Mohamed Khrouf

Clinique la Rose · FERTILLIA ART center

Background Primary Ovarian Insufficiency (POI), a public health problem, affects 1-3.7% of women under 40 yielding infertility and a shorter lifespan. Most causes are unknown. Recently, genetic causes were identified, mostly in single families. We studied an unprecedented large cohort of POI to unravel its molecular pathophysiology. Methods 375 pa...

Since 2007, the Oncofertility Consortium Annual Conference has brought together a diverse network of individuals from a wide range of backgrounds and professional levels to disseminate emerging basic and clinical research findings in fertility preservation. This network also developed enduring educational materials to accelerate the pace and qualit...

Study question Would the use of theophylline have an effect on ICSI outcomes? Summary answer The cumulative pregnancy rate after the transfer of fresh and frozen embryos (FET) becomes more important justifying the addition of theophylline as an efficacy variable. What is known already Absolute immotile spermatozoa is one of the most important cau...

PurposeToday, male and female adult and pediatric cancer patients, individuals transitioning between gender identities, and other individuals facing health extending but fertility limiting treatments can look forward to a fertile future. This is, in part, due to the work of members associated with the Oncofertility Consortium.Methods The Oncofertil...

Purpose Little is known about oncofertility practice in developing countries that usually suffer from a shortage of health services, especially those related to cancer care. Materials and Methods To learn more about oncofertility practice in developing countries, we generated a survey to explore the barriers and opportunities associated with oncof...

VARICOCELE INDUCE OXIDATIVE STRESS AND SPERM DNA DAMAGES IN INFERTILES PATIENTS Mariem ben Khelifa, PhD, Hanen Elloumi, Dr, Sonia Mnallah, Dr, med Habib BEN Aribia, Dr, Mohamed Khrouf, Dr, Fethi Zhioua, Dr, Khaled Terras, Dr, Moncef Benkhalifa, PhD and Khaled Mahmoud, Dr, FERTILLIA center, Tunis, QC, Tunisia Abstract Text: OBJECTIVE: Varicocel...

76th Scientific Congress of the American-Society-for-Reproductive-Medicine, ELECTR NETWORK, OCT 17-21, 2020

Purpose: The state of limited resource settings that Coronavirus (COVID-19) pandemic has created globally should be taken seriously into account especially in healthcare sector. In oncofertility, patients should receive their fertility preservation treatments urgently even in limited resource settings before initiation of anticancer therapy. Theref...

The activity of the Reproductive Medicine poses a dilemma in this pandemic Covid-19. In fact, this is a theoretically non-emergency activity except for fertility preservation with oncological reasons. The majority of fertility societies in the world such as the American Society for Reproductive Medicine (ASRM) and the European Society of Human Repr...

NT is a 15-year-old post-menarchal girl; she was complaining of cervical enlargement, a weight loss of 21 kg in 3 months, night sweats, and fever. Clinical examination of the patient found a 2 cm fixed painless and firm right lateral jugular lymphadenopathy. The left cervical lymphadenopathy biopsy revealed a scleronodular Hodgkin’s disease. The pa...

KG is a 31-year-old engineer, married for the past 4 years, with no children so far. In her family history, her mother was diagnosed with breast cancer and treated at age 45 and passed away at age 55, after a relapse. Her aunt is alive and survived breast cancer.

This study aimed to identify the epidemio-clinic, diagnostic, therapeutic and evolutionary features of genital tuberculosis (GT) among Tunisian women. We conducted a retrospective, descriptive study in the Department of Infectious Diseases at the La Rabta Hospital, Tunisia, over a period of 15 and a half years (January 2000 - June 2014). All patien...

Study group: 28 pubertal young women affected by malignancies, referred for fertility preservation and refusing transvaginal (TV) procedure. Control group: 28 infertile patients, aged less than 25 years, who have undergone in vitro fertilization with TV oocyte retrieval. The ovarian stimulation was significantly longer on the study group. There...

Little is known about oncofertility practice in developing countries that usually suffer from shortage of health services especially those related to cancer care. To learn more about oncofertility practice in developing countries, a survey was generated to explore the barriers and opportunities associated with oncofertility practice in five develop...

Introduction Poser avec certitude le diagnostic d’un SOPK reste difficile chez les adolescentes car les manifestations cliniques d’un authentique SOPK peuvent être interprétées à tort comme des troubles pubertaires physiologiques banals. Notre objectif était d’identifier si les spanioménorrhées pendant l’adolescence étaient prédictives d’un SOPK co...

Introduction Poser avec certitude le diagnostic d’un SOPK reste difficile chez les adolescentes. Notre objectif était d’identifier si l’hyperandrogénie pendant l’adolescence était prédictive d’un SOPK confirmé à l’âge adulte. Méthodes Étude transversale type cas-témoins. Cinquante patientes présentant un SOPK diagnostiqué selon les critères de Rot...

Purpose: In the accompanying article, “Analysis of Fertility Preservation Options Available to Patients With Cancer Around the Globe,” we showed that specific fertility preservation services may not be offered at various sites around the world because of cultural and legal barriers. We assessed global and regional experiences as well as the legal s...

Purpose Oncofertility focuses on providing fertility and endocrine-sparing options to patients who undergo life-preserving but gonadotoxic cancer treatment. The resources needed to meet patient demand often are fragmented along disciplinary lines. We quantify assets and gaps in oncofertility care on a global scale. Methods Survey-based questionnair...

BACKGROUND In IVF, Luteal phase support is usually performed using vaginal progesterone. A part of patients using this route reports being uncomfortable with this route. We tried to study whether the rectal route could be an effective alternative and associated with less discomfort. PATIENTS AND METHODS A prospective randomized controlled study. A...

Vitamin D deficiency is widespread: 50 to 80% of the world population. In reproduction medicine, the literature remains discordant about the influence of vitamin D on intracytoplasmic sperm injection outcomes. In this context, a study was conducted whose, its main objective was to evaluate the association between the vitamin D levels and pregnancy...

After the publication of our article titled “Extensive Thrombosis of the Inferior Vena Cava and Left Renal Vein in a Neonate” [1], a reader noted that in the Discussion (treatment paragraph) we have not taken into consideration some references when we discussed surgical treatment of renal vein thrombosis, especially when we talked about thrombectom...

Antenatal renal vein thrombosis is a rarely described diagnostic finding, with variable consequences on kidney function. We present the case of an affected fetus, born at 35-week gestation, with intrauterine oligohydramnios and two small kidneys. A renal ultrasound carried out after birth confirmed the presence of prenatal abnormalities. Renal vein...

Objective: Intrauterine adhesions (IUAs) are the most common complication after hysteroscopy in patients of reproductive age. Intra-abdominal anti-adhesion gel reduces the incidence of adhesions, but effects on fertility after uterine surgery are not known. The objective of our work was to evaluate the effect of intrauterine anti-adhesion gel on s...

In 2011, the FIGO classification system (PALM-COEIN) was published to standardize terminology, diagnostic and investigations of causes of abnormal uterine bleeding (AUB). According to FIGO new classification, in the absence of structural etiology, the formerly called "dysfunctional uterine bleeding" should be avoided and clinicians should state if...

Background: Intrauterine adhesions (IUAs) or synechiae consist of partial or total (Asherman's syndrome) apposition of the walls of the uterus and are the most common complications after operative hysteroscopy in patients of reproductive age. Occurrence rates can range from 4% to 45%. These adhesions cause several complications, including obstetric...

Male infertility is the cause in half of all childless partnerships. Numerous factors contribute to male infertility, including chromosomal aberrations and gene defects. Few data exist regarding the association of these chromosomal aberrations with male infertility in Arab and North African populations. We therefore aimed to evaluate the frequency...

Seminal vesicle malformations are a rare cause of obstructive azoospermia, often associated with other internal genitalia and upper urinary tract birth defects. We report 5 new cases of seminal vesicle agenesis in men presenting with hypospermia and azoospermia. Imaging showed seminal vesicle unilateral agenesis in all patients. The remaining semin...

Les anticorps anti-spermatozoïdes (ASA) forment une catégorie de glycoprotéines fréquemment rencontrée chez les hommes infertiles. Les facteurs physiopathologiques à l’origine du développement de cette auto-immunité sont à nos jours mal définis. Cependant, les traumatismes testiculaires, les antécédents d’infections urogénitales, les cures de varic...

La tuberculose génitale de la femme fait partie des formes extrapulmonaires de la tuberculose. Il s'agit d'une pathologie peu fréquente dans les pays développés, mais elle reste endémique dans les régions défavorisées. L'agent causal est, dans la majorité des cas, Mycobacterium tuberculosis et moins souvent Mycobacterium bovis. La tuberculose génit...

Background: For some teams, hysteroscopy, should be performed before each IVF attempt to maximize the chances of implantation because of the high cost, the investment in time and the psychological impact of each IVF cycle, but answer to the question of the systematic practice of hysteroscopy prior to IVF is far from settled. Aim: Assess the bene...

Background: The ectopic pregnancy can be treated surgically (conservative or radical) or medically. Currently, the choice between medical and surgical treatment is a critical issue. One of the parameters of this choice is the total cost of management. Aim: To compare the cost of the management of ectopic pregnancy by medical treatment (methotrex...

Background: Menstruations, by their abundance and their duration, can be a source of impaired quality of life. Women with inherited bleeding disorders appear to be, specially at risk. Aim: Assess the impact of menstrual blood loss on the quality of life for women with inherited bleeding disorders. Methods: 31 women with various inherited bleed...

Introduction Inclusion in an IVF program requires several additional morphological examinations such as pelvic ultrasound, hysterosalpingography (HSG) and hysteroscopy. The exploration of the uterine cavity is an essential step and the contribution of each of these morphological examinations is variably appreciated. Aim To evaluate the contributio...

Introduction: The impact of endometrial thickness and aspect on the day of triggerring on in vitro fertilization (IVF)/intracytoplasmic injection (ICSI) outcome have been evaluated by several studies with conflicting results. We aimed to evaluate the predictive value of those parameters for the occurrence of preganacy, earlier, on the sixth day of...

Background: Determination FSH and LH at day 3 of the menstrual cycle predicts the response to stimulation. Aim: To evaluate the value of FSH and LH measurements compared with women's age in predicting qualitative and quantitative ovarian response to gonadotrophin stimulation. Methods: 305 patients underwent at least one intra cytoplasmic sperm...

Objective To evaluate the results of controlled ovarian hyperstimulation (COH) for IVF in patients with low anti-Müllerian hormone (AMH) and normal basal follicle stimulating hormone (FSH) and Estradiol levels (≤ 50 pg/mL).Patients and methodsA retrospective cohort study including 704 patients for whom AMH and FSH levels (measured between days 3 an...

Pathogenesis of uterine synechia remains unsolved, the causal relationship between synechia and infertility is not clearly established. To evaluate the rabbit as an experimental model for Asherman's syndrome using the endometrial curettage as trigger mechanism then to evaluate its impact on fertility. Experimental study 13 female rabbits. All submi...

To evaluate the results of controlled ovarian hyperstimulation (COH) for IVF in patients with low anti-Müllerian hormone (AMH) and normal basal follicle stimulating hormone (FSH) and Estradiol levels (≤50 pg/mL). A retrospective cohort study including 704 patients for whom AMH and FSH levels (measured between days 3 and 5 of the menstrual cycle) we...

The conduct and delivery of twin pregnancies are interspersed with as well as maternal fetal and neonatal complications. The obstetrician is faced with the birth of 2 children often fragile and a uterus often exposed to dynamic dystocia. To study the maternal and newborn morbidity and mortality in twins, in order to clear the optimal route of deliv...

Cesarean scar pregnancy is a rare type of ectopic pregnancy associated with severe complications such as uterine rupture, uncontrollable bleeding which may lead to hysterectomy, and definitive infertility. Many therapeutic options are available such as Dilatation & Curetage, excision of trophoblastic tissues using either laparotomy or laparoscopy,...

Background. Intramural pregnancy is a rare form of ectopic pregnancy, difficult to diagnose and generally complicated by uterine rupture. Case. A 38-year-old woman, gravida 5 para 1, was diagnosed with intramural pregnancy by ultrasound and confirmed with MRI. A uterine rupture occurred, which lead to laparotomy and a conservative treatment. Conclu...

We report a case of sirenomelia sequence observed in an incident of preterm labor during the 29th gestational week. According to some authors, this syndrome should be classified separately from caudal regression syndrome and is likely to be the result of an abnormality taking place during the fourth gestational week, causing developmental abnormali...

Endometrial adenocarcinoma usually occurs after menopause, but in 2%-14% of cases, it occurs in young patients (less than 40 years of age) who are eager to preserve their fertility. Its treatment includes hysterectomy, bilateral salpingo-oophorectomy and pelvic lymphadenectomy, and, in some cases, radiation therapy. To describe a case of endometria...

Introduction Recent publications suggest that elevated serum progesterone levels at the start of controlled ovarian stimulation (COS) were associated with decreased pregnancy rates following in vitro fertilization (IVF) using gonadotropin-releasing hormone (GnRH). The reference arm of a recent, randomized, double-blind, multicenter, international c...

To analyse clinical et biological pecularities of Polycystics Ovarian Syndrome (PCOS) patients enrolled on ICSI cycles and compare them to normo-ovulatory women. 100 controlled ovarian stimulation cycles for ICSI in women with PCOS and 200 cycles in normo-ovulatory women. There was no significant difference in term of cancellation rate (5.5% in PCO...