Mogens Kilian

Mogens Kilian
Aarhus University | AU · Department of Biomedicine

Professor, DMD, D.Sc., Dr.h.c.

About

411
Publications
36,583
Reads
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20,555
Citations
Additional affiliations
August 1991 - present
Aarhus University
Position
  • Professor (Full) of Medical Microbiology
January 1978 - September 1979
University of Alabama at Birmingham
Position
  • Professor

Publications

Publications (411)
Article
Full-text available
Streptococcus pneumoniae and Streptococcus mitis are genetically closely related and both frequently colonise the naso-oropharynx, yet S. pneumoniae is a common cause of invasive infections whereas S. mitis is only weakly pathogenic. We hypothesise that sensitivity to innate immunity may underlie these differences in virulence phenotype. We compare...
Article
Full-text available
Background: The aim of the study was to determine if periodontitis, which often causes transient bacteraemia, associates with viable bacteria in standard blood donations. Materials and methods: This was a cross-sectional study of 60 self-reported medically healthy blood donors aged over 50 years. According to standard procedures, whole blood was...
Article
Full-text available
In common with many bacterial pathogens, Streptococcus pneumoniae has a polysaccharide capsule, which facilitates immune evasion and determines virulence. Recent data has shown that the closely related Streptococcus mitis also express polysaccharide capsules including those with an identical chemical structure to S. pneumoniae capsular serotypes. W...
Preprint
Full-text available
In common with many bacterial pathogens, Streptococcus pneumoniae has a polysaccharide capsule, which facilitates immune evasion and is a key virulence determinant. However, recent data has shown that the closely related Streptococcus mitis can also express polysaccharide capsules including those with an identical chemical structure to S. pneumonia...
Article
It has been proposed that CD4 T-cell responses to Staphylococcus aureus (SA) can inadvertently enhance neoplastic progression in models of skin cancer and cutaneous T-cell lymphoma (CTCL). In this prospective study, we explored the effect of transient antibiotic treatment on tumor cells and disease activity in 8 patients with advanced-stage CTCL. A...
Article
The microbiome and the human body constitute an integrated superorganism, which is the result of millions of years of coevolution with mutual adaptation and functional integration, and confers significant benefits for both parties. This evolutionary process has resulted in a highly diverse oral microbiome, which covers the full spectrum of acidogen...
Article
Full-text available
Objectives: To analyse the epidemiology and genetic evolution of PMEN3 (Spain9V-156), a penicillin-non-susceptible clone of Streptococcus pneumoniae, causing invasive pneumococcal disease (IPD) in Barcelona during 1987-2016. Methods: WGS was performed on 46 representative isolates and the data were used to design additional molecular typing meth...
Article
Full-text available
Liver cirrhosis is a severe disease with major impact on the overall health of the patient including poor oral health. Lately, there has been increasing focus on oral diseases as cirrhosis-related complications due to the potential impact on systemic health and ultimately mortality. Periodontitis is one of the most common oral diseases in cirrhosis...
Article
Full-text available
Encapsulated Haemophilus influenzae strains belong to type-specific genetic lineages. Reliable capsule typing requires PCR, but a more efficient method would be useful. We evaluated capsule typing by using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Isolates of all capsule types (a–f and nontypeable; n...
Data
Additional information on capsule typing of Haemophilus influenzae by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Article
Being the principal causative agent of bacterial pneumonia, otitis media, meningitis and septicemia, the bacterium Streptococcus pneumoniae is a major global health problem. To highlight the molecular basis of this problem, we have portrayed essential biological processes of the pneumococcal life cycle in eight watercolor paintings. The paintings a...
Article
Background: Cutibacterium (Propionibacterium) acnes is assumed to play an important role in the pathogenesis of acne. Objectives: To examine if clones with distinct virulence properties are associated with acne. Methods: Multiple C. acnes isolates from follicles and surface skin of patients with moderate to severe acne and healthy controls wer...
Data
Comparison of classical and non-classical cps2 loci in S. mitis SK137 and SK321. Download
Data
Diagrammatic representation of the type I restriction modification system (SpnD39III) locus involved in regulation of virulence traits in strains of S. pneumoniae, including production of capsular polysaccharide. The comparison with strains of S. mitis and S. oralis demonstrates its absence in representatives of commensal species. Download
Data
Chemical structure of the SK137 teichoic acid-like capsular polysaccharide and suggested functions of proteins encoded by genes located in its cps locus. (A) Structure as reported in reference 16. (B) The same structure presented with a different repeat unit. The Roman numerals I to VII refer to the individual residues. Residues I and VII are the t...
Data
Summary of strains and sequences used in the analysis of cps loci in commensal streptococci and their characteristics.
Data
Annotation of genes in the SK137 cps locus located in the genome between the genes dexB and aliA
Data
Capsular biosynthesis loci (cps) in selected commensal species of the genus Streptococcus
Data
Phylogenetic analysis of selected cps locus genes. (a) Cluster analysis of nucleotide sequences of aliB-like genes in the cps locus of streptococci. The aliC and aliD references are indicated in bold. Note that the aliD genes in S. pneumoniae serotypes 25F, 25A, and 38 are pseudogenes with numerous premature stop codons and gaps. The number followi...
Data
Results of serological analysis by double immunodiffusion of capsular polysaccharides from commensal Streptococcus strains with antisera against 12 selected strains and pneumococcal serotypes.
Article
Importance: Expression of a capsular polysaccharide is among the principal virulence factors of Streptococcus pneumoniae and is the basis for successful vaccines against infections caused by this important pathogen. Contrasting with previous assumptions, this study showed that expression of capsular polysaccharides by the same genetic mechanisms i...
Data
Diagrammatic representation of truncated cps loci in strains of S. mitis, S. oralis, and S. pseudopneumoniae. Download
Data
Proteins encoded by cps loci in commensal Streptococcus species with no or limited homology to proteins in S. pneumoniae
Article
Full-text available
The occurrence and distribution of clinically relevant bacterial virulence genes across natural (non-human) environments is not well understood. We aimed to investigate the occurrence of homologs to bacterial human virulence genes in a variety of ecological niches to better understand the role of natural environments in the evolution of bacterial v...
Article
Full-text available
The occurrence and distribution of clinically relevant bacterial virulence genes across natural (non-human) environments is not well understood. We aimed to investigate the occurrence of homologs to bacterial human virulence genes in a variety of ecological niches to better understand the role of natural environments in the evolution of bacterial v...
Article
Full-text available
For millions of years, our resident microbes have coevolved and coexisted with us in a mostly harmonious symbiotic relationship. We are not distinct entities from our microbiome, but together we form a ‘superorganism’ or holobiont, with the microbiome playing a significant role in our physiology and health. The mouth houses the second most diverse...
Article
The Mitis group of the genus Streptococcus currently consists of 20 formally describes species, including the pathogen S. pneumoniae. They have been the subject of much taxonomic confusion, due to phenotypic overlap and genetic heterogeneity, which has hampered the full appreciation of their clinical significance. The purpose of this study was to c...
Article
The genus Propionibacterium in the family of Propionibacteriaceae constitutes species of various habitats, including mature cheese, cattle rumen and human skin. Traditionally, these species have been grouped as either classical or cutaneous propionibacteria based on characteristic phenotypes and source of isolation. To re-evaluate the taxonomy of t...
Article
Cutaneous T-cell lymphoma (CTCL) is characterized by proliferation of malignant T cells in a chronic inflammatory environment. With disease progression, bacteria colonize the compromised skin barrier and half of CTCL patients die of infection rather than from direct organ involvement by the malignancy. Clinical data indicate that bacteria play a di...
Article
Full-text available
Background: Propionibacterium acnes and Staphylococcus epidermidis live in close proximity on human skin, and both bacterial species can be isolated from normal and acne vulgaris-affected skin sites. The antagonistic interactions between the two species are poorly understood, as well as the potential significance of bacterial interferences for the...
Article
Full-text available
We present a species-wide comparative analysis of 90 genomes of Propionibacterium acnes that represent the known diversity of the species. Our results are augmented by six high-quality genomes and a manual investigation of all gene-sized indels found in the strains. Overall, the order of genes is conserved throughout the species. A public sybil dat...
Article
Full-text available
Cutaneous T cell lymphoma (CTCL) is characterized by proliferation of malignant T cells in a chronic inflammatory environment. With disease progression, bacteria colonize the compromised skin barrier and half of CTCL patients die from infection rather than from direct organ involvement by the malignancy. Clinical data indicate that bacteria play a...
Chapter
Hae.mo' phi.lus. Gr. n. haima blood; Gr. n. philos lover; M.L masc. Haemophilus blood-lover. Proteobacteria / Gammaproteobacteria / Pasteurellales / Pasteurellaceae / Haemophilus Minute to medium-sized coccobacilli or rods, generally less than 1 µm in width and variable in length, sometimes forming threads or filaments and showing marked pleomorphi...
Article
Full-text available
The human and bovine bacterial pathogen Streptococcus agalactiae (Group B Streptococ-cus, GBS) expresses a thick polysaccharide capsule that constitutes a major virulence factor and vaccine target. GBS can be classified into ten distinct serotypes differing in the chemical composition of their capsular polysaccharide. However, non-typeable strains...
Article
Full-text available
The human and bovine bacterial pathogen Streptococcus agalactiae (Group B Streptococ-cus, GBS) expresses a thick polysaccharide capsule that constitutes a major virulence factor and vaccine target. GBS can be classified into ten distinct serotypes differing in the chemical composition of their capsular polysaccharide. However, non-typeable strains...
Article
Streptococcus pneumoniae is a leading cause of pneumonia, meningitis, septicemia, and middle ear infections. The incidence of S. pneumoniae isolates non-susceptible to antibiotics has risen worldwide and may be above 20% in some countries. Beta-lactam antibiotic resistance in pneumococci is associated with significant sequence polymorphism in penic...
Article
Full-text available
The Gram-positive anaerobic bacterium Propionibacterium acnes is a prevalent member of the normal skin microbiota of human adults. In addition to its suspected role in acne vulgaris it is involved in a variety of opportunistic infections. Multi-locus sequence-typing (MLST) schemes identified distinct phylotypes associated with health and disease. B...
Article
Full-text available
The bacterium Streptococcus pneumoniae is one of the leading causes of fatal infections affecting humans. Intriguingly, phylogenetic analysis shows that the species constitutes one evolutionary lineage in a cluster of the otherwise commensal Streptococcus mitis strains, with which humans live in harmony. In a comparative analysis of 35 genomes, inc...
Article
Full-text available
Key Points Staphylococcal enterotoxins stimulate benign T cells to induce activation of the immunoregulatory Stat3/IL-10 axis in malignant T cells. Colonization with enterotoxin-producing Staphylococcus aureus may promote immune dysregulation in cutaneous T-cell lymphoma.
Article
Full-text available
Patients with IgA nephropathy (IgAN) have elevated circulating levels of IgA1 with some O-glycans consisting of galactose (Gal)-deficient N-acetylgalactosamine (GalNAc) with or without N-acetylneuraminic acid (NeuAc). We have analyzed O-glycosylation heterogeneity of naturally asialo-IgA1 (Ale) myeloma protein that mimics Gal-deficient IgA1 (Gd-IgA...
Article
Increasing antibiotic resistance in the population of Propionibacterium acnes is a major concern. Our aims were to examine the clonal relationships and anatomical distribution of resistant and sensitive P. acnes. A collection of 350 P. acnes isolates was therefore used to determine the minimum inhibitory concentration of tetracycline, erythro-mycin...
Article
The third edition of the Handbook of Proteolytic Enzymes aims to be a comprehensive reference work for the enzymes that cleave proteins and peptides, and contains over 800 chapters. Each chapter is organized into sections describing the name and history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguis...
Article
Immunoglobulins (Igs, antibodies) are key players in adaptive immunity, and pathways mediated through the effector Fc portion of Ig are instrumental in controlling bacterial infections. Therefore, it is not very surprising that bacterial pathogens and commensals through co-evolution with their hosts have learned many tricks to interfere with Fc eff...
Article
Full-text available
In patients with cutaneous T-cell lymphoma (CTCL) bacterial infections constitute a major clinical problem caused by compromised skin barrier and a progressive immunodeficiency. Indeed, the majority of patients with advanced disease die from infections with bacteria, e.g., Staphylococcus aureus. Bacterial toxins such as staphylococcal enterotoxins...
Article
Full-text available
The occurrence of 22 bacterial human virulence genes (encoding toxins, adhesins, secretion systems, regulators of virulence, inflammatory mediators, and bacterial resistance) was investigated by nested PCR in beech wood soil, roadside soil, organic agricultural soil, and freshwater biofilm. The presence of clinically relevant bacterial groups known...
Article
Full-text available
Dental decay is one of the most prevalent chronic diseases worldwide. A variety of factors, including microbial, genetic, immunological, behavioral and environmental, interact to contribute to dental caries onset and development. Previous studies focused on the microbial basis for dental caries have identified species associated with both dental he...
Data
Population Structure of Dental Plaque Biofilm Microbiome. The dental plaque microbiome is comprised of a small group of 16 highly abundant OTUs (>1% abundance, blue) followed by 117 OTUs representing moderately abundant phylotypes (>0.1% abundance, green), 500 OTUs representing low abundance phylotypes (>0.01% yellow) and finally a large and incomp...