Mohamed Addi

Mohamed I University | UMP · Department of Biology

This study evaluates the antioxidant, anti-inflammatory and anticancer activities of camphor, menthol and their equimolar combination. In silico toxicity analysis confirmed the absence of toxic effects for both compounds. Antioxidant activity, assessed by 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic aci...

This review explores the significant role of specialized plant metabolites (SPMs) in the burgeoning field of cosmeceuticals, emphasizing their diverse biological activities and multifunctional benefits for skin health. SPMs, including flavonoids, phenolic acids, terpenoids, alkaloids, saponins, and polysaccharides, are recognized for their potent a...

Background/Objectives: The rise of antibiotic-resistant pathogens has become a global health crisis, necessitating the development of alternative antimicrobial strategies. This study aimed to optimize the antibacterial effects of essential oils (EOs) from Thymus satureioides, Lavandula angustifolia, and Origanum majorana, enhancing their efficacy t...

Thymus serpyllum L., often known as wild thyme, has been used since ancient times due to its multifaceted culinary and medicinal attributes. It is usually utilized in folk medicine to manage different health issues. This work aimed to investigate the chemical composition and biological characteristics of T. serpyllum essential oil (EO), including i...

Plant-derived insecticides based on essential oils (EOs) are currently considered as an excellent option to reduce the adverse effects associated with synthetic pesticides. In this study, we attempted to analyze the chemical composition, insecticidal properties, and inhibition of biological parameters, as well as to evaluate the mode of action of t...

The phytochemical, nutritional, and biological features of wild carob pulp from Tanzight (TN), Ait-Waada (AW), and Tizi-ghnayn (TG) in Azilal were studied. The results of the study reveal that the carob pulp examined has a low-fat level. AW had the most total sugar (78.34 ± 3.00%), total reducing sugar (27.20 ± 2.89%), crude fiber (14.21 ± 1.23%),...

Growing concerns over metal pollution highlight the need for effective remediation strategies. This study evaluates the accumulation capacity and tolerance of Melia azedarach and Ailanthus altissima for trace elements (Pb, Zn, and Cu), aiming to assess their phytoremediation potential. Three-month-old seedlings of both species, grown from seeds col...

Salvia officinalis has been used for so many years as a traditional remedy and still used in pharmaceutical, cosmetics, and food industries, which made it an interesting subject for researcher of natural alternatives. Enhancing the value of Moroccan S. officinalis essential oil, which is grown at Sidi Taibi in the Rabat-Salé-Kénitra Region, was the...

Plant secondary metabolites are crucial for medicinal, cosmetic, and industrial applications. These metabolites, including phenolic compounds, alkaloids, and terpenoids, accumulate in response to environmental stresses. Plant cell culture technologies, such as hairy roots, callus, and suspension cultures, are effective for studying and producing th...

Genetic diversity plays a pivotal role in fostering resilient crops amidst the escalating challenges posed by a changing climate. Within the broader context of agricultural adaptation to climatic shifts, the utilization and harnessing of genetic diversity is a significant means to bolster agricultural resilience. Due to the significance of genetic...

Background/Objectives: Essential oils (EO) from Citrus species have attracted attention for their diverse properties, including anti-inflammatory, antioxidant and cytotoxic effects, which address critical health challenges such as chronic diseases and skin disorders. Citrus sinensis (L.) Osbeck, which is widely cultivated citrus fruit, is attractin...

Global distribution of prickly pear spans worldwide, with limited cladode exploitation, particularly in Mediterranean regions, excluding American continent nations. Our research reports on three species found in eastern Morocco, including Opuntia ficus indica and the two newly introduced species Opuntia robusta and Opuntia dillenii. The study aims...

Introduction Many beneficial compounds found in fig leaves can be used in tea and medicine. These compounds aid with digestion, reduce inflammation, and treat diabetes and bronchitis. Chetoui, Malha, Ghoudane, and Onk Hmam fig leaf hydro-ethanol extracts from Eastern Morocco were analyzed for metabolites and biological activities. Methods, results...

The study evaluates the phytochemical composition of Lavandula pinnata essential oil (LPEO) and its interactions with three common antibiotics against various bacterial strains. The strains include Gram-negative species (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae) and Gram-positive species (Staphylococcus aureus, Micrococcus lu...

Anabasis aretioïdes contain numerous bioactive compounds that provide several advantages, including antioxidant, antibacterial, anticancer, neuroprotective, anti-inflammatory, and antidiabetic characteristics. This study aimed to make a hydroethanolic extract from the aerial part of the plant, analyze its biochemical compounds, and test its biologi...

The aim of this study was the phytochemical characterization of essential oil extracted from the aerial parts (stems, leaves, and flowers) of Ammoides pusilla (Brot.) Breistr (APEO) by use of GC–MS. Importantly, GC–MS results revealed that APEO oil composed of 10 terpene compounds, of which carvacrol (52.84%), d-limonene (17.78%), β-Cymene (13.18%)...

Introduction Liver diseases represent a significant global health challenge, with primary causes including excessive alcohol consumption, infections, chemotherapy, and autoimmune disorders. Medicinal plants, due to their natural bioactive compounds, hold promise for developing effective treatments and preventive measures against liver ailments. Thi...

The principal objective of the present study is to evaluate both the chemical composition and antibacterial effectiveness of essential oil of Clinopodium nepeta subs ascendens (CNEO) against three Gram-positive bacteria (Staphylococcus aureus, Micrococcus luteus, and Bacillus subtilis) and three Gram-negative bacteria (Escherichia coli, Pseudomonas...

Opuntia (Cactaceae) species are native to arid and semi-arid regions of Mexico and the southern United States and grow in various climatic zones. Opuntia dillenii is a cactus fruit with many beneficial properties, and it is used as a medicinal plant in various countries. This review paper provides updated information on the phytochemical and pharma...

The objective of this study was to evaluate the antioxidant, anti-inflammatory, and anticancer properties of thymol, carvacrol, and their equimolar mixture. Antioxidant activities were assessed using the DPPH, ABTS, and ORAC methods. The thymol/carvacrol mixture exhibited significant synergism, surpassing the individual compounds and ascorbic acid...

The optimization of existing natural antioxidants that are highly effective is crucial for advancements in medicine and the food industry. Due to growing concerns regarding the safety of synthetic antioxidants, researchers are increasingly focusing on natural sources, particularly essential oils (EOs). Combining EOs might enhance antioxidant activi...

The aim of this study was to determine the phytochemical composition and evaluate the antifungal and insecticidal properties of Rosmarinus officinalis essential oil (EO). GC-MS was employed to analyze the phytochemical profile of the EO. The antifungal activity of the EO was assessed by calculating growth inhibition rates for Alternaria alternata,...

Abstract: This study focused on developing an innovative, straightforward, and economical method utilizing a mixture of readily available solvents to extract arborescin (C2OH2OO8) crystals from Artemisia absinthium L. (A. absinthium). The structural elucidation and characterization were conducted using a suite of techniques including IR spectroscop...

The edible part of the prickly pear fruit is most commonly consumed, while the peel is often discarded, leading to the loss of valuable bioactive components, such as phenolic compounds. This research aims to assess the antioxidant activity, total phenolic content, and quantities of phenolic and flavonoid contents of fruit peel of Opuntia ficus-indi...

Mining activities produce waste materials and effluents with very high metal concentrations that can negatively impact ecosystems and human health. Consequently, data on soil and plant metal levels are crucial for evaluating pollution severity and formulating soil reclamation strategies, such as phytoremediation. Our research focused on soils and v...

This study delves into the biological characteristics of Clinopodium nepeta subsp. ascendens (CNEO) essential oil, an indigenous subspecies of eastern Morocco. Distinguished by its purple or pale pinkish-white flowers, CNEO was subjected to thorough phytochemical analysis via gas chromatography-mass spectrometry (GC-MS), revealing 21 terpene compou...

This study explores the effects of chitosan (CHT) and jasmonic acid (JA) elicitors on rose-scented geranium (Pelargonium graveolens Hort.) cell suspension cultures, aiming to enhance the production of phenolics and flavonoids and antioxidant properties. Elicitation with CHT and JA resulted in varied biomass yields and callus characteristics, with h...

The objective of this investigation was to assess the chemical makeup of essential oil derived from Ptychotis verticillata (PVEO), and to examine its antifungal, insecticidal, and repellent properties. PVEO was extracted through hydrodistillation, and its volatile constituents were analyzed using Headspace Solid-Phase Microextraction Gas Chromatogr...

This extensive investigation investigates the many biological properties found in the essential oil extracted from Clinopodium nepeta subsp. ascendens (CNEO), a previously unknown subspecies native to eastern Morocco. The study begins with a detailed examination of the phytochemical makeup of CNEO using gas chromatography-mass spectrometry, whic...

In recent years, there has been a significant upsurge in the utilization of molecular docking and related computational techniques in the field of botanical research, especially in the quest to unveil secondary metabolites and bioactive compounds. This chapter provides a comprehensive and indepth examination of the profound potential inherent in th...

The aim of this study is to explore the pharmacological properties of the essential oil derived from Ptychotis verticillata Duby (PVEO), a medicinal plant native to Morocco, focusing on its an-tidiabetic, anti-tyrosinase, and anti-inflammatory effects. Additionally, the study aims to characterize the phytochemical composition of PVEO and evaluate i...

Introduction: This study investigates the biological activities of Lavandula pinnata essential oil (LPEO), an endemic lavender species from the Canary Islands, traditionally used in treating various ailments. Methods: LPEO was extracted by hydrodistillation and analyzed using GC-MS. Antioxidant activity was assessed by DPPH radical scavenging and t...

Human health has constantly been improved using medicinal plants. Notwithstanding synthetic chemistry advancements, medicinal plants remain widely used due to their effectiveness, reduced toxicity, and therapeutic use. This investigation examines the antioxidant, antimicrobial, and insecticidal properties of essential oil extracted from Moroccan cu...

The escalating phenomenon of bacterial resistance to antibiotics over time, coupled with the conse-quential detrimental effects of oxidative stress on cellular aging, and the usage of pesticides with vary-ing degrees of toxicity, thereby impacting both human health and the environment, represents a pressing global concern. Consequently, researchers...

Cistus albidus: L., also known as Grey-leaved rockrose and locally addressed as šṭab or tûzzâla lbîḍa, is a plant species with a well-established reputation for its health-promoting properties and traditional use for the treatment of various diseases. This research delves into exploring the essential oil extracted from the aerial components of Cist...

Prickly pear serves as a signifcant source of income for farmers worldwide, with production taking place in temperate, subtropical, and cold regions. Te objective of the present investigation is to explore the morphological parameters of Opuntia robusta and Opuntia dillenii which are resistant to the white cochineal (Dactylopius opuntiae), as well...

In this investigation, the study focused on the chemical constitution and the antioxidative as well as anti-inflammatory characteristics of oils and pulpy variants (Imatchan (IM), Harmocha (HA), and Aknari (AK)) sourced from O. dillenii. This inquiry encompassed both in vitro and in silico analyses. High-performance liquid chromatography (HPLC) was...

Our research focused on assessing essential oils (MSEO) and aqueous extracts (MSAE) derived from M. subtomentella leaves, with a primary focus on evaluating their properties. From 1 kg of leaves, we successfully obtained 18 mL of essential oil. Upon conducting GC/MS analysis, we identified eleven compounds within the oil, collectively accounting fo...

Introduction: The primary aim of the current investigation is to assess the chemical composition and antibacterial efficacy of Ptychotis verticillata essential oil (PVEO) against three Gram-positive bacteria (Staphylococcus aureus, Micrococcus luteus, and Bacillus subtilis) and three Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa,...

This study investigates the impact of dietary nonindustrial Moroccan hemp seed (HS) on the fatty acid profile, cholesterol, and tocopherol levels, in the liver of 120 Lohmann brown laying hens aged 22 weeks during 12 weeks of treatment. The hens are randomly allocated into four treatment groups, each subdivided into six replicates with five birds i...

Eucalyptus globulus Labill., une plante médicinale originaire de l'est du Maroc, est renommée pour ses qualités thérapeutiques et son agréable parfum. Cette étude visait à examiner l'effet de l'altitude sur la composition chimique et les activités biologiques de l'huile essentielle des feuilles d'E. globulus. Les feuilles d'E. globulus ont été coll...

Carob (Ceratonia siliqua L.) is a tree species native to the Mediterranean region and belongs to the Fabaceae family. Te tree is well-known for its sweet and nutritious fruits, which have been used for long time as a nutritious food. In addition to the edible fruits, the carob tree also produces seeds that are highly prized for their ability to pro...

Juncus acutus, acknowledged through its indigenous nomenclature “samar”, is part of the Juncaceae taxonomic lineage, bearing considerable import as a botanical reservoir harboring conceivable therapeutic attributes. Its historical precedence in traditional curative methodologies for the alleviation of infections and inflammatory conditions is notab...

In recent years, the global health community has become increasingly interested in harnessing the therapeutic potential of traditional plants. This study focuses on Atriplex halimus L., a halophytic plant known as Mediterranean saltbush or "Lgtef", traditionally heralded for its medicinal properties. Our primary objective was to scientifically vali...

Morocco has a long history of domesticating cannabis and refuges a local Beldia population, which lacks detailed information on genetic diversity. In this study, the genetic diversity of cannabis grown in four Moroccan regions was assessed with six genomic simple sequence repeat (SSR) markers involving two cannabis populations: the local Beldia and...

The eastern region of Morocco is renowned for the production of two varieties of figs, Ghoudane (GD) and Chetoui (CH), which are characterized by their high productivity and quality. To ensure a profitable selling price, producers often dry these figs, a process that not only increases their storage capability but also enhances their nutritional an...

Arbuscular mycorrhizal fungi (AMF) have emerged as a promising and environmentally friendly solution for sustainable agriculture, offering a reduction in dependence on chemical inputs. The objective of this greenhouse experiment was to assess the efficacy of a natural endomycorrhizal inoculum obtained from leek root fragments, which acted as a trap...

The recent coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged and is responsible for coronavirus disease 2019 (COVID-19). It has become a major global challenge for public health. Since the first confirmed case in Wuhan, China, COVID-19 continued its spread causing to date about 2,510,781 deaths worldwide. Corona...

This study examines the impact of irrigation water quality on the synthesis of secondary metabolites and the chemical composition of Mentha piperita essential oil (MPEO). Three essential oils from Mentha piperita plants, irrigated with different water sources commonly used for mint irrigation in Morocco's Oriental region, were analyzed. The water s...

Breast cancer is a disease characterized by the uncontrolled proliferation of malignant cells in breast tissue, and oxidative stress activated by an accumulation of reactive oxygen species (ROS) is associated with its development and progression. Essential oils from medicinal plants, known for their antioxidant and therapeutic properties, are being...

Salinity stress is an abiotic factor that limits the growth of agricultural crops. Salinity affects over 800 million hectares of worldwide land. Aloe species are xerophytes, perennial plants with succulent leaves that have a crassulaceous acid metabolism also known as CAM photosynthesis, which allows these plants to conserve water during dry period...

The mastic tree, scientifically known as Pistacia lentiscus, which belongs to the Anacardi-aceae family, was used in this study. The aim of this research was to analyze the chemical composition of this plant and assess its antioxidant and antibacterial properties using both laboratory experiments and computer simulations through molecular docking,...

The botanical species Ceratonia siliqua L., commonly referred to as the Carob tree, and locally as “L’Kharrûb”, holds significance as an agro-sylvo-pastoral species, and is traditionally utilized in Morocco for treating a variety of ailments. This current investigation aims to ascertain the antioxidant, antimicrobial, and cytotoxic properties of th...

The purpose of this study was to evaluate how cannabis-derived nonindustrial hemp seed (HS) inclusion in laying hen diets, as well as treatment duration, affected the fatty acid (FA) profile, cholesterol level, and tocopherol composition of egg yolks. Ninety-six (n = 96) Lohmann Brown classic laying hens were randomly assigned to one of the four gr...

The botanical species Ceratonia siliqua L., commonly referred to as the Carob tree, and locally as "L'Kharrûb", holds significance as an agro-sylvo-pastoral species, and is traditionally utilized in Morocco for treating a variety of ailments. This current investigation aims to ascertain the antioxidant, antimicrobial, and cytotoxic properties of th...

The Opuntia genus is widely recognized as a significant member of the Cactaceae family. The eastern Moroccan prickly pear's wild ecotype is renowned for its production of fruits of superior quality, which are in high demand. Nonetheless, the white cochineal (Dactylopius opuntiae) has emerged as a significant hazard to the persistence of the indigen...

Morocco has a long history of domesticating cannabis and refuges a local Beldia population, which lacks detailed information on genetic diversity. In this study, the genetic diversity of cannabis grown in four Moroccan regions was assessed with six genomic SSR markers involving two cannabis populations: the local Beldia and the introduced Critical...