Mohamed Khodeary

• Benha University

Acetaminophen (APAP) is a commonly used analgesic-antipyretic drug. Overdose of APAP is significant global clinical problem in humans. Sitagliptin (Sitg), an anti-diabetic drug, has shown protective effects against organs toxicities. This work aimed to evaluate the protective effect of Sitg against APAP-induced hepatotoxicity. Forty male rats were...

Introduction: Chloroquine phosphate (CQP) and hydroxychloroquine sulfate (HCS) are antimalarial drugs commonly used for treatment of malaria and numerous rheumatic diseases. Their widespread prescriptions may accompany with prolonged duration of therapy and higher daily dosages, leading to several toxic effects, including disturbance of reproductiv...

The present study was to develop a buoyant Hydrodynamically Balanced System (BHBS) for metronidazole (MN) using different formulations to show their effect on the floating time and in turn improving the sustained release pattern as a single unit floating capsule. The formulated blends were prepared using physical mixing of finely pulverized ingredi...

Tramadol, a synthetic opioid derivative of codeine, is an extensively prescribed analgesic as it is considered a safe and effective drug. However, tramadol poisoning is increasingly reported and becoming a serious health problem worldwide, including Egypt. Despite this, the likelihood of tramadol-induced hepato-renal complications is infrequently s...