Mitsuhiro Enomoto

Mitsuhiro Enomoto
Tokyo Medical and Dental University | TMDU · Department of Orthopaedic Surgery

MD, PhD

About

76
Publications
9,662
Reads
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1,731
Citations
Citations since 2016
31 Research Items
1272 Citations
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
Additional affiliations
July 2011 - present
Tokyo Medical and Dental University
Position
  • Lecturer

Publications

Publications (76)
Article
Full-text available
Neuropathic pain, a heterogeneous condition, affects 7-10% of the general population. To date, efficacious and safe therapeutic approaches remain limited. Antisense oligonucleotide (ASO) therapy has opened the door to treat spinal muscular atrophy, with many ongoing clinical studies determining its therapeutic utility. ASO therapy for neuropathic p...
Article
Full-text available
Purpose: Pathological stimuli or injury to the peripheral nervous system can trigger neuropathic pain with common clinical features such as allodynia and hypersensitivity. Although various studies have identified molecules or genes related to neuropathic pain, the essential components are still unclear. Therefore, in this study, we investigated th...
Article
Schwann cell proliferation in peripheral nerve injury (PNI) enhances axonal regeneration compared to central nerve injury. However, even in PNI, long-term nerve damage without repair induces degeneration of neuromuscular junctions (NMJs), and muscle atrophy results in irreversible dysfunction. The peripheral regeneration of motor axons depends on t...
Article
Full-text available
Objective Magnetospinography (MSG) has been developed for clinical application and is expected to be a novel neurophysiological examination. Here, we used an MSG system with sensors positioned in three orthogonal directions to record lumbar canal evoked magnetic fields (LCEFs) in response to peripheral nerve stimulation and to evaluate methods for...
Article
Full-text available
Hyperbaric oxygen (HBO) treatment promotes early recovery from muscle injury. Reactive oxygen species (ROS) upregulation is a key mechanism of HBO, which produces high O2 content in tissues through increased dissolution of oxygen at high pressure. Nitric oxide (NO), a type of ROS, generally stabilizes hypoxia-inducible factor (HIF) 1α and stimulate...
Article
Introduction: The effects of hyperbaric oxygen (HBO2) therapy on sprains, ligament injuries, and muscle strains have been reported in several animal studies. In a dog model of compartment syndrome and in a rat contused skeletal muscle injury model, the significant effects of HBO2 therapy on the reduction of edema and muscle necrosis have been repo...
Article
Full-text available
Plasmon-based devices are powerful for use in highly sensitive evanescent-field detection and analysis, but they exhibit the problem of limited frequency tunability for fixed structures. This feature causes problems in the multi-frequency investigations required for materials characterization, bio-related research, etc. Here, we propose and fabrica...
Article
Full-text available
This study sought to evaluate the facilitation effect of repetitive multi-train transcranial electrical stimulation (mt-TES) at 2 repetition rates on transcranial electrical motor evoked potential (Tc-MEP) monitoring during spinal surgery, and to assess the induction rate in patients with impaired motor function from a compromised spinal cord or sp...
Article
Background: Decompression sickness (DCS) is a rare condition that is often difficult to diagnose in deep-sea divers. Because of this, prevention and early diagnosis are important. In this case-control study, we examined the risk and preventive factors associated with DCS. Methods: Our original questionnaire survey was conducted among 269 recreat...
Article
Full-text available
Hyperbaric oxygen treatment (HBO) promotes rapid recovery from soft tissue injuries. However, the healing mechanism is unclear. Here we assessed the effects of HBO on contused calf muscles in a rat skeletal muscle injury model. An experimental HBO chamber was developed and rats were treated with 100% oxygen, 2.5 atmospheres absolute for 2 h/day aft...
Article
Full-text available
Background An anterior decompression and fusion (ADF) with the floating method is an effective procedure for treating ossification of the posterior longitudinal ligament (OPLL), allowing a direct decompressive effect on the spinal cord. However, the procedure is skill-intensive, particularly in cases of OPLL with a high canal-occupying ratio. In su...
Article
We report the case of a 54-year-old male compressed-air worker with gas bubbles detected by computed tomography (CT). He had complained of strong abdominal pain 30 minutes after decompression after working at a pressure equivalent to 17 meters of sea water for three hours. The initial CT images revealed gas bubbles in the intrahepatic portal vein,...
Article
Full-text available
Background Radiation therapy is performed as an adjuvant therapy when indicated following surgical resection of malignant tumors. However, radiation exposure induces acute or chronic dermatitis, depending on the radiation dose, interval, tissue volume, or irradiated area of the body. Radiation-induced skin ulcers and osteomyelitis of the underlying...
Article
The aim of this study was to analyze the effect of teeth clenching on dynamic balance at jump-landing. Twenty-five healthy subjects performed jump-landing tasks with or without teeth clenching. The first three trials were performed with no instruction; subsequently, subjects were ordered to clench at the time of landing in the following three trial...
Article
The significant complication rate associated with harvesting autologous iliac bone or fibula has encouraged development of alternative graft substitutes. In this study, the authors investigated the efficacy and safety of synthetic porous hydroxyapatite (HA) combined with local vertebral bone graft for use in anterior cervical corpectomy and fusion...
Article
Full-text available
[Purpose] Fatigue may be an important contributing factor to non-contact anterior cruciate ligament injuries in sports. The purpose of this study was to evaluate the effects of controlled lower limb fatigue, induced by a short-term, high-intensity exercise protocol, on the profile of the ground reaction force during landings from single-leg anterio...
Article
Introduction: Transient osteoporosis of the hip (TOH) is a self-limiting disorder characterized by bone marrow edema at the femoral head and neck. Patients report pain as moderate or severe at onset; pain gradually subsides at about six months (range four to 12 months). Differential diagnosis of the early stages of osteonecrosis of the femoral hea...
Article
Full-text available
The objective of the present study was to clarify the features of otological complications for hyperbaric oxygen therapy (HBOT) and the risk factors for these complications. We enrolled 1115 patients (776 males and 339 females; age 5–89 years) who underwent HBOT. All otological symptoms experienced during HBOT sessions were evaluated, and risk fact...
Article
Background context: Previous studies have shown that compared with laminoplasty, anterior decompression with fusion (ADF) is superior for postoperative neurologic improvement in patients with massive cervical ossification of the posterior longitudinal ligament (OPLL) with a ≥50% canal occupying ratio. However, it is unknown which method, ADF or po...
Article
Full-text available
Mitsuhiro Enomoto1,21Department of Orthopaedic and Spinal Surgery, Graduate School, 2Hyperbaric Medical Center, Tokyo Medical and Dental University, Tokyo, JapanAbstract: Neurotrophic factors (NFs) play important roles in regenerative medicine approaches to mitigate primary and secondary damage after spinal cord injury (SCI) because their receptors...
Article
Full-text available
We examined the effect of hyperbaric oxygen (HBO2) treatment on bone wound healing in a rat calvarial defect. Critical-sized defects were created in the calvaria of adult Wistar rats. The animals were divided into four groups - HBO2, normobaric oxygen, hyperbaric air, and no treatment. Treatments were performed five days a week, for two weeks. Micr...
Article
RNA interference is a powerful tool used to induce loss-of-function phenotypes through post-transcriptional gene silencing. Small interfering RNA (siRNA) molecules have been used to target the central nervous system (CNS) and are expected to have clinical utility against refractory neurodegenerative diseases. However, siRNA is characterized by low...
Article
Full-text available
Pedicle screw insertions are commonly used for posterior fixation to treat various spine disorders. However, the misplacement of pedicle screws can lead to disastrous complications. Inaccurate pedicle screw placement is relatively common even when placement is performed under fluoroscopic control. In order to improve the accuracy of the screw place...
Article
The purpose of this study was to investigate the effects of hyperbaric oxygen (HBO) treatment on muscle fatigue after maximal intermittent plantar flexion exercise. Twenty healthy male volunteers (aged from 21 to 24) were randomly assigned to either HBO or normoxic group and were blinded to their treatment and group assignment. The HBO group breath...
Conference Paper
Objective: Hyperbaric oxygen treatment (HBO) is used for decompression sickness, gas poisoning, fracture of the limbs, and so on. However, HBO is unpopular yet in orofacial fields. Therefore, we examined the facilitatory effect to bone wound healing by HBO in a rat calvarial defect model. Method: Thirty-two adult Wistar rats were divided into HBO...
Article
Full-text available
In the last decade, researchers and clinicians have reported that transplantation of bone marrow stromal cells (BMSCs) promotes functional recovery after brain or spinal cord injury (SCI). However, an appropriate scaffold designed for the injured spinal cord is needed to enhance the survival of transplanted BMSCs and to promote nerve regeneration....
Chapter
The effectiveness of cell transplantation therapy for spinal cord injury (SCI) has been increasingly demonstrated in basic and clinical studies. Ethical considerations specific to Japan and a possible immune response justify the use of autologous cells obtained from patients with SCI. Currently available candidates for autologous cells include bone...
Article
Recently, the use of hyperbaric oxygen (HBO) treatments by elite athletes to accelerate recovery from muscle injuries has become increasingly popular. However, the mechanism of promoting muscle regeneration under HBO conditions has not yet been defined. In this study, we investigated whether HBO treatments promoted muscle regeneration and modulated...
Article
Study design: A prospective comparative study. Objective: To compare prospectively 2 different types of minimally invasive surgery for lumbar spinal canal stenosis (LSCS): unilateral laminotomy for bilateral decompression (ULBD), and muscle-preserving interlaminar decompression (MILD). Summary of background data: Although previous studies have...
Article
Full-text available
Gene therapy for neuropathic pain requires efficient gene delivery to both central and peripheral nervous systems. We previously showed that an adenoassociated virus serotype 9 (AAV9) vector expressing short-hairpin RNA (shRNA) could suppress target molecule expression in the dorsal root ganglia (DRG) and spinal cord upon intrathecal injection. To...
Article
Full-text available
Study design: Retrospective analysis of prospectively collected data from consecutive patients undergoing 2 methods of transcranial electrical motor evoked potential (TCE-MEP) monitoring during cervical spine surgery. Objective: To investigate the efficacy of biphasic transcranial electric stimulation, the deviation rate, amplitude of TCE-MEPs,...
Article
Study design: A prospective clinical study. Objective: To investigate the dynamic causative factor in the pathogenesis of myelopathy in patients with cervical ossification of the posterior longitudinal ligament (OPLL) using kinematic computed tomography (CT) myelography. Summary of background data: Kinematic CT myelography is useful for dynami...
Article
The lack of regeneration of axonal pathways after SCI is associated with the presence of inhibitory molecules within the glial scar, the loss of the neuron's intrinsic capacity to grow and the absence of growth factors. The NGF family of neurotrophins are potent growth factors for several types of supraspinal and sensory axons. It is unclear, howev...
Article
Full-text available
Semaphorin 3A (Sema3A) is a diffusible axonal chemorepellent that has an important role in axon guidance. Previous studies have demonstrated that Sema3a(-/-) mice have multiple developmental defects due to abnormal neuronal innervations. Here we show in mice that Sema3A is abundantly expressed in bone, and cell-based assays showed that Sema3A affec...
Article
Study design: A prospective analysis Objective: Our aim was to investigate the efficacy of new synthetic porous/dense composite hydroxyapatite (HA) for use in anterior cervical discectomy and fusion (ACDF). Summary of background data: Iliac crest bone graft (ICBG) has been traditionally used as the "gold standard" for ACDF. The significant com...
Article
The high prevalence of persistent pain in patients with spinal cord injury (SCI) makes pain management an additional and important consideration in an overall rehabilitation scheme for SCI patients. A number of novel pain mechanisms have been elucidated and potential treatments derived from these mechanisms have been developed, which could be appli...
Article
Full-text available
Study design: A retrospective single-center study. Objective: To clarify preoperative factors predicting unsatisfactory indirect decompression after laminoplasty in patients with cervical spondylotic myelopathy. Summary of background data: Many authors have shown that inadequate indirect decompression after laminoplasty can inhibit neural reco...
Article
Paravertebral muscle activity measurement by surface electromyography (EMG) in lumbar degenerative patients and healthy volunteers. Muscle activity was tested in the standing position, and the influence of low back pain and alignment of the lumbar spine was assessed in the patients with lumbar kyphosis (LDK) or canal stenosis. The number of kyphosi...
Article
Full-text available
Gene therapy for neurological diseases requires efficient gene delivery to target tissues in the central and peripheral nervous systems. Although adeno-associated virus is one of the most promising vectors for clinical use against neurological diseases, it is difficult to get it across the blood-brain barrier. A clinically practical approach to usi...
Article
Flap necrosis remains a major complication of reconstructive surgery. To improve skin flap survival, various treatments with vasodilators, antiplatelet drugs, or the local administration of growth factors have been performed. However, the sufficient prevention of skin necrosis is not well established. Platelet-rich plasma has been used as an autolo...
Article
Full-text available
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by progressive motoneuron loss. Redistribution of transactive response deoxyribonucleic acid-binding protein 43 from the nucleus to the cytoplasm and the presence of cystatin C-positive Bunina bodies are considered pathological hallmarks of amyotrophic lateral sclerosi...
Article
Results: There was a total of 91 excised BCC and 48 excised SCC. In the BCC subgroup, incomplete excision rate was 19% with no recurrences. Additionally , the rate of incomplete excisions in the SCC subgroup was 20% with a 4.17% rate of recurrence. These were either dealt conservatively or re-excised Discussion: Our re-audit revealed that the depar...
Article
A case report of a patient with adhesive arachnoiditis after combined spinal and epidural anesthesia. To report an extremely rare case of paraplegia due to adhesive arachnoiditis with extensive syringomyelia (ES) and a giant anterior arachnoid spinal cyst (AASC) after spinal and epidural anesthesia for obstetric surgery. Progressive inflammation of...
Article
A retrospective single-center study. To investigate how functional recovery is influenced by anterior compression of the spinal cord (ACS) and instability at the level of ACS after laminoplasty in patients with cervical spondylotic myelopathy. There have been many reports that patients whose spinal cord cannot be decompressed sufficiently after lam...
Article
Prospective, comparative clinical study. To compare the clinical outcome of anterior decompression and fusion with floating method and laminoplasty in the treatment of cervical myelopathy caused by ossification of the posterior longitudinal ligament (OPLL). There have been no reports that have accurately and prospectively compared surgical outcomes...
Article
Retrospective case series. To investigate risk factors for early reconstruction failure of multilevel cervical corpectomy with dynamic plate fixation. For anterior cervical decompression and fusion, reinforcement by plate fixation was performed to decrease early reconstruction failure and to increase the fusion rate. However, a relatively high comp...
Article
It is known that Rho family small GTPases activate a number of signal transduction pathways involved in cell cycle progression, gene expression, and cell survival. These small G proteins play an important role in neuronal survival and axon regeneration in neural injury. In this study, we tested whether the activity of RhoA or Rac1 regulates neurite...
Article
A clinical prospective study. To assess whether clinical and radiologic outcomes differ between anterior decompression and fusion (ADF) and laminoplasty (LAMP) in the treatment of cervical spondylotic myelopathy (CSM). No reports to date have accurately and prospectively compared middle-term clinical outcomes after anterior and posterior decompress...