Mohammad Ali Yousef Alqudah

Mohammad Ali Yousef Alqudah
University of Sharjah | US · Department of Pharmacy Practice and Pharmacotherapeutics

PharmD, MSc, PhD

About

47
Publications
11,088
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347
Citations
Citations since 2017
32 Research Items
301 Citations
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20172018201920202021202220230204060

Publications

Publications (47)
Article
Aflatoxins (AFs) are frequent contaminants of herbs, which pose a health risk to regular consumers. This study quantified AFs (AFB1, AFB2, AFG1, AFG2, and Total AFs) in 100 of frequently used herbal medicine formulations in Northern Jordan, and assessed the health risk associated with its intake. About half of the samples had levels lower than the...
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Full-text available
Skin cancer, including malignant melanoma (MM) and keratinocyte carcinoma (KC), historically named non-melanoma skin cancers (NMSC), represents the most common type of cancer among the white skin population. Despite decades of clinical research, the incidence rate of melanoma is increasing globally. Therefore, a better understanding of disease path...
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Untargeted multi-omics analysis of plasma is an emerging tool for the identification of novel biomarkers for evaluating disease prognosis, and for developing a better understanding of molecular mechanisms underlying human disease. The successful application of metabolomic and proteomic approaches relies on reproducibly quantifying a wide range of m...
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Glioblastoma (GB) is a primary malignancy of the central nervous system that is classified by the WHO as a grade IV astrocytoma. Despite decades of research, several aspects about the biology of GB are still unclear. Its pathogenesis and resistance mechanisms are poorly understood, and methods to optimize patient diagnosis and prognosis remain a bo...
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The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has captivated the globe’s attention since its emergence in 2019. This highly infectious, spreadable, and dangerous pathogen has caused health, social, and economic crises. Therefore, a worldwide collaborative effort was made to find an efficient stra...
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Cancer of the central nervous system (CNS) is ranked as the 19th most prevalent form of the disease in 2020. This study aims to identify candidate biomarkers and metabolic pathways affected by paclitaxel and etoposide, which serve as potential treatments for glioblas-toma, and are linked to the pathogenesis of glioblastoma. We utilized an untargete...
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Background Uncontrolled diabetes mellitus (DM) is accompanied by progressive cognitive deterioration mediated by neurodegeneration due to chronic hyperglycemia and subsequent oxidative damage. Oxidative stress damage due to high blood glucose is associated with functional and structural changes in the hippocampus, responsible for cognitive properti...
Article
Chemoresistance is one of the major challenges in lung cancer treatment. The identification of new chemotherapeutic therapies with increased efficacy and minimal toxicity over those currently in use is a key area of current research. Calcium channel blockers are emerging as anticancer agents in lung and other cancers. This study evaluates the abili...
Article
Background Colorectal cancer is a leading cause of mortality worldwide. Resistance of this cancer to the available chemotherapeutic agents creates a need to develop new therapeutic agents. Pentoxifylline (PTX) has been shown to have anticancer effects on multiple cancer types. Objective In this study, we evaluated the anticancer effect of PTX in C...
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Rheumatoid Arthritis (RA) disease is an inflammatory disease, which is characterized by persistent synovitis and autoantibodies that eventually lead to joint damage and reduced quality of life. This paper implements two data mining methodologies to explore the most important attributes that correlated with RA disease activity: (1) Feature selection...
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Calcium channel upregulation has been implicated in cancer cell proliferation and progression including in breast cancer. Fortunately, the function of calcium channels can be manipulated pharmacologically using calcium channel blockers (CCBs). Amlodipine, a dihydropyridine CCB, has been demonstrated to exert cytotoxic effects in several types of ca...
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Prostate cancer (PC) screening aims to detect PC in early stages, amenable to curative treatment and reduction in disease morbidity and mortality. However, PC screening may be associated with overdiagnosis and complications of unnecessary treatment for indolent disease. Therefore, careful patient selection for PC screening is critical to avoid over...
Article
OBJECTIVE The aim of this study was to determine pharmacists' perceived knowledge and expertise required to deliver pharmaceutical care services to pediatric patients. METHODS Once ethical approval was obtained, a questionnaire was posted on local pharmacy groups. The questionnaire is composed of 4 domains: 1) Demographics, 2) Perceived knowledge...
Article
In a previous report, we described the discovery of (E)-5-((8-hydroxyquinolin-5-yl)diazenyl)-2-methylbenzenesulfonamide as a potent inhibitor of GLO-I enzyme with IC50 of 1.28±0.12 μM. Herein, lead optimization of this compound was achieved through targeting the central zinc atom and hydrophilic amino acid residues in the active site of the enzyme....
Article
Objectives: Metformin is widely used for the treatment of type 2 diabetes mellitus and found to have a crucial rule in the induction of apoptosis in several cancer types including pancreatic cell carcinoma, epithelial ovarian cancer, breast cancer, and renal cell carcinoma. In this study, we propose to explore the potential role of metformin as an...
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Purpose: Calcium-sensing receptor (CaSR) has been associated with breast cancer metastasis to the bone. Targeting chemoattractant factors, such as calcium, that are released in response to bone resorption could prevent metastasis and induce apoptosis of cancer cells. In the present study, we investigated the potential caspase 3/7 activation followi...
Article
Aims of the study The purpose of this study was to assess pharmacists’ knowledge and attitude towards early detection of colorectal cancer (CRC) in Jordan and to explore potential predictor variables of such knowledge and attitude. Methods used to conduct the study An electronic, self‐reported questionnaire was used to collect data about demograph...
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Background: Hypoglycemia is a common complication of insulin therapy in patients with Type 1 Diabetes Mellitus (DM). Awareness of hypoglycemic symptoms helps patients to recognize hypoglycemia and initiate self-treatment. Impaired Awareness of Hypoglycemia (IAH) exposes patients to severe hypoglycemia, which could be associated with seizures and u...
Article
Aims: Psychological symptoms are prevalent in hemodialysis (HD) patients. Previous investigations showed that brain-derived neurotrophic factor (BDNF) and interleukin-6 (IL-6) as well as the interaction with neuropeptide S receptor 1 (NPSR1) are linked to the development of psychological distress. This study examined the association of polymorphis...
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Background Chrysin (5,7-dihydroxyflavone) is a widely distributed natural flavonoid found in many plant extracts, honey and propolis. Several studies revealed that chrysin possesses multiple biological activities including anti-cancer effects. It has been established that activation of apoptosis is the key molecular mechanism responsible for the cy...
Article
Background: Patients with Type 2 Diabetes Mellitus (T2DM) may develop hypoglycemia as an adverse effect of insulin therapy. Hypoglycemia has dangerous consequences that result from neuroglycopenia and hypersecretion of counter-regulatory hormones. Patients who recognize early symptoms of hypoglycemia can initiate self-treatment and rectify the sit...
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MET is a receptor tyrosine kinase known to be associated with cancer development and progression. Dysregulations of MET expression and/or signaling have been reported in breast cancer patients and determined to be associated with inferior outcomes rendering MET an appealing target for therapeutic interventions. Crizotinib is a multi-targeted small-...
Article
Waterpipe tobacco smoking (WTS) was previously shown to be associated with memory deficits, which were related to oxidative stress. Vitamin C (VitC) has established antioxidant properties against memory deficits associated with several diseases and conditions. In this study, the potential protective effect of VitC on memory impairment induced by WT...
Article
Objective This study assessed the possible association of serum brain-derived neurotrophic factor (BDNF) and interleukin-6 (IL-6) with depressive and anxiety symptoms in hemodialysis (HD) patients. Method An analytical cross-sectional study was conducted over 274 HD patients from March to October 2017. The Hospital Anxiety and Depression Scale (HA...
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Amlodipine, a dihydropyridine Ca2+ channel blocker, was previously shown to exhibits antitumor effects on different human cancer cells both in vitro and in vivo, through inhibition of Ca2+ cell entry. However, up to our knowledge, amlodipine antitumor effect has not been examined before on colorectal cancer cells (CRC). In this study, the effect of...
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Prostate cancer is one of the most common malignant tumors around the world. Hyperlipidemia is considered as one of the most important risk factors for the development of prostate cancer. Simvastatin is widely used for the treatment of hyperlipidemia and was previously shown to induce apoptosis in several cancer types including lung, colon, pancrea...
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Oxaliplatin is a platinum-based anticancer drug that has been shown to be genotoxic to the normal cells. Vitamin E is a potent antioxidant that may protect and enhance the repair of the damaged DNA. In this study, we aimed to evaluate the genotoxic effect of oxaliplatin on DNA by measuring the frequency of chromosomal aberrations (CAs) and sister c...
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The extensive hypervariability of human immunodeficiency virus type-1 (HIV-1) populations represents a major barrier against the success of currently available antiretroviral therapy. Moreover, it is still the most important obstacle that faces the development of an effective preventive vaccine against this infectious virus. Indeed, several factors...
Article
Full-text available
MET is a receptor tyrosine kinase known for its pleiotropic effects in tumorigenesis. Dysregulations of MET expression and/or signaling have been reported and determined to be associated with inferior outcomes in breast cancer patients rendering MET a versatile candidate for targeted therapeutic intervention. Crizotinib is a multi-targeted small-mo...
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Full-text available
Background Following the recommended guidelines is crucial for achieving patient remission in rheumatoid arthritis. The aim of this study was to assess the effect of proper drug utilization of antirheumatic drugs on disease activity and drug safety in Jordan. Methods In a retrospective cross-sectional study, patient’s demographics, clinical variabl...
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Although available antiretroviral therapy (ART) has changed human immunodeficiency virus (HIV)-1 infection to a non-fatal chronic disease, the economic burden of life-long therapy, severe adverse ART effects, daily ART-adherence, and emergence of ART resistant HIV-1 mutants require prospecting for alternative therapeutic modalities. Indeed, a growi...
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Objective: To determine the frequency of inappropriate proton pump inhibitor (PPI) prescriptions during hospitalization for stress ulcer prophylaxis on the general medical ward in a tertiary Jordanian hospital. Materials and methods: A retrospective chart review was executed on 236 patient admissions prescribed any PPI in a tertiary Jordanian ho...
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Objective: To assess self-medication practices and to evaluate the impact of obtaining medical knowledge on selfmedication among medical and pharmacy students at Jordan University of Science and Technology. Methods: This was a cross-sectional study. A well-validated questionnaire that included 3 sections about self-medication was administered to th...
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HIV-1 infection is a major public health problem and an important cause of death among adults. In light of innate immune system being the first, rapid and nonspecific response, this highlights the importance of exploiting the active arms of innate immunity to eradicate the invader and triggering a more specific immune response, the adaptive immune...
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Using a GWA analysis of a comprehensive glioma specimen population, we identified whole gain of chromosome 19 as one of the major chromosomal aberrations that correlates to patients' outcomes. Our analysis of significant loci revealed for the first time NOTCH3 as one of the most significant amplification. NOTCH3 amplification is associated with wor...
Article
Malignant Glioma is the most common type of primary brain tumors in adults accounting for about 80% of all gliomas. Despite the advances in treatment and diagnosis, the prognosis of malignant glioma is still poor with a median survival less than a year for glioblastoma patients. Targeting DNA-repair mechanisms is a clinically relevant option for en...
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Poor prognosis and resistance to therapy in malignant gliomas is mainly due to the highly dispersive nature of glioma cells. This dispersive characteristic results from genetic alterations in key regulators of cell migration and diffusion. A better understanding of these regulatory signals holds promise to improve overall survival and response to t...
Data
PTPRK Sequences alignment. Sequence traces depicting the five mutations of PTPRK in coding regions of PTPRK transcripts from glioma patient samples. Sequences alignment was performed using DNAbaser program. The reference sequence NM_001135648.1 was used as a template. (TIF)
Data
Post-translational processing of PTPRK in malignant glioma. (A) A diagrammatic representation of post-translational modification of PTPRK in glioma cells. PTPRK is processed in a sequential manner by activity of three proteases 1) furin-like protease yielding PTPRK E- and P-subunit fragment, 2) α-secretase yielding a PΔE subunit, and 3) γ-secretase...
Data
Mutations altered PTPRK growth inhibitory and anti-migratory effects in U87-MG cells. (A) Cell images were taken 72 h post-transfection to observe growth characteristics of U87-MG cells. (B) Confluent monolayers U87 cells transfected with empty, wild-type or mutants PTPRK were scratched and imaged at 0 and 24 h. Changes in wound area per time were...
Data
Mutations altered suppressive effects of PTPRK on growth and migration of U251-MG cells. (A) Images of transfected cells were taken after 72 h to observe growth characteristics of U251-MG cells. (B) Confluent monolayers U251 cells transfected with empty, wild-type or mutants PTPRK were scratched and imaged at 0 and 24 h. Changes in wound area per t...
Data
Wild-type PTPRK expression increases sensitivity of glioma cells to chemotherapy. Association of PTPRK genetic variants with response to therapeutic agents is shown for (A and B) U87-MG cells and (C and D) U251-MG cells. The graphs are plotted after controlling for anti-growth effect of PTPRK expression. (TIF)
Article
Full-text available
Malignant gliomas are the most frequent type of primary brain tumors. Patients' outcome has not improved despite new therapeutics, thus underscoring the need for a better understanding of their genetics and a fresh approach to treatment. The lack of reproducibility in the classification of many gliomas presents an opportunity where genomics may be...
Article
Malignant gliomas are the most frequent type of primitive brain tumors. Their outcome did not improve despite new therapeutics, resulting mainly from their genetic heterogeneity and complexity. By using genome-wide explorations we have recently identified, for the first time, that chr.19 amplification correlates with a grim therapeutic outcome. The...

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