Mohammad Hassanshahi

Mohammad Hassanshahi
University of South Australia | UniSA

Interested in wound healing, skin regeneration, stem cells and vascularization

About

23
Publications
29,833
Reads
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269
Citations
Citations since 2017
19 Research Items
269 Citations
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Introduction
I am a stem cell biologist, passionate about angiogenesis, and harnessing stem cells for tissue vascularization.
Additional affiliations
September 2013 - September 2017
University of South Australia
Position
  • PhD Student
September 2011 - September 2012
University of East Anglia
Position
  • Master's Student
Education
September 2011 - September 2012
University of East Anglia
Field of study
  • Molecular Medicine

Publications

Publications (23)
Article
Full-text available
Macrophages are key immune cells that respond to infections, and modulate pathophysiological conditions such as wound healing. By possessing phagocytic activities and through the secretion of cytokines and growth factors, macrophages are pivotal orchestrators of inflammation, fibrosis, and wound repair. Macrophages orchestrate the process of wound...
Article
Full-text available
Intensive cancer chemotherapy is well known to cause bone vasculature disfunction and damage, but the mechanism is poorly understood and there is a lack of treatment. Using a rat model of methotrexate (MTX) chemotherapy (five once-daily dosses at 0.75 mg/kg), this study investigated the roles of the Notch2 signalling pathway in MTX chemotherapy-ind...
Article
Methotrexate (MTX) is a commonly used anti-metabolite in cancer treatment. Its intensive use is linked with skeletal adverse effects such as reduced bone formation and bone loss, and yet little information is available on molecular mechanisms underlying MTX-induced impaired bone formation. This study investigated the effects of MTX treatment at a c...
Preprint
Converging evidence indicates that extra-embryonic yolk sac is the source of both macrophages and endothelial cells in adult mouse tissues. Prevailing views are that these yolk sac-derived cells are maintained after birth by proliferative self-renewal in their differentiated states. Here we identify clonogenic, self-renewing endothelial-macrophage...
Article
Cancer chemotherapy can significantly impair the bone formation and cause myelosuppression; however, their recovery potentials and mechanisms remain unclear. This study investigated the roles of the β‐catenin signaling pathway in bone and bone marrow recovery potentials in rats treated with antimetabolite methotrexate (MTX) (five once‐daily injecti...
Article
Vitamin D activity is associated with the modulation of a wide variety of biological systems, in addition to its roles in calcium homeostatic mechanisms. While vitamin D is well known to promote gastrointestinal calcium absorption, vitamin D also plays a role in attenuating and/or preventing the progression of several gastrointestinal diseases incl...
Article
Despite more attention to cell migration from circulation into the bone marrow (BM), particularly homing of haematopoietic stem/progenitor cells, the process and mechanisms of cell mobilisation from the BM into the circulation remain largely underexplored. The process of cell mobilisation or transcellular cell migration from BM into the circulation...
Article
Methotrexate (MTX), a widely used antimetabolite in paediatric cancer to treatment, has been widely reported to cause bone loss and bone marrow (BM) microvascular (particularly sinusoids) damage. Investigations must now investigate how MTX‐induced bone loss and microvasculature damage can be attenuated/prevented. In the present study, we examined t...
Article
Full-text available
Opioids are widely administered to alleviate pain, including chronic pain in advanced cancer patients. Among opioids, morphine is one of the most clinically effective drugs for the palliative management of severe pain. In the last few decades, there has been a debate around the possible influence of opioids such as morphine on tumour growth and met...
Article
Critical limb ischemia (CLI) is the advanced stage of peripheral artery disease spectrum and is defined by limb pain or impending limb loss because of compromised blood flow to the affected extremity. Current conventional therapies for CLI include amputation, bypass surgery, endovascular therapy, and pharmacological approaches. Although these conve...
Article
Wound healing is a complex but a fine‐tuned biological process in which human skin has the ability to regenerate itself following damage. However, in particular conditions such as deep burn or diabetes the process of wound healing is compromised. Despite investigations on the potency of a wide variety of stem cells for wound healing, adipose‐derive...
Article
Dexamethasone (Dex) is known to cause significant bone growth impairment in childhood. Although previous studies have suggested roles of osteocyte apoptosis in the enhanced osteoclastic recruitment and local bone loss, whether it is so in the growing bone following Dex treatment requires to be established. The current study addressed the potential...
Article
Cancer chemotherapy can cause significant damage to the bone marrow (BM) microvascular (sinusoidal) system. Investigations must now address whether and how BM sinusoidal endothelial cells (SECs) can be protected during chemotherapy. Herein we examined the potential protective effects of genistein, a soy‐derived flavonoid, against BM sinusoidal dama...
Article
Chemotherapeutic agents are very well evident extrinsic stimuli for causing damage to endothelial cells. Methotrexate is an antimetabolite commonly used to treat solid tumours and paediatric cancers. However, studies on the effect(s) of methotrexate on bone marrow microvascular system are inadequate. In the current study, we observed a significant...
Article
Faulty bony repair causes dysrepair of injured growth plate cartilage and bone growth defects in children; however, the underlying mechanisms are unclear. Recently, we observed the prominent induction of neurotrophin‑3 (NT-3) and its important roles as an osteogenic and angiogenic factor promoting the bony repair. The current study investigated its...
Article
Full-text available
It is very well known that bone marrow (BM) microvasculature may possess a crucial role in the maintenance of homeostasis of BM due to mutual interactions between BM microvascular system and other physiological functions including haematopoiesis and osteogenesis. Chemotherapy and radiotherapy are known as main approaches for cancer treatment and al...
Article
Intensive cancer chemotherapy causes significant bone loss, for which the mechanisms remain unclear and effective treatments are lacking. This is a significant issue particularly for childhood cancers, as the most common ones have a >75% cure rate following chemotherapy; there is an increasing population of survivors who live with chronic bone defe...
Article
Full-text available
Injured growth plate is often repaired by bony tissue causing bone growth defects, for which the mechanisms remain unclear. Because neurotrophins have been implicated in bone fracture repair, here we investigated their potential roles in growth plate bony repair in rats. After a drill-hole injury was made in the tibial growth plate and bone, increa...
Article
Extracellular matrix (ECM) proteins are a large family of macromolecular proteins which play crucial role in a wide range of biological activities such as cell adhesion, migration, proliferation, survival and differentiation. Matricellular proteins are a novel group of ECM proteins which are postulated to have regulatory activities and modify the f...
Article
Angiogenesis, which is the formation of blood vessels from pre-existing vessels, normally supply nutrition and oxygen to cells and tissues. In medicine point of view, regulation of angiogenesis is disrupted in many diseases such as cancers, psoriasis, age related macular degeneration, diabetes, proliferative retinopathies and rheumatoid arthritis....

Questions

Questions (20)
Question
Just wondering if you have some info on what percentage (roughly) of haematopoietic stem cells reach bone marrow following transplantation.
Question
Hi,
I am planning to do tube formation assay and stain the tubes with anti-CD31 in an indirect immunofluorescence approach. I was wondering whether it is possible and has been done so far? if so, can I have a detailed protocol for that matter?
Question
Hi
I am planning to differentiate rat BM MSCs to adipocytes, in vitro. However, I was wondering for how long I can keep those adipocytes in the medium and also whether I can passage those adipocytes for further studies of mine.
Thank you for your advice in advance.
Question
Hi
I was wondering if you could help me to find a detailed protocol to make formaldehyde treated bovine serum albumin.
Question
Hi
I was wondering to know about the name of fatty acids which are secreted by adipocytes.
Question
Hi
As far as I know when a monocyte enters a tissue it differentiates to tissue specific macrophages (eg. osteoclasts in bone). However, my confusion is why in bone marrow sections we still see a subset of cells called macrophages?
Question
Hi
 what does a pan marker mean? for example: pan endothelial cells marker

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