Mohamed A Akl

The Islamic University, Najaf 54001, Iraq · pharmacuticus

The successful development of atorvastatin calcium-loaded ultraflexible nanovesicles (ATC-UFNVs) in this study offers promising applications for researchers and healthcare professionals. The ability of these nanovesicles to bypass hepatic first-pass metabolism and enhance drug delivery to the skin presents a potential alternative to oral administra...

Transdermal administration techniques have gained popularity due to their advantages over oral and parenteral methods. Noninvasive, self-administered delivery devices improve patient compliance and control drug release. Transdermal delivery devices struggle with the skin's barrier function. Molecules over 500 Dalton (Da) and ionized compounds don't...

Transdermal administration techniques have gained popularity due to their advantages over oral and parenteral methods. Noninvasive, self-administered delivery devices improve patient compliance and control drug release. Transdermal delivery devices struggle with the skin's barrier function. Molecules over 500 Da and ionized compounds don't pass thr...

Treatment of colon diseases presents one of the most significant obstacles to drug delivery due to the inability to deliver sufficient drug concentration selectively to the colon. The goal of the proposed study was to develop, optimize, and assess an effective colon target delivery system of theophylline-based nanovesicles (TP-NVs) surrounded by a...

Atorvastatin calcium (AC), a cholesterol-lowering medication, has limited oral bioavailability (14%) and adverse impacts on the gastrointestinal tract (GIT), liver, and muscle. So, in an effort to improve the poor availability and overcome the hepatotoxicity complications attendant to peroral AC administration, transdermal transfersomal gel (AC-TFG...

Introduction Chitosan and curcumin are natural products that have a wide range of beneficial effects including wound healing. However, their high molecular weight and poor water solubility limit their applications. Aims Therefore, the current study aims to evaluate the effects of chitosan (Cs) and curcumin (Cn) nanoparticles (NPs) on fibrosis and...

Melasma is a chronic recurrent, acquired hyper-melanosis that arises exclusively in sun-exposed areas. With a high recurrence rate, melasma presents a great therapeutic challenge. Conventionally, the cornerstones of melasma therapies have been topical whitening agents and stringent photoprotection. Chemical peels, dermabrasion, and laser treatments...

Luliconazole (LCZ) is a novel topical imidazole medication with broad-spectrum antifungal activity. Unfortunately, the high potential of LCZ for topical antifungal activity is hampered by its low solubility and low skin permeability that required long-term therapy with frequent administration for a full recovery. So, this study aimed to enhance the...

The use of peptide ligand modified PEGylated liposomes has been widely investigated for tumor targeting. Peptides are mainly inserted in the liposomal lipid bilayer using PEG2K-lipid spacer)Peptide-PEG2K-DSPE(. However, a lower cellular uptake from longer nonlinear PEG2K spacer was reported, we here synthesized a high functionality and quality)HFQ(...

The study aimed to investigate the feasibility of incorporation of metoclopramide hydrochloride (MCP HCl) in mucoadhesive thermoreversible liquid suppository (MCP HCl-LS) to bypass the first-pass metabolism and maximize its efficacy to be a promising substitute for parenteral therapy. MCP HCl-LS was formulated using Pluronic (PF127/PF68) and hydrox...

The main objective of this study was to develop, characterize and evaluate the potential use of dapsone-loaded nanostructured lipid carriers (NLCs) as a topical treatment for acne. Differently charged NLC formulations were successfully prepared using an emulsification/sonication method. The particle sizes ranged from 106.2±5.6 nm to 151.3±7.4 nm, a...

The exploitation of curcumin for oral disease treatment is limited by its low solubility, poor bioavailability, and low stability. Surface-functionalized poly-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) have shown promising results to ameliorate selective delivery of drugs to the gastro-intestinal tract. In this study, curcumin-loaded PLGA N...

Tolmetin sodium (TS) is a non-steroidal anti-inflammatory drug (NSAID) indicated for treatment of musculoskeletal issues. As other NSAID, TS displays a marked side effects on the gastro-intestinal (GI) tract after oral administration. Tradational solid suppositories can cause pain and discomfort for patients, may reach the end of the colon; consequ...

We have employed a 23 factorial design approach for optimizing curcumin-loaded PLGA nanoparticles with a specific interest in colon treatment. Curcumin-loaded PLGA nanoparticles were prepared by using the single emulsion solvent evaporation technique. In vitro characterizations of the curcumin-loaded nanoparticles revealed that the mean particle si...

A major limitation in the drug treatment of colon cancer disease is the inability to deliver the drug selectively toward the colon. Nanotechnology-based drug delivery systems have led to an amelioration of the therapeutic selectivity but still the majority of the entrapped drug is eliminated without exercising a therapeutic effect. The purpose of t...