Mohammad Feroze Fazaludeen

• Planner/Manufacturing Lead Specialist at Finvector

Microglia are brain resident immune cells that maintain proteostasis and cellular homeostasis. Recent findings suggest that microglia dysfunction could contribute to the pathogenesis of Parkinson's disease (PD). One of the hallmarks of PD is the aggregation and accumulation of alpha-synuclein (αSyn) into Lewy bodies inside nerve cells. Microglia ma...

Microglia are brain resident immune cells that maintain proteostasis and cellular homeostasis. Recent findings suggest that microglia dysfunction could contribute to the pathogenesis of Parkinson's disease (PD). One of the hallmarks of PD is the aggregation and accumulation of alpha-synuclein (αSyn) into Lewy bodies inside nerve cells. Microglia ma...

Background: Nonsynonymous mutations in the coding regions of human genes are responsible for phenotypic differences between humans and for their susceptibility to genetic disease. Methods: We performed Exome sequencing on CKD patients’ genomic DNA and put the focus in understanding the role played by the amino-acid mutation spectrum (PAM) in human...

Microglia are brain resident immune cells that maintain proteostasis and cellular homeostasis. Recent findings suggest that microglia dysfunction could contribute to the pathogenesis of Parkinson’s disease. One of the hallmarks of Parkinson’s disease is the aggregation and accumulation of alpha-synuclein into Lewy bodies inside nerve cells. Microgl...

Background Air pollution is recognized as an emerging environmental risk factor for neurological diseases. Large-scale epidemiological studies associate traffic-related particulate matter (PM) with impaired cognitive functions and increased incidence of neurodegenerative diseases such as Alzheimer’s disease. Inhaled components of PM may directly in...

Chronic kidney disease is a combination of many vascular diseases involving mutations of many genes. Hypertension diabetes and atherosclerosis are the most common causes of kidney disease, with hypertension causing just over a quarter of all cases of kidney failure and diabetes causing one-third of them. Other much less common conditions that can c...

LRRK2‑G2019S is one of the most common Parkinson’s disease (PD)‑associated mutations and has been shown to alter microglial functionality. However, the impact of LRRK2‑G2019S on transcriptional profile of human induced pluripotent stem cell‑derived microglia‑like cells (iMGLs) and how it corresponds to microglia in idiopathic PD brain is not known....

Background Microglia are the endogenous immune cells of the brain and act as sensors of pathology to maintain brain homeostasis and eliminate potential threats. In Alzheimer's disease (AD), toxic amyloid beta (Aβ) accumulates in the brain and forms stiff plaques. In late-onset AD accounting for 95% of all cases, this is thought to be due to reduced...

Background Microglia are the endogenous immune cells of the brain and act as sensors of pathology to maintain brain homeostasis and eliminate potential threats. In Alzheimer’s disease (AD), toxic amyloid beta (Aβ) accumulates in the brain and forms stiff plaques. In late-onset AD accounting for 95% of all cases, this is thought to be due to reduced...

Olfaction is orchestrated by olfactory mucosal cells located in the upper nasal cavity. Olfactory dysfunction manifests early in several neurodegenerative disorders including Alzheimer’s disease, however, disease-related alterations to the olfactory mucosal cells remain poorly described. The aim of this study was to evaluate the olfactory mucosa di...

Human cerebral organoids, derived from induced pluripotent stem cells, offer a unique in vitro research window to the development of the cerebral cortex. However, a key player in the developing brain, the microglia, do not natively emerge in cerebral organoids. Here we show that erythromyeloid progenitors (EMPs), differentiated from induced pluripo...

Human stem cell-derived brain organoids provide a physiologically relevant in vitro 3D brain model for studies of neurological development that are unique to the human nervous system. Prior studies have reported protocols that support the maturation of microglia from mesodermal progenitors leading to innately developing microglia within the organoi...

Olfactory dysfunction manifests in early stages of neurodegeneration in several disorders of the central nervous system. The sense of smell is orchestrated by the cells of the olfactory mucosa located in the upper nasal cavity, however, it is unclear how this tissue reflects key neurodegenerative features in Alzheimer’s disease (AD). Here we report...

Renal failure and kidney disease are major concerns worldwide and are commonly coupled to diseases like hypertension, diabetes, obesity, and hypercholesterolemia. We undertook this study to explore the scope of genetic spectrum underlying the physiopathology of end-stage renal disease (ESRD) using whole exome sequencing (WES) on genomic DNA (gDNA)...

Patients diagnosed with Anaplastic Large Cell Lymphoma (ALCL) are still treated with toxic multi-agent chemotherapy and as many as 25-50% of patients relapse. To understand disease pathology and to uncover novel targets for therapy, Whole-Exome Sequencing (WES) of Anaplastic Lymphoma Kinase (ALK)+ ALCL was performed as well as Gene-Set Enrichment A...

Here we elucidate the effect of Alzheimer disease (AD)-predisposing genetic backgrounds, APOE4, PSEN1DE9, and APPswe, on function-ality of human microglia-like cells (iMGLs). We present a physiologically relevant high-yield protocol for producing iMGLs from induced pluripotent stem cells. Differentiation is directed with small molecules through pri...

The Finnish variant Late Infantile Neuronal Ceroid Lipofuscinosis (vLINCLFin), also known as CLN5 disease, is caused by mutations in the CLN5 gene. Cln5 is strongly expressed in the developing brain and expression continues into adulthood. CLN5, a protein of unknown function, is implicated in neurodevelopment but detailed investigation is lacking....

Non-synonymous single-nucleotide polymorphism (SNPs) in the gene for proprotein convertase subtilisin/kexin type 9 (PCSK9) can influence cholesterol and glucose metabolism, leading to increased risk of cardiovascular disease and diabetes. To determine the frequency of four common PCSK9 SNPs, L10Ins, A56V, I474V, and E670G, in a population sample (n...

In order to understand the biology of Anaplastic Large Cell Lymphoma (ALCL) and to develop biomarkers, we performed Whole-Exome Sequencing (WES) of DNA extracted from patient tumor samples (of at least 90% tumor cell content; n=31), and are exploring the functional implications of the mutations detected. Bioinformatics processing involved variant c...

Malarial disease mainly caused by the Plasmodium falciparum is creating a worsened situation for mankind, and there were around 214 million new cases of malaria in 2015 (range 149-303 million) all over the world. Now, it has become the challenging task to sort out the problem because malarial parasites are becoming increasingly resistant to several...

Dementia is a progressive disorder associated with neuronal loss, cognitive impairment and different levels of synaptic damage. These changes are not only complex but also very dynamic as aging progresses. Dementia is irreversible when caused by disease or injury but may be reversible when caused by drugs, alcohol, hormone or vitamin imbalances or...

Dementia is a progressive disorder associated with neuronal loss, cognitive impairment and different levels of synaptic damage. These changes are not only complex but also very dynamic as aging progresses. Dementia is irreversible when caused by disease or injury but may be reversible when caused by drugs, alcohol, hormone or vitamin imbalances or...

Aims: Chronic kidney disease and renal failure are major health concerns in Saudi Arabia, especially in the Hail region. These diseases are commonly coupled with hypertension and hypercholesterolemia. Genetic factors strongly contribute to them. This study was undertaken in an effort to identify genetic variations that might contribute to renal fai...

Signal transducer and activator of transcription (STAT) transcription factors family are involved in diverse cellular biological functions. Reports regarding the prognostic impact of STAT3 expression in breast cancer (BC) are variable whether being a factor of poor or good prognosis. Immunohistochemical expression of phospho-STAT3 (pSTAT3) was stud...

Exome sequencing has been conducted on a panel of frozen paediatric Anaplastic Large Cell Lymphoma (ALCL) tissue samples. Exome sequencing was conducted using an Illumina MiSeq. Variants (indels/SNPs) were identified using the GATK (Genome Analysis Tool Kit) pipeline using the hg19 reference genome. A molecular characterisation has been undertaken...

Genetic heterogeneity of breast cancer represents a significant challenge with respect to disease course and patient clinical management. Understanding molecular evolution of tumours both temporally and spatially would contribute further insight into molecular derangements driving disease progression. Exploratory analyses have been conducted on exo...

The unusual physio and chemical properties of gold nanoparticles have found to have more advantage in the field of medicine, diagnostics and biosensors. In the present document, it is reported that Justicia gendarussa leaf extract mediated synthesis of gold nanoparticles by the reduction of gold ions. Three different phytochemical fractions were pr...

Cancer is a group of disease characterized by unregulated cell growth and spread of cells from the site of origin to other sites in the body. Two main genetic changes lead to cancer they are inactivation of tumor suppressor gene and activation of the proto-oncogene. Ras gene is a proto-oncogene when this gene activated it stimulates signaling pathw...

The unusual physio and chemical properties of gold nanoparticles have found to have more advantage in the field of medicine, diagnostics and biosensors. In the present document, it is reported that Justicia gendarussa leaf extract mediated synthesis of gold nanoparticles by the reduction of gold ions. Three different phytochemical fractions were pr...

Objectives: The study was conducted to characterize the citywide epidemiology of ESBLs in. Hail, to detect the frequency and types of enzymes.y determining whether the responsible genes.are spreading among different strains, or whether one or few strains are account for the spread.of these enzymes among the local population. Methods: One hundred ur...

The present investigation has aimed to evaluate the anti-inflammatory activity of Justicia gendarussa in freund’s complete adjuvant induced arthritic rats. The methanolic leaf extract of Justicia gendarussa was administered orally at a limit dose of 300 mg/kg b.w. for 14 days to the experimental rats. The anti-inflammatory activity of Justicia gend...

In this case study, a women aged 40 was diagnosed with Metastatic breast cancer. Metastatic breast cancer is a complex multi-stage disease involving the expansion of cancerous cells from the breast to other parts of the body. It is a serious complication of breast cancer, with limited treatments avail, as metastatic disease in breast cancer is ofte...