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Mohamad Reza Eskandari

Mohamad Reza Eskandari

M.D, Psychiatrist, Psychotherapist, Toronto, ON

About

22
Publications
2,064
Reads
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252
Citations
Additional affiliations
February 2008 - January 2011
Harvard Medical School
Position
  • PostDoc Position
February 2008 - January 2011
Harvard Medical School
Position
  • PostDoc Position
November 1999 - December 2008
Zanjan University of Medical Sciences
Position
  • Professor (Associate)
Education
October 1996 - July 1999
Iran University of Medical Sciences
Field of study
  • Psychiatry
September 1989 - September 1996

Publications

Publications (22)
Article
Full-text available
Autism spectrum disorders (ASD) are strikingly more prevalent in males, but the molecular mechanisms responsible for ASD sex-differential risk are poorly understood. Abnormally shorter telomeres have been associated with autism. Examination of relative telomere lengths (RTL) among non-syndromic male (N = 14) and female (N = 10) children with autism...
Preprint
Full-text available
A bstract The underlying molecular mechanisms responsible for the etiology of autism and its sex-biased prevalence remain largely elusive. Abnormally shortened telomeres have recently been associated with autism. We have previously shown that children with non-syndromic autism exhibit a sexually dimorphic pattern of relative telomere length (RTL)....
Preprint
Full-text available
Autism spectrum disorders (ASD) are lifelong heterogeneous set of neurodevelopmental conditions with strikingly profound male prevalence. Differences in sex biology and hormones are thought to play key roles in ASD prevalence and outcome, but the underlying molecular mechanisms responsible for ASD sex-differential risk are not well understood. Two...
Article
Full-text available
In this paper, mathematical models have been evaluated using differential equations in order to evaluate the tumor behavior and the main components of the immune system on deal with each other. One of main purposes of mathematical modeling of cancer, which has been discussed here, is finding quality and structure of growth of cancer cells and deter...
Article
Full-text available
Childhood autism is a severe form of complex genetically heterogeneous and behaviorally defined set of neurodevelopmental diseases, collectively termed as autism spectrum disorders (ASD). Reverse transcriptase quantitative real-time PCR (RT-qPCR) is a highly sensitive technique for transcriptome analysis, and it has been frequently used in ASD gene...
Conference Paper
Full-text available
Conclusion: Our findings from the analysis of telomere length in saliva samples taken form drug-naïve patients with non-syndromic childhood autism among the Iranian population are in line with the earlier report by from the Chinese population. Considering significant differences between the two studied populations, the similar findings regarding te...
Chapter
Although genetic and epigenetic codes instruct cellular regeneration that is required to maintain structural integrity and to secure normal functionality of living organisms, food is the main source of materials to construct the building units and the whole structure of an organism. Naturally, any shortage or surplus of these materials may lead to...
Chapter
Schizophrenia (SCZ), a major mental disease, is associated with reduced risk for different types of cancers, with the exception of breast, endometrial and pancreatic cancers. The lower risk of cancer in first-degree relatives of SCZ patients rules out the drug effects as the cause of reduced cancer risk in SCZ. While genetic polymorphisms were attr...
Chapter
Although genetic and epigenetic codes instruct cellular regeneration that is required to maintain structural integrity and to secure normal functionality of living organisms, food is the main source of materials to construct the building units and the whole structure of an organism. Naturally, any shortage or surplus of these materials may lead to...
Conference Paper
Background: Alcohol abuse is the 3rd preventable leading cause of death in the US. In (2001-2002), only 10% of the 18 million Americans with alcohol problem sought treatment and less than 5% received Pharmacotherapy. NIAAA strongly recommends adjunctive pharmacotherapy to the conventional treatment methods and calls for new medication to improve th...
Article
The failure in the discovery of etiology of psychiatric diseases, despite extensive genetic studies, has directed the attention of neuroscientists to the contribution of epigenetic modulations, which play important roles in fine-tuning of gene expression in response to environmental factors. Previously, we analyzed 115 human post-mortem brain sampl...
Article
Several lines of evidence indicate that dysfunction of serotonin signaling and HTR2A receptor are involved in the pathogenesis of schizophrenia (SCZ) and bipolar disorder (BD). DNA methylation of HTR2A at T102C polymorphic site influences HTR2A expression and aberrant DNA methylation of HTR2A promoter was reported in postmortem brain of patients wi...
Article
Huntingtin protein (Htt) interplays with a large numbers of proteins and participates in diverse cellular pathways. Wide variety of Htt binding partners have been identified, including the Htt‐Interacting protein‐1 (HIP1) and Htt‐associated protein‐1 (HAP1). Htt has been shown pro‐apoptotic activity, and malfunctioning of Htt may result in cell out...
Conference Paper
Introduction: Run away Behavior in young girls is a complex social problem in Iranian adolescents. Psychiatric disorders may play an important role in run away behavior in young girls. Method: Homeless young girls between the ages of 12 and 18 years (n = 100) referred to Zanjan Welfare Organization conducted structured clinical interview for DSM a...
Article
Background Stubbornness, disobedience and, talking back to parents may cause parents to be anxious and defiant about their children. Researches suggest that proper parenting has an important role to play in helping children to become adjusted, and that the first few months and years of a child's life are especially important in establishing pattern...
Conference Paper
Introduction: Addicts have two kinds of control factors: external locus of control and internal locus of control. Internal control factors depend on one's personality and causes internal control on addiction. By the external locus of controls patient believe in chance and luck. Patients with internal locus of control try more than other group to tr...
Conference Paper
Full-text available
Objectives: This study aimed to comprehensively study childhood-onset schizophrenia and its treatment response to Clozapine, as they were unresponsive to traditional antipsychotics. Method: Two cases (one seven years girl and one five years boy), with their parents' consent, without any premorbid neurodevelopmental abnormalities (versus previous st...

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Projects

Projects (3)
Project
Gene expression (RT-qPCR) and DNA methylation analysis of candidate genes related to dysregulated biological pathways of the drug naive autistic children.