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Mohamed L Elsaie

Mohamed L Elsaie
National Research Centre

MD

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158
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Publications

Publications (158)
Article
Full-text available
BACKGROUND Safety, pain, duration of effect, and patient satisfaction are important concerns for physicians performing dermal filler injections.OBJECTIVE This randomized, double-blind, split-face study compared the 6-month safety profile of dermal injections of calcium hydroxylapatite (CaHA) mixed with lidocaine (RDF-L) with that of CaHA alone (RDF...
Article
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Background: Leptin, an adipocyte-derived hormone, has been shown to have several immunological effects similar to those of proinflammatory cytokines. The relationship between serum leptin, psoriasis, and obesity is still conflicted, and very few studies have investigated its role in skin diseases other than psoriasis. Aim: To evaluate the possib...
Article
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ABST RACT Introduction: Laser and light-based procedures provide a good and safe modality for treatment of active acne lesions when used properly. Aim: To compare the clinical efficacy of intense pulsed light (IPL) versus 1,064 long-pulsed Neodymium:Yttrium–Aluminum– Garnet (Nd: YAG) in treatment of facial acne vulgaris. M aterials and Methods: Sev...
Article
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Background: Pruritus is one of the commonest skin complaints. Peppermint oil can be effective in reducing the severity of such a condition. Aim: The aim of this study was to assess the efficacy of topically applied peppermint oil in the treatment of chronic pruritus. Subjects and methods: Fifty selected subjects diagnosed with chronic pruritus...
Article
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Different skin presentations and patterns of cutaneous signs were reported in COVID19 patients. Varicella-zoster virus (VZV) infection is responsible for two very common skin conditions. Varicella (chichkenpox) is the initial presentation for infection with VZV and is characterized by a diffuse vesicular rash. It is after this initial attack, that...
Article
Background: Androgenetic alopecia (AGA) is a common chronic dermatological illness that affects both men and women. Aim the work: To assess and compare dermoscopically the impact of a combination of topical minoxidil solution (5%) and topical spironolactone solution (5%) in treating AGA in both sexes. Patients and methods: one hundred and twen...
Chapter
The head louse, Pediculus humanus capitis, is the most important ectoparasite causing many health problems. Several linkages are presented for this parasite, each representing a particular geographical distribution, prevalence rate, vector competence, susceptibility to pediculicides, and infestation rate.
Chapter
Tinea capitis remains a common childhood infection in many parts of the world. Yet knowledge of the underlying pathogenetic mechanisms and the development of effective immunity have shown striking advances, and new methods of diagnosis ranging from dermoscopy to molecular laboratory tests have been developed even though they have not been assimilat...
Chapter
Lichen planopilaris (LPP) is a primary cicatricial alopecia caused by chronic lymphocytic inflammation around the upper portion of the hair follicle. The origin of LPP, and the other primary cicatricial alopecias, remains poorly understood, but they all have in common a targeted folliculocentric attack, which leads to irreversible follicular destru...
Chapter
Tinea capitis remains a common childhood infection in many parts of the world. Yet knowledge of the underlying pathogenetic mechanisms and the development of effective immunity have shown striking advances. Moreover, new methods of diagnosis ranging from dermoscopy to molecular laboratory tests have been developed even though they have not been ass...
Chapter
Trichotillomania is an often debilitating psychiatric condition characterized by recurrent pulling out of one’s own hair, leading to hair loss and marked functional impairment. Although discussed in the medical literature for over a century, trichotillomania was not officially included as a mental disorder in DSM until 1987, when it was classified...
Article
Background: Sexual relationships, sexual functions are all parts of the female sexual identity and which influence physiological, psychological and reproductive functions of women. Aim of the work: The study aimed to identify prevalence of Female Sexual Dysfunction (FSD) in women affected by type 1 and type 2 Diabetes Mellitus (DM) and to evalua...
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Background: Tinea capitis (TC) is the most common dermatophyte infection in children. Fungal culture; although a gold standard of diagnosis, requires time for the final results which can favor horizontal transmission. Trichoscopy helps in rapid diagnosis and could work as a monitoring tool during antifungal therapy. Aim of the work: The objectiv...
Article
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Background: Post acne scars following sebaceous injury and abnormal wound healing during the course of acne is a prevalent and challenging to treat condition. Aim of the work: To evaluate microneedling by dermapen with topical vitamin C versus microneedling with topical insulin in treating atrophic post-acne scars. Patients and methods: A spli...
Article
Background: Leprosy is a chronic granulomatous disease affecting skin and nerves with a range of clinical and immunological responses. Objectives: The study aimed to identify levels of IL-4 and antibodies to ceramide in the sera of leprosy patients and healthy subjects using enzyme linked immunosorbent assay (ELISA) to evaluate their possible ro...
Chapter
Congenital triangular alopecia (CTA), also known as Brauer nevus or temporal triangular alopecia, may be present at birth or acquired during the first decade of life. It is a benign and unusual non-scarring triangular, oval, or lancet-shaped patch of alopecia. CTA Usually involving the temporal scalp. There are few reports of occipital scalp involv...
Chapter
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Port wine stains are vascular malformations composed of postcapillary venules in the dermis. The distribution of vessel size and depth varies among patients and even within the same lesion (superficial, deep or both). Capillary malformation is present at birth and persists throughout life. It may be localized or extensive. We report a 12 years old...
Chapter
Basosquamous carcinoma (BSC) is a distinct tumor with particular clinical and dermoscopic behavior that is considered as an apparent continuum between BCC and squamous cell carcinoma (SCC). Dermoscopy increases the diagnostic specificity and sensitivity for both pigmented and non-pigmented skin tumors including BCC, Bowen’s disease, SCC and actinic...
Chapter
Pediculosis capitis is a worldwide infestation caused by Pediculus humanus capitis ectoparasite that only lives on the hairs of the scalp. As a result of severe itching excoriation, secondary bacterial infection, lymphadenopathy are seen frequently where, sometimes bite reaction, viral exanthema mimicking hypersensitivity eruption and conjunctiviti...
Chapter
Juvenile Xanthogranuloma (JXG) is a non-Langerhans cell histiocytosis disorder. The lesions usually present as asymptomatic yellow-brown papules and nodules that are mostly self-limited. JXG can present anywhere in the body but primarily occurs as a solitary lesion on the head, the neck, or upper trunk. We report a 2 years old boy presenting with a...
Chapter
Genital psoriasis affects approximately 63% of psoriasis patients at least once in their lifetime. More than any other area on the body, genital lesions significantly impair patients’ quality of life. In 2–5% of psoriasis patients, lesions only occur in the genital region. We report a 9 years old male presenting with 4 years itchy scaly lesion on h...
Chapter
Griscelli syndrome (GS) is a rare autosomal recessive disorder, characterized by unusual hypopigmentation of skin and hair. Its onset appears soon after birth between 4 months and 7 years of age with no sex predilection. We report a case of a 6 years old presenting with unusual hypopigmentation of the skin and hair and intellectual retardation. Der...
Chapter
Keloids and hypertrophic scars are abnormal wound responses characterized by the overgrowth of fibroblastic tissues during skin healing. They not only cause aesthetic problems, but also symptomatic problems such as pruritus and pain. Keloids and hypertrophic scars are thought to have the same clinical course. We report an 11 years old girl presenti...
Chapter
Lichen planus is a chronic inflammatory disease that affects approximately 1–2% of the general population. About half of the patients with skin lesions have oral lesions, whereas about 25% present with oral lesions alone. They often occur bilaterally on the flexor surfaces of the extremities. We report a 9 years old boy presenting with an erythemat...
Chapter
Molluscum contagiosum is a viral infection of the epidermal keratinocytes with characteristic intracytoplasmic inclusions. Lesions are generally multiple, translucent appearing with umbilicated skin-colored papules, located at various sites on the skin surface. We report an 8 years old girl presenting with multiple asymptomatic papules on her trunk...
Chapter
Infantile hemangiomas (IHs) are the most common benign childhood tumors, characterized by a rapid growth phase (0–12 months) followed by a slow involution phase (5–9 years). Up to 70% of IHs resolve with problems that can range from telangiectasia, hyper/hypo pigmentation, atrophic/hypertrophic scars. We report a 9 years old boy presenting with a s...
Article
Background: Melasma is an acquired common pigmentary condition that mostly presents as pigmented macules on the face. Triple combination creams (TCC), commonly known as kligman's formula had been regarded as the mainstay of treatment for years. Topical metformin was recently studied for its melanopenic effects and potential use in melasma. Aim of...
Chapter
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Tinea capitis (TC) is a widespread scalp infection caused by dermatophytes, occurring predominantly in children. The distribution of causative species of dermatophytes varies greatly in different geographic regions. Kerion is an inflammatory type of TC and occurs commonly in rural areas with poor hygienic conditions and prepubertal children are mor...
Article
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Alpha-lipoic acid (ALA) is a natural short chain fatty acid containing sulfhydryl groups generated from octanoic acid and cysteine in the mitochondria, and is found in both the aqueous and lipid phases. The present study aimed to assess the efficacy of ALA supplementation in primary infertile males complaining of idiopathic asthenozoospermia. Eight...
Article
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Background Cutaneous warts represent a challenging condition to treat. Objective To evaluate the safety and efficacy of intralesional injection of MMR (mumps, measles, and rubella) antigen, BCG (bacillus Calmette-Guerin) vaccine, and candida antigen for the treatment of multiple warts. Methods A total of ninety (90) clinically confirmed adult pat...
Chapter
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Acne vulgaris results from a complex interaction between environment and genetic factors. While colonization of the pilosebaceous unit with Propionibacterium was previously considered to be the main cause of acne, the contribution of host-related factors that allow the growth of the bacteria and its immune response against bacterial components are...
Chapter
Frontal fibrosing alopecia, first described by Kossard in the early 1990s, is a form of primary lymphocytic cicatricial alopecia characterized by selective involvement of the frontotemporal hairline and eyebrows. Since the original description, an increasing number of cases have been reported worldwide and the clinical aspects of the disease have b...
Article
Background Granulocyte-macrophage colony-stimulating factor (GM-CSF) is believed to play an important role in the development of acne vulgaris. Aim of the Work To investigate the presence of GM-CSF 3928C/T and GM-CSF 3606 T/C promoter gene polymorphisms in Egyptian acne patients. Methods To examine whether GM-CSF single nucleotide polymorphisms (...
Article
Background Psoriasis is a chronic inflammatory hyper proliferative skin disease. Angiogenesis play an important role in Psoriasis pathogenesis, occurring even before plaque formation. Angiopoietins play an important role in angiogenesis and hence are described as angiogenic factors. Aims To evaluate serum levels of angiopoeitin 2 (Ang-2) following...
Article
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Background: Melasma, also known as chloasma or mask of pregnancy, is a common, acquired, hyperpigmentary disorder usually affecting females. Tranexamic acid (TA), a derivative of amino acid lysine, has shown promising results over the past few years when used along with other therapies and when used as a stand-alone therapy. Aim of the work: In...
Article
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Background Major epidemic outbreaks create an increased demand for healthcare workers (HCWs) and pose increased health risk and psychological distress to them as well. Aim The aim of this cross sectional study was to find out the prevalence of depression, anxiety and stress among Egyptian dermatologists and their possible predictor factors. Patie...
Article
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Aim: Female pattern hair loss (FPHL) is a common condition that is influenced by many external and internal factors. We aimed to identify the prevalence of FPHL among secondary school girls and identify possible associated factors. Methods: FPHL among 3405 adolescent females was identified using detailed history, physical examination, and dermos...
Article
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Numerous therapeutic strategies have been described for prevention and reduction of hypertrophic scars and keloids, but none of the treatments is effective in all patients. No universal consensus in treatment regimen has been established, and there is limited evidence‐based literature to guide the correct management. The process of scar development...
Article
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Background Acrochordons (fibroepithelial polyps, skin tags, papillomas) are common benign neoplasms of the skin. Aim To identify the prevalence of colonic polyps among patients presenting with skin tags and to determine a useful criteria for screening with colonoscopy. Methods Two hundred patients who fulfilled the selection criteria underwent ph...
Article
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Background: Warts, or verrucae, are mucosal human papilloma virus (HPV) infections that are very challenging to treat. Objective: To compare the safety and efficacy of intralesional injection of vitamin D3 versus intralesional injection of candida albicans antigen for plantar warts. Methods: Forty patients were included in the study and were d...
Article
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Background Cutaneous warts are frequent conditions that possess much challenge to treat. Objective To verify the potential role of vitamin D in the pathogenesis of viral warts by measuring the serum levels of vitamin D in patients diagnosed with viral warts compared to healthy controls and to verify whether oral vitamin D supplementation of those...
Preprint
Background Melasma, also known as chloasma or mask of pregnancy, is a common, acquired, hyperpigmentary disorder usually affecting females. Tranexamic acid (TA), a derivative of amino acid lysine has shown promising results over the past few years when used along with other therapies as well as when used as a stand-alone therapy. Aim of the Work In...
Article
Full-text available
The COVID‐19 pandemic has had a multitude of effects on daily life. Aesthetic and cosmetic surgery practices have been significantly reduced in their working capacity or closed during this time.1 Interest in elective procedures as judged by search engine popularity has increased to almost pre‐pandemic levels but expectedly started to decline again...
Article
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Alopecia areata (AA) is an autoimmune disease that targets anagen follicles causing nonscarring hair loss through chronic follicular inflammation. Despite presenting mostly as areas of localized hair loss, it can progress into alopecia totalis (AT) with complete hair loss of the scalp, or into a more severe form of entire body hair loss known as al...
Article
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Aim This case controlled study aimed at eluating if enthesistis is possibly associated with acne vulgaris. Methods This study was carried out on 90 patients with acne vulgaris and 30 normal individuals who were subjected to full history talking, acne scoring system, general, dermatological, musculoskeletal examination as well as musculoskeletal ul...
Article
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Background Pumpkin (Cucurbita pepo L.) is an annual climber plant and its seeds have considerable amount of oil with nutritional and medicinal importance. Aim The present study aimed to investigate the clinical efficacy of pumkin seed oil (PSO) in the treatment of female pattern hair loss (FPHL) and compare its effects with minoxidil 5% foam. Met...
Article
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Lipocalin‐2 (LCN2) has been identified as an adipokine but its role in psoriasis has not been fully elucidated. The study aimed to evaluate serum and tissue levels of LCN2 in patients with plaque‐type psoriasis and its correlation with C‐reactive protein (CRP), disease duration, severity, and subclinical atherosclerosis. Thirty patients with psoria...
Article
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Background Androgentic alopecia (AGA) is the most common form of alopecia in men. Cetrizine, a second generation H1 blocker is known for its anti‐inflammatory properties as well as its ability to decrease prostaglandin D2 (PGD2) production. Aim To evaluate the efficacy and tolerability of topical cetirizine in male patients with AGA. Methods Two g...
Article
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Varicella-zoster virus infection causes 2 distinct forms of disease: varicella (commonly known as chickenpox) and herpes zoster (HZ)(commonly known as shingles). Primary varicella-zoster virus infection results in the diffuse vesicular rash that is characteristic of chickenpox. Following primary infection, varicella-zoster virus remains dormant in...
Article
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Acute phase reactants (APR) are proteins that had been associated with psoriasis severity. We aimed to evaluate the association between psoriasis disease severity and some inflammatory markers as (CRP, ESR and fibrinogen) before and after narrow band ultraviolet NB (NB‐UVB) therapy. The present study included 38 psoriatic patients and 38 controls o...
Article
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Cancer stem cells (CSC) are populations of cells responsible for tumor initiation, progression and therapeutic resistance in many cancers. In the present study, we aimed to investigate the expression pattern and clinical significance of the stem cell marker nestin, in Squaous cell carcinoma (SCC) and basal cell carcinoma (BCC). The samples (23 case...
Article
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Sphingolipids (SLs), are structural components of the skin that contribute to the regulation of the proliferation and differentiation of keratinocytes as well as regulation of the skin epidermal barrier. A prospective cross sectional comparative controlled study was designed to evaluate the serum level of sphingosine 1 phosphate(S1P) and ceramide(C...
Article
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Vitiligo is an autoimmune disease characterized by patches of depigmentation. Zinc is an antiapoptotic molecule that exhibits antioxidant properties. The study aimed to investigate the serum levels of zinc in vitiligo patients compared to healthy controls and to whether exists a correlation between disease severity and serum levels of zinc. Fifty p...
Article
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The merging of psychiatry and dermatology has resulted in a relatively newer emerging field known as psychodermatology (PD). The aim of this cross sectional study was to assess knowledge, attitudes and practice patterns of Egyptian dermatologists towards psychodermatology. A cross sectional study was designed and data were collected using structure...
Article
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Burnout among physicians and dermatologists is gaining a wide attention in the recent decade. The aim of this cross sectional study was to assess the prevalence and predicting factors for burnout among Egyptian dermatologists. A cross sectional study was designed and data were collected using structured open access survey. A total of 144 dermatolog...
Article
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Background and Objectives Striae distensae (SD) is a challenging skin condition. Striae alba (SA) represents the chronic late atrophic stage of SD. Fractional laser technology is among the modalities used for treating SD. Lately, fractional microneedling radiofrequency (FMR) is gaining increased popularity in treating SD. The aim of our study was t...
Article
Full-text available
Background Cutaneous warts are frequent conditions that possess much challenge to treat. Objective To evaluate safety and efficacy of intralesional injection of tuberculin purified protein derivative (PPD) antigen injection vs MMR (mumps, measles, rubella) antigen for the treatment of multiple warts. Methods The study included 90 Patients who wer...
Article
Background Androgenetic alopecia (AGA) is a condition affecting both males and females. Aims We aimed to assess the demographic and clinical features of early‐onset AGA among smokers and nonsmokers and to evaluate whether prevalence of AGA was affected by smoking. Paatients/Methods One thousand (1000) healthy males aged between 20 and 35 years not...
Article
Full-text available
The World Health Organization has recently defined the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infections as a pandemic. The infection, that may cause a potentially very severe respiratory disease, now called coronavirus disease 2019 (COVID‐19), has airborne transmission via droplets while less attention focused on aerosol tran...
Article
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Background: Telemedicine involves distant exchange of medical information between health providers and patients via a telecommunication device with/without the aid of an audiovisual interactive assistance. The current COVID 19 pandemic impact on health services mandated an utmost readiness to implement telemedicine which in part is dependent on he...
Article
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Nonsteroidal anti-inflammatory drugs (NSAIDs) have been an important therapy in the treatment of a large number of cutaneous pathologies for more than three decades. Concerns have been raised that NSAIDs may be associated with an increased risk of adverse effects when used in patients with acute viral respiratory infections. Given the current SARS-...
Article
Melasma is common skin condition presenting with hyperpigmentation. To evaluate the efficacy, tolerance, and complications of one session of combined chemical peels compared to traditional serial sessions of trichloroacetic acid (TCA) peeling in treating melasma. One session of combined chemical peels was carried out at the left side of the face, w...
Article
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Various cutaneous manifestations have been observed in patients with COVID‐19 infection. Herpes Zoster is a viral skin disease caused by varicella zoster that remains dormant in the dorsal root ganglia of cutaneous nerves following a primary chicken pox infection. In this report we describe two cases COVID infection who first presented with herpes...
Article
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Background Assessment of quality of life (QOL) of patients with androgenetic alopecia (AGA) has become increasingly important, both in order to evaluate the influence of the disease on patients and the therapy they require. Objective We aimed to assess QOL in subjects complaining from AGA and evaluated the effects of various sociodemographic facto...
Article
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Background Hypertrophic scars (HS) are a challenging disorder that mostly develops during wound healing process following skin injuries. Methods A split‐scar, double‐blind randomized controlled trial was held to assess the safety and efficacy of botulinum toxin type A (BTA) injection in hypertrophic scars (HS). Thirty patients with old scars (rang...
Article
Background Laser treatment of vascular skin conditions is very useful option yet remains to be a very challenging task. Objective To evaluate the efficacy of 577‐nm diode laser for treating facial telangiectasia. Patients and methods Thirty patients with facial telangiectasia were included in this prospective study. All participants received 3 se...
Article
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Background Approaches to improve keloid scars include intralesional corticosteroid injections and fractional lasers exclusively. The combinative use of ablative fractional laser therapy and occluded topical corticosteroid as a drug delivery method enhances therapeutic outcome of two efficient scar therapy modules into one simple synergistic module....
Article
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Background Fractional CO2 laser is one of the most effective treatment options used to resurface scars. Objective To evaluate the efficacy and safety of early treatment of postsurgical scar by fractional ablative CO2 laser. Methods A total of 27 Egyptian patients with recent postoperative scars were enrolled in this study. Three sessions of fract...
Article
Background: Scabies is a contagious skin infestation that mainly presents with itching at night and skin burrows that are visible to the naked eye. Diagnosing scabies with dermoscopy is still a matter of controversy. The aim of our study was to compare the diagnostic properties of adhesive tape, skin scraping, and dermoscopy in diagnosing scabies....