Mitchell Klenner

Mitchell Klenner
Australian Nuclear Science and Technology Organisation | ANSTO · Biosciences

About

32
Publications
1,335
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Publications

Publications (32)
Presentation
Full-text available
ISTR2022 is postponded Scope and background The International Symposium on Technetium and Rhenium – Science and Utilization (ISTR) aims at covering all aspects of Technetium and Rhenium chemistry, from the role of Tc in the nuclear fuel cycle to nuclear medicine applications, extending to catalysis chemistry of Re in the industry. Like the very su...
Presentation
Full-text available
The International Symposium on Technetium and Rhenium – Science and Utilization (ISTR) aims at covering all aspects of Technetium and Rhenium chemistry, from the role of Tc in the nuclear fuel cycle to nuclear medicine applications, extending to catalysis chemistry of Re in the industry. Like the very successful earlier meetings in this series of s...
Article
The deuterium labelling of pharmaceuticals is a useful strategy for altering pharmacokinetic properties, particularly for improving metabolic resistance. The pharmacological effects of such metabolites are often assumed to be negligible during standard drug discovery and are factored in later at the clinical phases of development, where the risks a...
Article
PET–fluorescence multimodal probes provide complimentary information for medical diagnoses. Such probes enable specific functional imaging of a disease state from initial diagnostic positron emission tomography (PET) scans, followed by high spatial resolution, real‐time fluorescence imaging during intraoperative excision of the diseased tissue. Som...
Article
The syntheses of rhenium(I) complexes were achieved under flow microfluidic conditions. The use of a single microreactor was applied towards complexation of the 6‐chloro‐2,2'‐bipyridine diimine ligand, with ideal complexation conditions around 170 °C. Subsequent radiolabelling with [18F]fluoride was further achieved by flowing through a second heat...
Poster
The design of novel radiotracers for use as positron emission tomography (PET) radiopharmaceuticals is contingent on the discovery of novel reactions for incorporating the radioisotope of interest. The most common radioisotope utilised in PET radiopharmaceuticals is fluorine-18, which can be oftentimes difficult to implement due to its relatively s...
Article
Positron emission tomography (PET)‐fluorescence imaging is an emerging field of multimodality imaging seeking to attain synergy between the two techniques. The probes employed in PET‐fluorescence imaging incorporate both a fluorophore and radioisotope which enable complementary information to be obtained from both imaging techniques via the adminis...
Article
Decagram scale syntheses of deuterated mineral oil (d-MO) and poly(1-decene) (d-PD) were achieved by direct catalytic hydrothermal H/D exchange reaction in D2O. Nuclear magnetic resonance (NMR), mass density and small angle neutron scattering (SANS) analyses collectively revealed deuteration ratios of 54±12% and 88±4% for d-MO and d-PD, respectivel...
Article
Full-text available
A novel fluorine-18 method employing rhenium(I) mediation is described herein. The method was found to afford moderate to high radiochemical yields of labelled rhenium(I) complexes. Subsequent thermal dissociation of the complexes enabled the radiosynthesis of fluorine-18 labelled pyridine bidentate structures which could not be radiofluorinated hi...
Presentation
Fluorine-18 radiotracers are commonly employed in positron emission tomography (PET) imaging to investigate biochemical systems and to diagnose disease pathologies. The discovery of new fluorine-18 radiolabelling methods is thus critical to the improved synthesis of new tracers which can image different biochemical interactions or diagnose untreate...
Article
Fluorine‐18 is the most utilized radioisotope in Positron Emission Tomography (PET), but the wide application of fluorine‐18 radiopharmaceuticals is hindered by its challenging labelling conditions. As such, many potentially important radiotracers remain underutilized. Herein, we describe the use of [18F]ethenesulfonyl fluoride (ESF) as a novel rad...
Article
Conjugations with the recently developed [¹⁸F]ethenesulfonyl fluoride ([¹⁸F]ESF) were performed on 5-amino-1,10-phenanthroline, in its free form and coordinated to a rhenium(i) tricarbonyl complex, as a means of radiosynthesizing dual-modal optical and positron emission tomography (PET) tracers. The Michael-donating ability of the aromatic amine wa...
Presentation
Radiotracers are commonly used to investigate biochemical systems in living organisms, and are routinely employed as nuclear medicines to diagnose cancers and other disease pathologies. The discovery of new radiolabeling methods is critical to the improved synthesis of currently existing nuclear medicines, and to enable the synthesis of new radiotr...
Poster
A novel method of producing fluorine-18 radiotracers was discovered when chelating radiolabelling precursor molecules to a source of rhenium for its optical properties. We have found that the fluorine-18 incorporation of such small molecule pyridine-based bidentate molecules increases when complexed to a rhenium metal centre due to both an electron...
Article
Fluorine‐18 labelled prosthetic groups (PGs) are often necessary for radiolabelling sensitive biological molecules such as peptides and proteins. Several shortcomings, however, often diminish the final yield of radiotracer. In an attempt to provide higher yielding and operationally efficient tools for radiolabelling biological molecules, we describ...
Presentation
Nuclear Medicines are used to diagnose cancers and other disease states, and are also often used to study the biochemistry of living organisms. Synthesizing nuclear medicines is typically more difficult than traditional syntheses, particularly due to time-restraints imposed by the decay half-life of the radioisotope. Thus, the design of novel radio...
Poster
The use of metal catalysis/mediation is receiving considerable attention in the field of 18F fluorinations. This is due to the increased molecular scope that such reactions allow, and different metals and substrates have been already demonstrated in literature. In our investigations on the design and synthesis of prospective PET-optical tags, we ha...
Presentation
An initial design concept towards a nuclear-optical hybrid imaging agent was pursued, whereupon rhenium(I) was incorporated to allow for optical imaging, and fluorine-18 was implemented to allow for nuclear imaging via positron emission tomography (PET). However, in the process of radiolabelling this molecule it was discovered that rhenium(I) coord...
Presentation
The discovery of new fluorine-18 radiolabelling methods is critical towards improving the production of positron emission tomography (PET) nuclear medicines. Herein we report on a novel rhenium activation method which improved the synthesis of a radiofluorinated phenanthroline analogue, achieving a four-fold improvement in the radiochemical yield (...
Presentation
Introduction A new radiolabelling method is reported herein1, which not only improves the synthesis of current positron emission tomography (PET) nuclear medicines, though also enables the accessibility of PET nuclear medicines which were previously unobtainable. Results and Discussion Complexation to rhenium(I) was initially intended to provide an...
Presentation
A novel approach to designing positron emission tomography (PET) and optically emitting hybrid medicines was sought, encompassing the chelation of a heterocyclic precursor for fluorine-18 radiolabelling to a phosphorescent rhenium(I) metal centre. The automated radiosynthesis of the multimodal tricarbonyl complex was performed using microfluidic te...
Presentation
The discovery of new radiolabelling methods is critical to the improved synthesis of current nuclear medicines, and to enable the synthesis of new nuclear medicines previously thought to be inaccessible. This presentation will report on such a novel method, which explored the use of transition metals (in particular, rhenium) in order to improve the...
Conference Paper
Objectives Based upon our experience with Re(I) optical emission, we sought to develop a new class of PET/Optical multimodal agents by radiolabelling Re(I) complexes with [18F]fluorine radioisotope. Methods Following the syntheses of the non-radioactive analogues, we trialled the radiosyntheses of [18F]2-fluoro-phenanthroline ([18F]2FPhen) and [...
Presentation
An initial attempt towards designing a multimodal radiotracer for combined positron emission tomography (PET) and optical imaging lead to the discovery of a novel radiofluorination method. Rhenium(I) was used to complex a 2-chloro substituted diimine ligand in order to provide an optical emission profile, alongside a means of substituting an 18F ra...
Article
Azeotropic distillation is typically required to achieve fluorine-18 radiolabelling during the production of positron emission tomography (PET) imaging agents. However, this time consuming process also limits fluorine-18 incorporation, due to radioactive decay of the isotope and its adsorption to the drying vessel. In addressing these limitations,...
Presentation
The contents of this presentation demonstrate the applicable outcomes of using a cyclotron particle accelerator to generate radioisotopes used in the development of new nuclear medicines, such as Positron Emission Tomography (PET) agents. An automated set-up was constructed using microfluidic technologies to perform multiple radiosyntheses of a nov...