorphisms with the risk of prostate cancer in the Bangladeshi population. Materials and metho...

Objective: Alterations in common DNA repair genes (RAD51 and XRCC2) may lead to cervical cancer (CC) development. In the present study, we analyzed the association between RAD51 rs1801320 and XRCC2 rs3218536 polymorphisms and CC. Methods: Variants were selected based on their associations with some cancers in several ethnicities and the risk allele...

Background The prevalence of Cervical Cancer (CC) is disproportionately higher in developing countries. It is the second most frequent cancer type among Bangladeshi women and the primary cause of morbidity and mortality. However, no previous data reported the association of miR-218-2 gene polymorphisms in Bangladeshi cervical cancer patients. Aim...

Objective The pro-inflammatory cytokine IL-32 has high susceptibility to develop cancer. But no previous meta-analysis was done to provide firm evidence. This systematic review and meta-analysis was designed to evaluate the association of IL-32 gene polymorphisms (rs28372698 and rs12934561) with cancer. Method Eligible studies were selected using...

Introduction: Antithrombotic agents are the basic therapeutic option for patients with arterial thrombosis who underwent percutaneous coronary intervention (PCI). In Bangladesh, aspirin and clopidogrel are frequently prescribed as antithrombotics or platelet inhibitors. Studies reported the genetic polymorphisms of CYP2C19*2, CYP2C19*17, and ITGB3...

Background: Antiplatelet agent clopidogrel has been widely used for stroke management for many years, although resistance to clopidogrel may increase the chance of stroke recurrence. CYP2C19 loss-of-function (LoF) polymorphism is assumed to be responsible for the poor metabolism of clopidogrel that ultimately turns to resistance. Previous publicat...

Purpose This study was conducted to detect the two single-nucleotide polymorphisms (SNPs) (g.333509A > C and g.504742G > A) of the reelin (RELN) gene and to detect their association with autism spectrum disorder (ASD) in the Bangladeshi population. Methods and materials Polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP)...

Background: Schizophrenia (SCZ) is an incurable neuropsychiatric disorder generally described by impaired social behavior and altered recognition of reality. For the first time, this study explored serum levels of antioxidants (vitamin A, E, and C), malondialdehyde (MDA), macro-minerals (calcium, potassium, and sodium), and trace elements (zinc, ir...

Autism spectrum disorder (ASD) is a multifactorial neurodevelopmental disorder characterized by communication deficits, impaired social interactions, repetitive and stereotyped behaviors with restricted interests, and connected with the interaction between environmental factors and genetic vulnerability. CNTNAP2 gene has been extensively investigat...

Schizophrenia (SCZ) is a destructive neuropsychiatric illness affecting millions of people worldwide. The correlation between RELN gene polymorphisms and SCZ was investigated by previous researches, though the results remained conflicting. Based on the available studies, we conducted this meta-analysis to provide a more comprehensive outcome on whe...

The polymorphism rs2853669 in the telomerase reverse transcriptase gene (TERT) promoter region is widely investigated for the risk of different cancers. However, previous results remained inconclusive. Thus, we performed this updated metaanalysis to comprehensively evaluate the association between rs2853669 and the susceptibility of human cancer. A...

Background Alzheimer's disease (AD) is an irreversible and leading neurodegenerative disorder throughout the world. Several studies have investigated the association between the GOLPH2 gene polymorphisms and AD, but the results were controversial. Objective We performed a meta-analysis to provide a more precise outcome on the correlation of the GO...

Introduction Nephrotic syndrome is a common pediatric kidney disease. Investigations on several genetic polymorphisms revealed an inconsistent influence on the resistance of patients to steroids. Objectives This study aimed to identify the association of ABCB1 (1236C>T, 2677G>T, 3435C>T), NR3C1 (rs10482634, rs6877893), and CYP3A5 (CYP3A5*3) gene p...

Objective: Cervical cancer is a gynecological health problem, affecting nearly 500,000 women each year worldwide. Genome-wide association studies have revealed multiple susceptible genes and their polymorphisms for cervical carcinoma risk. We have carried out this case-control study to investigate the association of INSIG2 rs6726538 (A; T), HLA-DR...

Thymoquinone (TQ) is one of the leading phytochemicals, which is abundantly found in Nigella sativa L. seeds. TQ exhibited various biological effects such as antioxidant, anti-inflammatory, antimicrobial, and anti-tumoral in several pre-clinical studies. Parkinson's disease (PD) is a long-term neurodegenerative disease with movement difficulties, a...

Background Multiple studies around the world revealed that genetic polymorphism in different genes of the DNA repair system might affect the DNA repair capabilities and accelerate the chances of cervical cancer (CC) development. Therefore, we aimed to evaluate the association of DNA repair gene- ECCR1 rs11615, ERCC4 rs2276466, XPC rs2228000 and rs2...

Cancer is accounted as the second-highest cause of morbidity and mortality throughout the world. Numerous preclinical and clinical investigations have consistently highlighted the role of natural polyphenolic compounds against various cancers. A plethora of potential bioactive polyphenolic molecules, primarily flavonoids, phenolic acids, lignans an...

Online Supporting Material of 'Impact of age, sex, comorbidities and clinical symptoms on the severity of COVID-19 cases: a meta-analysis with 55 studies and 10014 cases' article

Purpose Severe acute respiratory coronavirus 2 (SARS-CoV-2) cases are overgrowing globally and now become a pandemic. A meta-analysis was conducted to evaluate the impact of age, sex, comorbidities, and clinical characteristics on the severity of COVID-19 to help diagnose and evaluate the current outbreak in clinical decision-making. Methods PubMe...

The study aims to address issues related to valuing women entrepreneurship in the informal economy in Bangladesh. To achieve the above objective, both qualitative and quantitative methods have been used. The author reviewed several articles, research reports, and included face to face in-depth interviews of fifteen entrepreneurs. Moreover, the appl...

Background Cervical cancer (CC) is the main cause of cancer-related deaths among women in developing countries. It is the second leading female malignancy in Bangladesh in terms of incidence and mortality. Our present study aimed to investigate the association of IL1β (rs16944), IL4R (rs1801275), and IL6 (rs1800797) gene polymorphisms with the susc...

Background Autism spectrum disorder (ASD) is an intense, highly heritable complex neurodevelopmental disorder in children. Genetic association studies have demonstrated the correlation of different genetic polymorphisms with ASD. We investigated the contribution of genetic variants in ZNF385B (rs11885327 and rs1964081) and COMT (rs165774) genes wit...

Background Brassica nigra is a plant of Brassicaceae family, which possesses numerous medicinal values. Our present study is intended to assess the potential in vitro thrombolytic, anthelminthic, cytotoxic and in vivo anxiolytic properties of MCE of B. nigra flowers. MCE was fractioned for separating the compound on the basis of polarity by using c...

Background: Ischemic heart disease (IHD) is a major cause of death globally. Countries vary in their rates, and changes have occurred over time. Nowadays, developing countries pose new public health challenges. Objectives: The objective of the present study was to appraise the alterations in the levels of serum Zn, Cu, Fe, and Mn that occur in p...