Modesto T López-López

Modesto T López-López
University of Granada | UGR · Department of Applied Physics

PhD

About

145
Publications
16,403
Reads
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3,009
Citations
Citations since 2017
55 Research Items
1757 Citations
20172018201920202021202220230100200300
20172018201920202021202220230100200300
20172018201920202021202220230100200300
20172018201920202021202220230100200300
Additional affiliations
August 2012 - present
University of Granada
Position
  • Professor (Associate)
June 2006 - May 2008
University of Nice Sophia Antipolis
Position
  • PostDoc Position

Publications

Publications (145)
Article
Full-text available
We investigated the effect of partial dehydration under mechanical stress in the properties of alginate hydrogels. For this aim, we characterized the mechanical properties of the hydrogels under tensile and shear stress, as well as their swelling behavior, macroscopic appearance, and microscopic structure. We found that the processes of dehydration...
Article
Objective To investigate the effect of novel polymeric nanoparticles (NPs) doped with dexamethasone (Dex) on viscoelasticity, crystallinity and ultra-nanostructure of the formed hydroxyapatite after NPs dentin infiltration. Methods Undoped-NPs, Dex-doped NPs (Dex-NPs) and zinc-doped-Dex-NPs (Zn-Dex-NPs) were tested at dentin, after 24 h and 21 d....
Article
Most recent advances in the synthesis of supramolecular hydrogels based on low molecular weight gelators (LMWGs) have focused on the development of novel hybrid hydrogels, combining LMWGs and different additives. The dynamic nature of the noncovalent interactions of supramolecular hydrogels, together with the specific properties of the additives in...
Article
Full-text available
Sonocrystallization implies the application of ultrasound radiation to control the nucleation and crystal growth depending on the actuation time and intensity. Its application allows to induce nucleation at lower supersaturations than required under standard conditions. Although extended in inorganic and organic crystallization, it has been scarcel...
Article
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Self-assembled peptides and proteins have turned out to be excellent templates for the growth of inorganic minerals trying to emulate natural biomineralization processes. Doing this, researchers have developed complex sophisticate...
Article
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The inclusion of magnetic nanoparticles (MNP) in a hydrogel matrix to produce magnetic hydrogels has broadened the scope of these materials in biomedical research. Embedded MNP offer the possibility to modulate the physical properties of the hydrogel remotely and on demand by applying an external magnetic field. Moreover, they enable permanent chan...
Article
In this paper, we study the shear-induced flow of magneto-polymer composites, consisting of dispersions of magnetic particles in solutions of polymers, as a competition between the colloidal forces amid particles and their bulk transport induced by the hydrodynamic forces. For this aim, we analyse the role of different experimental parameters. Firs...
Article
Objective: To investigate the effect of novel polymeric nanoparticles (NPs) doped with melatonin (ML) on nano-hardness, crystallinity and ultrastructure of the formed hydroxyapatite after endodontic treatment. Methods: Undoped-NPs and ML-doped NPs (ML-NPs) were tested at radicular dentin, after 24 h and 6 m. A control group without NPs was inclu...
Article
The field of soft actuators is dominated by elastomers that experience mechanical deformations in response to external stimuli. In this context, magnetic stimuli attract considerable interest because of their easy application, tunability, fast response, remote actuation, and safe penetration in biological environments. Since very recently, research...
Article
Making use of the combination of multiparametric Fluorescence Lifetime Imaging Microscopy (FLIM) and single-molecule Fluorescence Lifetime Correlation Spectroscopy (FLCS), we have been able to study for the early stages of the fluorenylmethyloxycarbonyl-diphenylalanine (Fmoc-FF) self-assembly process with single-molecule resolution, the kinetics of...
Data
List of contributors for the Book named "Magnetic Nanoparticle-Based Hybrid Materials" by Woodhead Publishing Series in Electronic and Optical Materials, 2021, Pages xv-xxi.
Article
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Protein therapeutics have a major role in medicine in that they are used to treat diverse pathologies. Their three-dimensional structures not only offer higher specificity and lower toxicity than small organic compounds but also make them less stable, limiting their in vivo half-life. Protein analogues obtained by recombinant DNA technology or by c...
Article
This study embraces the evaluation of the rheological and magneto-rheological properties of heavy and extra-heavy crude oils by applying nanotechnology and magnetism as technological solutions in reducing viscosity. Mixtures of heavy oils with ferrofluids were used to study the viscous effects induced by the action of external magnetic fields. The...
Chapter
Hydrogels are used in biomedical applications because of their high water content, their porosity, and the ability to easily modify their properties (mechanical, chemical, microstructure, etc.). Hydrogels are the materials that most resemble the extracellular matrix of mammals. In recent years, magnetic hydrogels have become especially important. T...
Article
We have investigated the co-self-assembly, in water and at room temperature, of different aromatic short-peptides containing Fmoc- (Fluorenylmethyloxycarbonyl-) and Nap- (2-(naphthalen-2-yloxy)acetyl) groups having also different chirality. Using a combination of...
Article
Novel artificial tissues with potential usefulness in local-based therapies have been generated by tissue engineering using magnetic-responsive nanoparticles (MNPs). In this study, we performed a comprehensive in vivo characterization of bioengineered magnetic fibrin-agarose tissue-like biomaterials. First, in vitro analyses were performed and the...
Article
Iron/silica core-shell microparticles (IMPs) were functionalized by different functional groups including amine, glycidoxy, phenyl, and thiocyanate. Many of the IMPs modifications are reported for the first time. The resulting surface chemistry turned out to affect the properties of magnetic alginate hydrogels fabricated from sodium alginate and di...
Article
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Generation of biocompatible and biomimetic tissue-like biomaterials is crucial to ensure the success of engineered substitutes in tissue repair. Natural biomaterials able to mimic the structure and composition of native extracellular matrices typically show better results than synthetic biomaterials. The aim of this study was to perform an in vivo...
Article
Magnetic hydrogels (ferrogels) are soft materials with a wide range of applications, especially in biomedicine because (i) they can be provided with the required biocompatibility; (ii) their heterogeneous structure allows their use as scaffolds for tissue engineering; (iii) their mechanical properties can be modified by changing different design pa...
Article
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Even in the absence of cross-linking, at large enough concentration, long polymer strands have a strong influence on the rheology of aqueous systems. In this work, we show that solutions of medium molecular weight (120 000–190 000 g mol ⁻¹ ) alginate polymer retained a liquid-like behaviour even for concentrations as large as 20% w/v. On the contra...
Article
The encapsulation of cells into biopolymer matrices enables the preparation of engineered substitute tissues. Here we report the generation of novel 3D magnetic biomaterials by encapsulation of magnetic nanoparticles and human hyaline chondrocytes within fibrin-agarose hydrogels, with potential use as articular hyaline cartilage-like tissues. By rh...
Article
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This study investigated the steady shear flow and viscoelastic properties of composite materials elaborated by introduction of positively charged polyol-made maghemite nanoparticles (NPs) in aqueous solutions of negatively charged sodium alginate polymers. Two different ligands were covalently attached to the particle surface, the 3-aminopropyl tri...
Article
Objective: To investigate crystallinity and ultrastructure of the formed hydroxyapatite at radicular cervical and apical dentin after being treated with three different canal sealers. Methods: Cervical and apical root dentin surfaces were treated with two experimental hydroxyapatite-based sealers, containing sodium hydroxide (calcypatite) or zin...
Article
The effectiveness of novel polymeric nanoparticles (NPs) application in reducing dentin permeability and facilitating dentin remineralization after endodontic treatment was evaluated. The effect of undoped NPs, zinc, calcium and doxycycline-doped NPs (Zn-NPs, Ca-NPs and D-NPs, respectively) was tested in radicular dentin. A control group without NP...
Cover Page
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Inside cover of the article: Atmospheric water triggers supramolecular gel formation of novel low molecular weight maslinic and oleanolic triterpenic derivatives
Cover Page
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The cover features a lysozyme crystal with an incorporated hydrogel that can protect the enzyme against local radiation damage from radicals generated by X-rays.
Article
Pentacyclic triterpenes have a rigid lypophilic backbone decorated with polar functional groups such as hydroxyl, carbonyl and carboxyl, which make them attractive natural amphiphiles. The ability of this type of compounds to self-assemble into complex nanostructures has recently gained interest due in part to the abundant existing renewable feedst...
Article
Lysozyme crystals grown in Fmoc-CF hydrogels, unlike those grown in agarose, give rise to compo-site crystals that have an enhanced resistance against degradation caused by an intense exposure to X-ray irradiation. Fmoc-CF dipeptide shows a clear protection of the most sensitive groups (di-sulfide bonds and methionines) of the protein. The protecti...
Article
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Short-peptide supramolecular (SPS) hydrogels are a class of materials that have been found to be useful for (bio)technological applications thanks to their biocompatible nature. Among the advantages reported for these peptides, their economic affordability and easy functionalization or modulation have turned them into excellent candidates for the d...
Article
We present results of theoretical study of magnetorheological effect in ferrogels with magnetizable spherical particles chaotically distributed in a current gel. To avoid intuitive constructions with uncontrolled accuracy and adequacy, the analysis is done in the frames of the mathematically regular pair approximation. Our results demonstrate non m...
Article
Full-text available
Magnetic gels (ferrogels) are heterogeneous systems structured at the nanoscale that contains magnetic particles dispersed in three-dimensional networks of polymer chains. In the present work, the magnetic particles were synthesized with a core–shell structure, consisting of sepiolite particles covered by magnetite nanoparticles. These composite pa...
Article
Anisotropy is an intrinsic feature of most of the human tissues (e.g. muscle, skin or cartilage). Because of this, there has been an intense effort in the search of methods for the induction of permanent anisotropy in hydrogels intended for biomedical applications. The dispersion of magnetic particles or beads in the hydrogel precursor solution pri...
Article
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Background The aim was to evaluate the effect of silver loaded nanoparticles (NPs) application on the triboscopic, crystallographic and viscoelastic properties of demineralized dentin. Polymethylmetacrylate-based NPs and Ag loaded NPs were applied on demineralized dentin. Material and Methods Treated and untreated surfaces were probed by a nanoind...
Article
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Novel reinforced cross‐linked lysozyme crystals containing homogeneous dispersions of single‐walled carbon nanotubes bundles (SWCNTs) are produced and characterized. The incorporation of SWCNTs inside lysozyme crystals gives rise to reinforced composite materials with tunable mechanical strength and electronic conductivity, while preserving the cry...
Article
The paper deals with theoretical study of effect of ferrogels uniaxial elongation on magnetic susceptibilities of these composite materials. We have considered the systems with magnetically soft ellipsoidal and spherical particles. The results show that elongation of the composites with the ellipsoidal particles enhances the susceptibility in the d...
Article
Magnetorheological (MR) effect is a phenomenon typical of suspensions of magnetizable particles in a liquid carrier, characterized by strong changes of their mechanical properties in response to applied magnetic fields. Its origin is on the migration of magnetized particles and their aggregation into chain-like structures. However, for ferrogels, c...
Article
Full-text available
We report an experimental and theoretical study of the rheological properties of magnetic biogels consisting of fibrin polymer networks with embedded magnetite nanoparticles, swollen by aqueous solutions. We studied two types of magnetic biogels, differenced by the presence or absence of an applied magnetic field during the initial steps of cross-l...
Article
The aim of this research was to ascertain the mechanical and chemical behavior of sound and caries-affected dentin (CAD), after the placement of Zn-free vs containing amalgam restorations. Peritubular and intertubular dentin were evaluated using, a) nanoindenter in scanning mode; the load and displacement responses were used to perform the nano-Dyn...
Article
Magnetic hydrogels are becoming increasingly in demand for technical and biomedical applications, especially for tissue engineering purposes. Among them, alginate-based magnetic hydrogels emerge as one of the preferred formulations, due to the abundance, low cost, and biocompatibility of alginate polymers. However, their relatively slow gelation ki...
Article
Full-text available
Suspensions of bentonite clays are usually employed at industrial scale in different processes as drilling fluids as well as adsorbents for removing pollutants in muds or natural waters. For these purposes, avoiding the gravitational settling of the particles is a requirement for achieving a high efficiency and a low cost operation. Unfortunately,...
Article
Full-text available
Generation of biomimetic and biocompatible artificial tissues is the basic research objective for tissue engineering (TE). In this sense, the biofabrication of scaffolds that resemble the tissues' extracellular matrix (ECM) is an essential aim in this field. Uncompressed and nanostructured fibrin-agarose hydrogels (FAH and NFAH respectively) emerge...
Article
Aim: To investigate if crystallinity and ultrastructure is modified when cervical dentine is treated with four different nanogels-based solutions for remineralizing purposes. Methodology: Experimental nanogels based on polymeric nanoparticles (NPs) and zinc, calcium, or doxycycline-loaded NPs were applied on citric acid etched dentine to facilit...
Article
Micron-sized particles (microbeads) dispersed in a suspension of magnetic nanoparticles, i.e., ferrofluids, can be assembled into different types of structures upon application of an external magnetic field. This paper is devoted to theoretical modeling of a relative motion of a pair of microbeads (either soft ferromagnetic or diamagnetic) in the f...
Article
Two types of PHEMA-based particles, exhibiting either carboxyl or tertiary ammine functional groups, were incorporated to fibrin-agarose hydrogels, and the effect of the addition of these synthetic particles on the viscoelastic and microstructural properties of the biomaterials was evaluated. Experimental results indicated that the incorporation of...
Article
Full-text available
A novel torsional wave sensor designed to characterize mechanical properties of soft tissues is presented in this work. Elastography is a widely used technique since the 1990s to map tissue stiffness. Moreover, quantitative elastography uses the velocity of shear waves to achieve the shear stiffness. This technique exhibits significant limitations...
Article
The paper deals with theoretical study of elastic shear properties of a magnetic gel, consisting of spherical magnetizable particles, randomly (gas-like) distributed in an elastic matrix. We suppose that the composite is placed in a magnetic field, perpendicular to the direction of the sample shear. In order to get mathematically rigorous results,...
Article
The paper deals with a theoretical study of the effective shear modulus of a magnetic gel, consisting of magnetizable particles randomly and isotropically distributed in an elastic matrix. The effect of an external magnetic field on the composite modulus is the focus of our consideration. We take into account that magnetic interaction between the p...
Article
Full-text available
The aim of this study was to evaluate the changes in the mechanical behavior and bonding capability of Zn-doped resin-infiltrated caries-affected dentin interfaces. Dentin surfaces were treated with 37% phosphoric acid (PA) followed by application of a dentin adhesive, single bond (SB) (PA+SB) or by 0.5 M ethylenediaminetetraacetic acid (EDTA) foll...
Article
We analyze the effect of nanoparticle concentration on the physical properties of magnetic hydrogels consisting of polymer networks of human fibrin biopolymer with embedded magnetic particles, swollen by a water-based solution. We prepared these magnetic hydrogels by polymerization of mixtures consisting mainly of human plasma and magnetic nanopart...
Article
We study the effect of wall slip on the measured values of the yield stress of magnetorheological (MR) fluids. For this aim we used a rheometer provided with parallel-plate geometries of two types, distinguished by having smooth or rough surfaces. We found that wall slip led to the underestimation of the yield stress when measuring geometries with...
Article
Here we report the synthesis and structural characterization of novel iron nanoparticles (FeNPs)-based short-peptide supramolecular hydrogels. These hybrid hydrogels composed of Fmoc-diphenylalanine (Fmoc-FF) peptide and FeNPs were prepared through the self-assembly of Fmoc-FF in a suspension containing FeNPs in the presence or absence of an extern...
Article
Full-text available
The generation of biomaterials with adequate biomechanical and structural properties remains a challenge in tissue engineering and regenerative medicine. Earlier research has shown that nanostructuration and cross-linking techniques improved the biomechanical and structural properties of different biomaterials. Currently, uncompressed and nanost...
Article
The aim of this research was to assess the ability of amalgam restorations to induce amorphous mineral precipitation at the caries-affected dentin substrate. Sound and caries-affected dentin surfaces were subjected to both Zn-free and Zn-containing dental amalgam restorations. Specimens were submitted to thermocycling (100,000 cycles/5°C–55°C, 3 mo...
Article
Full-text available
Magnetopolymer materials such as ferrogels, magnetic hydrogels and magnetic elastomers are new kind of smart materials, whose physical and mechanical properties can be controlled by an external magnetic field. They have several technological applications. We present an overview of experimental, theoretical and computer studies of magentomechanical...
Article
(FREE ACCESS LINK: https://authors.elsevier.com/a/1UlC415Kga~VLU) A hydrogel is a 3-D network of polymer chains in which water is the dispersion medium. Hydrogels have found extensive applications in the biomedical field due to their resemblance to living tissues. Furthermore, hydrogels can be endowed with exceptional properties by addition of synt...
Article
The study addresses the phenomenon of mechanoelectrical transduction in polyelectrolyte hydrogels and, in particular, the search of the driving force for the change of the electrical potential of a gel under the applied mechanical stretch. Polyelectrolyte gels of calcium and magnesium salts of polymethacrylic acid were synthesized by the radical po...
Article
The aim of this study was to ascertain the crystal morphology and to assess the ultrastructure and texture changes of sound (SD) and caries-affected dentin (CAD) after being restored with Zn-free and Zn-containing amalgam. Dentin surfaces were studied before amalgam placement and after amalgam removal by X-ray diffraction (μXRD2) and transmission e...
Article
Full-text available
The inclusion of magnetic nanoparticles into biopolymer matrixes enables the preparation of magnetic field-responsive engineered tissues. Here we describe a synthetic route to prepare biocompatible core-shell nanostructures consisting of a polymeric core and a magnetic shell, which are used for this purpose. We show that using a core-shell architec...
Article
Full-text available
We investigate the rheograms of concentrated suspensions of magnetic particles obtained under imposed shear rate in parallel plate geometry. We show that under magnetic field application the usual trend of the rheogram, i.e., increasing shear stress for the whole range of shear rates, is altered by the appearance of a region in which the shear stre...
Article
The paper deals with theoretical study of deformation of a ferrogel filled by magnetizable particles united in the chain-like aggregates. The sample is placed in a magnetic field parallel to the chains. Uniaxial elongation of the sample along the field is studied. Analysis shows that interaction of the particles in the chains and rupture of the cha...
Book
Full-text available
In this work we review our recent experimental and theoretical results on the flow instabilities observed in magnetorheological (MR) fluids subjected to applied magnetic fields. We study three types of MR fluids, consisting of suspensions of respectively silica-coated iron particles, carbonyl iron particles and CoNi fibers dispersed in a liquid car...
Article
The aim of this research was to assess the influence of mechanical loading on the ability of Zn-free versus Zn -containing amalgams to promote remineralization at the dentin interface. Sound and caries-affected dentin surfaces (CAD) were restored using Zn-free or Zn-containing dental amalgams. Midcoronal dentin surfaces were studied by (1) atomic f...
Article
The aim of this study was to evaluate the induced changes in mechanical behavior and bonding capability of resin-infiltrated dentine interfaces, after application of mechanical stimuli. Dentine surfaces were subjected to partial demineralization through 37% phosphoric acid etching followed by the application of an etch-and-rinse dentine adhesive, S...
Article
Magnetic field (MF)-directed assembly of colloidal particles provides a step towards the bottom-up manufacturing of smart materials whose properties can be precisely modulated by non-contact forces. Here, we study the MF-directed assembly in binary colloids made up of strong ferromagnetic and diamagnetic microparticles dispersed in ferrofluids. We...
Article
Full-text available
We report the preparation of novel magnetic field-responsive tissue substitutes based on biocompatible multi-domain magnetic particles dispersed in a fibrin – agarose biopolymer scaffold. We characterized our biomaterials with several experimental techniques. First we analyzed their microstructure and found that it was strongly affected by the pres...
Article
Full-text available
In this work, we have studied the magnetorheological (MR) fluid rheology in the magnetic field parallel to the fluid vorticity. Experimentally, the MR fluid flow was realized in the Couette coaxial cylinder geometry with the magnetic field parallel to the symmetry axis. The rheological measurements were compared to those obtained in the cone-plate...
Article
A theoretical model of magnetoviscous effect in a suspension of nonBrownian linearly magnetizable particles is suggested. A simple shear flow in the presence of an external magnetic field aligned with the velocity gradient is considered. Under the action of the applied field, the particles are supposed to form dense highly elongated droplike aggreg...