Mizanur Rahman

Mizanur Rahman
Evercare Hospital Dhaka · Molecular Diagnostics

MBBS, PhD
Genome analysis of SARS-Cov-2, influenza, dengue, chikungunya virus in Bangladesh

About

37
Publications
7,233
Reads
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271
Citations
Citations since 2017
24 Research Items
156 Citations
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201720182019202020212022202301020304050
Introduction
Dr. Md. Mizanur Rahman Graduated from Sir Salimullah Medical College, Dhaka in 1993, awarded Japanese Government Scholarship (Monbusho) in 1995 for study immunology and earned PhD in Immunology from TohokuUniversity, Sendai, Japan on March 23, 2000.His thesis work was published in international journal "Gene". Just 1 week after PhD Dr. Mizan joined in faculty position as Assistant professor in TohokuUniversityHospital. He got research fellowship from Virginia Commonwealth University, USA and grant from Ministry of Education, Japan. He returned Bangladesh in 2001 and joined in Labaid Diagnostics as "Consultant Immunologist". Along with that, he worked as Assistant professor and Coordinator of School of Health Sciences of State University of Bangladesh. He is the introducer of real time PCR technology in Diagnostics in Bangladesh in 2002 while he was consultant in Labaid and established PCR and Genetic lab. Dr. Mizan again got faculty position as Assistant professor in the department of Immunology of Yamagata University, Japan on November 1, 2004 and worked till June 12, 2011. During this time Dr. Mizan showed (by cloning) existence of an isoform of "interleukin-21", a cytokine which has multiple role in innate, adaptive and autoimmunity. Dr. Mizan published many articles in peer reviewed international journals which can be seen in http://tinyurl.com/drmizanurrahman
Additional affiliations
June 2011 - March 2012
Tohoku University School of Health Sciences
Position
  • Researcher
November 2004 - June 2011
Yamagata University
Position
  • Professor (Assistant)
April 2000 - March 2001
Tohoku University
Position
  • Professor (Assistant)
Description
  • 1. Mizanur Rahman, Yasuhiko Hirabayashi, Ishii Tomonori, Takao Kodera, Miki watanabe, Naruhiko, Takasawa, Takeshi Sasaki. A repressor element in the 5`-untranslated region of human Pax5 exon 1A Gene 263 (2001) 59-66

Publications

Publications (37)
Article
Full-text available
With an increasing number of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) sequences gathered worldwide, we recognize that deletion mutants and nucleotide substitutions that may affect whole-genome sequencing are accumulating. Here, we propose an additional strategy for tiling PCR for whole-genome resequencing, which can make the pip...
Article
Full-text available
Given the breadth of pathogens that cause infections, a single approach that can detect a wide range of pathogens is ideal but is impractical due to the available tests being highly specific to a certain pathogen. Recent developments in sequencing technology have introduced mNGS as an alternative that provides detection of a wide-range of pathogens...
Article
Full-text available
Influenza is one of the most common respiratory virus infections. We analyzed hemagglutinin (HA) and neuraminidase (NA) gene segments of viruses isolated from influenza patients who visited Evercare Hospital Dhaka, Bangladesh, in early 2020 immediately before the coronavirus disease 2019 (COVID-19) pandemic. All of them were influenza virus type A...
Article
Full-text available
Genomic sequences from a complete SARS-CoV-2 open reading frame (ORF) were obtained from 24 patients diagnosed in May 2020 in Dhaka, Bangladesh. All sequences belonged to clade 20A or 20B, and none were variants of concern. Interestingly, one sequence showed a 161-nucleotide deletion in ORF7a.
Article
Full-text available
This is a retrospective observational study aimed to search the alteration of circulating dengue virus (DENV) serotypes in Dhaka City for five consecutive years (2017-2021) along with disease outcome. Methods: Routine dengue NS1 or PCR positive dengue samples from patients who visited Evercare Hospital Dhaka (ex. Apollo Hospitals Dhaka) were select...
Article
Full-text available
Coronavirus Disease 2019 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2). This is a retrospective observational study aimed to find the alteration of some biochemical and hematological parameters of 121 COVID-19 patients admitted in intensive care unit (ICU) of Evercare Hospital Dhaka duri...
Article
Full-text available
In recent decades, chikungunya virus (CHIKV) has become geographically widespread. In 2004, the CHIKV East/Central/South African (ECSA) genotype moved from Africa to Indian ocean islands and India followed by a large epidemic in Southeast Asia. In 2013, the CHIKV Asian genotype drove an outbreak in the Americas. Since 2016, CHIKV has re-emerged in...
Article
Full-text available
Background: Three different genotypes of chikungunya virus (CHIKV) have been classified: East/Central/South African (ECSA), West African (WA), and Asian. Previously, a rapid immunochromatographic (IC) test detecting CHIKV E1-antigen showed high sensitivity for certain ECSA-genotype viruses, but this test showed poor performance against the Asian-g...
Article
Full-text available
Background: Dual antiplatelet (DAPT) treatment with Clopidegrol and Aspirin after percutaneous coronary intervention(PCI) is common practice for the interventionist to prevent thrombotic event after coronary stent placement. In spite of this, significant number of thrombotic events still occur. Exact data on our population regarding the thrombotic...
Article
Full-text available
Background: Dengue virus (DENV) infection is one of the biggest challenges for human health in the world. In addition, a secondary DENV infection sometimes causes dengue hemorrhagic fever (DHF), which frequently leads to death. For this reason, accurate diagnosis record management is useful for prediction of DHF. Therefore, the demand for DENV rap...
Article
Full-text available
Dengue is a mosquito-borne disease that has spread to>100 countries and is caused by the dengue virus (DENV), which belongs to the Flavivirus genus of the family Flaviviridae. DENV comprises 4 serotypes (DENV-1 to -4), and each serotype is further divided into distinct genotypes. In India, it is reported that all 4 serotypes of DENV co-circulate. A...
Preprint
Full-text available
In 2017, an unprecedented increase in febrile illness was observed in Dhaka, Bangladesh. Real-time reverse transcription PCR confirmed that 603 (40.2%) of 1,500 cases were chikungunya fever. Phylogenetic analysis revealed circulation of the non-A226V East/Central/So
Article
Full-text available
Independent outbreaks of dengue virus (DENV) infection and sporadic cases of chikungunya virus (CHIKV) have been reported in Bangladesh on several occasions in the past. However, a massive febrile outbreak was observed in Dhaka city in summer 2017 and many cases turned negative for DENV. As there was high clinical suspicion of chikungunya, routine...
Article
Full-text available
Dengue is a major public health problem in Bangladesh similar to many other tropical regions of the world. There are four serotypes of dengue virus and circulation of all four serotypes were reported in our neighbor countries. Disease severity depends on serotype of dengue virus and serotype changes. So, serotype determination each year and observa...
Article
Full-text available
Chikungunya viral infection in Bangladesh has marked 2017 summer with unprecedented magnitude for the first time. Chikungunya virus (CHIKV) and Dengue virus (DENV) are arboviruses that share the same Aedes mosquito vectors and thus overlap in their endemic areas. These two viruses cause similar clinical presentations, especially in the initial stag...
Article
The cytokine interleukin-21 (IL-21) is mainly produced from activated CD4+T cells and natural killer T (NKT) cells. IL-21 enhances the proliferation and differentiation of T cells and B cells and also increases cytotoxicity of CD8+T cells and NK cells through the IL-21 receptor and its downstream signaling molecules such as signal transducers and a...
Article
Full-text available
p> Background: Chikungunya infection is a Aedes mosquito transmitted viral disease caused by Chikungunya virus (CHIKV), a member of the Alphavirus genus. It is an important human pathogen that causes a syndrome characterized by fever, chills, headache and severe joint pain usually of the smaller joints, with or without swelling. Though the disease...
Article
Mycobacteria are subdivided into three groups: the Mycobacterium tuberculosis complex, the non-tuberculous mycobacteria called NTM or MOTT (Mycobacteria Other Than Tuberculosis) and Mycobacterium leprae. Over the past few decades, the incidence of infections caused by NTM has increased world wide. The differentiation of Mycobacterium tuberculosis c...
Article
Full-text available
Mycobacteria are subdivided into three groups: the Mycobacterium tuberculosis complex, the non-tuberculous mycobacteria called NTM or MOTT (Mycobacteria Other Than Tuberculosis) and Mycobacterium leprae. Over the past few decades, the incidence of infections caused by NTM has increased world wide. The differentiation of Mycobacterium tuberculosis c...
Article
p>Abstract not available Pulse Vol.9 January-December 2016 p.6</p
Article
Full-text available
p> Aim: Nontuberculous mycobacterium (NTM) causes many types of infections including respiratory and non-respiratory infections such as skin and soft tissue infections, lymphadenitis, meningitis, gastro-intestinal infections, disseminated infections and even intravenous catheter-related infections. Increasing incidence of NTM is reported worldwide...
Article
Full-text available
p>Molecular diagnosis is rapidly becoming an inseparable part of disease diagnosis. This cutting edge technology can be used to diagnose both infectious and malignant diseases as well as to help in determining drug dosage, tissue types for organ transplant and risk of inherent disorders. An added advantage is that it provides an indication of thera...
Article
Full-text available
IL-21 is a pleiotropic cytokine that regulates the function of T cells, B cells, natural killer cells, and myeloid cells. We previously identified an IL-21 isoform, IL-21iso, in humans and mice, and found that IL-21iso was secreted in much smaller amounts than conventional IL-21. In this study, we determined that secreted IL-21iso also has less sig...
Article
Interleukin-21 (IL-21) is a pleiotropic cytokine that regulates T-cell, B-cell, NK-cell, and myeloid-cell functions. IL-21 binds with its cognate receptor complex, which consists of the IL-21 receptor (IL-21R) and the common gamma chain (gammac) receptor subunit. We identified novel IL-21R-binding molecule, WD-40 repeats containing SOCS-box-2, WSB-...
Article
Janus kinase 3-severe combined immunodeficiency (JAK3-SCID) is an autosomal recessive immunodeficiency disease caused by various mutations in the JAK3 gene. Typical JAK3-SCID is characterized by a phenotype in which B cells are present but T and NK cells are not, the T(-)B(+)NK(-) phenotype, and by impaired signaling through cytokine receptors that...
Article
Interleukin-21 (IL-21) has pleiotropic functions on the cells, which play roles in both innate and acquired immunity, such as T cells, B cells, natural killer (NK) cells and dendritic cells. In this study we identified a novel isoform of IL-21, IL-21iso in human and mouse. IL-21iso might be an alternative splicing variant form and the C-terminal re...
Article
Pax-5 gene is important transcription factor in B-lymphopoiesis and B-cell development. To understand the regulatory mechanism of pax-5 expression, the immediate 5'-flanking region (6 671 bp) of human pax-gene exon 1B was isolated and characterized. Analysis of the total sequence showed that the proximal promoter includes 3 CAT boxes, 1 SP1 and 1 E...
Article
Full-text available
Glucocorticoids (GCs) induce growth arrest and apoptosis of B lineage cells, especially pre-B and immature B cells, but little is known about this mechanism. Since B cell-specific activator protein (BSAP) encoded by the Pax5 gene is an essential transcription factor for B-cell proliferation, we have investigated the effect of prednisolone sodium su...
Article
Full-text available
B-cell-specific activator protein (BSAP) encoded by the Pax5 gene plays a critical role during B-cell development. We have analyzed the 5′-flanking region plus the 5′-untranslated region (5′-UTR) of human Pax5 exon1A to clarify its regulatory mechanisms. Functional dissection of these regions by luciferase reporter assays indicated that a cluster o...

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Projects

Projects (7)
Project
1. Alteration of biochemical & hematological parameters of COVID-19 patients in ICU 2. Genome sequence analysis of corona virus-2 (SARS-COV-2) in Bangladesh
Project
Dengue virus infection is reported in Bangladesh at least 5 decades ago and its severe form dengue hemorrhagic fever (DHF) is reported about 2 decades ago and since then it is endemic.