Mira Meeus

Mira Meeus
Ghent University | UGhent · Department of Rehabilitation Sciences and Physiotherapy

PhD Rehabilitation Sciences

About

296
Publications
146,710
Reads
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9,581
Citations
Additional affiliations
October 2013 - present
University of Antwerp
Position
  • Professor (Associate)
Education
October 1999 - June 2008
Vrije Universiteit Brussel
Field of study
  • Rehabilitation Sciences and Physiotherapy

Publications

Publications (296)
Article
Introduction: Prognosis following surgical rotator cuff repair (RCR) is often established through the assessment of non-modifiable biomedical factors such as tear size. This understates the complex nature of recovery following RCR. There is a need to identify modifiable psychosocial and sleep-related variables, and to find out whether changes in c...
Article
Introduction: Despite the fact that joint bleeds (haemarthrosis) frequently occur in people with haemophilia (PwH) with invalidating arthropathies as result, the clinical pain experience has received only limited attention. A sudden increase in pain intensity can be linked to a bleed, but in most cases, no acute bleed is confirmed. Nevertheless, a...
Article
Full-text available
Objective Although there has been increasing interest in the role of systemic cytokines in chronic spinal pain (CSP), the evidence on their potential contribution is still unclear. Therefore, the current study systematically reviewed the evidence on systemic cytokine level differences between people with CSP compared to healthy controls (HCs) and t...
Article
All studies that investigated personal factors influencing pressure pain threshold (PPT) in healthy people were synthesized. Data was summarized, and risk of bias (RoB) and level of evidence were determined. Results were pooled per influencing factor, grouped by body region and included in meta-analyses. Fifty-four studies were eligible. Five had l...
Article
The majority of people who have nonspecific chronic spinal pain (nCSP) report comorbid insomnia. However, in current treatment strategies for nCSP, insomnia is usually not addressed. Considering the bidirectional interaction between pain and sleep and its underlying psychophysiological mechanisms, insomnia may increase the risk of developing advers...
Article
Full-text available
Frozen shoulder (FS) is a pathology that is difficult to understand and difficult to manage. Over the last ten years, contradictory and new evidence is provided regarding the recovery and its natural course. This narrative review provides new information about the diagnosis and conservative treatment of patients with FS and ongoing research hypothe...
Article
Purpose: Pain and sensory disturbances are common side effects of breast cancer treatment. Differential somatosensory functioning may reflect distinct pathophysiological backgrounds and therapeutic needs. Aim was to examine whether questionnaires evaluating signs and symptoms related to somatosensory functioning correlate sufficiently with quantit...
Presentation
Full-text available
Great multidisciplinary experience for the team of the University of Antwerp and UCLouvain during the World Federation of Haemophilia congress. Nathalie Roussel and Valérie-Anne Chantrain were invited to speak on the necessity of implementing the biopsychosocial model to pain in men with haemophilia and women with bleedings disorders. The interplay...
Article
Psychologically based interventions aim to improve pain-related functioning by targeting pain-related fears, cognitions and behaviors. Mediation and moderation analyses permit further examination of the effect of treatment on an outcome. This systematic review and meta-analysis aims to synthetize the evidence of specific mediators and moderators (i...
Article
Full-text available
Purpose Knowledge regarding risk factors for pain in the long term after surgery for breast cancer may be of great value in preventing this prevalent and debilitating side effect. Despite the biopsychosocial nature of pain, the predictive value of both pre- and postoperative biopsychosocial functioning for long-term pain intensity and pain-related...
Article
Background: Whiplash injuries typically occur from a motor vehicle collision and lead to chronic whiplash-associated disorders (CWAD) in 20% to 50% of cases. Changes in neurotransmission, metabolism, and networks seem to play a role in the pathogenic mechanism of CWAD. Objectives: To further elucidate the functional brain alterations, a neurophy...
Article
Full-text available
Background: Pain after breast cancer surgery is a common and disabling problem. A reliable and valid questionnaire to assess pain-related disability is the Pain Disability Index (0-70). However, properties of the Dutch version (PDI-DLV) have never been investigated in this population. Objective: To assess psychometric properties of the PDI-DLV a...
Article
Background: The hypermobile type of Ehlers-Danlos syndrome (hEDS) is a heritable connective tissue disorder, associated with joint hypermobility and prominent chronic pain. Because experimental pain testing in hEDS is scarce, the underlying mechanisms are still poorly understood. Objective: The present study assesses endogenous pain facilitation...
Article
Full-text available
This paper discusses the growing problem of persisting pain after successful treatment of breast cancer and presents recommendations for improving pain-related outcomes for this group. We discuss the dominant treatment approach for persisting pain post-breast cancer treatment and draw contrasts with contemporary treatment approaches to persistent p...
Article
Background: Conflicting results exist between somatosensory profiles of patients with temporomandibular myalgia (TMDm). The objective of this review was to examine whether adults with TMDm show altered responses to dynamic quantitative sensory tests compared with healthy controls. Methods: We searched five electronic databases for studies, exclu...
Article
Background: Patients with chronic health conditions risk aggravation of their health status due to reduced access to health services during the COVID-19 related lockdown. Objectives: To investigate the impact of Belgian COVID-19 measures on general health status (i.e. worse or stable/better) of patients, adult and pediatric, with chronic health...
Poster
Introduction: Many people with haemophilia (PwH) report invalidating ankle pain. As the ankle is a weight bearing joint, its role in daily functioning is extremely important. While some studies investigated alterations in structure in the talocrural joint (TCJ), studies assessing the subtalar joint (STJ) are lacking and ankle pain in PwH is only po...
Article
Background: Chronic Whiplash Associated Disorders (CWAD) are characterized by long-lasting symptoms of neck pain occurring after an acceleration-deceleration injury. Central sensitization (CS) has been suggested as the possible underlying mechanism for these symptoms, and is characterized by changes in the central nervous system. Besides CS, psych...
Article
Objective: Quantitative sensory testing (QST) are non-invasive psychophysical assessment techniques to evaluate functioning of the somatosensory nervous system. Despite the importance of reliability for correct use of QST results in research and clinical practice, the relative and absolute intra-and inter-rater reliability of a comprehensive QST p...
Article
Full-text available
The current systematic review aimed to compare the effect of injury-focused (specific) exercises versus more general (non-specific) exercises on pain in patients with chronic neck or shoulder pain. We searched PubMed, EMBASE, and Web of Science. Two reviewers screened and selected studies, extracted outcomes, assessed risk of bias, and rated the qu...
Article
Full-text available
Background: The biopsychosocial-spiritual model recognizes the impact of religious factors in modulating the experience of pain. Religious beliefs are factors that can influence perceptions, emotions, and behavior, all of which have important implications on health, pain experience, and treatment outcomes. Objectives: The aim of the present stud...
Article
Background Current evidence supports the use of pain neuroscience education (PNE) in several chronic pain populations. However, the effects of PNE at group level are rather small and little is known about the influence of personal factors (e.g. level of education [LoE]). Objective To examine whether the effectiveness of PNE differs in chronic spin...
Article
Full-text available
Frozen shoulder (FS) is a poorly understood condition resulting in substantial shoulder pain and mobility deficits. The mechanisms behind FS are not yet fully understood, but, similar to other persistent pain states, central pain mechanisms may contribute to ongoing symptoms in this population. The objective of this research was to investigate cond...
Article
Purpose To pilot feasibility and assess preliminary effectiveness of standard and culture-sensitive Pain Neuroscience Education (PNE) among Hausa-speaking patients with Chronic Neck Pain (CNP). Methods Adverts (online & clinic-based) were used to recruit Hausa-speaking patients with nonspecific CNP in Kano, Nigeria. Selected participants were rand...
Article
Full-text available
Although autonomic nervous system (ANS) dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) has been proposed, conflicting evidence makes it difficult to draw firm conclusions regarding ANS activity at rest in ME/CFS patients. Although severe exercise intolerance is one of the core features of ME/CFS, little attempts have bee...
Article
Full-text available
Background Altered lower back muscle activity is proposed as a contributing factor to the reoccurrence and chronicity of low back pain (LBP). This study compared lumbar muscle activity during trunk extension in patients with continuous chronic LBP (CLBP), non-continuous CLBP, recurrent LBP (RLBP) and healthy subjects. Methods In 75 subjects (16 co...
Article
Context: Pain is one of the most complex and prevalent symptoms in the cancer population. Despite the protective role of acute cancer-related pain, it is also an important predictor for the likelihood of developing chronic pain after cancer treatment. Objectives: Since the last systematic review on pain prevalence rates during cancer treatment d...
Article
Full-text available
Chronic spinal pain, including both neck and low back pain, is a common disabling disorder in which sleep problems are frequently reported as a comorbidity. The complex processes of both sleep and chronic pain seem to have overlapping mechanisms, which may explain their often established bidirectional relationship. This systematic review aims to in...
Article
Objective: This explorative study investigates the moderating effect of sex and baseline pain characteristics on the effectiveness of preoperative pain neuroscience education (PNE) plus knee joint mobilization versus biomedical education plus knee joint mobilization in patients who have knee osteoarthritis and are scheduled to undergo total knee a...
Article
Objective : To determine 1) the effect of exercise therapy alone or in combination with other interventions compared to solely exercises and programs with or without exercises? And 2) what kind of exercise therapy or combination with other interventions is most effective? Design : Systematic review and meta-analysis. Participants : Patients with...
Article
Background and Objective After whiplash injury, some patients develop chronic Whiplash Associated Disorders. The exact pathophysiology of this chronification is still unclear and more knowledge is needed regarding the different post-injury phases. Therefore, studies were searched that examined temporal changes in pain processing, measured by Quanti...
Article
Full-text available
Insomnia is a major problem in the chronic spinal pain (CSP) population and has a negative impact on health and well-being. While insomnia is commonly reported, underlying mechanisms explaining the relation between sleep and pain are still not fully understood. Additionally, no reviews regarding the prevention of insomnia and/or associated factors...
Article
Full-text available
This study aimed to develop culturally sensitive pain neuroscience education (PNE) materials for Hausa speaking patients with chronic spinal pain (CSP). PNE is a program of teaching patients about pain that has gained considerable attention in research and is increasingly used during physical therapy for patients with chronic pain. It helps in decr...
Article
Objective This systematic review summarizes the relevant literature on the effectiveness of tailored interventions in non-specific low back pain (NSLBP). Methods The search strategy has been executed in December 2019 in the electronic databases PubMed, Web of Science and Embase. Study selection, data extraction and quality assessment were done ind...
Article
Full-text available
Pediatric chronic pain is a challenging problem for children and their families, although it is still under-recognized and under-treated. The aim of this study was to investigate whether a pain neuroscience education program for children (PNE4Kids) delivered to healthy children aged 8 to 12 years old and attended by their parents would result in im...
Article
Objectives: Quantitative sensory testing (QST) is a non-invasive technique to evaluate functioning of the somatosensory system. In many women surgically treated for breast cancer (BC), somatosensory functioning is disturbed with high prevalence of sensory loss and/or pain. Aims of this systematic review were (1) to summarize literature about QST m...
Presentation
Background Hemophilia is an X-linked hereditary bleeding disorder caused by deficiency in coagulation and a tendency for bleeding in muscles and large synovial joints (i.e. elbows, knees and ankles). Intra-articular bleeding (hemarthrosis) causes synovial hypertrophy and cartilage damage, with gradual but inexorable joint destruction (hemophilic ar...
Article
Full-text available
Objective To synthesize the evidence on the effectiveness of pain science education on pain, psychological factors and physical functioning in adults who underwent surgery. Data sources A systematic literature search of English articles using PubMed/Medline, Embase, Web of Science Core Collection, and Cochrane Library. Review methods The search s...
Article
Patients classified as having whiplash-associated disorder (WAD) grade II, which reflects approximately 93% of patients with WAD who are commonly managed by health care professionals, exhibit both physical (eg, pain and disability) and psychological (eg, fear of movement, anxiety, posttraumatic stress) problems that, in approximately 50% of cases,...
Article
Objective To explore the ability of a self-report activity diary to measure the physical activity level (PAL) in female patients with chronic fatigue syndrome (CFS) and whether illness-related complaints, health-related quality of life domains (HRQOL) or demographic factors are associated with discrepancies between self-reported and objectively mea...
Article
Introduction Breast cancer survivors with secondary upper limb lymphoedema (ULL) may report a wide range of self‐reported symptoms. At the moment, no overview of ULL‐specific symptoms is available. The first aim, therefore, was to compare the prevalence rates of self‐reported signs and symptoms in people with and without secondary ULL due to breast...
Article
Background Pain neuroscience education (PNE) combined with cognition-targeted exercises is an effective treatment for people with chronic spinal pain (CSP). However, it is unclear as to why some patients benefit more from this treatment. We expect that patients with more pronounced maladaptive pain cognitions, such as kinesiophobia, might show poor...
Poster
Introduction: Chronic pain related to haemophilic arthropathy is a major concern in patients with haemophilia (PwH) and impacts their quality of life (QoL). At the present time, the majority of studies dedicated to pain assessment in haemophilia evaluated mainly severe and moderate PwH. Instead, this study focuses on two PwH subgroups that are negl...
Article
A number of hands-off therapies have been widely reported and are used in the management of headache. This systematic review and meta-analysis aimed to assess evidence supporting these therapies on selected headache outcomes. A systematic literature search for randomized clinical trials reporting on the effects of hands-off therapies for headache w...
Article
Objective: To assess centrally induced pain processing with pressure pain thresholds (PPT) bilaterally and remotely in active volleyball and basketball athletes with mild patellar tendinopathy compared to asymptomatic control athletes. Secondary objective was to explore the role of exercised induced analgesia during a training session in athletes...
Article
Study design: Population based cross-sectional study OBJECTIVE.: The aim of this study was to gain a better understanding of changes in muscle morphology in patients with chronic idiopathic neck pain (CINP) and whiplash associated disorder (CWAD). Summary of background data: Worldwide, neck pain is a common health problem with high socio-economi...
Article
Full-text available
Purpose The EU COST Action 15111 collaboration on myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) aims to assess current research and identify knowledge gaps in Europe. Presently, our purpose is to map the effects of non-pharmacological therapies (NPTs) for ME/CFS, and what patients find important in the treatment process. Methods A sc...
Article
Full-text available
Background: Pain can be influenced by several factors, including stress. Stress can have various reactions on pain. These reactions are influenced by several internal factors such as gender, age, and experience with stress or pain. Objectives: To determine the effect of acute stress on mechanical hyperalgesia (with pressure pain thresholds [PPT]...
Article
Background To address the need for a better treatment of chronic whiplash associated disorders (WAD), a contemporary neuroscience approach can be proposed. Objective To examine the effectiveness of a contemporary neuroscience approach, comprising pain neuroscience education, stress management, and cognition-targeted exercise therapy versus convent...
Article
Purpose To summarise factors that might influence treatment outcomes of physical therapy in patients with frozen shoulder. Methods A systematic literature study was performed by searching electronic bibliographies PubMed and Web of Science. Original full text research articles about human adults with frozen shoulder, assessing influencing factors...
Article
Background and objective: To compare different exercise prescriptions for patients with chronic pain along the continuum of nociplastic pain: fibromyalgia, chronic whiplash-associated disorders (CWAD), and chronic idiopathic neck pain (CINP). Databases and data treatment: Randomized controlled trials comparing different exercise parameters were...
Article
Background: Conditioned pain modulation (CPM) methods are experimental procedures to assess presumed descending nociceptive modulatory pathways. Various CPM-methods are currently used, making the comparison of results difficult. The aim of this study was to compare five conditioning stimuli and to evaluate the influencing effects of personal facto...
Article
Full-text available
Purpose Pain is one of the most prevalent problems reported by breast cancer survivors. As this long-lasting complication can result in disabilities on all different domains of functioning, we aimed to clarify the contribution of different factors (pain-related factors, psychosocial factors, and fatigue) to pain-related disability in female breast...
Article
Objective Kinesiophobia is a clinically relevant factor in the management of chronic musculoskeletal pain. The aim of this study was to explore the cross-sectional association between kinesiophobia and both pain intensity and disability among individuals with chronic shoulder pain. Methods A total of 65 participants with chronic unilateral subacro...
Article
Unexplained yet persisting general and widespread non-articular musculoskeletal pain and the associated complaints, known as fibromyalgia (FM), is a common disorder with major social and economic impact. We postulate that in FM dysregulation of neurotransmitter balances at the brain’s insula not only leads to aberrant pain processing but could also...
Article
Background: Differences in pain processing, muscle structure and function have been reported in patients with low back pain (LBP) with different grades of pain chronicity. Objective: The present study aims to examine differences in psychological factors, disability and subjective fatigue between subgroups of LBP based on their chronification gra...
Article
Full-text available
This article explores the effectiveness of a newly developed Pain Neuroscience Education program for children (PNE4Kids) with functional abdominal pain disorder (FAPD). Children (6–12 years) with FAPD were randomly assigned to 1) the experimental group (n = 14), participating in one hypnotherapy session (i.e., usual care) and one additional PNE4Kid...
Article
Background With its high temporal resolution, electroencephalography (EEG), a technique that records electrical activity of cortical neuronal cells, is a potentially suitable technique to investigate human somatosensory processing. By using EEG, the processing of (nociceptive) stimuli can be investigated, along with the functionality of the nocicep...
Article
Background: In the context of interventions aimed at reducing pain, disability and maladaptive pain cognitions in chronic neck pain, it is hypothesized that patients who have greater symptom reduction, possibly also demonstrate greater improvement in cervical motor output. Therefore, the aim of this study was to examine the effect of pain neurosci...
Article
Objective: Acupuncture is a common modality in the therapy of musculoskeletal disorders. The evidence for acupuncture has already been examined frequently but a clear synthesis of previous research is currently lacking. This meta-analysis aims to summarize the evidence for non-immediate effects of acupuncture on pain, functionality and quality of...
Article
Chronic pain is known to alter the brain's network dynamics. These dynamics are often demonstrated by identifying alterations in the brain network topology. A common approach used for this purpose is graph theory. To date, little is known on how these potentially altered networks in chronic pain relate to the symptoms reported by these patients. He...
Poster
Full-text available
BACKGROUND: Pain can be influenced by several factors, including stress. Stress can have various reactions on pain. These reactions are influenced by several internal factors such as gender, age, and experience with stress or pain. OBJECTIVES: To determine the effect of acute stress on mechanical hyperalgesia (with pressure pain thresholds [PPT]),...
Article
Full-text available
Purpose of review Central sensitization (CS) is present in a variety of chronic pain conditions including rheumatoid arthritis (RA). An overview of the treatment options for desensitizing the central nervous system in RA patients, with CS as their dominant pain mechanism, is provided. Recent findings The treatment of pain in RA patients has mostly...
Article
Objectives: To explore the association between psychological factors and shoulder pain intensity, function, as well as local and generalized pressure pain hypersensitivity. Design: a cross-sectional study. Methods: 90 participants with chronic shoulder pain were included. Pressure pain thresholds determined the presence of pain hypersensitivit...
Article
Purpose: Examining whether socio-demographic variables, pain or functionality are related to the degree of clinic-based therapy adherence in patients suffering from nonspecific chronic spinal pain (nCSP). Design: Secondary analysis of a randomized clinical trial. Setting: University hospital of Ghent and Brussels. Methods: Dutch speakers, 18...