Miso Virag

• MD
• Klinička bolnica Dubrava

The early techniques of cleft lip repair involved the straight-line technique, the triangular flap technique or some kind of geometric line (triangular, quadrangular closure). A turning point in cleft lip surgery was in 1955 when doctor. Millard presented his method: the rotation-advancement technique or flap, at the First International Congress of...

Objective: Our aim was to compare HPV and p16 expression and their influence on survival and prognosis in oral cavity squamous cell cancer (OCSCC), between non smokers non drinkers (NSND) and smokers drinkers (SD). Subjects and methods: Patients with OCSCC treated with surgery from 2000 to 2010 were included in the study. Patients that did not s...

An 11-year-old girl was referred because of a painless firm swelling in the right posterior mandible that had started 2 months previously. A panoramic radiograph showed a nonspecific finding of a tiny discreet shadow following the lower border of the mandible, without any radiographic signs of radiolucency in the affected area or discontinuity of t...

Objective: Radical neck dissection (RND), utilized for treatment of lymph node metastases in patients with head and neck cancers, can result in clinically significant functional disturbance secondary to the corresponding nerve damage. However, there is only limited data relative to post-operative analysis of impact of RND on the cranial and cervica...

The aim of the present study was to assess the frequency of appearance of stromal myofibroblasts in patients with oral squamous cell carcinoma (OSCC) and to further clarify whether myofibroblasts influence tumour suppression or progression. Surgical resection specimens from 152 patients with cT1-T3N0 OSCC were analysed. The frequency of myofibrobla...

Sclerosing polycystic adenosis (SPA) of salivary glands is a tumorous lesion of salivary glands, with clinical presentation of a slow-growing mass characterized by a combination of histological features some of which are reminiscent of mammary fibrocystic disease. SPA is mostly unifocal, but rarely may be multifocal and/or bilateral. Recurrences ha...

It is still a matter of debate whether sentinel node biopsy might replace neck dissection in patients with clinically neg-ative neck lymph nodes who suffer from oral squamous cell carcinoma. In 30 patients (26 male, 4 female, average age 59.4 years) with oral squamous cell carcinoma we performed ultrasound guided punction of the lymph nodes which w...

Tumours arising from oral minor salivary glands may exhibit an overlap of clinical and morphological features that may produce diagnostic and therapeutic dilemmas. The aim of this study is to asses the value of fine needle aspiration cytology (FNAC) in differentiation of benign and malignant tumours and to render a specific diagnosis. We evaluated...

The aim of this study was to analyse patterns of metastatic spread from cutaneous head and neck melanoma, which are said to be highly variable. The medical records of 145 patients with pathologically proven metastatic melanoma were reviewed retrospectively. The location of pathologically positive lymph nodes was compared with clinically predicted s...

In 2002, International Agency for Research on Cancer launched a multicentric case-control study of head and neck cancer in 15 centres in 11 European countries, Croatia included. The Alcohol-related Cancers and Genetic Susceptibility in Europe (ARCAGE) study database with approximately 2500 case-control pairs is currently the largest head and neck c...

Melanotic neuroectodermal tumour of infancy (MNTI) is an uncommon tumour affecting predominantly the craniofacial bones of the newborn infants. The neural crest origin of the tumour has been confirmed. MNTI is generally accepted as a benign tumour despite of its rapid and locally infiltrative growth. Recurrence rate varies between 10% and 60%, and...

The aim of this study was to determine the types, frequency, distribution, and demographic characteristics of salivary gland tumours in a large representative sample. We retrospectively analysed the medical records of 779 patients with tumours of the salivary glands surgically treated from 1985 to 2009 at a single institution. There were 500 benign...

The sensitivity of teeth anterior to a fracture between the mental and mandibular foramina has been tested and followed up until reinnervation or 3 years has passed. This study assessed the reinnervation period, the number of denervated teeth, and their clinical importance. Fifty patients and 459 teeth were examined. Two hundred and seventy-three t...

Synovial sarcoma (SS) is a malignant mesenchymal tumour, predominantly found in the deep soft tissues of lower extremities, whereas only 3% occur in the head and neck region. Primary synovial sarcoma of the parotid gland is exceptionally uncommon. This is a report of a 15-year-old boy with a synovial sarcoma arising in the parotid gland, and, to th...

A schwannoma or neurilemmoma is a benign, slow growing, usually solitary and encapsulated tumour originating from Schwann cells of the nerve sheath. Approximately 25-40% of all schwannomas are seen in the soft tissues of the head and neck, often originate from the acoustic nerve. Intraoral schwannomas are rare and account for 1% of schwannomas of t...

Chondroid syringoma (CS) is a rare, benign, appendageal tumor with diagnostic feature of myxochondroid stroma supporting eccrine and apocrine epithelial structures. The usual presentation is a painless, slowly growing mass, typically located in the head and neck region. It usually affects middle-aged and older male patients. Because of its unremark...

Tumors of the lip are squamous cell carcinomas in 95% of the cases. Also, in 95% of the cases they arise on a vermilion of the lower lip, because of greater exposure of the lower lip vermilion to direct, cumulative UV radiation which is main etiologic factor in development of squamous cell carcinoma. We have reviewed patients that have been treated...

A total of 21 patients with latissimus dorsi-scapula free flap reconstruction immediately following radical maxillectomy together with orbital exenteration are presented. Orbital exenteration was performed in all patients due to tumour invasion at the time of diagnosis. There was no total flap failure. Two tissue components subdivided into separate...

The aim of this study was to evaluate almost 20 years of using the pectoralis major flap in head and neck reconstruction at the Department of Maxillofacial Surgery, Zagreb. In the period from 1981 to 1999, a total of 506 pectoralis major flaps were used for head and neck reconstruction in 500 patients. In all cases the flap was used after surgical...

Mucoepidermoid carcinoma (MEC) constituting less than 10% of all salivary gland tumors, account for approximately 30% of all malignant tumors, approximately 60% occur in the parotid and 30% in minor salivary glands. The palate is the most frequent localisation for those arising in minor salivary glands. Although the prognosis correlates with the hi...

A role of various cytokines has been implicated in the pathogenesis of many carcinomas, and albeit the role of interleukin 6 (IL-6) and basic fibroblast growth factor (bFGF) in sera has been studied in patients with oral carcinomas, data upon salivary IL-6 and bFGF are lacking. The aim of this study was to evaluate levels of IL-6 and bFGF in the sa...

Role of various cytokines have been implicated in the development and perpetuation of Sjogren's syndrome (SS), but no specific cytokine could be determined as a major contributor to the SS. Salivary and serum interleukin 6 (IL-6) levels have been studied previously in patients with SS, but data upon salivary and serum basic fibroblast growth factor...

For correct diagnosis case history and clinical appearance have the most important role, and diagnostic methods later merely supplement initial knowledge of the disease. Unfortunately, in the daily practice of the maxillofacial surgeon malignant tumours are more frequent than benign tumours and nontumorous lesions, with which they can be confused....

Data can be found in the literature on the roles of interleukin 6 (IL-6) and basic growth factor of fibroblasts (bFGF) in patients with oral carcinomas, although there are no data on salivary IL-6 and bFGF in such patients. The aim of this study was to determine the values of salivary and serum IL-6 and bFGF in 35 patients with planocellular carcin...

The mucous membrane of the oral cavity, covered with multilayered squamous epithelium, is a source of benign and malignant lesions, from simple fibroma to carcinoma of the oral cavity. Because of accessibility of the pathological lesions dental practitioners can, by a routine clinical examination, with no additional diagnostic methods, diagnose and...

The risk of malignant transformation of oral lichen planus remains a controversial issue in the literature. Chronicity of oral lesions has been shown to present low risk of oral cancer which has been identified as arising from areas of erythematous atrophic and erosive lichen planus. It is estimated that malignant transformation of OLP occurs in 0....

The authors present their experience of 27 cases with repairs of defects following radical maxillectomies with free flaps. A total of 28 flaps were used (five latissimus dorsi, six scapula, 16 combination flaps of scapula and latissimus dorsi and one combination of scapula, latissimus dorsi and serratus anterior flap). Only one scapula flap was com...

To evaluate and discuss the free flap reconstructive options for patients with partial and total maxillectomy defects. Retrospective review of cases. Two tertiary referral centers. Fifty-one patients had partial or total maxillectomy defects resulting from oncologic surgical resection, and 7 had partial maxillectomy defects resulting from trauma. I...

In order to find whether the changes in primary tumor definition influence the distribution of T (tumor extent) stages and prognoses, a retrospective study was undertaken. There were 1,040 patients with adequate data for staging and 868 of those patients underwent surgical treatment. Among the surgically treated patients, 187 fulfilled the new (Ame...

The extended anterior subcranial approach differs significantly from more traditional surgical approaches to the skull base in that it allows a broad inferior access to the anterior skull base planes with tumor exposure from below rather than via the transfrontal route. The authors initially used the subcranial approach in 1978 for the treatment of...

Although civilian populations have been heavily involved in most of the recent wars and conflicts throughout the world, most reports analyzed casualty data of military personnel, often leaving civilian casualties excluded or underestimated. A comparison of epidemiologic and medical data for maxillofacial injuries between civilians and servicemen (p...

A modification of the musculomucosal nasolabial island flap based on the facial artery for reconstruction of anterior floor of mouth defects is presented. Surgical technique and advantages in comparison to conventional nasolabial flaps are described. A series of 14 flaps in 8 patients is presented.

A new method for zygomatic arch stabilization with a silicone tube placed under the zygomatic arch is described. The method is safe, easy to perform and, in our experience, without complications.

A total of 124 patients treated for mandibular fractures were analyzed. Patients were divided into three groups according to treatment: intermaxillary fixation, wire fixation and mini-plate fixation. For each method, the success of treatment was evaluated with respect to surgical approach, fracture site and injury to treatment interval. Five basic...

In order to determine whether an in-transit metastasis on the lingual periosteum might be a cause for recurrences of oral cancer, a retrospective review of 576 surgically treated patients was undertaken. In two patients, a simultaneous discontinuous involvement of the periosteum was verified. In 91 patients, a local recurrence was found, and, in 19...

In a prospective randomized study postoperative infections in 54 patients having undergone a 'commando' operation were analysed. The patient were divided into two groups of 27 patients: a group of patients treated with clindamycin 3x80 mg and gentamycin 3x80 mg and a group of patients treated with metronidazol 3x500 mg and gentamycin 3x80 mg. The a...

Malignant tumors of the nasopharynx have their origin in the mucosa or submucosa of the lateral wall, including the Rosenmüller’s fossa, the roof, or the posterior wall of the nasopharynx [1]. Early clinical signs and symptoms of the nasopharyngeal cancer are atypical. Symptoms of the advanced tumors depend on the pathway of their spread and includ...

Summary. The lymphoid stromal reaction in 127 epidermoid carcinomas of the oral cavity has been evaluated. The histological appearance of the peritumoral stroma was analysed with respect to four parametres: stromal thickness, (lymphoid "wall"), density of cellular reaction, penetration of the "wall" and cellular reaction at the penetration site.The...

Summary. The lymphoid stromal reaction in T1 and T2 oral cancer of 75 patients is evaluated. The histological appearance of peritumoral stroma was analysed with respect to four parametres: stromal thickness (lymphoid "wall"), density of cellular reaction, penetration of the wall and cellular reaction at the penetration site. The parametres of the l...

30 patients with carcinoma of the larynx or hypopharynx were irradiated preoperatively with a dosis of 1,500 to 4,500 rads. The results are compared with those of an identical group of patients who were only operated. The operation was mostly partial (20 cases). In laryngeal cancer the cure rate after two years was 69% and 47%, in hypopharyngeal ca...