Moelyono Moektiwardoyo

Universitas Padjadjaran | UNPAD · Department of Biological Pharmacy

Objective: This study aims to find antimalarial candidates from 32 terpenoids and three flavonoid compounds found in miana leaves in silico using plasmepsin protein as a receptor through docking simulations, molecular dynamics simulations, and pharmacokinetic predictions. Methods: The research was conducted in silico through molecular docking simul...

Malaria is a deadly disease that still occurs in some tropical countries. Medicines derived from plant parts have long been used as herbal medicines to treat malaria as part of Indonesian traditional medicine practice. Miana has been used as one of the antimalarial herbs by the South Sulawesi community. This study describes the in-silico study by t...

Objective: Noni fruit (Morinda citrifolia L) and cinnamon bark (Cinnamomum burmannii) are plants that have the hypoglycemic effect on their ethyl acetate fraction in the single dose. This study was to determine the hypoglycemic activity of the combination of ethyl acetate fraction (FEM) and cinnamon bark (FEC) in glucose-induced mice, as well as th...

The aim of this study was to investigate medicinal plants used to treat malaria by a society in Pamotan village, Pangandaran Regency, West Java Province, Indonesia. The work was conducted using the Participatory Rural Appraisal (PRA) method, which is an assessment process-oriented to active community involvement in the form of direct interview acti...

Virus influenza A (H5N1) merupakan wabah utama yang berpotensi menyebabkan epidemik di seluruh dunia. Telah ditemukan banyaknya kasus resistensi terhadap obat antivirus influenza A sehingga penggunaannya mulai dibatasi. Oleh karena itu, perlu dilakukan penelitian untuk melakukan pengembangan obat baru yang lebih efektif dan aman untuk melawan virus...

Malaria is a major infectious disease caused by Plasmodium sp., and it can infect human's trough females' mosquitos Anopheles sp. bite. Plasmodium resistance to malarial drugs used today occurs mostly in endemic areas, so it is necessary to look for alternative medicines for malaria, especially medicines derived from plants Objective: The objective...

Malaria is a disease that occurs in tropical countries like Indonesia. The incidence of malaria in the world is still quite high and the occurrence of cases of Plasmodium resistance to antimalarial drugs and the widespread of resistance have prompted researchers to look for new antimalarial drugs, especially from natural materials. Betel leaf (Pipe...

Objective: This study was purposed to assess the anti-shigellosis activity of the soybean leaves (Glycine max (L.) Merrill) ethanol extracts on Shigella dysenteriae ATCC13313. Materials and Methods: The dried soybean leaves were extracted using 70% ethanol by a maceration method. Phytochemical analysis was performed by the standard assays and the t...

Aim: The aim of this study was to investigate the immunomodulatory activity of the ethanolic extract and fractions (n-hexane, ethyl acetate, and water fraction) obtained from Plectranthus scutellarioides (L.) R.Br. leaves which employed in the immunity experimental model. Materials and Methods: The cellular immunity was conducted by a carbon cleara...

The pharmacological activities of Plecranthus sp include anti-oxidant, antimicrobial, inhibition on cyclooxygenase (COX) and xanthine oxidase, and cytotoxic activity. The aim of this work was to study the antipyretic activity of P. scutellarioides (L.) extract on animal model. Twenty seven Swiss Webster male mice were divided into nine groups and w...

The compilation of the research on Jawer Kotok (Plectranthus scutellarioides (L.)R.Br. starting from ethnopharmacy, standardised extract of the leaves, volatile oils of the leaves, and activity of the leaves extract covers anti-microbes, anti- inflammation, anti-piretic, anti-oxidants, anti-hiperglicemic, anti-hyperlipidemic, cytotoxic activity to...

Lycopersicon esculentum leaves had traditionally been used to stimulate hair growth in Lampung Pesisir tribes, Tanggamus Regency, Lampung, Indonesia. This study aimed to examine the active compounds from the n-hexane L. esculentum leaves. The study based on our previous research showing that the n-hexane had hair growth stimulating effects. The stu...

ABSTRAK. Tanaman obat merupakan salah satu kekayaan alam Indonesia. Pengetahuan mengenai tanaman obat berkhasiat seyogyanya perlu dimiliki oleh masyarakat Indonesia sejak usia muda agar kelak masyarakat dapat memanfaatkan tanaman obat berdasarkan pengetahuan yang sudah dimiliki. Berdasarkan pengamatan, daerah desa Babakan merupakan daerah pesantren...

Hair loss is a hair problem that often occurs in every individual. Side effects caused by the use of synthetic drugs cause herbal remedies to be an option in overcoming hair loss and to stimulate hair growth. Rampai leaves (Lycopersicon esculentum Mill.) has traditionally been used to stimulate hair growth in the Lampung tribe. This study aim was t...

Gedi (Abelmoschus manihot L.) is a plant from Malvaceae family studied for variety of activities including anti-inflammatory. Empirically, Gedi leaves were used as anti-inflammatory with topical administration. Study of topical anti-inflammatory activity from the ethanolic extract of Gedi leaves (Abelmoschus manihot L.) in topical gel preparation o...

Crotalaria pallida Aiton (C. pallida Aiton) is empirically used as dietary supplement to treat cancer by the people of North Sulawesi. However, its scientific pharmacology activity has not been explored yet. Therefore, this study was conducted to evaluate anti-proliferative activity of C. pallida Aiton on MCF-7 breast cancer cells. The extraction o...

Drugs consultation by pharmacist is an important service to improve the quality of medication use in patients with type 2 diabetes mellitus (T2DM). Perception of patients regarding this service is very useful to boost pharmacists confidence to conduct such service. The purpose of this study is to provide an overview regarding interests and categori...

Objective: This study aims to isolate, identify and characterize determine and verify of essential oil of Iler leaves (Plectranthus scutellarioides (L.) R.Br. Methods: Iler (Indonesian), P.scutellarioides, obtained from Lembang Plantation, Bandung, West Java. Isolation of essential oils based on methods of sterilization by distillation with Stahl a...

The aim of this study is to investigate the active fraction of Curcuma zedoaria ethanol extracts against Aspergillus niger. The simplisia of C. zedoaria rhizome was extracted with ethanol using a maceration method. The phytochemical screening of ethanol extract was performed to detect antifungal secondary metabolites. All of the antifungal activity...

Quality of crude drug extract of coffee bean (Coffeea arabica L.) determined by the value of crude drug and extract standard parameter. In this research, coffee bean derived from Pangalengan, Garut, and Tasikmalaya. Standard parameters determined consisted of non-specific parameters and specific parameters. The results of crude drug determination o...

Drugs consultation by pharmacist is an important service to improve the quality of medication use in patients with type 2 diabetes mellitus (T2DM). Perception of patients regarding this service is very useful to boost pharmacists confidence to conduct such service. The purpose of this study is to provide an overview regarding interests and categori...

The research of decoction of lia berueng (Zingiber zerumbet) rhizomes, a herbal medicine using by Kutai sub ethnic, West Kalimantan, Indonesia, as the inhibitor of the cyclooxygenase (COX) enzyme in vitro has been done. In vitro anti-inflammatory activity of COX-1 and COX-2 enzymes used TMPD (N,N,N',N'-tetramethyl-p-phenylediamine) by spectrophotom...

AbstrakSenyawa triterpenoid damaran, damara-20,24-dien-3-on telah diisolasi dari kulit batang Chisocheton Marcrophyllus (Meliaceae). Struktur kimia kedua senyawa tersebut telah ditetapkan berdasarkan data spektroskopi dan perbandingan data spektra yang diperoleh dari literatur. Senyawa damara-20,24-dien-3-on menunjukkan aktivitas sitotoksik terhada...

There are a lot of natural resources that potentially used as herbal medicines in Indonesia. Some of the herbs, like Dewa leaves (Gynura pseudochina (L) D.C) and temu ireng rhizome (Curcuma aeruginosa Roxb.), were ussually used to increase number of thrombocytes in dengue patient. This current study was to determine the potential of dewa leaves (Gy...

The aim of this study was to obtain prediction docking properties as well as information regarding pharmacokinetic properties of oral absorption, distribution, metabolism, and toxicity (ADMET) using in silico methods of some potential anti-cancer compounds normally derived from plants. Our previous study proved that quercetin, casticin, β-sitostero...

Introduction: Andaliman (Zanthoxylum acanthopodium DC.) is spices from North Sumatra that have potent as aromatherapy material. Objective: The objective study is to evaluate the inhibitory effect of Andaliman (Zanthoxylum acanthopodium DC.) fruits essential oil on the locomotor activity of mice in a wheel cage Methods: The study on analysing of ess...

Pemanfaatan bahan alam yang berpotensi sebagai obat di pekarangan rumah pendudukterdorong oleh adanya pemahaman yang benar mengenai obat herbal. Potensi desa di Kabupaten Garut, yaitu Desa Sukamaju dan Desa Girijaya memberikan peluang yang besar untuk dikembangkannya hal tersebut. Dalam hal ini, kegiatanPengabdian kepada Masyarakat Program Integrat...

Oncom ethanol extracts in our previous study contains geneistein which is a potent flavonoid antioxidants and anti-cancer activity. This study is a series of studies to prove that oncom, a traditional Indonesian food, has antioxidant properties, anti-inflammatory and anti-cancer properties. Anti-inflammatory properties are also our previous report....