Mkolo N.M.- Doctor of Philosophy
- Professor (Associate) at Sefako Makgatho Health Sciences University
Mkolo N.M.
- Doctor of Philosophy
- Professor (Associate) at Sefako Makgatho Health Sciences University
Looking for African collaborators to work on Anti-SARS-COV 2 using plant based product.
About
21
Publications
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Citations
Introduction
Current institution
Publications
Publications (21)
Exercise is one of the main challenges to the body’s homeostasis since it needs an immediate, substantial rise in ATP re-synthesis, which leads to the prevention of response capacity and performance of players. Therefore, it is vital to monitor sweat metabolites in soccer players during vigorous exercise to comprehend their functional variations. T...
Coronavirus disease (COVID-19) is still a severe concern, especially in Africa with suboptimal intention rates of vaccination. This flagged the requirement of plant-based remedies as an alternative treatment. In this study we integrated metabolomics and chemometrics approaches with In silico and In vitro approaches to accelerate and unravel compoun...
The valuation of neuroblastoma research heterogeneity at African country level is unspecified. Therefore, the study assesses the heterogeneity of neuroblastoma research in 54 African countries and develops recommendations for national cancer-control plans. Metadata of peer-reviewed scientific publications allied to African neuroblastoma research we...
Background: Artificial intelligence (AI) and digital technology, as advanced human-created tools, are influencing the healthcare sector.Aim: This review provides a comprehensive and structured exploration of the opportunities presented by AI and digital technology to laboratory diagnostics and management of communicable and non-communicable disease...
The expected progress in SARS-CoV-2 vaccinations, as anticipated in 2020 and 2021, has fallen short, exacerbating global disparities due to a lack of universally recognized “safe and effective” vaccines. This study focuses on extracts of South African medicinal plants, Artemisia annua and Artemisia afra, to identify metabolomic bioactive compounds...
The dietary habits of seals play a pivotal role in shaping management and administration policies, especially in regions with potential interactions with fisheries. Previous studies have utilized various methods, including traditional approaches, to predict seal diets by retrieving indigestible prey parts, such as calcified structures, from intesti...
Objective
To determine the prevalence of tick-borne pathogens with a particular focus on Rickettsia spp. in ticks collected from cattle in Gauteng and Limpopo Provinces, South Africa.
Methods
A total of 200 ticks were collected from cattle within the Madala livestock, Pretoria, Gauteng Province and in Mankweng Township, Polokwane, Limpopo Province...
Background
Previous studies in our laboratory in ex vivo assays have demonstrated H. hemerocallidea extract as potential antidiabetic agent through increased insulin release from pancreatic beta cells. Thus, for this study the early stage type II spontaneous diabetic mutant mice model was used to evaluate and determine the degree of the antidiabeti...
![Chemical structure of naringenin (Álvarez-Álvarez et al. [34]).](publication/360650555/figure/fig1/AS:11431281393952348@1745424412017/Chemical-structure-of-naringenin-Alvarez-Alvarez-et-al-34_Q320.jpg)
Englerophytum magalismontanum, a medicinal plant with ethnopharmacology use, has a dearth of information regarding its antidiabetic properties. This study evaluated the crude methanol leaf extract of E. magalismontanum and its fractions for total phenolic content, antioxidant activity, and digestive enzymes (α-amylase and α-glucosidase) inhibitory...
The advancement of the livestock farming in sub-Saharan Africa is restricted by tick infestation. With conventional pesticides posing a threat to human and the environment, natural products are alternative anti-tick source. This study characterized the essential oils from Tithonia diversifolia, Lavandula angustifolia and Cymbopogon citratus leaves...
Objectives
As microorganisms are developing resistance to therapies, the search for potent antimicrobial compounds continues. The potential of detecting new compound(s) with antimicrobial activities from extracts of Artemisia afra, a South African plant frequently used for the treatment of diseases and widely traded in the market was explored. A. a...
Hypoxis hemerocallidea is wild harvested and widely used due inter alia to its strong antioxidant activity. Antioxidant activity is linked to plant stressors like soil heavy metals concentrations and pH. If high antioxidant activity is caused by heavy metals stressing the plant, the plant may not be completely safe. Soils and H. hemerocallidea corm...
Traditionally Elephantorrhiza elephantina is used in Southern Africa for treating ailments with over utilisation of the roots, placing the plant on the Red Data List. Consequently, the leaf is proposed as alternative for preservation and sustainable use. However, there is a dearth of information on the leaves’ biological activity and no report on t...
Biological and medicinal properties of plants
Medicinal plants are important in the treatment of human diseases. The medicinal properties of plants are attributed to the presence of secondary plant metabolites. Polyphenols, particularly fl avonoids, are phytochemicals that possess antioxidant and anti-infl ammatory activity, and modulate pathways involved in obesity and glucose metabolism. In...
Contamination of soils around mines by heavy metals has not yet received the serious attention that it
deserves in South Africa. The current study evaluated the concentrations and levels of pollution by trace metals in soils around a Ferro-chromium mine in South Africa. Soil samples were collected from 20 locations in
four different directions, nam...
Contamination of soils around mines by heavy metals has not yet received the serious attention that it deserves in South Africa. The current study evaluated the concentrations and levels of pollution by trace metals in soils around a Ferro-chromium mine in South Africa. Soil samples were collected from 20 locations in four different directions, nam...
The repellency effects of Mentha piperita leaves, collected from two different locations in South Africa, (Ga-Rankuwa and Malelane) on adults of Amblyomma hebreaum were studied. Leaves extraction was carried out using two different solvents (dichloromethane (DCM) and ethylacetate) to make concentrations of 0.24 g/10 ml, 0.24 g/15 ml and 0.24 g/20 m...
The study investigated the uptake and translocation pattern of trace metals from two different plant species from a waste dump site in Pretoria,
South Africa. Datura stramonium is used as an anti-asthmatic treatment and Amaranthus spinosus may either be used as a medicinal herb or
consumed as a vegetable. The trace metal contents from different par...
The repellent effects of the essential oil of Lavendula angustifolia on adults of Hyalomma marginatum rufipes was studied at concentrations of 5, 10 and 20% v/v. A suitable tick climbing bioassay based on the questing behaviour of ticks was used to test for repellency. High percentage repellency (range 70-100) was shown at all concentrations of the...
The toxicity and repellency effects of essential oils of M. piperita and M. spicata at concentrations of 5%, 10% and 20% v/v were evaluated against adults of Amblyomma hebraeum using fumigant toxicity and glass plate repellency bioassays. The feeding deterrent of essential oils of M. piperita and M. spicata on larvae of Amblyomma hebraeum was also...
