Mohamed Bouhrim

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• Professor
• Laboratory of Biological Engineering, Team of Functional and Pathological Biology. at Université Sultan Moulay Slimane

Opuntia species belong to semi-arid and arid regions of Mexico and the United States. O. ficus-indica and O. dillenii are commonly used in alternative medicine to treat various diseases. Up to date, several scientific works have been carried out on the different parts of these plants. However, over the last few years, studies have been focusing on...

Herbal medicine and its therapeutic applications are widely practiced in northeastern Morocco, and people are knowledgeable about it. Nonetheless, there is a significant knowledge gap regarding their safety. In this study, we reveal the toxic and potential toxic species used as medicines by people in northeastern Morocco in order to compile and doc...

Origanum genus is one of the most widely used herbs in folk medicine for its biological properties. e present investigation aims to characterize, for the first time, endemic Origanum grosii collected from the Taounate region, Morocco. is characterization was realized by determining the concentration of metals in different parts of the plant (flower...

This study aims to assess the safety of the Opuntia dillenii (Ker-Gawl) haw. seed oil (ODSO) and its effect on the glucose absorption activity of the isolated rat hemidiaphragm. This oil’s safety was studied by exploring its acute (doses 1, 3, 5, and 7 mL/kg) and subacute (doses 1 and 2 mL/kg) toxicities in albino mice and Wistar rats, respectively...

Pollen is a male flower gametophyte located in the anthers of stamens in angiosperms and a considerable source of compounds with health protective potential. In the present work, phytochemical screening was carried out as well as analysis of the antioxidant and antibacterial properties of pollen extracts from Micromeria fruticosa, Achillea fragrant...

Introduction Goat milk (GM) is highly valued for its rich nutritional content, easy digestibilityand low allergenic potential, making it an excellent alternative in the dairy industry.Quinoa, an Andean pseudo cereal, offers significant nutritional benefits, including high protein, fiber, and antioxidant properties. This study aims to assess the imp...

A rich source of natural color, beetroot (Beta vulgaris L. subsp. vulgaris) extracts and colorants offer deep red color to the dishes and boost their nutritional and antioxidant value. This research extracted beetroot color using Soxhlet, cold press, and ultrasonic methods. After testing the extracts for yield %, color (L*, a*, and b*), betalains,...

Figs are delectable, beneficial, nutritious, and seasonal; nevertheless, they deteriorate quickly, making processing the optimal method for preservation. Drying figs is the most practical and efficient way to preserve them. Paste is another possibility. The present study emphasizes the nutritional value of two fig pastes, as well as their antioxida...

The present study introduces an innovative approach to sustainable corrosion inhibition by utilizing the aerial parts of Ephedra fragilis (EF) as a natural inhibitor for steel in hydrochloric acid solutions. Unlike conventional synthetic inhibitors, EF extracts offer an eco-friendly and renewable alternative, emphasizing their potential for industr...

Essential oils and aromatic and medicinal plants play a vital role in the pharmaceutical, cosmetic, and food industries due to their therapeutic properties and diverse applications. Morocco’s rich biodiversity offers great potential for the exploration and development of these natural resources. However, in order to fully exploit this potential, it...

The fig tree is a multifaceted plant with a wide range of nutritional and health benefits. The employment of the Aksoy weighted classification method, predicated on biological characteristics pertaining to the ripening period, in conjunction with pomological and chemical characteristics of the fresh fruit, yielded favorable outcomes in the assessme...

This study evaluates the phenolic and flavonoid contents, as well as the antioxidant, antidiabetic, and anti-glycation properties of aqueous and methanolic extracts from Pistacia lentiscus L. leaves. The antioxidant activity was assessed using DPPH, ABTS, FRAP, and iron-chelation assays, revealing superior activity in the aqueous extract. Both extr...

Background: Methotrexate (MTX) is associated with several side effects, including hepatic and renal toxicities, which limit its effectiveness as an anticancer medication. These toxicities can lead to hepatotoxicity, nephrotoxicity, and potential liver and kidney failure. On the other hand, the fruit of the giant fennel plant (Ferula communis) conta...

The aim of this research is to assess the genetic potential of plum cultivars in an ex situ collection at the National Institute for Agronomic Research in Meknes, Morocco, under the conditions of the Saïss plain. This is an essential preliminary stage in the study of varietal adaptation to climate change. Twenty-eight cultivars will be analyzed, us...

Lactic acid bacteria (LAB) are widely recognized for their role in food preservation and their potential to produce bacteriocins, natural antimicrobial peptides effective against a broad spectrum of foodborne pathogens. This study focuses on the isolation and characterization of bacteriocin-producing LAB strains from raw milk samples collected in s...

Introduction New alternate food and pharma sources, halophyte plants have long been displaying exceptional nutritional and functional qualities. Methods Present investigations were carried out to explore three important halophyte herbs; Anabasis articulata, Lycium shawii, and Zilla spinosa,harvested from deserts, for phytochemical composition and...

The phytochemical, nutritional, and biological features of wild carob pulp from Tanzight (TN), Ait-Waada (AW), and Tizi-ghnayn (TG) in Azilal were studied. The results of the study reveal that the carob pulp examined has a low-fat level. AW had the most total sugar (78.34 ± 3.00%), total reducing sugar (27.20 ± 2.89%), crude fiber (14.21 ± 1.23%),...

The corrosion of metals in acidic environments remains a significant challenge, driving the search for sustainable and eco-friendly inhibitors derived from natural sources. This study evaluates the corrosion inhibition potential of three extracts from Cannabis sativa L., namely ethanol extract (EET), hexane extract (EHX), and dichloromethane extrac...

Introduction Many beneficial compounds found in fig leaves can be used in tea and medicine. These compounds aid with digestion, reduce inflammation, and treat diabetes and bronchitis. Chetoui, Malha, Ghoudane, and Onk Hmam fig leaf hydro-ethanol extracts from Eastern Morocco were analyzed for metabolites and biological activities. Methods, results...

Background/Objectives: The use of dietary supplements (DSs) has become common among fitness enthusiasts, aiming to enhance performance, recovery, and overall well-being. Methods: A cross-sectional study was conducted in the city of Beni Mellal from April to July 2024, assessed dietary practices, motivations for supplement use, and associated advers...

Introduction Carrot (Daucus carota) is a nutrient-dense root vegetable, and carrot pomace is a by-product of the juice extraction procedure, which is recognized a source of phytochemicals and functional components. Almonds (Prunus dulcis) are packed with a decent amount of nutrients and bioactives. Methods This study investigates the utilization o...

This bibliometric analysis investigates the scope and evolution of research on the supercritical CO2 extraction of essential oils from aromatic and medicinal plants. Utilizing the Scopus database, we examine publications from 1995 to 2024, revealing advancements in extraction technologies and collaborative efforts across 42 countries. Key findings...

Anabasis aretioïdes contain numerous bioactive compounds that provide several advantages, including antioxidant, antibacterial, anticancer, neuroprotective, anti-inflammatory, and antidiabetic characteristics. This study aimed to make a hydroethanolic extract from the aerial part of the plant, analyze its biochemical compounds, and test its biologi...

This study provides a detailed bibliometric analysis of research on medicinal plant extracts conducted over the past decade, with a focus on their therapeutic applications. Using the Scopus database, 1105 publications from 2014 to 2024 were analyzed to uncover trends in publication volume, collaboration networks, and research clusters. The analysis...

Background With the increasing global prevalence of type 2 diabetes (T2D) and obesity, there is a pressing need for novel therapeutic interventions. Lavandula stoechas, a medicinal plant traditionally used for various ailments, holds promise as a potential agent for T2D management, particularly in Morocco, where it is commonly used to treat diabete...

Introduction Melons are highly sought after worldwide due to their exquisite and delectable taste. However, the peels of these fruits, which are rich in phytochemicals and sustainable components for innovative culinary formulations, are often discarded as waste. Methods This study explored the phytochemistry and valorization of three melon fruit,...

Ceratonia siliqua L. is a medicinal plant that has long been used in traditional Moroccan medicine to treat many diseases. This study aimed to assess the impact of the stages of the immature phase of carob pulp (M1, M2, M3, M4, and M5) on phytochemical composition, antioxidant activity, and antidiabetic activity of Ceratonia siliqua L. The identifi...

Citation: Ellouz, M.; Ihammi, A.; Baraich, A.; Farihi, A.; Addichi, D.; Loughmari, S.; Sebbar, N.K.; Bouhrim, M.; A. Mothana, R.; M. Noman, O.; et al. Synthesis and In Silico Analysis of New Polyheterocyclic Molecules Derived from [1,4]-Benzoxazin-3-one and Their Inhibitory Effect against Pancreatic α-Amylase and Intestinal α-Glucosidase. Molecules...

Climate change poses a threat to plant and animal biodiversity. It induces physiological and morphological changes in plants. This study aimed to assess the effect of climate change on the phytochemical constituents, essential oil yield and chemical composition of Inula viscosa leaves. Three samples of I. viscosa from the Taounate region of Morocco...

Although giant fennel is recognized as a “superfood” rich in phytochemicals with antioxidant activity, research into the antibacterial properties of its fruits has been relatively limited, compared to studies involving the root and aerial parts of the plant. In this study, seven solvents—acetone, methanol, ethanol, ethyl acetate, chloroform, water,...

Glyphosate-based Herbicide (GBH) is a widely used pesticide that functions as a broad-spectrum, non-selective herbicide. Despite advanced research to describe the neurotoxic potential of GBH, the harmful effects on maternal behavior and neurodevelopment of offspring remain unclear. This study was conducted to highlight the effects of GBH on the ant...

In this study, we aimed to compare the phytochemical compounds (polyphenols and flavonoids), antioxidant activity, functional groups present in the compounds (FTIR), and anti-microbial effects, in aqueous and methanol extracts obtained from flowers of commercial Hypericum perforatum and native Papaver Rhoeas from Morocco. P. Rhoeas L was collected...

Thymus vulgaris L. (family Lamiaceae) is an aromatic medicinal plant well-known for its essential oil and therapeutic values. It thrives across Europe, Western Asia, the Mediterranean, and Northwestern Africa. This study aims to investigate the effect of climate change on the chemical composition, antioxidant, and antidiabetic activities of Thymus...

Cannabis is considered (Cannabis sativa L.) a sacred herb in many countries and is vastly employed in traditional medicine to remedy numerous diseases, such as diabetes. This research investigates the chemical composition of the aqueous extracts from Cannabis sativa L. seeds. Furthermore, the impact of these extracts on pancreatic α-amylase and lip...

Background: Aromatic and medicinal plants are a source of biologically active secondary metabolites, such as polyphenols. These substances have several biological properties, such as antioxidant, antimicrobial, and antihyperglycemic activities. This study aims to evaluate the phenolic compound content and antioxidant, antibacterial, antifungal, and...

For the valorization of the medicinal flora of the region of Taounate, an ethnobotanical survey was carried out among the local population. The results obtained allowed us to identify a total of 80 species of MAP used by the rural population of which the most exploited are: Inula viscosa, Salvia officinalis, Mentha pulégium, Thymus vulgaris et Rosm...

Climate change is a pressing ecological issue that poses a significant threat to life on Earth. In light of this, a scientific study has been conducted in the Taounate region to investigate this phenomenon. The main objective of the study is to predict the impact of climate change on the content of secondary metabolites and chemical compounds of es...

Juncus acutus, acknowledged through its indigenous nomenclature “samar”, is part of the Juncaceae taxonomic lineage, bearing considerable import as a botanical reservoir harboring conceivable therapeutic attributes. Its historical precedence in traditional curative methodologies for the alleviation of infections and inflammatory conditions is notab...

In the present investigation, the phenolic compounds of Solanum elaeagnifolium were identified, and the plant’s anti-lipase and anti-glycation effects on hemoglobin were discovered through in vitro experiments, as well as its short-term antihyperglycemic and anti-inflammatory effects. The chemical compound composition was detected using HPLC-DAD, t...

Backgrounds: Protein biosynthesis takes place in the ribosome. Some antibiotic and antitumor molecules show more reactivity and affinity with ribosome proteins. These observations encourage the search for protein synthesis inhibitors of targets in the fight against infectious diseases and cancer. This study assessed the utilization of Lepidium sati...

Enzymatic hydrolysis of bovine and human hemoglobin generates a diversity of bioactive peptides, mainly recognized for their antimicrobial properties. However, antimicrobial peptides stand out for their ability to specifically target cancer cells while preserving rapidly proliferating healthy cells. This study focuses on the production of bioactive...

Background and Objectives: Alzheimer’s disease (AD) stands as a pervasive neurodegener- ative ailment of global concern, necessitating a relentless pursuit of remedies. This study aims to furnish a comprehensive exposition, delving into the intricate mechanistic actions of medicinal herbs and phytochemicals. Furthermore, we assess the potential of...

The eastern region of Morocco is renowned for the production of two varieties of figs, Ghoudane (GD) and Chetoui (CH), which are characterized by their high productivity and quality. To ensure a profitable selling price, producers often dry these figs, a process that not only increases their storage capability but also enhances their nutritional an...

Background: Diabetes mellitus is a widespread metabolic disorder affecting global populations. Lavandula stoechas from Moroccan traditional medicine is used for its potential anti-diabetic effects. Objective: This study aims to evaluate the antihyperglycemic impact of the aqueous extract of L. stoechas (AqLs) and explore its mechanisms. Methods: Th...

Pistacia lentiscus L. has traditionally been employed as a diuretic and stimulant in the treatment of hypertension. Our interest centered on analyzing the chemical profile of the plant’s leaves and its in vitro, in vivo, and in silico antioxidant, antimicrobial, anticoagulant, and antidiabetic effects in order to valorize this species and prepare n...

Objective This study aims to evaluate the phytochemical composition, antioxidant, and antihyperglycemic (in vivo, in vitro, and in silico) activities and acute toxicity of Crataegus monogyna Jacq ( C monogyna) aqueous extracts. Methods The study analyzed the aqueous extract of C monogyna through various methods such as phytochemical screening, and...

The recent coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged and is responsible for coronavirus disease 2019 (COVID-19). It has become a major global challenge for public health. Since the first confirmed case in Wuhan, China, COVID-19 continued its spread causing to date about 2,510,781 deaths worldwide. Corona...

The current study aimed to evaluate the phytochemical composition, quality control, and antioxidant, antibacterial, antifungal, antihyperglycemic activities, and toxicity assessment of Crataegus monogyna Jacq (C. monogyna) and Crataegus laciniata Ucria (C. laciniata) fruits aqueous extracts. The quality control of the plant material revealed that i...

Currently, the pressing issue of climate change presents a substantial ecological peril to life on Earth, causing deterioration in plant biodiversity and disruptions in physiological and morphological processes within plants. The assessment of secondary metabolites across various treatments unveils noteworthy revelations. In treatment 1 (plant 1),...

The aqueous extract of Lavandula stoechas (AqLs) is employed as a diabetic cure in Eastern Moroccan traditional medicine. The aim of this study was to confirm and search for the antidiabetic mechanisms of this plant. The goal of this research is to look into the in vitro antioxidant activity of L. stoechas’s aqueous extract which was analyzed by us...

In Morocco, many applications in ethnomedicine on Ajuga iva (L.) have been recognized as able to treat various pathologies such as diabetes, stress, and microbial infections. The objective of this work is to carry out phytochemical, biological, and pharmacological investigations on the extracts of Ajuga iva leaves in order to confirm its therapeuti...

Ziziphus lotus (L.) Lam. (Rhamnaceae) is a plant species found across the Mediterranean area. This comprehensive overview aims to summarize the botanical description and ethnobotanical uses of Z. lotus and its phytochemical compounds derived with recent updates on its pharmacological and toxicological properties. The data were collected from electr...

In order to valorize the species Crocus sativus from Morocco and to prepare new products with high added value that can be used in the food and pharmaceutical industry, our interest was focused on the phytochemical characterization and the biological and pharmacological properties of the stigmas of this plant. For this purpose, the essential oil of...

Salvia lavandulifolia Vahl essential oil is becoming more popular as a cognitive enhancer and treatment for memory loss. It is high in natural antioxidants and has spasmolytic, antiseptic, analgesic, sedative, and anti-inflammatory properties. Its aqueous extract has hypoglycemic activity and is used to treat diabetic hyperglycemia, but few studies...

The aim of this research is to profile the chemical composition of the essential oil (EO) extracted from the aerial parts of Origanum elongatum (O. elongatum) and to evaluate its antioxidant, antibacterial and insecticidal activities on Ceratitis capitata adults. Gas chromatography coupled with mass spectrometry (GC/MS) revealed a total of 27 const...

Medicinal plants represent an inexhaustible source of traditional and effective remedies thanks to the various active ingredients they contain. Secondary metabolites present in plant extracts, such as essential oils (EO), have remarkable pharmacological properties, including antimicrobial effects. Here, the chemical composition and antimicrobial ef...

Background: This is the first ethnobotanical study focused on medicinal plants traditionally recommended by traditional healers (THs) of Eastern Morocco. In this work, we documented the medicinal plants recommended by THs and highlighted the value and importance of medicinal plants recommended by specialist healers. Methods: A quali-quantitative et...

Origanum compactum Benth (O. compactum) is widely used traditionally in Morocco to treat a broad range of illnesses, including infectious diseases. The aim of this study was to evaluate the phytochemical composition, quality control, and antibacterial activity of O. compactum leaf and flower essential oil. First, a quality control study on soil and...

The present work was aimed to study the toxicity of the essential oils of three aromatic and medicinal plants on the tomato leaf miner Tuta absoluta and the Medfly Ceratitis capitata as an alternative to conventional pesticides. We carried out a phytochemical and insecticide study of T. zygis L., S. officinalis L. and M. suaveolens Ehrh. essential...

Opuntia dillenii (Ker Gawl.) Haw. belongs to the Cactaceae family and is native to the arid and semi-arid regions of Mexico and the southern United States. O. dillenii are now used as medicinal plants in various countries. In this study, we investigated the chemical composition of ethanolic extracts obtained from seeds, juice, and peel of O. dillen...

Atriplex halimus L., also known as Mediterranean saltbush, and locally as "Lgtef", an hal-ophytic shrub, is used extensively to treat a wide variety of ailments in Morocco. The present study was undertaken to determine the antioxidant activity and cytotoxicity of the ethanolic extract of A. halimus leaves (AHEE). We first determined the phytochemic...

Background: In Morocco, Argan oil is one of the products used for antidiabetic purposes. Objective: This work aims to study the acute and subchronic effect treatment of the roasted (Roil) and unroasted (UnRoil) Argan oils on oral glucose tolerance test (OGTT) and body weight in normal and diabetic rats, evaluate the effect of these oils on glucose...

Punica granatum is a tree of the Punicaceae family which is widespread all over the world with several types of varieties. Its fruit juice is highly prized, whereas the bark, rich in in phyto-chemicals such as flavonoids, hydrolysable tannins, phenolic acids, and fatty acids, is regarded an agro-industrial waste. It is utilized in traditional medic...

The species of Artemisia are well known in the Mediterranean region, especially in Morocco, for their traditional uses and health benefit. In this study, we were interested in two species of Artemisia, namely A. herba alba Asso and A. mesatlantica Maire. These species were collected from different soils of the Central Middle Atlas (loamy, stony, li...

Thymus capitatus and Thymus broussonnetii are two Moroccan endemic medicinal plants used traditionally by the local population. The present study aims to investigate their essential oil chemical composition, antioxidant and antibacterial activities. The chemical composition of the essential oils was determined using the GC-MS analysis, the antioxid...

Cedrus atlantica (Endl.) Manetti ex Carrière is an endemic tree with spiritual value, and it was used since immemorial time in folk medicine. The present study aims to evaluate the anti-inflammatory (carrageenan-induced paw edema and formalin tests) and analgesic effects (hot plate and acetic acid writhing tests) of the cedarwood essential oil, as...

Cedrus atlantica (Endl.) Manetti ex Carrière is an endemic tree with spiritual value, and it was used since immemorial time in folk medicine. The present study aims to evaluate the antiinflammatory (carrageenan-induced paw edema and formalin tests) and analgesic effects (hot plate and acetic acid writhing tests) of the cedarwood essential oil, as w...

Introduction: Aldose reductase (AR) is an enzyme that catalyzes the reduction of glucose to sorbitol responsible for the development of diabetic complications like cataracts. Medicinal plants contain several phytocompounds that can inhibit this enzyme. Objective: The purpose of this review is to cite medicinal plants that have been tested for their...

Citation: Boutahiri, S.; Eto, B.; Bouhrim, M.; Mechchate, H.; Saleh, A.; Al kamaly, O.; Drioiche, A.; Remok, F.; Samaillie, J.; Neut, C.; et al. Lavandula pedunculata (Mill.) Cav. Aqueous Extract Antibacterial Activity Improved by the Addition of Salvia rosmarinus Spenn., Salvia lavandulifolia Vahl and Origanum compactum Benth. Life 2022, 12, 328.

Artemisia absinthium L. is one of the plants which has been used in folk medicine for many diseases over many centuries. This study aims to analyze the chemical composition of the Artemisia absinthium ethyl acetate and its aqueous extracts and to evaluate their effect on the pancreatic α-amylase enzyme and the intestinal α-glucosidase enzyme. In th...

Essential oils (EOs) are chemical products produced by odoriferous glands from a variety of plants. These essential oils have many health benefits: antiseptic, anti-inflammatory and antimicrobial activities. So due to these medicinal properties, the present study was designed to analyze essential oils of Thymus zygis L. and Thymus willdenowii Boiss...

Dysphania ambrosioides (L.) Mosyakin and Clemants is an annual or ephemeral perennial herb used traditionally in the Mediterranean region in folk medicine to treat various illnesses, including those related to the digestive system. This study aims to assess the antispasmodic, myorelaxant, and antioxidant effects of D. ambrosioides flower hydroethan...

Lavandula pedunculata (Mill.) Cav. (LP) is one of lavender species traditionally used in Morocco to prevent or cure diabetes, alone or in the form of polyherbal preparations (PHP). Therefore, the primary objective of this study was to test the antihyperglycemic effect of the aqueous extract of LP, alone and in combination with Punica granatum L. (P...