Mitchell Booth

Mitchell Booth
University of Western Australia | UWA · School of Biological Sciences

BSc (Hons) Genetics

About

5
Publications
456
Reads
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43
Citations
Additional affiliations
October 2017 - July 2018
Sir Charles Gairdner Hospital
Position
  • Data Manager
Description
  • Overseeing multiple clinical trial coordination and data management for industry backed projects.
April 2016 - July 2017
Telethon Kids Institute
Position
  • Research Assistant
Description
  • Identifying novel chemotherapeutic agents to treat childhood AM/AL Leukaemia. Optimising and using CRISPR/Cas9 to edit novel mutations
November 2015 - April 2016
QAAFI
Position
  • Research Assistant
Description
  • Exploring the Ixodes holocyclus (Paralysis Tick) transcriptome for putative targets for control methods.
Education
February 2019 - February 2022
University of Western Australia
Field of study
  • Plant Science - Genetics
January 2015 - November 2015
The University of Queensland
Field of study
  • Genetics
February 2009 - November 2014
The University of Queensland
Field of study
  • Genetics

Publications

Publications (5)
Article
Full-text available
Plants endure environmental stressors via adaptation and phenotypic plasticity. Studying these mechanisms in seagrasses is extremely relevant as they are important primary producers and functionally significant carbon sinks. These mechanisms are not well understood at the tissue level in seagrasses. Using RNA-seq, we generated transcriptome sequenc...
Article
Full-text available
Venom producing animals are ubiquitously disseminated among vertebrates and invertebrates such as fish, snakes, scorpions, spiders, and ticks. Of the ~890 tick species worldwide, 27 have been confirmed to cause paralysis in mammalian hosts. The Australian paralysis tick ( Ixodes holocyclus ) is the most potent paralyzing tick species known. It is a...
Article
Full-text available
Activation of naïve CD8⁺ T cells stimulates proliferation and differentiation into cytotoxic T-lymphocytes (CTLs). Adoptive T Cell Therapy (ACT) involves multiple rounds of ex vivo activation to generate enough CTLs for reinfusion into patients, but this drives differentiation into terminal effector T cells. Less differentiated CTL populations, suc...
Article
Full-text available
Immunotherapies such as adoptive cell therapy (ACT) are promising treatments for solid cancers. However, relapsing disease remains a problem and the molecular mechanisms underlying resistance are poorly defined. We postulated that the deregulated epigenetic landscape in cancer cells could underpin the acquisition of resistance to immunotherapy. To...
Article
Full-text available
The Australian paralysis tick (Ixodes holocyclus) secretes neuropathic toxins into saliva that induce host paralysis. Salivary glands and viscera were dissected from fully engorged female I. holocyclus ticks collected from dogs and cats with paralysis symptoms. cDNA from both tissue samples were sequenced using Illumina HiSeq 100 bp pair end read t...

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