Mohamed Abd Ellatif

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• Professor of Clinical Biochemistry and Molecular Biology, College of Medicine
• Professor at King Khalid University

Chronic hepatotoxicity is a debilitating and frequently life-threatening disease resulting in progressive liver failure. The toxic chemical, thioacetamide (TAA) is used to evaluate hepatoprotective agents, and the polyphenolic compound, resveratrol was proposed as a novel treatment for diseases with hyperactivation of the mammalian target of rapamy...

Background Acute pancreatitis (AP) associated with the modulation of TNF-α-AMPK axis in the presence and absence of vitamin E has not been investigated before. Material and methods Rats were either injected with L-arginine (2.5 gm/kg) before being sacrificed after 48 h or were pre-treated with vitamin E (60 mg/kg) and continued receiving vitamin E...

Chronic liver injury can lead to hepatic failure and the only available method of treatment would be liver transplantation. The link between inflammation (TNF-α), nuclear factor-kappa B (NF-kB), nitrosative stress (iNOS) and hypoxia-inducible factor-1α (HIF-1α) in thioacetamide (TAA) induced liver fibrosis, and hypertension with and without the inc...

ELLATIF, M. A.; DALLAK, M.; DAWOOD, A. F.; EID, R. A.; BAYOUMY, N. M. & EBRAHIM, H. A. Vitamin E suppresses aortic ultrastructural alterations induced by toxic doses of monosodium glutamate. Int, J. Morphol., 40(3):697-705, 2022. SUMMARY: An association between certain food additives and chronic diseases is reported. Current study determined whethe...

Lower extremity arterial disease (LEAD) is a major risk factor for amputation in diabetic patients. The advanced glycation end products (AGEs)/endothelin-1 (ET-1)/nitric oxide synthase (NOS) axis-mediated femoral artery injury with and without metformin has not been previously investigated. Type 2 diabetes mellitus (T2DM) was established in rats, w...

Background: CDK4 play a pivotal role in cell cycle regulation, making it a critical players in the development and progression of cancer. In recent years, there has been a growing interest in targeting CDK4 for cancer therapeutics, with a focus on the identification and development of small molecule inhibitors. Materials and Methods: This work, usi...

The response of the immune system to harmful stimuli leads to inflammation, and the adverse effects of the toxic hepatitis chemical, thioacetamide (TAA) on the human body are well documented. This article investigated the degree of protection provided by the combined pleotropic drug, metformin (Met) and the plant polyphenolic and the antiinflammato...

Rheumatoid arthritis (RA) that affects the synovial knee joint causes swelling of the synovial membrane and tissue damage. Interleukin-17A (IL-17A) and the enzyme glycogen synthase kinase-3β (GSK3β) are involved in the pathogenesis of RA. The link between IL-17A, GSK3β, the oxidative stress, and the profibrogenic marker alpha-smooth muscle actin (α...

Prostate cancer (PC) is a heterogeneous disease that kills a significant number of people all over the world. It is the most common cancer in men, especially in the western world, and causes morbidity and mortality. There are several important risk factors known for PC like age, ethnicity, and inherited genetic variants which contribute significant...

Prostate cancer (PC) is a heterogeneous disease that kills a significant number of people all over the world. It is the most common cancer in men, especially in the western world, and causes morbidity and mortality. There are several important risk factors known for PC like age, ethnicity, and inherited genetic variants which contribute significant...

Humans are exposed to aflatoxins by consuming foods contaminated with products of fungal growth. Because aflatoxins, especially aflatoxin B1, are potent carcinogens in some animals, there has beengreat interest to study the effects of long-term exposure to low levels of these important mycotoxins on humans.The main aim of the present study was to d...

An association between certain food additives and chronic diseases is reported. Current study determined whether administering toxic doses of the food additive monosodium glutamate (MSG) into rats can induce aortopathy in association with the oxidative stress and inflammatory biomarkers upregulation and whether the effects of MSG overdose can be in...

Dengue virus (DENV) causes dengue, which is a very common mosquito-borne viral disease. The global incidence of dengue has increased dramatically in recent decades. About half of the world's population is now at risk. This virus is widespread throughout the tropics, which are influenced by rainfall, temperature, and humidity; however, severe dengue...

Chronic liver injury can lead to hepatic failure and the only available method of treatment would be liver transplantation. The link between nitrosative stress (iNOS), hypoxia-inducible factor-1α (HIF-1α), and alpha-smooth muscle actin (α-SMA), in thioacetamide (TAA)-induced liver fibrosis and hypertension in treatment with the anti-inflammatory an...

Background: Coronaviruses are classified as pH dependent. Alkaline media induced by sodium bicarbonate (SB) could impede viral entry into cells. We aimed to study the possible role of SB as an adjuvant treatment of nonsevere COVID‑19 pneumonia. Methods: The study included 182 adults with confirmed nonsevere COVID‑19 and chest computed tomography (C...

Abstract: Crz1p regulates Calcineurin, a serine-threonine-specific protein phosphatase, in Rhizoctonia solani. It has attracted consideration as a novel target of antifungal therapy based on studies in numerous pathogenic fungi, including, Cryptococcus neoformans, Candida albicans and Aspergillus fumigatus. To investigate whether Calcineurin can be...

EID, R. A.; DALLAK, M.; AL-SHRAIM, M.; ELLATIF, M. A.; AL-ANI, R.; KAMAR, S. S.; NEGM, S. & HAIDARA, M. A. Suppression of monosodium glutamate-induced acute kidney injury and renal ultrastructural damage in rats by vitamin E. Int. J. Morphol., 37(4):1335-1341, 2019. SUMMARY: Food additives and flavour enhancers used in the food industry are potenti...

Excessive consumption of carbohydrate and fat increases the risk of cardiovascular disease. We sought to determine the potential ultrastructural alterations in large blood vessels induced by a high fat and fructose diet (HFD) in a rat model of prediabetes. Rats were either fed with HFD (model group) or a standard laboratory chow (control group) for...

Crz1p regulates Calcineurin, a serine-threonine-specific protein phosphatase, in Rhizoctonia solani. It has attracted consideration as a novel target of antifungal therapy based on studies in numerous pathogenic fungi, including, Cryptococcus neoformans, Candida albicans and Aspergillus fumigatus. To investigate whether Calcineurin can be a useful...

SUMMARY: Excessive consumption of carbohydrate and fat increases the risk of cardiovascular disease. We sought to determine the potential ultrastructural alterations in large blood vessels induced by a high fat and fructose diet (HFD) in a rat model of prediabetes. Rats were either fed with HFD (model group) or a standard laboratory chow (control g...

Homocysteine (Hcy) is an intermediate sulfur-containing amino acid produced by demethylation of the essential amino acid methionine (Ay et al., 2003). Homocystiene is metabolized by one of two pathways; remethylation and transsulfuration. Thus, hyperhomocystienemia may be due to deficiency of enzymes of the remethylation pathway that recycles homoc...

The insulin-like growth factor-binding proteins (IGFBPs) carry insulin-like growth factors (IGFs) in the serum and regulate their activity and bioavailability. The high capacity binding protein that binds most circulating IGFs in blood is insulin-like growth factor-binding protein-3 (IGFBP-3). The present work was carried out to evaluate the change...

Tumor necrosis factor-alpha (TNF-α) is a pleiotropic cytokine derived from activated macrophages and other cells, and proved to have tremendously diverse functions. Long term experimental diabetes has been found to be associated with enhanced serum TNF- α activity. We attempted to study the serum TNF- α levels in insulin-dependent diabetes mellitu...

Homocysteine (Hcy) is an intermediate sulfur-containing amino acid produced by demethylation of the essential amino acid methionine (Ay et al., 2003). Homocystiene is metabolized by one of two pathways; remethylation and transsulfuration. Thus, hyperhomocystienemia may be due to deficiency of enzymes of the remethylation pathway that recycles homoc...

Pre-Diabetes Induces Ultrastructural Alterations in the Large Blood Vessel Aorta in Rats SUMMARY: Excessive consumption of carbohydrate and fat increases the risk of cardiovascular disease. We sought to determine the potential ultrastructural alterations in large blood vessels induced by a high fat and fructose diet (HFD) in a rat model of prediabe...

ELLATIF, M. A.; EL KARIB, A. O; DALLAK, M.; EID, R. A.; AL-ANI, R. & HAIDARA, M. A. Vitamin E protects against hepatocyte ultrastructural damageinduced by high fat diet in a rat model of pre-diabetes. Int. J. Morphol., 36(4):1350-1355, 2018. SUMMARY: We sought to investigate the potential protective effect of Vitamin E supplementation against hepat...

We sought to investigate the potential protective effect of Vitamin E supplementation against hepatocyte ultrastructural alterations induced by high fat diet (HFD) in a rat model of pre-diabetes. Therefore, rats were either fed with HFD (model group) or a standard laboratory chow (control group) for 12 weeks before being sacrificed. The protective...

Diabetic complications that affect vital organs such as the heart and liver represent a major public health concern. The potential protective effects of the hormone insulin against hepatocyte ultrastructural alterations induced secondary to type 1 diabetes mellitus (T1DM) in a rat model of the disease have not been investigated before. Therefore, r...

Background: We tested the hypothesis that vitamin E may protect against pre-diabetes-induced aortic injury (aortopathy), and exercise can augment the action of vitamin E. Material and methods: Rats were either fed with a high fat and fructose diet (HFD) (model group) or a standard laboratory chow (control group) for 15 weeks before being sacrifi...

The potential inhibitory effect of the antidiabetic and anti‐inflammatory drug, metformin on thioacetamide (TAA)‐induced hepatotoxicity associated with the inhibition of mammalian target of rapamycin (mTOR)–hypoxia‐inducible factor‐1α (HIF‐1α) axis has not been investigated before. Therefore, we tested whether metformin can protect against liver in...

Potent heptatotoxic chemicals such as carbon tetrachloride and thioacetamide (TAA) are used to evaluate hepatoprotective agents. Here we sought to investigate the potential protective effect of the antidiabetic and antioxidant drug, metformin against liver injury induced by TAA. Model group rats received several injections of TAA (200 mg/kg) before...

Angiogenesis is an important component in tumor development, progression and spread. As a result, there are ongoing efforts to combine existing cytotoxic therapy with anti-angiogenic therapy to enhance the efficacy of cancer treatment. However, the optimal scheduling of anti-angiogenic therapy with cytotoxic therapy, although crucial for maximizing...

AL-HASHEM, F.; ALHUMAYED, S.; ELLATIFF, M. A.; AMIN, S. N.; KAMAR, S. S.; AL-ANI, B. & HAIDARA, M. A. Metformin protects against thioacetamide-induced liver injury in rats. Int. J. Morphol., 36(3):984-990, 2018. SUMMARY: Potent heptatotoxic chemicals such as carbon tetrachloride and thioacetamide (TAA) are used to evaluate hepatoprotective agents....

Hashimoto's thyroiditis (HT) is the most prevalent autoimmune thyroid disorder. Autoimmune thyroid diseases (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis, arise due to complex interactions between environmental and genetic factors. Each is presenting with distinct clinical features. Significant progress has been made in our und...

The aim of this study was to investigate the biochemical effect of high altitude on modulation of the adaptive response of endothelial functions in persons' living at high altitude in Saudi Arabia. Materials and Methods: this study included 90 apparently healthy individuals, composed of 2 groups: High altitude group; 45 apparently healthy male volu...

The aim of this work is to evaluate the DNA methylation status and expression of different cell cycle regulators during multistage carcinogenesis of rat urinary bladder. Materials and Methods: This experimental study included 64 male (fisher 344) rats (6 weeks old). They were divided into experimental group (n= 48) and control group (n= 16). Urinar...

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL/Apo2L) is a promising candidate for cancer therapy, however, emergence of drug resistance limits its potential use. Here, we report that Del-phinidin the major constituent of pigmented fruits and vegetables, sensitizes TRAIL-resistant LNCaP cells to TRAIL-mediated apoptosis throug...

ABSTRACT: Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL/Apo2L) is a promising candidate for cancer therapy, however, emergence of drug resistance limits its potential use. Here, we report that Delphinidin the major constituent of pigmented fruits and vegetables, sensitizes TRAIL-resistant LNCaP cells to TRAIL-mediated apoptos...

High-altitude dwellers have successfully evolved adaptive regulatory mechanisms to survive in a chronic hypoxic environment. Risk assessment regarding high altitude exposure of patients with coronary heart disease (CHD) is of increasing interest. The aim of our study, therefore, was to investigate the biochemical effect of high altitude on modulati...

To evaluate mannose-binding lectin (MBL) serum levels as a marker for predicting sepsis, septic shock, and their outcomes in neonates. A prospective study was conducted on 62 neonates (27 preterm and 35 full term) with culture-proven sepsis and 35 controls. Serum levels of MBL were measured by immunoassay. Of 62 infants with positive blood cultures...

Diabetes mellitus (DM) is the single most common cause of erectile dysfunction (ED) seen in clinical practice. Evaluation of penile arterial insufficiency in diabetic patients currently entails expensive and invasive testing. We assessed the diagnostic value of certain peripheral and cavernous blood markers as predictors of penile arterial insuffic...

Nitric oxide (NO) is a key regulator of vascular homeostasis. The present study was conducted to study the expression of the inducible isoform of NO synthase (iNOS) gene and the levels of NO, in the form of nitrite, in patients with peripheral vascular insufficiency, either diabetics or non diabetics. The study included 40 male patients with periph...

37 Human kallikreins are a cluster of 15 serine protease genes located in the chromosomal band 19q13.4, a non-randomly rearranged region in many solid tumors, including pancreatic cancer. We utilized the SAGE and EST databases of the Cancer Genome Anatomy Project to perform in-silico analysis of kallikrein gene expression in normal and cancerous pa...

Hypothyroidism is associated with increased cardiovascular morbidity, which cannot be fully explained by the atherogenic lipid profile observed in these patients. Elevation of total plasma concentrations of homocystein (t-Hcy) is an important and independent risk factor for cardiovascular disease. Because hypothyroidism decreases hepatic levels of...

The objective of this study was to evaluate the level of cytokeratin 19 related tumor marker CYFRA 21-1 in the sera of patients with chronic liver diseases (chronic viral hepatitis and liver cirrhosis) and primary hepatic malignancy. Also, to find if it could be a significant tumor marker that can be used in the diagnosis of cholangiocarcinoma. The...

Many members of the human kallikrein gene family are differentially expressed in cancer and a few have potential as diagnostic/prognostic markers. KLK14 is a newly discovered human kallikrein gene that is mainly expressed in the central nervous system and endocrine tissues. Since KLK14 was found to be regulated by steroid hormones in prostate cance...

Abstract Many members of the human kallikrein gene family are differentially expressed in cancer and a few have potential as diagnostic/prognostic markers. KLK14 is a newly discovered human kallikrein gene that is mainly expressed in the central nervous system and endocrine tissues. Since KLK14 was found to be regulated by steroid hormones in prost...

The aim of the present work was to study the vascular cell adhesion molecule (VCAM-1) as well as the antioxidant enzyme (GPx) and the lipid peroxidation product (MDA), in patients with varicose veins before and after surgical treatment. This study was done on 40 patients with varicose veins aged 3510 years in addition to 20 healthy controls. The p...

Background. Many members of the human kallikrein gene family were found to be differentially expressed in various malignancies and some of them are useful diagnostic/prognostic markers. KLK9 is a newly discovered human kallikrein gene that is expressed in several tissues including thymus, spinal cord, testis, prostate, breast, and ovary. Like other...

BACKGROUND. Many members of the human kallikrein gene family are differentially expressed in cancer and a few have potential as diagnostic/prognostic markers. KLK14 is a newly discovered human kallikrein gene that is mainly expressed in the central nervous system and endocrine tissues. Since KLK14 was found to be regulated by steroid hormones in pr...

Many kallikrein genes were found to be differentially expressed in various malignancies, and prostate specific antigen (encoded by the KLK3 gene) is the best tumour marker for prostate cancer. Prostate specific antigen has recently been shown to be an independent favourable prognostic marker for breast cancer. KLK15 is newly discovered kallikrein g...

This study was done to assess the oxidative status in children with post-streptococcal acute glomerulonephritis (PSAGN). For this purpose, 32 children with PSAGN during the activity of the disease (group I) and 16 children out of them, 3 months after control of the disease activity (group II) were studied. In addition, 16 age-and sex-matched health...

Abstract: Background: Global LV ejection fraction, a tool for assessment of left ventricular function, is a powerful predictor of prognosis after AMI. Also, serum cTnT, a myocardial contractile protein has been reported to be a sensitive and specific marker for AMI, providing both diagnostic and prognostic information. Aim: to study the ability of...