Mohammad Esmaeil Akbari

Mohammad Esmaeil Akbari
Shahid Beheshti University of Medical Sciences · Research Center of Cancer

professor of surgical oncology

About

66
Publications
13,914
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1,225
Citations
Citations since 2017
6 Research Items
719 Citations
2017201820192020202120222023020406080100120140
2017201820192020202120222023020406080100120140
2017201820192020202120222023020406080100120140
2017201820192020202120222023020406080100120140

Publications

Publications (66)
Article
Background We aimed to evaluate the anti-cancer and immune system enhancing properties of Vitamin E succinate (VES) and methylselenic acid (MSA) administration on 4T1 breast tumor model under high-dose methotrexate (HDMTX) therapy and folinic acid (FA) rescue. Methods Thirty six 4T1 mammary carcinoma bearing mice were randomly divided into six grou...
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Background: Breast sarcomas are a group of rare and non-epithelial malignancies that account for less than 1% of breast cancers. There are few epidemiologic studies on this type of cancer due to its rarity. was used to calculate the age-specific incidence rate for breast sarcoma in Iran. Moreover, age-standardized incidence rate (ASR) for pathologi...
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Background: Childhood cancers are among the leading causes of child mortality worldwide. We aimed to analyze the spatiotemporal incidence patterns of five common cancer types in Iran. Material and Methods: A total of 17155 incident malignant 0-14 years old cases during 2005-2013 recorded by the Iran National Cancer Registry were included. An adapt...
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Background: Soft-Tissue Sarcoma (STS) is a heterogeneous group of neoplasms of mesenchymal origin, occurring in connective tissues. According to previously conducted studies, STS accounts for approximately 1% and 7-%15% of adult and pediatric malignancies, respectively. Almost 50%-60% of sarcomas arise from extremities and usually present as a lar...
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Introduction: Chordoma is a rare sarcoma of the axial skeleton. The incidence of this tumor is different between races. To understand the epidemiologic characteristic and due to rarity of this pathology, large number of cases should be evaluated through national data registries. Materials and Methods: All pathologically confirmed cases of chordoma...
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Introduction: The effect of race and ethnicity on some kind of malignant bone tumors including Ewing sarcoma has been proven in different studies. In order to evaluate the latter, national cancer registries may help to increase understanding about potential cancer causes, prevention and control strategies and apply these findings to control health...
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Background: Normally, surgery is the first choice of treatment for breast cancer which brings about side effects as chronic pain. Post mastectomy pain syndrome (PMPS) is one of the most prevalent side effects in breast cancer survivors as a chronic neuropathic pain lasting more than three months. The precise mechanisms and risk factors connected to...
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This article presents a new approach for estimating the depth, size, and metabolic heat generation rate of a tumour. For this purpose, the surface temperature distribution of a breast thermal image and the dynamic neural network were used. The research consisted of two steps: forward and inverse. For the forward section, a finite element model was...
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Background: The Cox model is known as one of the most frequently-used methods for analyzing survival data. However, in some situations parametric methods may provide better estimates. In this study, a Weibull parametric model was employed to assess possible prognostic factors that may affect the survival of patients with breast cancer. Materials...
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Background: As a result of significant progress made in treatment of many types of cancers during the last few decades, there have been an increased number of patients who do not experience mortality. We refer to these observations as cure or immune and models for survival data which include cure fraction are known as cure rate models or long-term...
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Surgery is usually the first treatment for breast cancer which is followed by some complications such as chronic pain. Post mastectomy pain syndrome (PMPS) is a common complication among breast cancer survivors and is considered as a chronic neuropathic pain in the side of surgery which persists more than three months. The exact mechanisms and rela...
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Pain has been one of the most debilitating symptoms of cancer. The aim of this study was to evaluate residents' knowledge, attitude, and practice regarding pain control in cancer patients. In a descriptive study, 69 randomly selected third-year various residents practicing in teaching hospitals of Shahid Beheshti School of medicine participated in...
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Not only the expand development of knowledge for reducing risk factors, but also the improvement in early diagnosis and treatment of cancer, and socioeconomic inequalities could affect cancer incidence, diagnosis stage, and mortality. The aim of this study was investigation the relationships between family levels of socioeconomic status and distrib...
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Because of limitation of human visual system, computer-aided diagnosis has been playing an important role in early breast cancer detection. Clinical interpretation of dynamic breast thermograms first depends on the similarity analysis between vascular pattern in thermal images before and after applying a cold challenge. To analyse the thermal image...
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14th St.Gallen International Breast Cancer Conference / The Breast 24S1 (2015) S87–S150 S129 outcomes and complications attributable to risk factors: diabetes mellitus, obesity, and smoking. Both groups were evaluated at six months after reconstruction. Cosmetic score was defined as using a subscale consisting of volume, contour, placement of infra...
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Breast cancer is the most common cancer in women that as a sudden event has profound effects on all aspects of patients' lives. Psychosocial interventions may play important roles in reducing anxiety and depression among breast-cancer survivors. Therefore, group training based on acceptance and commitment therapy may help women to cope better with...
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Guidelines have produced and used in complex environment of health care system with its ethical, economical, legal and other aspects; that should be taken into account in any country. Modifying the format and content of guidelines might facilitate their usage and lead to improved quality of care and cost containment. We have produced this tool for...
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Introduction: Breast cancer is the most incident cancer and the fifth cause of death due to malignancies among Iranian women. A strong sense of meaning and purpose in life of breast cancer patients appears to decrease hopelessness in their life. The present study has investigated effectiveness of group logo therapy on decreasing hopelessness in wom...
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Breast cancer is the most common cancer among women which leaves a profound impact on psychosocial health, and quality of life in women. The aim of this study was to determine the effectiveness of group psychotherapy based on acceptance and commitment on quality of life in women with breast cancer. To this end, in a semi-experimental study, 30 wome...
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The purpose of this study was to evaluate the effectiveness of spiritual interventions in reducing distress in mothers of children with cancer. In a quasi-experimental study 12 mothers of children with cancer aged between 19 to 50 years old were selected and studied within six 90-minute group sessions in a spiritual intervention based program. Part...
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The purpose of this study was to investigate the effect of creating hope in distress of women with breast cancer. For this purpose 18 women who were diagnosed with breast cancer at Shohaday-e Tajrish hospital affiliated to Shahid Beheshti University of Medical Sciences were chosen from available samples and were divided into two groups of experimen...
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Background Alpha particle irradiation from radon progeny is one of the major natural sources of effective dose in the public population. Oncogenic transformation is a biological effectiveness of radon progeny alpha particle hits. The biological effects which has caused by exposure to radon, were the main result of a complex series of physical, chem...
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Background Breast Cancer (BC) is the most common cancer in Iranian women, meanwhile the Iranian patients are relatively young. Granzyme H (GZMH) is a functional cytotoxic serine protease of NK cell granules, which expands the cell death-inducing repertoire of innate immune system. GZMH is constitutively and highly expressed in human NK cells, in or...
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Background Despite the fact that being exposed to traumatic and stressful events could have severe consequences, studies have shown that even in the wake of negative events such as cancer diagnosis, we see some changes and positive impacts in scheme, philosophy of life and self-perception, a process which is called Post Traumatic Growth (PTG). The...
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Background Breast cancer is the most incident cancer and the fifth cause of death due to malignancies among Iranian women. A strong breast cancer patients' sense of meaning and purpose in life appears to decrease anxiety in their life. The present study has investigated the effectiveness of group Logotherapy on the reduction of anxiety in women wit...
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Background: The EMSY gene encodes a BRCA2-binding partner protein that represses the DNA repair function of BRCA2 in non-hereditary breast cancer. Although amplification of EMSY gene has been proposed to have prognostic value in breast cancer, no data have been available concerning EMSY tissue expression patterns and its associations with clinicop...
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Background Colon cancer is the third cause of cancer deaths. Although colon cancer survival time has increased in recent years, the mortality rate is still high. The Cox model is the most common regression model often used in medical research in survival analysis, but most of the time the effect of at least one of the independent factors changes ov...
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Background Surgery is one of the important palliative methods for patients withesophageal cancer. In addition to concerns related to clinical decision making, various moral challenges are encountered in palliative surgery. Some of them are related to patients and their illness, others to surgeons, their attitudes, skills and knowledge base. Method...
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Background: Sentinel node biopsy (SLNB) is the standard of care for breast cancer treatment and it is getting wide acceptance in Iran. The radiation safety of the procedure has been investigated under controlled conditions, but the standard dose of radiotracer and techniques are not always observed in the community setting. The aim of this study wa...
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Breast cancer is the most prevalent cancer and the fifth cause of cancer death in Iranian women. Early detection and treatment are important for appropriate management of this disease. Mammography and ultrasonography are used for screening and evaluation of symptomatic cases and the main diagnostic test for breast cancer is pathological. In this st...
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Objective: The policy makers and social managers need some criteria for building up the appropriate health status of the community and observe the equity and equality on it. They have to know the burden of diseases as a main determining factor for decision making, planning and programming. Disability adjusted life years (DALYs) is a criteria which...
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Mammography is the primary imaging technique for detection and diagnosis of breast cancer; however, the contrast of a mammogram image is often poor, especially for dense and glandular tissues. In these cases the radiologist may miss some diagnostically important microcalcifications. In order to improve diagnosis of cancer correctly, image enhanceme...
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Breast cancer (BC) is the most common cancer among Iranian women. It is recommended that women be under national screening for early detection of cases to improve survival and decrease mortality. Because of shortage of facilities, breast self-examination (BSE) instead of clinical-based examination (CBE) and mammography is advocated as the first ste...
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A descriptive overview of the literature. To present a comprehensive descriptive overview of the published papers about epidemiologic features, burden, and current management of low back pain (LBP) in Iran. Little is known about the epidemiology, burden, and management of LBP in developing and low- to middle-income countries, such as Iran. A litera...
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In spite of a significant relation between spirituality and hope, happiness and life satisfaction, the effectiveness of spiritual interventions in the mentioned mental strengths has been less dealt with. The present study is conducted in order to determine the effectiveness of spiritual group intervention on the increase of hope, life satisfaction...
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The aim of this study was to model the geographical variation in incidence and risk factors of seven prevalent cancers in Iran. The data for cancers of esophagus, stomach, bladder, colorectal, lung, prostate, and female breast along with their risk factors in all 30 provinces of Iran for the year 2007 were included into study. Smoking, overweight,...
Article
Background: Breast conserving surgery (BCS) is a widely accepted form of operation in patients with early breast cancer. Recurrence remains one of the greatest concerns in breast conserving surgery. It can provoke serious anxiety in the patient and, when treated by mastectomy, negate the objective of conservation. Methods: In this study we investig...
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Thyroid cancer is the most common endocrine system malignancy in the world, being the 7th most common cancer in females, 14th in males and 11th in both sexes in the Iranian population. The present study aimed to determine survival of thyroid cancers in Iran based on sex, age group, pathology and geographical location. The patients selected for this...
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Ovarian cancer is one of the most common gynecologic malignancies. The present study was designed to compare age-standardized incidence rate (ASR) of ovarian cancer in Iran with that in Australia and some other developed countries. Data from the Cancer Registry Program of Iran, as a base, were compared with the cancer registry reports of surveillan...
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The purpose of this study was to report age-specific incidence rates of histopathological subtypes of ovarian cancer in Iran. Data published by the pathology-based Cancer Registry, Iranian Ministry of Health and Medical Education for the year 2004, was utilized. This study included 793 new ovarian cancer cases which were analyzed by SPSS software (...
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Retaining of gauzes and surgical sponges in the abdomen is one of the most frequent medical errors usually manifesting as abscess or abdominocutaneus fistulas with no definite symptoms during lifetime. Here, we introduce a 35 year old woman with symptoms and signs of partial bowel obstruction and enterocutaneous fistulas caused by migration of reta...
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Breast cancer (BC) is the most prevalent cancer in Iranian women and the fifth most common cause of cancer-related death in Iran. Among predicting factors and preventive measures for BC, the parity and breastfeeding (BF) are controversial issues. We therefore conducted this case-control study to find out the relation of parity and BF to incidence a...
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Retaining of long gauzes and surgical sponges in the abdomen is one of the most frequent medical errors usually manifests as abscess or abdomino- cutaneus fistulas and with no definite symptoms during lifetime. Here, we introduce a 35 year old woman with an intestino-cutaneal fistula caused by retained long gauze in the abdomen entered the terminal...
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Introduction: Verses in Holy Quran; 233 surat Al-Baghare , 15 Al-Ahghaf , 14 Loghman and 6 Al-Talagh, breastfeeding, gravidity, and parity recommended to the parents and expected their children to be accountable to the parents; particularly to mothers due to tolerate of pregnancy and breastfeeding duration.Methods: The case-control study included 3...
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effects of 3, 4-methylenedioxy-methamphetamine (ecstasy) on survival and apoptosis of primary hippocampal neurons. Neural Regen Res. 2009;4(12): Abstract BACKGROUND: 3, 4-methylenedioxymethamphetamine (MDMA, also known as "ecstasy") has been shown to exhibit neurotoxic effects on the hippocampus. However, exposure to sub-lethal insults of MDMA has...
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The aim of this study was to estimate the 5-year survival of ovarian cancer in Iran between 2000 and 2004, according to age and histology. Cancer registry of Iran, 2000-2004, was used covering nearly 80% of all ovarian cancers and 100% of all pathologically diagnosed ovarian cancers. Of 1,246 new ovarian cancer cases, 451 were available for further...
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Colorectal cancer is the fourth cause of cancer after stomach, bladder, prostate in men and second cause after breast in women in Iran. It is estimated that 4,000 new cases occur each year with 1,150 deaths annually. The present study aimed to determine survival of colorectal cancers in Iran in a national manner. The data from national cancer regis...
Article
Severe ischemia to nerve results in fiber degeneration and reperfusion results in oxidative injury to endothelial cells and augments fiber degeneration. Statins, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, the most widely used lipid-lowering drugs, have been demonstrated to play a neuroprotective role. So we evaluated the...
Article
This study evaluated the effectiveness of simvastatin in protecting sciatic nerve from ischemia-reperfusion (I/R) injury using the model of experimental nerve ischemia. Sixty adult male Sprague-Dawley rats weighing 250-300 g were used. They were divided into ten groups (N = 6 per group). We used ischemia model in these groups. All ischemia groups w...
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Rate of in vitro maturation of oocytes is one of the challenges of assisted reproductive techniques. In this study we investigated the effects of supplementation of cysteamine on the rate of in vitro maturation of oocytes in two different media. Germinal vesicle oocytes were collected from mouse ovary and cultured in two media (TCM199 and MEME) wit...
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A 1-year study of fatal injuries was carried out in 10 provinces of the Islamic Republic of Iran based on a population of 16 740 637 in 2000-01. All reported deaths were compared and validated with other sources of death registration. Out of 66 846 deaths, 9733 (58/100 000) resulted from injuries. Overall, 14.9% of all deaths with 26.9% of years of...
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There is an increased risk of neural tube defects and axial skeletal malformations among infants born by mothers who had received Valproic acid...The aim of the present study is, if administration of valproic acid can induce maternal hepatic Metallothionein (MT) synthesis and so secondary decrease of plasma Zn. In the present experimental study, ma...
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The aim of this study was to evaluate changes that occur in motility parameters of progesterone treated mouse spermatozoa during course of hyperactivation. Mouse spermatozoa treated with different doses of progesterone were videotaped after 10 min and 90 min of incubation. For each sperm, one second of movement of the head-midpiece junction was tra...
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In this study effect of recombinant human leukemia inhibitory factor on invitro development of 2 cells embryos and isolated blastomeres derived from mouse 2 cell embryos were investigated. Female ICR mice that were between 8 to 10 weeks old received intraperitoneal injection of 7.5 IU of PMSG for super ovulation followed by intraperitoneal administ...
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Clinical studies have shown that in pathological conditions such as endometriosis and reproductive tract infection (male and female) there is an activation status of macrophages that produce large quantities of nitric oxide (NO) in addition to other effector molecules. Large amounts of NO may have embryotoxic roles and produce infertility. This stu...
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Background: Various approaches have been used in the attempts to improve the quality of frozen–thawed mouse sperms. According to literatures, it seems that hyaluronic acid (HA) has an important role on the permeability and motility of sperms and their interaction with gametes. Objective: For evaluation of HA supplementation on sperm characteristics...

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Projects (4)
Project
We aimed to calculate the incidence rate of childhood cancer aged 0 to 14 in Iran between 2005 and 2014.